| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Zurutuza, P Verpillat, G Raux, D Hannequin, M Puel, S Belliard, A Michon, Y Pothin, A Camuzat, C Penet, C Martin, A Brice, D Campion, F Clerget-Darpoux, T Frebour. APOE promoter polymorphisms do not confer independent risk for Alzheimer's disease in a French population. European journal of human genetics : EJHG. vol 8. issue 9. 2000-10-12. PMID:10980578. |
the apolipoprotein e (apoe, gene; apoe, protein) isoforms are associated with differential risk of alzheimer's disease (ad). |
2000-10-12 |
2023-08-12 |
Not clear |
| T Rodriguez Martin, A M Calella, S Silva, E Munna, P Modena, R Chiesa, S Terrevazzi, R M Ruggieri, R Palermo, F Piccoli, R Confalonieri, P Tiraboschi, C Fragiacomo, P Quadri, U Lucca, G Forlon. Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 11. issue 5. 2000-10-11. PMID:10940674. |
apolipoprotein e (apoe) genotypes, presenilin 1 (ps-1) and alpha(1)-antichymotrypsin (act) polymorphism and the association of the genotypes were examined in patients with alzheimer's disease (ad, n = 121) or vascular dementia (vd, n = 68) in comparison with elderly controls (n = 125). |
2000-10-11 |
2023-08-12 |
Not clear |
| M J Bullido, F Valdivies. Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936877. |
the increasing body of data, both epidemiological and functional, is strengthening the evidence that apolipoprotein e (apoe, gene; apoe, protein) is a true susceptibility factor for the onset of the common form of alzheimer's disease. |
2000-10-04 |
2023-08-12 |
Not clear |
| L Baum, L Chen, H K Ng, C P Pan. Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936880. |
the apolipoprotein e (apoe) epsilon4 allele increases risk of alzheimer's disease (ad), perhaps by accelerating plaque formation, or by impairing neuron repair. |
2000-10-04 |
2023-08-12 |
mouse |
| C N Bassett, K S Montine, M D Neely, L L Swift, T J Montin. Cerebrospinal fluid lipoproteins in Alzheimer's disease. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936881. |
interest in cerebrospinal fluid (csf) lipoproteins has been stimulated by the association of certain alleles of the human apolipoprotein e gene (apoe) with an increased risk of alzheimer's disease (ad), and because apolipoprotein e (apoe) is one of the major apolipoproteins in csf. |
2000-10-04 |
2023-08-12 |
human |
| L Baum, H Wiebusch, C P Pan. Roles for lipoprotein lipase in Alzheimer's disease: an association study. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936883. |
because apoe and lrp polymorphisms alter alzheimer's disease (ad) risk, and lpl itself is found in ad amyloid plaques, we examined whether lpl variants also affect ad risk. |
2000-10-04 |
2023-08-12 |
human |
| A M Fagan, D M Holtzma. Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936884. |
the genetic association between the e4 isoform of apolipoprotein e (apoe) and increased risk for alzheimer's disease (ad) has prompted interest in the neurobiology of apoe and the possible relationship between lipoprotein metabolism in the brain and neurodegenerative disease. |
2000-10-04 |
2023-08-12 |
mouse |
| G M Cole, M D Ar. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936886. |
amyloid beta-protein (abeta), the major component of plaques in alzheimer's disease, is a small hydrophobic protein that is carried on apolipoprotein e (apoe)- and apoj-containing lipoprotein particles in plasma and cerebrospinal fluid (csf). |
2000-10-04 |
2023-08-12 |
Not clear |
| A A Golabek, E Kida, M Walus, C Perez, T Wisniewski, C Sot. Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophysical journal. vol 79. issue 2. 2000-09-29. PMID:10920030. |
sodium dodecyl sulfate-resistant complexes of alzheimer's amyloid beta-peptide with the n-terminal, receptor binding domain of apolipoprotein e. immunocytochemical, biochemical, and molecular genetic studies indicate that apolipoprotein e (apoe) plays an important role in the process of amyloidogenesis-beta. |
2000-09-29 |
2023-08-12 |
Not clear |
| A A Golabek, E Kida, M Walus, C Perez, T Wisniewski, C Sot. Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophysical journal. vol 79. issue 2. 2000-09-29. PMID:10920030. |
