| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
in contrast to apoe, no apoa-ii immunoreactivity was observed with pathological structures in alzheimer's disease brain. |
1999-02-11 |
2023-08-12 |
human |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
these differences in cerebrospinal fluid apolipoproteins may influence lipoprotein trafficking and may be an element in the stratification of risk for alzheimer's disease with apoe genotype. |
1999-02-11 |
2023-08-12 |
human |
| T Shinkai, O Ohmori, H Kojima, T Terao, T Suzuki, K Abe, J Nakamur. Apolipoprotein E regulatory region genotype in schizophrenia. Neuroscience letters. vol 256. issue 1. 1999-02-10. PMID:9832216. |
apolipoprotein e (apoe), which has been confirmed to be genetically associated with alzheimer's disease, is thus highlighted as a candidate gene for schizophrenia. |
1999-02-10 |
2023-08-12 |
Not clear |
| K R Williams, A M Saunders, A D Roses, P J Armat. Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons. Neurobiology of disease. vol 5. issue 4. 1999-02-02. PMID:9848097. |
apolipoprotein e (apoe) has been confirmed as a risk factor for late-onset alzheimer's disease (ad) and is associated with neurofibrillary tangles and senile plaques, the microscopic pathological characteristics of ad. |
1999-02-02 |
2023-08-12 |
human |
| W Müller, V Meske, K Berlin, H Scharnagl, W März, T G Oh. Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel. Brain pathology (Zurich, Switzerland). vol 8. issue 4. 1999-01-29. PMID:9804373. |
this novel mechanism is discussed with respect to alzheimer's disease, that is linked for most cases to the apoe epsilon-allelic variation (epsilon4 > epsilon3 > epsilon2). |
1999-01-29 |
2023-08-12 |
rat |
| C Russo, G Angelini, D Dapino, A Piccini, G Piombo, G Schettini, S Chen, J K Teller, D Zaccheo, P Gambetti, M Tabato. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 26. 1999-01-28. PMID:9861015. |
we have characterized the interaction between apolipoprotein e (apoe) and amyloid beta peptide (abeta) in the soluble fraction of the cerebral cortex of alzheimer's disease (ad) and control subjects. |
1999-01-28 |
2023-08-12 |
human |
| G S Zubenko, E Winwood, B Jacobs, I Teply, J S Stiffler, H B Hughes, F J Huff, T Sunderland, A J Martine. Prospective study of risk factors for Alzheimer's disease: results at 7.5 years. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892297. |
the primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for alzheimer's disease and its relationship to the apoe epsilon4 genotype. |
1999-01-27 |
2023-08-12 |
Not clear |
| T Pillot, M Goethals, J Najib, C Labeur, L Lins, J Chambaz, R Brasseur, J Vandekerckhove, M Rossene. Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886074. |
growing evidence indicates the involvement of apolipoprotein e (apoe) in the development of late-onset and sporadic forms of alzheimer's disease, although its exact role remains unclear. |
1999-01-21 |
2023-08-12 |
human |
| U Beffert, J Poirie. ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation. Neuroreport. vol 9. issue 14. 1999-01-20. PMID:9831470. |
apolipoprotein e (apoe) and the beta-amyloid peptide are both found in the senile plaques associated with alzheimer's disease. |
1999-01-20 |
2023-08-12 |
Not clear |
| V R Lombardi, M García, R Cacabelo. Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes. Journal of neuroscience research. vol 54. issue 4. 1999-01-19. PMID:9822164. |
in this study, in vitro cell cultures were established to investigate the effect of different concentrations of human sera (2.5% and 10%) with specific apoe genotypes from alzheimer's and non-alzheimer's subjects on ameboid and flat microglial cells obtained from neonatal rat hippocampi. |
1999-01-19 |
2023-08-12 |
human |
| P M Mattila, T Koskela, M Röyttä, T Lehtimäki, T A Pirttilä, E Ilveskoski, P Karhunen, J O Rinn. Apolipoprotein E epsilon4 allele frequency is increased in Parkinson's disease only with co-existing Alzheimer pathology. Acta neuropathologica. vol 96. issue 4. 1999-01-08. PMID:9797007. |
