| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
two hundred and three patients with alzheimer's disease and 288 age and sex matched controls were genotyped by polymerase chain reaction and restriction fragment length polymorphism for bche-k and apoe. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
the study failed to confirm the findings of a previous study which found a significantly higher incidence of bche-k in patients with alzheimer's disease with apoe epsilon4 allele than in controls. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
in the japanese population studied here, there was no association between bche-k and alzheimer's disease, nor an interaction between bche-k and apoe epsilon4 allele. |
1999-08-19 |
2023-08-12 |
Not clear |
| D Praticò, J Rokach, R K Tangiral. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428071. |
differential expression of apoe isoforms has been linked to longevity and to the pathogenesis of alzheimer's disease. |
1999-08-13 |
2023-08-12 |
mouse |
| M F Weiner, G Vega, R C Risser, L S Honig, C M Cullum, D Crumpacker, R N Rosenber. Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimer's disease. Biological psychiatry. vol 45. issue 5. 1999-08-10. PMID:10088051. |
the epsilon 4 allele of apolipoprotein e (apoe epsilon 4) is associated with late-onset alzheimer's disease (ad), but its relationship to various aspects of ad has become increasingly unclear. |
1999-08-10 |
2023-08-12 |
Not clear |
| A Papassotiropoulos, M Bagli, F Jessen, M L Rao, S G Schwab, R Heu. Early-onset and late-onset depression are independent of the genetic polymorphism of apolipoprotein E. Dementia and geriatric cognitive disorders. vol 10. issue 4. 1999-08-05. PMID:10364642. |
we examined the association between depression and the genetic polymorphism of apoe in a large sample of depressed patients, alzheimer's disease (ad) patients, and healthy controls following clear definitions for late-life depression. |
1999-08-05 |
2023-08-12 |
Not clear |
| M Michikawa, K Yanagisaw. Apolipoprotein E4 isoform-specific actions on neuronal cells in culture. Mechanisms of ageing and development. vol 107. issue 3. 1999-08-03. PMID:10360679. |
apolipoprotein e (apoe) allele epsilon4 is a major risk factor for alzheimer's disease (ad); however, the molecular mechanism underlying the acceleration of the development of ad in patients possessing epsilon4 remains to be determined. |
1999-08-03 |
2023-08-12 |
rat |
| M O McCarron, J A Nicoll, J Stewart, J W Ironside, D M Mann, S Love, D I Graham, D Dewa. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411341. |
we performed immunohistochemistry for amyloid beta-protein (a beta), apoe, cystatin c, and activated microglia, and examined the morphology of cortical and leptomeningeal vessels in 37 caa-related hemorrhage (caah), 26 alzheimer disease (ad) patients, and 20 controls. |
1999-07-27 |
2023-08-12 |
Not clear |
| U Beffert, N Aumont, D Dea, S Lussier-Cacan, J Davignon, J Poirie. Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures. Brain research. Molecular brain research. vol 68. issue 1-2. 1999-07-07. PMID:10320795. |
both apolipoprotein e (apoe) and amyloid peptides are associated with alzheimer's disease (ad). |
1999-07-07 |
2023-08-12 |
Not clear |
| S M Laws, K Taddei, G Martins, A Paton, C Fisher, R Clarnette, J Hallmayer, W S Brooks, S E Gandy, R N Martin. The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease. Neuroreport. vol 10. issue 4. 1999-06-29. PMID:10208564. |
the -491aa polymorphism in the apoe gene is associated with increased plasma apoe levels in alzheimer's disease. |
1999-06-29 |
2023-08-12 |
Not clear |
| S M Laws, K Taddei, G Martins, A Paton, C Fisher, R Clarnette, J Hallmayer, W S Brooks, S E Gandy, R N Martin. The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease. Neuroreport. vol 10. issue 4. 1999-06-29. PMID:10208564. |
recent evidence suggests that a polymorphism in the regulatory region of the apolipoprotein e gene (apoe) is associated with an increased risk for developing alzheimer's disease (ad) independent of that conveyed by the epsilon4 allele of apoe. |
