| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Durliat, M André, P J Babi. Conserved protein motifs and structural organization of a fish gene homologous to mammalian apolipoprotein E. European journal of biochemistry. vol 267. issue 2. 2000-03-07. PMID:10632725. |
besides its role in cardiovascular diseases, apoe polymorphism contributes to susceptibility to neurodegenerative diseases, such as alzheimer's disease. |
2000-03-07 |
2023-08-12 |
human |
| J C Lambert, T Brousseau, V Defosse, A Evans, D Arveiler, J B Ruidavets, B Haas, J P Cambou, G Luc, P Ducimetière, F Cambien, M C Chartier-Harlin, P Amouye. Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study. Human molecular genetics. vol 9. issue 1. 2000-02-29. PMID:10587578. |
the varepsilon4 allele of the apoe gene ( apoe ) coding for the apoe4 isoform is associated with an increased risk of myocardial infarction (mi) and of alzheimer's disease (ad). |
2000-02-29 |
2023-08-12 |
Not clear |
| M Lehtovirta, J Partanen, M Könönen, J Hiltunen, S Helisalmi, P Hartikainen, P Riekkinen, H Soinine. A longitudinal quantitative EEG study of Alzheimer's disease: relation to apolipoprotein E polymorphism. Dementia and geriatric cognitive disorders. vol 11. issue 1. 2000-02-29. PMID:10629359. |
apolipoprotein e (apoe) sigma4 allele is a risk factor for late-onset alzheimer's disease (ad) and is proposed to have an impact on cholinergic function in ad. |
2000-02-29 |
2023-08-12 |
Not clear |
| X A Alvarez, R Mouzo, V Pichel, P Pérez, M Laredo, L Fernández-Novoa, L Corzo, R Zas, M Alcaraz, J J Secades, R Lozano, R Cacabelo. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669911. |
double-blind placebo-controlled study with citicoline in apoe genotyped alzheimer's disease patients. |
2000-02-28 |
2023-08-12 |
Not clear |
| X A Alvarez, R Mouzo, V Pichel, P Pérez, M Laredo, L Fernández-Novoa, L Corzo, R Zas, M Alcaraz, J J Secades, R Lozano, R Cacabelo. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669911. |
as compared to placebo, citicoline improved cognitive performance in alzheimer's disease patients with apoe e4 (adas: difference between groups = -3.2 +/- 1.8 scores, p < 0.05; adas-cog: difference between groups = -2.3 +/- 1.5, ns); and this improvement on cognition was more pronounced (adas, p < 0.01; adas-cog: difference between groups = -2.8 +/- 1.3, p < 0.06) in patients with mild dementia (gds < 5). |
2000-02-28 |
2023-08-12 |
Not clear |
| X A Alvarez, R Mouzo, V Pichel, P Pérez, M Laredo, L Fernández-Novoa, L Corzo, R Zas, M Alcaraz, J J Secades, R Lozano, R Cacabelo. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669911. |
according to our results, it seems that citicoline might be a useful treatment in alzheimer's disease, and that the efficacy of this compound is greater in patients with mild mental deterioration and/or bearing the epsilon 4 allele of the apoe. |
2000-02-28 |
2023-08-12 |
Not clear |
| D K Lahiri, Y Xu, J Klaunig, O Baiyewu, A Ogunniyi, K Hall, H Hendrie, A Sahot. Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population. Annals of the New York Academy of Sciences. vol 893. 2000-02-25. PMID:10672260. |
the epsilon 4 allele of apolipoprotein e (apoe) is strongly associated with late-onset alzheimer's disease (ad) in caucasian populations, but our studies suggest that apoe epsilon 4 is not a risk factor for ad in nigerian blacks and is a weak risk factor in african-americans. |
2000-02-25 |
2023-08-12 |
human |
| F Panza, V Solfrizzi, F Torres, F Mastroianni, A Del Parigi, A M Colacicco, A M Basile, C Capurso, R Noya, A Capurs. Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. Neuroscience letters. vol 277. issue 1. 2000-02-15. PMID:10643896. |
apolipoprotein e (apoe) polymorphism was studied in 79 sporadic late onset alzheimer's disease (load) patients, 125 unrelated caregivers or volunteers (19-80 years), and 67 centenarians from apulia, southern italy. |
2000-02-15 |
2023-08-12 |
human |
| M K Bolla, N Wood, S E Humphrie. Rapid determination of apolipoprotein E genotype using a heteroduplex generator. Journal of lipid research. vol 40. issue 12. 2000-02-10. PMID:10588960. |
the apoe gene exhibits two common polymorphisms that have been associated with both coronary artery disease and alzheimer's disease. |
2000-02-10 |
2023-08-12 |
Not clear |
| C Geroldi, M P Laakso, C DeCarli, A Beltramello, A Bianchetti, H Soininen, M Trabucchi, G B Frison. Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study. Journal of neurology, neurosurgery, and psychiatry. vol 68. issue 1. 2000-02-10. PMID:10601411. |
recent evidence indicates that the allele epsilon4 of the apolipoprotein e (apoe), a well known risk factor for alzheimer's disease, might play a part in determining some brain morphological changes both in normal carriers and in patients with alzheimer's disease. |