we determined the apolipoprotein e (apoe) genotype in clinically diagnosed and neuropathologically verified cases of parkinson's disease (pd) (n = 45), with or without alzheimer (ad)-type changes, and compared the apoe genotype with that in healthy age-matched controls (n = 59). |
1999-01-08 |
2023-08-12 |
Not clear |
| B L Scott, K Welch, V deSerrano, N C Moss, A D Roses, W J Strittmatte. Human apolipoprotein E accelerates microtubule polymerization in vitro. Neuroscience letters. vol 245. issue 2. 1999-01-07. PMID:9605496. |
apolipoprotein e (apoe) is a 34-kda protein implicated in alzheimer's disease (ad) that has recently been identified in neuronal cytoplasm. |
1999-01-07 |
2023-08-12 |
human |
| G Einstein, V Patel, P Bautista, M Kenna, L Melone, R Fader, K Karson, S Mann, A M Saunders, C Hulette, D Mash, A D Roses, D E Schmeche. Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. Journal of neuropathology and experimental neurology. vol 57. issue 12. 1999-01-07. PMID:9862642. |
intraneuronal apoe in human visual cortical areas reflects the staging of alzheimer disease pathology. |
1999-01-07 |
2023-08-12 |
human |
| M J Artiga, M J Bullido, A Frank, I Sastre, M Recuero, M A García, C L Lendon, S W Han, J C Morris, J Vázquez, A Goate, F Valdivies. Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811931. |
risk for alzheimer's disease correlates with transcriptional activity of the apoe gene. |
1998-12-15 |
2023-08-12 |
Not clear |
| M J Artiga, M J Bullido, A Frank, I Sastre, M Recuero, M A García, C L Lendon, S W Han, J C Morris, J Vázquez, A Goate, F Valdivies. Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811931. |
while the straightepsilon4 allele of apolipoprotein e ( apoe, gene; apoe, protein) is widely accepted as a major genetic risk factor for the late onset form of alzheimer's disease (ad), recent evidence points to variations in apoe levels as another important factor. |
1998-12-15 |
2023-08-12 |
Not clear |
| M Michikawa, K Yanagisaw. Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. Journal of neuroscience research. vol 54. issue 1. 1998-12-11. PMID:9778150. |
the presence of the apolipoprotein e (apoe) allele epsilon4 is a major risk factor for the development of alzheimer's disease (ad); however, the molecular mechanism underlying the acceleration of ad development in individuals with epsilon4 remains to be determined. |
1998-12-11 |
2023-08-12 |
human |
| J Gelernter, H Kranzler, J Lacobell. Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)). Genomics. vol 52. issue 3. 1998-12-07. PMID:9790747. |
apoe alleles are related to risk of alzheimer disease. |
1998-12-07 |
2023-08-12 |
human |
| D B Marin, B Breuer, M L Marin, J Silverman, J Schmeidler, D Greenberg, S Flynn, M Mare, M Lantz, L Libow, R Neufeld, L Altstiel, K L Davis, R C Moh. The relationship between apolipoprotein E, dementia, and vascular illness. Atherosclerosis. vol 140. issue 1. 1998-11-24. PMID:9733229. |
four hundred fifty individuals met criteria for inclusion into one of the following groups: alzheimer's disease (n = 318), vascular dementia (n = 49), or not demented controls (n = 83) and were investigated for the relationship between apoe and these diagnostic categories. |
1998-11-24 |
2023-08-12 |
human |
| D B Marin, B Breuer, M L Marin, J Silverman, J Schmeidler, D Greenberg, S Flynn, M Mare, M Lantz, L Libow, R Neufeld, L Altstiel, K L Davis, R C Moh. The relationship between apolipoprotein E, dementia, and vascular illness. Atherosclerosis. vol 140. issue 1. 1998-11-24. PMID:9733229. |
in contrast, the apoe epsilon4 allele was more common in patients with alzheimer's disease (22%) and vascular dementia (26%) than in not demented controls (7%). |
1998-11-24 |
2023-08-12 |
human |
| T Town, D Paris, D Fallin, R Duara, W Barker, M Gold, F Crawford, M Mulla. The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neuroscience letters. vol 252. issue 2. 1998-11-23. PMID:9756330. |
the -491a/t apolipoprotein e promoter polymorphism association with alzheimer's disease: independent risk and linkage disequilibrium with the known apoe polymorphism. |
1998-11-23 |
2023-08-12 |
Not clear |