1999-06-29 |
2023-08-12 |
Not clear |
| S P McIlroy, M D Vahidassr, D A Savage, C C Patterson, J T Lawson, A P Passmor. Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in Northern Ireland. American journal of medical genetics. vol 88. issue 2. 1999-06-28. PMID:10206233. |
the epsilon-4 allele of apolipoprotein e (apoe) is associated with increased risk of alzheimer's disease (ad), but the pathogenic mechanism is unknown. |
1999-06-28 |
2023-08-12 |
human |
| M Buttini, M Orth, S Bellosta, H Akeefe, R E Pitas, T Wyss-Coray, L Mucke, R W Mahle. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366621. |
these differences in the effects of apoe isoforms on neuronal integrity may relate to the increased risk of alzheimer's disease and to the poor outcome after head trauma and stroke associated with apoe4 in humans. |
1999-06-28 |
2023-08-12 |
mouse |
| T Arai, K Ikeda, H Akiyama, C Haga, M Usami, N Sahara, S Iritani, H Mor. A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits. Acta neuropathologica. vol 97. issue 1. 1999-06-23. PMID:9930898. |
we examined the apolipoprotein e (apoe) genotypes of 19 middle-aged non-demented subjects with cerebral amyloid beta protein (abeta) deposits, and compared the results with those of 16 patients with sporadic alzheimer's disease (ad) and those of 34 age-matched controls. |
1999-06-23 |
2023-08-12 |
human |
| U Beffert, C Arguin, J Poirie. The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease. Neuroscience letters. vol 259. issue 1. 1999-06-14. PMID:10027548. |
the low density lipoprotein receptor-related protein (lrp) gene is a candidate gene for alzheimer's disease (ad) due to its role as a receptor for apolipoprotein e (apoe), a major genetic risk factor for late-onset familial and sporadic ad. |
1999-06-14 |
2023-08-12 |
Not clear |
| R Scacchi, G Gambina, M Ruggeri, M C Martini, G Ferrari, M Silvestri, R Schiavon, R M Corb. Plasma levels of apolipoprotein E and genetic markers in elderly patients with Alzheimer's disease. Neuroscience letters. vol 259. issue 1. 1999-06-14. PMID:10027549. |
besides apolipoprotein e (apoe) polymorphism, whose association with alzheimer's disease (ad) has been confirmed in most of the numerous population samples studied, other markers have been investigated. |
1999-06-14 |
2023-08-12 |
human |
| H Toji, H Maruyama, K Sasaki, S Nakamura, H Kawakam. Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population. Neuroscience letters. vol 259. issue 1. 1999-06-14. PMID:10027555. |
a recent observation has shown that a common polymorphism (-491 a) in the promoter of apolipoprotein e (apoe) was associated with an increased risk for alzheimer's disease (ad) in european decent. |
1999-06-14 |
2023-08-12 |
Not clear |
| M I Kamboh, C E Aston, J Perez-Tur, E Kokmen, R E Ferrell, J Hardy, S T DeKosk. A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease. Neuroscience letters. vol 263. issue 2-3. 1999-06-10. PMID:10213152. |
a novel mutation in the apolipoprotein e gene (apoe*4 pittsburgh) is associated with the risk of late-onset alzheimer's disease. |
1999-06-10 |
2023-08-12 |
human |
| A R Ahmed, S H MacGowan, D Culpan, R W Jones, G K Wilcoc. The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease. Neuroscience letters. vol 263. issue 2-3. 1999-06-10. PMID:10213175. |
several studies have attempted to confirm the association between the recently reported polymorphism located at position -491 in the transcriptional regulatory region of the apolipoprotein e (apoe) gene and alzheimer's disease (ad). |
1999-06-10 |
2023-08-12 |
human |
| R Mielke, K Zerres, S Uhlhaas, J Kessler, W D Heis. Apolipoprotein E polymorphism influences the cerebral metabolic pattern in Alzheimer's disease. Neuroscience letters. vol 254. issue 1. 1999-06-07. PMID:9780089. |
in 49 patients with the clinical diagnosis of probable alzheimer's disease (ad) apoe genotyping as well as regional cerebral glucose metabolism (rcmrgi) using positron emission tomography (pet) of [18f]2-fluoro-2-deoxy-d-glucose (fdg) were studied. |
1999-06-07 |
2023-08-12 |
Not clear |