| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Kowalska, M Wender, L Lannfel. Lack of association between an intronic polymorphism in the presenilin-1 gene and sporadic late-onset Alzheimer disease in Polish patients. Dementia and geriatric cognitive disorders. vol 9. issue 3. 1998-07-31. PMID:9622000. |
the apolipoprotein e (apoe) gene has in many studies been identified as a susceptibility factor in alzheimer's disease (ad). |
1998-07-31 |
2023-08-12 |
Not clear |
| J Chapman, N Wang, T A Treves, A D Korczyn, N M Bornstei. ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia. Stroke. vol 29. issue 7. 1998-07-30. PMID:9660395. |
ace, mthfr, factor v leiden, and apoe polymorphisms in patients with vascular and alzheimer's dementia. |
1998-07-30 |
2023-08-12 |
Not clear |
| E Drigalenko, S Poduslo, R Elsto. Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease. Neurology. vol 51. issue 1. 1998-07-30. PMID:9674791. |
the association between alzheimer's disease (ad) and alleles at the apoe and the apoci loci were tested. |
1998-07-30 |
2023-08-12 |
Not clear |
| P T Xu, J R Gilbert, H L Qiu, T Rothrock-Christian, D L Settles, A D Roses, D E Schmeche. Regionally specific neuronal expression of human APOE gene in transgenic mice. Neuroscience letters. vol 246. issue 2. 1998-07-28. PMID:9627181. |
apolipoprotein e (apoe, gene; apoe, protein) is a susceptibility gene for late-onset alzheimer's disease (ad). |
1998-07-28 |
2023-08-12 |
mouse |
| P Verpillat, P Margaritte-Jeannin, F Clerget-Darpou. About the use of APOE in Alzheimer's disease studies. American journal of medical genetics. vol 81. issue 2. 1998-07-24. PMID:9613862. |
about the use of apoe in alzheimer's disease studies. |
1998-07-24 |
2023-08-12 |
Not clear |
| Y Zhou, P D Elkins, L A Howell, D H Ryan, R B Harri. Apolipoprotein-E deficiency results in an altered stress responsiveness in addition to an impaired spatial memory in young mice. Brain research. vol 788. issue 1-2. 1998-07-23. PMID:9554991. |
it has been suggested that alzheimer's disease (ad) is associated with an altered neurotrophic function of apolipoprotein-e (apoe) and abnormal neuroendocrine activities. |
1998-07-23 |
2023-08-12 |
mouse |
| F S do Couto, A de Mendonça, C Garcia, L Rocha, M C Lechne. Age of onset in patients with Alzheimer's disease with different apoE genotypes. Journal of neurology, neurosurgery, and psychiatry. vol 64. issue 6. 1998-07-23. PMID:9647321. |
age of onset in patients with alzheimer's disease with different apoe genotypes. |
1998-07-23 |
2023-08-12 |
Not clear |
| F Thibaut, B Coron, D Hannequin, L Segard, C Martin, S Dollfus, D Campion, T Frebourg, M Peti. No association of apolipoprotein epsilon 4 allele with schizophrenia even in cognitively impaired patients. Schizophrenia research. vol 30. issue 2. 1998-07-13. PMID:9549778. |
given the strong association of the apolipoprotein e (apoe) allele epsilon 4 (epsilon 4) with alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the apoe epsilon 4 allele. |
1998-07-13 |
2023-08-12 |
human |
| K Wakabayashi, A Kakita, S Hayashi, K Okuizumi, O Onodera, H Tanaka, A Ishikawa, S Tsuji, H Takahash. Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's disease. Acta neuropathologica. vol 95. issue 5. 1998-07-13. PMID:9600590. |
to elucidate whether the apolipoprotein e epsilon4 allele (apoe4) affects cortical neuropathology in parkinson's disease (pd), we determined apoe genotypes and quantified the densities of cortical lewy bodies (lbs), amyloid plaques and neurofibrillary tangles in 22 autopsy-proven pd cases (12 with dementia; 10 without dementia) that were not accompanied by alzheimer's disease. |
1998-07-13 |
2023-08-12 |
Not clear |
| J E Stewart, E R Skinner, P V Bes. Receptor binding of an apolipoprotein E-rich subfraction of high density lipoprotein to rat and human brain membranes. The international journal of biochemistry & cell biology. vol 30. issue 3. 1998-07-10. PMID:9611781. |
characterisation of the receptor which mediates the uptake of cholesterol from hdl-like complexes by brain cells is important in understanding the role of apoe in the central nervous system and of the alterations which occur in disorders such as alzheimer's disease. |
1998-07-10 |
2023-08-12 |
human |
