| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E R Martin, E H Lai, J R Gilbert, A R Rogala, A J Afshari, J Riley, K L Finch, J F Stevens, K J Livak, B D Slotterbeck, S H Slifer, L L Warren, P M Conneally, D E Schmechel, I Purvis, M A Pericak-Vance, A D Roses, J M Vanc. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. American journal of human genetics. vol 67. issue 2. 2000-08-21. PMID:10869235. |
to begin to look at issues surrounding the use of snps in complex disease studies, we have initiated a collaborative snp mapping study around apoe, the well-established susceptibility gene for late-onset alzheimer disease (ad). |
2000-08-21 |
2023-08-12 |
human |
| S Helisalmi, R Valve, M K Karvonen, M Hiltunen, M Pirskanen, A Mannermaa, M Koulu, U Pesonen, M Uusitupa, H Soinine. The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E. Neuroscience letters. vol 287. issue 1. 2000-08-18. PMID:10841982. |
the leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with alzheimer's disease or the link apolipoprotein e. both apolipoprotein e varepsilon4 allele (apoe varepsilon4) and neuropeptide y (npy) pro(7)-variant have been reported to be associated with higher serum levels of total and ldl cholesterol. |
2000-08-18 |
2023-08-12 |
Not clear |
| S Helisalmi, R Valve, M K Karvonen, M Hiltunen, M Pirskanen, A Mannermaa, M Koulu, U Pesonen, M Uusitupa, H Soinine. The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E. Neuroscience letters. vol 287. issue 1. 2000-08-18. PMID:10841982. |
since apoe varepsilon4 allele is also a major risk factor for the development of alzheimer's disease (ad) and the genetic polymorphism of npy has not previously been studied in dementing disorders, we have examined whether a novel polymorphism in a signal peptide of npy gene is associated with ad alone or in combination with apoe varepsilon4. |
2000-08-18 |
2023-08-12 |
Not clear |
| S Deb, J Braganza, N Norton, H Williams, P G Kehoe, J Williams, M J Owe. APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome. The British journal of psychiatry : the journal of mental science. vol 176. 2000-08-17. PMID:10912224. |
apoe epsilon 4 influences the manifestation of alzheimer's disease in adults with down's syndrome. |
2000-08-17 |
2023-08-12 |
Not clear |
| S Deb, J Braganza, N Norton, H Williams, P G Kehoe, J Williams, M J Owe. APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome. The British journal of psychiatry : the journal of mental science. vol 176. 2000-08-17. PMID:10912224. |
recent studies of the relationship between the apolipoprotein e (apoe) gene and alzheimer's disease in adults with down's syndrome have revealed inconsistent results. |
2000-08-17 |
2023-08-12 |
Not clear |
| S Y Bookheimer, M H Strojwas, M S Cohen, A M Saunders, M A Pericak-Vance, J C Mazziotta, G W Smal. Patterns of brain activation in people at risk for Alzheimer's disease. The New England journal of medicine. vol 343. issue 7. 2000-08-17. PMID:10944562. |
the epsilon4 allele of the apolipoprotein e gene (apoe) is the chief known genetic risk factor for alzheimer's disease, the most common cause of dementia late in life. |
2000-08-17 |
2023-08-12 |
Not clear |
| S Y Bookheimer, M H Strojwas, M S Cohen, A M Saunders, M A Pericak-Vance, J C Mazziotta, G W Smal. Patterns of brain activation in people at risk for Alzheimer's disease. The New England journal of medicine. vol 343. issue 7. 2000-08-17. PMID:10944562. |
to determine the relation between brain responses to tasks requiring memory and the genetic risk of alzheimer's disease, we performed apoe genotyping and functional magnetic resonance imaging (mri) of the brain in older persons with intact cognition. |
2000-08-17 |
2023-08-12 |
Not clear |
| A M Cataldo, C M Peterhoff, J C Troncoso, T Gomez-Isla, B T Hyman, R A Nixo. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. The American journal of pathology. vol 157. issue 1. 2000-08-08. PMID:10880397. |
endocytic pathway abnormalities precede amyloid beta deposition in sporadic alzheimer's disease and down syndrome: differential effects of apoe genotype and presenilin mutations. |
2000-08-08 |
2023-08-12 |
Not clear |
| A M Cataldo, C M Peterhoff, J C Troncoso, T Gomez-Isla, B T Hyman, R A Nixo. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. The American journal of pathology. vol 157. issue 1. 2000-08-08. PMID:10880397. |
endocytosis is critical to the function and fate of molecules important to alzheimer's disease (ad) etiology, including the beta protein precursor (betapp), amyloid beta (abeta) peptide, and apolipoprotein e (apoe). |
2000-08-08 |
2023-08-12 |
Not clear |