previous studies demonstrated sodium dodecyl sulfate (sds)-resistant binding of apoe to the main component of alzheimer's amyloid-a beta and modulation of a beta aggregation by apoe in vitro. |
2000-09-29 |
2023-08-12 |
Not clear |
| A M Saunders, M K Trowers, R A Shimkets, S Blakemore, D J Crowther, T A Mansfield, D M Wallace, W J Strittmatter, A D Rose. The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochimica et biophysica acta. vol 1502. issue 1. 2000-09-25. PMID:10899434. |
the association of inheritance of different apolipoprotein e (apoe, gene; apoe, protein) alleles with the risk and rate of onset of alzheimer's disease (ad) is now well established and widely confirmed. |
2000-09-25 |
2023-08-12 |
Not clear |
| C L Lendon, B H Han, K Salimi, A M Fagan, M I Behrens, M C Muller, D M Holtzma. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947802. |
the epsilon4 allele of apolipoprotein e (apoe) is a genetic risk factor for alzheimer's disease. |
2000-09-19 |
2023-08-12 |
mouse |
| C L Lendon, B H Han, K Salimi, A M Fagan, M I Behrens, M C Muller, D M Holtzma. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947802. |
the mechanism by which the presence of an apoe epsilon4 allele and certain brain injuries act to predispose to alzheimer's disease and poor outcome following brain injury is unknown. |
2000-09-19 |
2023-08-12 |
mouse |
| O Hilkevich, J Chapman, B S Bone, A D Korczy. [Prevalence of APO e4 allele in Israeli ethnic groups]. Harefuah. vol 136. issue 11. 2000-09-19. PMID:10955124. |
the 4 allele of the apoe gene, coding for apo-lipoprotein e, is the most common genetic risk factor for alzheimer's disease and a significant risk factor for coronary atherosclerosis. |
2000-09-19 |
2023-08-12 |
Not clear |
| A M Fagan, L H Younkin, J C Morris, J D Fryer, T G Cole, S G Younkin, D M Holtzma. Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype. Annals of neurology. vol 48. issue 2. 2000-08-28. PMID:10939571. |
the epsilon4 allele of apolipoprotein e (apoe) is a risk factor for alzheimer's disease (ad). |
2000-08-28 |
2023-08-12 |
human |
| F M de-Andrade, M Larrandaburu, S M Callegari-Jacques, G Gastaldo, M H Hut. Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 33. issue 5. 2000-08-24. PMID:10775884. |
apolipoprotein e (protein: apo e; gene: apoe) plays an important role in the multifactorial etiology of both alzheimer's disease (ad) and lipid level concentrations. |
2000-08-24 |
2023-08-12 |
Not clear |
| K Horsburgh, M O McCarron, F White, J A Nicol. The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models. Neurobiology of aging. vol 21. issue 2. 2000-08-24. PMID:10867209. |
the epsilon 4 allele of apolipoprotein e (apoe denotes gene; apoe denotes protein) is a major risk factor for alzheimer's disease (ad). |
2000-08-24 |
2023-08-12 |
Not clear |
| A S Rigaud, L Traykov, L Caputo, M C Guelfi, F Latour, R Couderc, F Moulin, J de Rotrou, F Forette, F Bolle. The apolipoprotein E epsilon4 allele and the response to tacrine therapy in Alzheimer's disease. European journal of neurology. vol 7. issue 3. 2000-08-23. PMID:10886308. |
the objective of our study was to evaluate the effects of the apolipoprotein e (apoe) phenotype and gender on the response to tacrine treatment in alzheimer's disease (ad). |
2000-08-23 |
2023-08-12 |
Not clear |
| M Mauricio, R O'Hara, J A Yesavage, L Friedman, H C Kraemer, M Van De Water, G M Murph. A longitudinal study of apolipoprotein-E genotype and depressive symptoms in community-dwelling older adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 8. issue 3. 2000-08-23. PMID:10910416. |
the apolipoprotein-e (apoe) epsilon 4 allele is a risk factor for alzheimer's disease (ad) and cognitive decline in older adults. |
2000-08-23 |
2023-08-12 |
Not clear |
| E R Martin, E H Lai, J R Gilbert, A R Rogala, A J Afshari, J Riley, K L Finch, J F Stevens, K J Livak, B D Slotterbeck, S H Slifer, L L Warren, P M Conneally, D E Schmechel, I Purvis, M A Pericak-Vance, A D Roses, J M Vanc. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. American journal of human genetics. vol 67. issue 2. 2000-08-21. PMID:10869235. |
snping away at complex diseases: analysis of single-nucleotide polymorphisms around apoe in alzheimer disease. |
2000-08-21 |
2023-08-12 |
human |