| S Saarelainen, T Lehtimäki, E Kallonen, K Laasonen, T Poussa, M M Niemine. No relation between apolipoprotein E alleles and obstructive sleep apnea. Clinical genetics. vol 53. issue 2. 1998-07-09. PMID:9611077. |
apolipoprotein e (apoe) is a genetic risk factor influencing the development of cardiovascular diseases and alzheimer's disease. |
1998-07-09 |
2023-08-12 |
Not clear |
| A M Fagan, B A Murphy, S N Patel, J F Kilbridge, W C Mobley, G Bu, D M Holtzma. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Experimental neurology. vol 151. issue 2. 1998-07-09. PMID:9628766. |
the association of the epsilon4 allele of apoe with increased risk for alzheimer's disease (ad) and with poor clinical outcome after certain acute brain injuries has sparked interest in the neurobiology of apoe. |
1998-07-09 |
2023-08-12 |
mouse |
| T Tabir. [Molecular genetics of Alzheimer's disease--presenilin and other genes]. Rinsho shinkeigaku = Clinical neurology. vol 37. issue 12. 1998-07-01. PMID:9577654. |
we also examined association of apolipoprotein e (apoe)epsilon 4, allele a of alpha 1-antichymotrypsin (act), 5 repeat allele of very low density lipoprotein receptor (vldlr) and alzheimer's disease. |
1998-07-01 |
2023-08-12 |
Not clear |
| S Hass, F Fresser, S Köchl, K Beyreuther, G Utermann, G Baie. Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro. The Journal of biological chemistry. vol 273. issue 22. 1998-07-01. PMID:9593736. |
variation at the apoe gene locus has been shown to affect the risk for alzheimer's disease. |
1998-07-01 |
2023-08-12 |
Not clear |
| S Hass, F Fresser, S Köchl, K Beyreuther, G Utermann, G Baie. Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro. The Journal of biological chemistry. vol 273. issue 22. 1998-07-01. PMID:9593736. |
as a functional consequence of this novel app751 ectodomain-mediated apoe binding, the secretion of soluble app751 is differentially affected by distinct apoe isoforms in vitro, suggesting a new "chaperon-like" mechanism by which apoe isoforms may modulate app metabolism and consequently the risk for alzheimer's disease. |
1998-07-01 |
2023-08-12 |
Not clear |
| M Martinez, D Campion, A Brice, D Hannequin, B Dubois, O Didierjean, A Michon, C Thomas-Anterion, M Puel, T Frebourg, Y Agid, F Clerget-Darpou. Apolipoprotein E epsilon4 allele and familial aggregation of Alzheimer disease. Archives of neurology. vol 55. issue 6. 1998-06-25. PMID:9626772. |
to investigate the relationship among risk for alzheimer disease (ad), familial aggregation of ad, and the apolipoprotein e (apoe) epsilon4 allele in first-degree relatives of probands with ad and known apoe genotype. |
1998-06-25 |
2023-08-12 |
Not clear |
| A D Paterson, J L Kenned. Nonparametric linkage does not provide strong evidence for linkage to APOE in a large Alzheimer's kindred. American journal of medical genetics. vol 81. issue 3. 1998-06-24. PMID:9603616. |
nonparametric linkage does not provide strong evidence for linkage to apoe in a large alzheimer's kindred. |
1998-06-24 |
2023-08-12 |
Not clear |
| M Yasuda, E Mori, H Kitagaki, H Yamashita, N Hirono, K Shimada, K Maeda, C Tanak. Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease. The American journal of psychiatry. vol 155. issue 6. 1998-06-18. PMID:9619150. |
the epsilon 4 allele of apolipoprotein e (apoe) is a risk factor or susceptibility gene in late-onset sporadic alzheimer's disease and may influence the pathological changes associated with the disease. |
1998-06-18 |
2023-08-12 |
Not clear |
| M I Kamboh, R E Ferrell, S T DeKosk. Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene. Neuroscience letters. vol 244. issue 2. 1998-06-16. PMID:9572586. |
the e*4 allele of apolipoprotein e (apoe) is a major risk factor for alzheimer's disease (ad) but the underlying mechanism is unknown. |
1998-06-16 |
2023-08-12 |
Not clear |
| B Nacmias, G Marcon, A Tedde, P Forleo, S Latorraca, S Piacentini, L Amaducci, S Sorb. Implication of alpha1-antichymotrypsin polymorphism in familial Alzheimer's disease. Neuroscience letters. vol 244. issue 2. 1998-06-16. PMID:9572591. |
a common polymorphism in the alpha1-antichymotrypsin (act) gene has been shown to modify the apolipoprotein e (apoe) epsilon4-associated alzheimer's disease (ad) risk identifying the combination of the act/aa and apoe epsilon4/epsilon4 genotypes as a potential susceptibility marker for ad. |
1998-06-16 |
2023-08-12 |
Not clear |