| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Shinkai, O Ohmori, H Kojima, T Terao, T Suzuki, K Abe, J Nakamur. Apolipoprotein E regulatory region genotype in schizophrenia. Neuroscience letters. vol 256. issue 1. 1999-02-10. PMID:9832216. |
apolipoprotein e (apoe), which has been confirmed to be genetically associated with alzheimer's disease, is thus highlighted as a candidate gene for schizophrenia. |
1999-02-10 |
2023-08-12 |
Not clear |
| K R Williams, A M Saunders, A D Roses, P J Armat. Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons. Neurobiology of disease. vol 5. issue 4. 1999-02-02. PMID:9848097. |
apolipoprotein e (apoe) has been confirmed as a risk factor for late-onset alzheimer's disease (ad) and is associated with neurofibrillary tangles and senile plaques, the microscopic pathological characteristics of ad. |
1999-02-02 |
2023-08-12 |
human |
| W Müller, V Meske, K Berlin, H Scharnagl, W März, T G Oh. Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel. Brain pathology (Zurich, Switzerland). vol 8. issue 4. 1999-01-29. PMID:9804373. |
this novel mechanism is discussed with respect to alzheimer's disease, that is linked for most cases to the apoe epsilon-allelic variation (epsilon4 > epsilon3 > epsilon2). |
1999-01-29 |
2023-08-12 |
rat |
| C Russo, G Angelini, D Dapino, A Piccini, G Piombo, G Schettini, S Chen, J K Teller, D Zaccheo, P Gambetti, M Tabato. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 26. 1999-01-28. PMID:9861015. |
we have characterized the interaction between apolipoprotein e (apoe) and amyloid beta peptide (abeta) in the soluble fraction of the cerebral cortex of alzheimer's disease (ad) and control subjects. |
1999-01-28 |
2023-08-12 |
human |
| G S Zubenko, E Winwood, B Jacobs, I Teply, J S Stiffler, H B Hughes, F J Huff, T Sunderland, A J Martine. Prospective study of risk factors for Alzheimer's disease: results at 7.5 years. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892297. |
the primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for alzheimer's disease and its relationship to the apoe epsilon4 genotype. |
1999-01-27 |
2023-08-12 |
Not clear |
| T Pillot, M Goethals, J Najib, C Labeur, L Lins, J Chambaz, R Brasseur, J Vandekerckhove, M Rossene. Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886074. |
growing evidence indicates the involvement of apolipoprotein e (apoe) in the development of late-onset and sporadic forms of alzheimer's disease, although its exact role remains unclear. |
1999-01-21 |
2023-08-12 |
human |
| U Beffert, J Poirie. ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation. Neuroreport. vol 9. issue 14. 1999-01-20. PMID:9831470. |
apolipoprotein e (apoe) and the beta-amyloid peptide are both found in the senile plaques associated with alzheimer's disease. |
1999-01-20 |
2023-08-12 |
Not clear |
| V R Lombardi, M García, R Cacabelo. Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes. Journal of neuroscience research. vol 54. issue 4. 1999-01-19. PMID:9822164. |
in this study, in vitro cell cultures were established to investigate the effect of different concentrations of human sera (2.5% and 10%) with specific apoe genotypes from alzheimer's and non-alzheimer's subjects on ameboid and flat microglial cells obtained from neonatal rat hippocampi. |
1999-01-19 |
2023-08-12 |
human |
| P M Mattila, T Koskela, M Röyttä, T Lehtimäki, T A Pirttilä, E Ilveskoski, P Karhunen, J O Rinn. Apolipoprotein E epsilon4 allele frequency is increased in Parkinson's disease only with co-existing Alzheimer pathology. Acta neuropathologica. vol 96. issue 4. 1999-01-08. PMID:9797007. |
we determined the apolipoprotein e (apoe) genotype in clinically diagnosed and neuropathologically verified cases of parkinson's disease (pd) (n = 45), with or without alzheimer (ad)-type changes, and compared the apoe genotype with that in healthy age-matched controls (n = 59). |
1999-01-08 |
2023-08-12 |
Not clear |
| B L Scott, K Welch, V deSerrano, N C Moss, A D Roses, W J Strittmatte. Human apolipoprotein E accelerates microtubule polymerization in vitro. Neuroscience letters. vol 245. issue 2. 1999-01-07. PMID:9605496. |
apolipoprotein e (apoe) is a 34-kda protein implicated in alzheimer's disease (ad) that has recently been identified in neuronal cytoplasm. |
1999-01-07 |
2023-08-12 |
human |
