| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Garcia, T Pinho e Melo, L Rocha, M C Lechne. Cerebral hemorrhage and apoE. Journal of neurology. vol 246. issue 9. 1999-12-02. PMID:10525983. |
the epsilon4 allele of apolipoprotein e (apoe) is found more commonly among patients with alzheimer's disease (ad) than in the normal population. |
1999-12-02 |
2023-08-12 |
human |
| M E Kerr, M Krau. Genetics and the central nervous system: apolipoprotein E and brain injury. AACN clinical issues. vol 9. issue 4. 1999-11-26. PMID:9855862. |
this article presents an overview of the genetic relation between apoe and neuropsychological function in alzheimer disease and proposes a relation between apoe and recovery after head injury. |
1999-11-26 |
2023-08-12 |
Not clear |
| W B Growdon, B S Cheung, B T Hyman, G W Rebec. Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507547. |
lack of allelic imbalance in apoe epsilon3/4 brain mrna expression in alzheimer's disease. |
1999-11-24 |
2023-08-12 |
human |
| W B Growdon, B S Cheung, B T Hyman, G W Rebec. Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507547. |
although the apoe epsilon4 allele is a strong risk factor for alzheimer's disease (ad), it is not deterministic, as many apoe epsilon3/4 individuals do not develop ad. |
1999-11-24 |
2023-08-12 |
human |
| D C Steffens, J C Morgenlande. Initial evaluation of suspected dementia. Asking the right questions. Postgraduate medicine. vol 106. issue 5. 1999-11-24. PMID:10560469. |
genetic testing for the apoe epsilon 4 allele can help confirm the diagnosis in patients with late-onset familial or sporadic alzheimer's disease. |
1999-11-24 |
2023-08-12 |
Not clear |
| R L Oliveri, R Cittadella, G Sibilia, I Manna, P Valentino, A Gambardella, U Aguglia, M Zappia, N Romeo, V Andreoli, F Bono, M Caracciolo, A Quattron. APOE and risk of cognitive impairment in multiple sclerosis. Acta neurologica Scandinavica. vol 100. issue 5. 1999-11-23. PMID:10536914. |
the apoe gene polymorphism and the -491 a/t polymorphism in its regulatory region have been associated with an increased risk for developing alzheimer's disease. |
1999-11-23 |
2023-08-12 |
Not clear |
| T Kovács, N J Cairns, P L Lanto. Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease. Neuroscience letters. vol 273. issue 1. 1999-11-19. PMID:10505652. |
to corroborate this association, we analysed the a2m and apolipoprotein e (apoe) polymorphisms in autopsy cases of the mrc alzheimer's disease brain bank, institute of psychiatry, london. |
1999-11-19 |
2023-08-12 |
Not clear |
| A M Fagan, D M Holtzman, G Munson, T Mathur, D Schneider, L K Chang, G S Getz, C A Reardon, J Lukens, J A Shah, M J LaD. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. The Journal of biological chemistry. vol 274. issue 42. 1999-11-19. PMID:10514484. |
the epsilon4 allele of apolipoprotein e (apoe) is a risk factor for alzheimer's disease via an unknown mechanism(s). |
1999-11-19 |
2023-08-12 |
mouse |
| J M Goulding, D F Signorini, S Chatterjee, J A Nicoll, J Stewart, R Morris, G A Lammi. Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 5. 1999-11-19. PMID:10519874. |
log linear modelling was used to assess the relations between apoe genotype, alzheimer's disease, and cerebrovascular disease pathology scores. |
1999-11-19 |
2023-08-12 |
Not clear |
| L Chen, L Baum, H K Ng, L Y Chan, C P Pan. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human pathology. vol 30. issue 10. 1999-11-02. PMID:10534164. |
in this study, we attempted to find a relationship between apoliprotein e (apoe) genotypes and alzheimer's disease (ad) pathology in different areas of the brain in chinese. |
1999-11-02 |
2023-08-12 |
human |
| L Tilley, K Morgan, J Grainger, P Marsters, L Morgan, J Lowe, J Xuereb, C Wischik, C Harrington, N Kalsheke. Evaluation of polymorphisms in the presenilin-1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease. European journal of human genetics : EJHG. vol 7. issue 6. 1999-11-01. PMID:10482954. |
the e4 allele of the apolipoprotein e gene (apoe) is a major risk factor for late-onset alzheimer's disease (load) but is neither necessary nor sufficient to cause the disease. |
1999-11-01 |