| T Katsuya, N Sato, T Asai, M Fukuda, S Takiuchi, Y Fu, R Hanayama, A Moriguchi, H Rakugi, J Higaki, T Ogihar. Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese. Hypertension research : official journal of the Japanese Society of Hypertension. vol 23. issue 3. 2000-08-04. PMID:10821138. |
the epsilon4 allele of apolipoprotein e (apoe) is reported to be a genetic risk factor of atherosclerosis through hyperlipidemia and late-onset alzheimer's dementia. |
2000-08-04 |
2023-08-12 |
human |
| T Katsuya, N Sato, T Asai, M Fukuda, S Takiuchi, Y Fu, R Hanayama, A Moriguchi, H Rakugi, J Higaki, T Ogihar. Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese. Hypertension research : official journal of the Japanese Society of Hypertension. vol 23. issue 3. 2000-08-04. PMID:10821138. |
a recent report showed that a genetic variant (a -491t) in the promoter region of the apoe gene increases the risk of alzheimer's disease. |
2000-08-04 |
2023-08-12 |
human |
| A Hoy, B Leininger-Muller, C Jolivalt, G Sies. Effect of apolipoprotein E on cell viability in a human neuroblastoma cell line: influence of oxidation and lipid-association. Neuroscience letters. vol 285. issue 3. 2000-08-01. PMID:10806314. |
apolipoprotein e (apoe) whose polymorphic expression is widely associated with alzheimer's disease (ad) is one of the most studied protein present in cerebral amyloid deposits. |
2000-08-01 |
2023-08-12 |
human |
| T Tokuda, M Calero, E Matsubara, R Vidal, A Kumar, B Permanne, B Zlokovic, J D Smith, M J Ladu, A Rostagno, B Frangione, J Ghis. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. The Biochemical journal. vol 348 Pt 2. 2000-07-31. PMID:10816430. |
the inheritance of the apolipoprotein e (apoe) epsilon4 allele is a prevailing risk factor for sporadic and familial alzheimer's disease (ad). |
2000-07-31 |
2023-08-12 |
human |
| T Tokuda, M Calero, E Matsubara, R Vidal, A Kumar, B Permanne, B Zlokovic, J D Smith, M J Ladu, A Rostagno, B Frangione, J Ghis. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. The Biochemical journal. vol 348 Pt 2. 2000-07-31. PMID:10816430. |
apoe isoforms bind directly to alzheimer's amyloid beta (abeta) peptides both in vitro and in vivo. |
2000-07-31 |
2023-08-12 |
human |
| R A Samatovic. Genetics and brain injury: apolipoprotein E. The Journal of head trauma rehabilitation. vol 15. issue 3. 2000-07-27. PMID:10785619. |
the apoe epsilon4 genotype has been implicated as a risk factor for alzheimer's disease. |
2000-07-27 |
2023-08-12 |
Not clear |
| R A Samatovic. Genetics and brain injury: apolipoprotein E. The Journal of head trauma rehabilitation. vol 15. issue 3. 2000-07-27. PMID:10785619. |
this article presents an overview of the relationship between apo e, alzheimer's disease, and head injury and reviews recent studies implicating apoe epsilon4 as a possible genetic determinant in recovery from head injury. |
2000-07-27 |
2023-08-12 |
Not clear |
| M Ganguli, V Chandra, M I Kamboh, J M Johnston, H H Dodge, B K Thelma, R C Juyal, R Pandav, S H Belle, S T DeKosk. Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study. Archives of neurology. vol 57. issue 6. 2000-07-13. PMID:10867779. |
the apoe*e4 allele of the gene for apolipoprotein e (apoe) has been reported as a risk factor for alzheimer disease (ad) to varying degrees in different ethnic groups. |
2000-07-13 |
2023-08-12 |
Not clear |
| P Zill, F Padberg, S de Jonge, H Hampel, K Bürger, S Stübner, T Boetsch, H Jürgen Möller, M Ackenheil, B Bond. Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771175. |
several studies have attempted to confirm an association between a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-htt) and alzheimer's disease independent from the apolipoprotein e (apoe) varepsilon4 status. |
2000-07-03 |
2023-08-12 |
Not clear |
| D M Holtzman, A M Fagan, B Mackey, T Tenkova, L Sartorius, S M Paul, K Bales, K H Ashe, M C Irizarry, B T Hyma. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Annals of neurology. vol 47. issue 6. 2000-06-23. PMID:10852539. |
the epsilon4 allele of apolipoprotein e (apoe) is an important genetic risk factor for alzheimer's disease (ad). |
2000-06-23 |
2023-08-12 |
mouse |
| L Traykov, A S Rigaud, L Caputo, R Couderc, J Coste, J L Michot, J de Rotrou, P Amouyel, F Forette, F Bolle. Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. European journal of neurology. vol 6. issue 4. 2000-06-21. PMID:10362893. |
controversy exists regarding the apolipoprotein e (apoe) epsilon4 allele association with vascular dementia (vad), ranging from increased epsilon4 frequency, similar to that found for alzheimer's disease (ad), to no association between the epsilon4 allele and vad. |
2000-06-21 |
2023-08-12 |
Not clear |