| G Einstein, V Patel, P Bautista, M Kenna, L Melone, R Fader, K Karson, S Mann, A M Saunders, C Hulette, D Mash, A D Roses, D E Schmeche. Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. Journal of neuropathology and experimental neurology. vol 57. issue 12. 1999-01-07. PMID:9862642. |
intraneuronal apoe in human visual cortical areas reflects the staging of alzheimer disease pathology. |
1999-01-07 |
2023-08-12 |
human |
| M J Artiga, M J Bullido, A Frank, I Sastre, M Recuero, M A García, C L Lendon, S W Han, J C Morris, J Vázquez, A Goate, F Valdivies. Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811931. |
risk for alzheimer's disease correlates with transcriptional activity of the apoe gene. |
1998-12-15 |
2023-08-12 |
Not clear |
| M J Artiga, M J Bullido, A Frank, I Sastre, M Recuero, M A García, C L Lendon, S W Han, J C Morris, J Vázquez, A Goate, F Valdivies. Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811931. |
while the straightepsilon4 allele of apolipoprotein e ( apoe, gene; apoe, protein) is widely accepted as a major genetic risk factor for the late onset form of alzheimer's disease (ad), recent evidence points to variations in apoe levels as another important factor. |
1998-12-15 |
2023-08-12 |
Not clear |
| M Michikawa, K Yanagisaw. Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. Journal of neuroscience research. vol 54. issue 1. 1998-12-11. PMID:9778150. |
the presence of the apolipoprotein e (apoe) allele epsilon4 is a major risk factor for the development of alzheimer's disease (ad); however, the molecular mechanism underlying the acceleration of ad development in individuals with epsilon4 remains to be determined. |
1998-12-11 |
2023-08-12 |
human |
| J Gelernter, H Kranzler, J Lacobell. Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)). Genomics. vol 52. issue 3. 1998-12-07. PMID:9790747. |
apoe alleles are related to risk of alzheimer disease. |
1998-12-07 |
2023-08-12 |
human |
| D B Marin, B Breuer, M L Marin, J Silverman, J Schmeidler, D Greenberg, S Flynn, M Mare, M Lantz, L Libow, R Neufeld, L Altstiel, K L Davis, R C Moh. The relationship between apolipoprotein E, dementia, and vascular illness. Atherosclerosis. vol 140. issue 1. 1998-11-24. PMID:9733229. |
four hundred fifty individuals met criteria for inclusion into one of the following groups: alzheimer's disease (n = 318), vascular dementia (n = 49), or not demented controls (n = 83) and were investigated for the relationship between apoe and these diagnostic categories. |
1998-11-24 |
2023-08-12 |
human |
| D B Marin, B Breuer, M L Marin, J Silverman, J Schmeidler, D Greenberg, S Flynn, M Mare, M Lantz, L Libow, R Neufeld, L Altstiel, K L Davis, R C Moh. The relationship between apolipoprotein E, dementia, and vascular illness. Atherosclerosis. vol 140. issue 1. 1998-11-24. PMID:9733229. |
in contrast, the apoe epsilon4 allele was more common in patients with alzheimer's disease (22%) and vascular dementia (26%) than in not demented controls (7%). |
1998-11-24 |
2023-08-12 |
human |
| T Town, D Paris, D Fallin, R Duara, W Barker, M Gold, F Crawford, M Mulla. The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neuroscience letters. vol 252. issue 2. 1998-11-23. PMID:9756330. |
the -491a/t apolipoprotein e promoter polymorphism association with alzheimer's disease: independent risk and linkage disequilibrium with the known apoe polymorphism. |
1998-11-23 |
2023-08-12 |
Not clear |
| T Town, D Paris, D Fallin, R Duara, W Barker, M Gold, F Crawford, M Mulla. The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neuroscience letters. vol 252. issue 2. 1998-11-23. PMID:9756330. |
the epsilon4 allele of the apolipoprotein e gene (apoe) has repeatedly been associated with increased risk for alzheimer's disease (ad). |
1998-11-23 |
2023-08-12 |
Not clear |
| T Town, D Paris, D Fallin, R Duara, W Barker, M Gold, F Crawford, M Mulla. The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neuroscience letters. vol 252. issue 2. 1998-11-23. PMID:9756330. |
since the -491a/t polymorphism and the known apoe polymorphism must be in tight linkage disequilibrium, and the later polymorphism is know to be associated with the disease, we wished to determine to what extent this linkage disequilibrium explained the -491a/t polymorphism association with alzheimer's disease. |
1998-11-23 |
2023-08-12 |
Not clear |