2000-02-10 |
2023-08-12 |
Not clear |
| C Geroldi, M P Laakso, C DeCarli, A Beltramello, A Bianchetti, H Soininen, M Trabucchi, G B Frison. Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study. Journal of neurology, neurosurgery, and psychiatry. vol 68. issue 1. 2000-02-10. PMID:10601411. |
this study evaluated the effect of the apoe genotype on hippocampal asymmetry in patients with alzheimer's disease carrying 0, 1, and 2 copies of the allele. |
2000-02-10 |
2023-08-12 |
Not clear |
| C Geroldi, M P Laakso, C DeCarli, A Beltramello, A Bianchetti, H Soininen, M Trabucchi, G B Frison. Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study. Journal of neurology, neurosurgery, and psychiatry. vol 68. issue 1. 2000-02-10. PMID:10601411. |
the data indicate a dose dependent effect of the apoe epsilon4 allele on hippocampal volume asymmetry in alzheimer's disease. |
2000-02-10 |
2023-08-12 |
Not clear |
| T Gallard. [Alzheimer's disease and depression]. L'Encephale. vol 25 Spec No 5. 2000-02-08. PMID:10609097. |
those depressions are associated with risk factors shared with alzheimer's disease (sex, age, vascular function, apoe 4) and constitute a risk factor for progression to dementia, requiring regular clinical and neuropsychological follow-up. |
2000-02-08 |
2023-08-12 |
Not clear |
| R L Oliveri, G Nicoletti, R Cittadella, I Manna, D Branca, M Zappia, A Gambardella, M Caracciolo, A Quattron. Apolipoprotein E polymorphisms and Parkinson's disease. Neuroscience letters. vol 277. issue 2. 2000-02-08. PMID:10624815. |
recently, a newly described functional polymorphism in the regulatory region of the apoe gene, (-491 a/t), has been associated with late-onset alzheimer's disease. |
2000-02-08 |
2023-08-12 |
Not clear |
| J Thome, J C Gewirtz, N Sakai, V Zachariou, P Retz-Junginger, W Retz, R S Duman, M Rösle. Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia? Neuroscience letters. vol 274. issue 1. 2000-02-04. PMID:10530514. |
in addition to the apolipoprotein e (apoe) tri-allele polymorphism, genetic variants of the apolipoprotein e promoter (-491a/t) and the bleomycin hydrolase (bh-pen) gene have also been proposed as genetic risk factors for alzheimer's dementia (ad). |
2000-02-04 |
2023-08-12 |
human |
| O Combarros, A Alvarez-Arcaya, A Oterino, J Berciano, M Delgado-Rodríguez, N Peña, C Fernández-Viadero, J Luis Pérez-López, S Setién, A Carvaja. Polymorphisms in the presenilin 1 and presenilin 2 genes and risk for sporadic Alzheimer's disease. Journal of the neurological sciences. vol 171. issue 2. 2000-02-03. PMID:10581373. |
we examined the possible involvement of polymorphisms of the presenilin 1 (ps1) and presenilin 2 (ps2) genes in the risk for sporadic alzheimer's disease (ad), either through an independent effect or through interaction with the existing apolipoprotein e (apoe) risk, in 211 ad cases and 188 age-matched control subjects. |
2000-02-03 |
2023-08-12 |
human |
| K R Bales, T Verina, D J Cummins, Y Du, R C Dodel, J Saura, C E Fishman, C A DeLong, P Piccardo, V Petegnief, B Ghetti, S M Pau. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611368. |
apoe appears to play an essential role in amyloid deposition in brain, one of the neuropathological hallmarks of alzheimer's disease. |
2000-01-27 |
2023-08-12 |
mouse |
| R M Evans, C L Emsley, S Gao, A Sahota, K S Hall, M R Farlow, H Hendri. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans. Neurology. vol 54. issue 1. 2000-01-27. PMID:10636159. |
serum cholesterol, apoe genotype, and the risk of alzheimer's disease: a population-based study of african americans. |
2000-01-27 |
2023-08-12 |
Not clear |
| U Beffert, J S Cohn, C Petit-Turcotte, M Tremblay, N Aumont, C Ramassamy, J Davignon, J Poirie. Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent. Brain research. vol 843. issue 1-2. 2000-01-24. PMID:10528114. |
the epsilon4 allele of apolipoprotein e (apoe) is associated with increased risk for the development of alzheimer's disease (ad), possibly due to interactions with the beta-amyloid (abeta) protein. |
2000-01-24 |
2023-08-12 |
human |
| G I Korovaitseva, S Premkumar, A Grigorenko, Y Molyaka, V Galimbet, N Selezneva, S I Gavrilova, L A Farrer, E I Rogae. Alpha-2 macroglobulin gene in early- and late-onset Alzheimer disease. Neuroscience letters. vol 271. issue 2. 2000-01-21. PMID:10477119. |
recently it was reported that inheritance of the deletion allele (a2m-2) confers increased risk for late-onset alzheimer disease (ad) with significance of this effect similar to the epsilon4 allele of apolipoprotein e (apoe). |
2000-01-21 |
2023-08-12 |
Not clear |