| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Helisalmi, M Hiltunen, P Valonen, A Mannermaa, A M Koivisto, M Lehtovirta, M Ryynänen, H Soinine. Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals. Journal of neurology. vol 246. issue 9. 1999-12-02. PMID:10525981. |
promoter polymorphism (-491a/t) in the apoe gene of finnish alzheimer's disease patients and control individuals. |
1999-12-02 |
2023-08-12 |
Not clear |
| S Helisalmi, M Hiltunen, P Valonen, A Mannermaa, A M Koivisto, M Lehtovirta, M Ryynänen, H Soinine. Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals. Journal of neurology. vol 246. issue 9. 1999-12-02. PMID:10525981. |
apolipoprotein e (apoe) epsilon4 allele is a major risk factor for the development of alzheimer's disease (ad). |
1999-12-02 |
2023-08-12 |
Not clear |
| C Garcia, T Pinho e Melo, L Rocha, M C Lechne. Cerebral hemorrhage and apoE. Journal of neurology. vol 246. issue 9. 1999-12-02. PMID:10525983. |
the epsilon4 allele of apolipoprotein e (apoe) is found more commonly among patients with alzheimer's disease (ad) than in the normal population. |
1999-12-02 |
2023-08-12 |
human |
| M E Kerr, M Krau. Genetics and the central nervous system: apolipoprotein E and brain injury. AACN clinical issues. vol 9. issue 4. 1999-11-26. PMID:9855862. |
this article presents an overview of the genetic relation between apoe and neuropsychological function in alzheimer disease and proposes a relation between apoe and recovery after head injury. |
1999-11-26 |
2023-08-12 |
Not clear |
| W B Growdon, B S Cheung, B T Hyman, G W Rebec. Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507547. |
lack of allelic imbalance in apoe epsilon3/4 brain mrna expression in alzheimer's disease. |
1999-11-24 |
2023-08-12 |
human |
| W B Growdon, B S Cheung, B T Hyman, G W Rebec. Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507547. |
although the apoe epsilon4 allele is a strong risk factor for alzheimer's disease (ad), it is not deterministic, as many apoe epsilon3/4 individuals do not develop ad. |
1999-11-24 |
2023-08-12 |
human |
| D C Steffens, J C Morgenlande. Initial evaluation of suspected dementia. Asking the right questions. Postgraduate medicine. vol 106. issue 5. 1999-11-24. PMID:10560469. |
genetic testing for the apoe epsilon 4 allele can help confirm the diagnosis in patients with late-onset familial or sporadic alzheimer's disease. |
1999-11-24 |
2023-08-12 |
Not clear |
| R L Oliveri, R Cittadella, G Sibilia, I Manna, P Valentino, A Gambardella, U Aguglia, M Zappia, N Romeo, V Andreoli, F Bono, M Caracciolo, A Quattron. APOE and risk of cognitive impairment in multiple sclerosis. Acta neurologica Scandinavica. vol 100. issue 5. 1999-11-23. PMID:10536914. |
the apoe gene polymorphism and the -491 a/t polymorphism in its regulatory region have been associated with an increased risk for developing alzheimer's disease. |
1999-11-23 |
2023-08-12 |
Not clear |
| T Kovács, N J Cairns, P L Lanto. Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease. Neuroscience letters. vol 273. issue 1. 1999-11-19. PMID:10505652. |
to corroborate this association, we analysed the a2m and apolipoprotein e (apoe) polymorphisms in autopsy cases of the mrc alzheimer's disease brain bank, institute of psychiatry, london. |
1999-11-19 |
2023-08-12 |
Not clear |
| A M Fagan, D M Holtzman, G Munson, T Mathur, D Schneider, L K Chang, G S Getz, C A Reardon, J Lukens, J A Shah, M J LaD. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. The Journal of biological chemistry. vol 274. issue 42. 1999-11-19. PMID:10514484. |
the epsilon4 allele of apolipoprotein e (apoe) is a risk factor for alzheimer's disease via an unknown mechanism(s). |
1999-11-19 |
2023-08-12 |
mouse |
| J M Goulding, D F Signorini, S Chatterjee, J A Nicoll, J Stewart, R Morris, G A Lammi. Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 5. 1999-11-19. PMID:10519874. |
log linear modelling was used to assess the relations between apoe genotype, alzheimer's disease, and cerebrovascular disease pathology scores. |
1999-11-19 |
2023-08-12 |
Not clear |