2023-08-12 |
human |
| M Panas, D Avramopoulos, G Karadima, M B Petersen, D Vassilopoulo. Apolipoprotein E and presenilin-1 genotypes in Huntington's disease. Journal of neurology. vol 246. issue 7. 1999-10-26. PMID:10463359. |
the so-called aging genes [e.g., those for apolipoprotein e (apoe) and presenilin-1 (ps-1) have been implicated in determining the age at onset of alzheimer's disease, a disease sharing common clinical features with hd. |
1999-10-26 |
2023-08-12 |
Not clear |
| L M McConnell, G D Sanders, D K Owen. Evaluation of genetic tests: APOE genotyping for the diagnosis of Alzheimer disease. Genetic testing. vol 3. issue 1. 1999-10-21. PMID:10464577. |
evaluation of genetic tests: apoe genotyping for the diagnosis of alzheimer disease. |
1999-10-21 |
2023-08-12 |
Not clear |
| L M McConnell, G D Sanders, D K Owen. Evaluation of genetic tests: APOE genotyping for the diagnosis of Alzheimer disease. Genetic testing. vol 3. issue 1. 1999-10-21. PMID:10464577. |
many studies have now confirmed the association between inheritance of the epsilon 4 allele of the apolipoprotein e (apoe) gene and alzheimer disease (ad). |
1999-10-21 |
2023-08-12 |
Not clear |
| T G Ohm, H Scharnagl, W März, J Boh. Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions. Acta neuropathologica. vol 98. issue 3. 1999-10-20. PMID:10483785. |
in recent research, apolipoprotein-e (apoe) polymorphism has been shown to influence the formation of neurofibrillary changes and the accumulation of beta/a4-amyloid, the histopathological hallmarks of alzheimer's disease (ad). |
1999-10-20 |
2023-08-12 |
Not clear |
| D I Graham, K Horsburgh, J A Nicoll, G M Teasdal. Apolipoprotein E and the response of the brain to injury. Acta neurochirurgica. Supplement. vol 73. 1999-10-20. PMID:10494348. |
after the demonstration of an association between the apoe epsilon 4 and increased risk of subsequent development of both sporadic and late-onset form alzheimer's disease, recent studies have provided additional evidence for the possibility that apoe may play an isoform-specific role in determining both the initial response and the subsequent consequences to acute brain injury. |
1999-10-20 |
2023-08-12 |
Not clear |
| C Ramassamy, D Averill, U Beffert, S Bastianetto, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, J Davignon, R Quirion, J Poirie. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free radical biology & medicine. vol 27. issue 5-6. 1999-10-19. PMID:10490274. |
a great number of epidemiological studies have demonstrated that the frequency of the epsilon4 allele of the apolipoprotein e gene (apoe) is markedly higher in sporadic and in familial late onset alzheimer disease (ad). |
1999-10-19 |
2023-08-12 |
human |
| C Ramassamy, D Averill, U Beffert, S Bastianetto, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, J Davignon, R Quirion, J Poirie. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free radical biology & medicine. vol 27. issue 5-6. 1999-10-19. PMID:10490274. |
lpo levels were significantly elevated in tissues from alzheimer's cases which are homozygous for the epsilon4 allele of apoe, compared to ad epsilon3/epsilon3 cases and controls. |
1999-10-19 |
2023-08-12 |
human |
| L F Lue, Y M Kuo, A E Roher, L Brachova, Y Shen, L Sue, T Beach, J H Kurth, R E Rydel, J Roger. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487842. |
we have characterized amyloid beta peptide (abeta) concentration, abeta deposition, paired helical filament formation, cerebrovascular amyloid angiopathy, apolipoprotein e (apoe) allotype, and synaptophysin concentration in entorhinal cortex and superior frontal gyrus of normal elderly control (nd) patients, alzheimer's disease (ad) patients, and high pathology control (hpc) patients who meet pathological criteria for ad but show no synapse loss or overt antemortem symptoms of dementia. |
1999-10-07 |
2023-08-12 |
Not clear |
| T J Montine, W R Markesbery, W Zackert, S C Sanchez, L J Roberts, J D Morro. The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487843. |
the magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with apoe genotype in alzheimer's disease patients. |
1999-10-07 |
2023-08-12 |
Not clear |