| L Chen, L Baum, H K Ng, L Y Chan, C P Pan. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human pathology. vol 30. issue 10. 1999-11-02. PMID:10534164. |
in this study, we attempted to find a relationship between apoliprotein e (apoe) genotypes and alzheimer's disease (ad) pathology in different areas of the brain in chinese. |
1999-11-02 |
2023-08-12 |
human |
| L Tilley, K Morgan, J Grainger, P Marsters, L Morgan, J Lowe, J Xuereb, C Wischik, C Harrington, N Kalsheke. Evaluation of polymorphisms in the presenilin-1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease. European journal of human genetics : EJHG. vol 7. issue 6. 1999-11-01. PMID:10482954. |
the e4 allele of the apolipoprotein e gene (apoe) is a major risk factor for late-onset alzheimer's disease (load) but is neither necessary nor sufficient to cause the disease. |
1999-11-01 |
2023-08-12 |
human |
| M Panas, D Avramopoulos, G Karadima, M B Petersen, D Vassilopoulo. Apolipoprotein E and presenilin-1 genotypes in Huntington's disease. Journal of neurology. vol 246. issue 7. 1999-10-26. PMID:10463359. |
the so-called aging genes [e.g., those for apolipoprotein e (apoe) and presenilin-1 (ps-1) have been implicated in determining the age at onset of alzheimer's disease, a disease sharing common clinical features with hd. |
1999-10-26 |
2023-08-12 |
Not clear |
| L M McConnell, G D Sanders, D K Owen. Evaluation of genetic tests: APOE genotyping for the diagnosis of Alzheimer disease. Genetic testing. vol 3. issue 1. 1999-10-21. PMID:10464577. |
evaluation of genetic tests: apoe genotyping for the diagnosis of alzheimer disease. |
1999-10-21 |
2023-08-12 |
Not clear |
| L M McConnell, G D Sanders, D K Owen. Evaluation of genetic tests: APOE genotyping for the diagnosis of Alzheimer disease. Genetic testing. vol 3. issue 1. 1999-10-21. PMID:10464577. |
many studies have now confirmed the association between inheritance of the epsilon 4 allele of the apolipoprotein e (apoe) gene and alzheimer disease (ad). |
1999-10-21 |
2023-08-12 |
Not clear |
| T G Ohm, H Scharnagl, W März, J Boh. Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions. Acta neuropathologica. vol 98. issue 3. 1999-10-20. PMID:10483785. |
in recent research, apolipoprotein-e (apoe) polymorphism has been shown to influence the formation of neurofibrillary changes and the accumulation of beta/a4-amyloid, the histopathological hallmarks of alzheimer's disease (ad). |
1999-10-20 |
2023-08-12 |
Not clear |
| D I Graham, K Horsburgh, J A Nicoll, G M Teasdal. Apolipoprotein E and the response of the brain to injury. Acta neurochirurgica. Supplement. vol 73. 1999-10-20. PMID:10494348. |
after the demonstration of an association between the apoe epsilon 4 and increased risk of subsequent development of both sporadic and late-onset form alzheimer's disease, recent studies have provided additional evidence for the possibility that apoe may play an isoform-specific role in determining both the initial response and the subsequent consequences to acute brain injury. |
1999-10-20 |
2023-08-12 |
Not clear |
| C Ramassamy, D Averill, U Beffert, S Bastianetto, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, J Davignon, R Quirion, J Poirie. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free radical biology & medicine. vol 27. issue 5-6. 1999-10-19. PMID:10490274. |
a great number of epidemiological studies have demonstrated that the frequency of the epsilon4 allele of the apolipoprotein e gene (apoe) is markedly higher in sporadic and in familial late onset alzheimer disease (ad). |
1999-10-19 |
2023-08-12 |
human |
| C Ramassamy, D Averill, U Beffert, S Bastianetto, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, J Davignon, R Quirion, J Poirie. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free radical biology & medicine. vol 27. issue 5-6. 1999-10-19. PMID:10490274. |
lpo levels were significantly elevated in tissues from alzheimer's cases which are homozygous for the epsilon4 allele of apoe, compared to ad epsilon3/epsilon3 cases and controls. |
1999-10-19 |
2023-08-12 |
human |