| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Perugini, P Schuck, G J Howlet. Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid. The Journal of biological chemistry. vol 275. issue 47. 2001-01-08. PMID:10970893. |
human apolipoprotein e (apoe) exists as three main isoforms, differing by single amino acid substitutions, with the apoe4 isoform strongly linked to the incidence of late onset alzheimer's disease. |
2001-01-08 |
2023-08-12 |
human |
| A Myers, P Holmans, H Marshall, J Kwon, D Meyer, D Ramic, S Shears, J Booth, F W DeVrieze, R Crook, M Hamshere, R Abraham, N Tunstall, F Rice, S Carty, S Lillystone, P Kehoe, V Rudrasingham, L Jones, S Lovestone, J Perez-Tur, J Williams, M J Owen, J Hardy, A M Goat. Susceptibility locus for Alzheimer's disease on chromosome 10. Science (New York, N.Y.). vol 290. issue 5500. 2001-01-04. PMID:11125144. |
the apolipoprotein e (apoe) gene is the only genetic risk factor that has so far been linked to risk for late-onset alzheimer's disease (load). |
2001-01-04 |
2023-08-12 |
Not clear |
| A Myers, P Holmans, H Marshall, J Kwon, D Meyer, D Ramic, S Shears, J Booth, F W DeVrieze, R Crook, M Hamshere, R Abraham, N Tunstall, F Rice, S Carty, S Lillystone, P Kehoe, V Rudrasingham, L Jones, S Lovestone, J Perez-Tur, J Williams, M J Owen, J Hardy, A M Goat. Susceptibility locus for Alzheimer's disease on chromosome 10. Science (New York, N.Y.). vol 290. issue 5500. 2001-01-04. PMID:11125144. |
this locus modifies risk for alzheimer's disease independent of apoe genotype. |
2001-01-04 |
2023-08-12 |
Not clear |
| J D Flory, S B Manuck, R E Ferrell, C M Ryan, M F Muldoo. Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults. American journal of medical genetics. vol 96. issue 6. 2000-12-28. PMID:11121165. |
the apolipoprotein e genotype (apoe) is an established risk factor for alzheimer disease, with the age-at-onset occurring earlier in individuals having at least one apoe epsilon 4 allele, relative to the apoe epsilon 3 or apoe epsilon 2 isoforms. |
2000-12-28 |
2023-08-12 |
Not clear |
| J M Johnston, V Nazar-Stewart, S F Kelsey, M I Kamboh, M Gangul. Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's disease in a community sample. Neuroepidemiology. vol 19. issue 6. 2000-12-27. PMID:11060506. |
relationships between cerebrovascular events, apoe polymorphism and alzheimer's disease in a community sample. |
2000-12-27 |
2023-08-12 |
human |
| J M Johnston, V Nazar-Stewart, S F Kelsey, M I Kamboh, M Gangul. Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's disease in a community sample. Neuroepidemiology. vol 19. issue 6. 2000-12-27. PMID:11060506. |
to investigate whether the apoe*4 allele modified the relationship between cerebrovascular events and alzheimer's disease (ad), we collected evidence of previous stroke or transient ischemic attack (tia) and determined apoe genotype among 102 subjects with ad and 375 nondemented subjects in a community-based study of dementia. |
2000-12-27 |
2023-08-12 |
human |
| C Andersen, S Froelich Fabre, P Ostberg, L Lannfelt, L Wahlun. Tau protein in cerebrospinal fluid from semantic dementia patients. Neuroscience letters. vol 294. issue 3. 2000-12-27. PMID:11072138. |
apolipoprotein e (apoe) genotypes and cerebrospinal fluid (csf) tau protein concentration were evaluated in patients suffering from semantic dementia, with the aim of determining whether these markers could help to differentiate this condition from alzheimer's disease (ad) in early stages. |
2000-12-27 |
2023-08-12 |
human |
| Y W Yu, C H Lin, S P Chen, C J Hong, S J Tsa. Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers. Neuroscience letters. vol 294. issue 3. 2000-12-27. PMID:11072144. |
the apolipoprotein e (apoe) epsilon4 allele is associated with late-onset alzheimer's disease and cognitive function in aging normal populations. |
2000-12-27 |
2023-08-12 |
human |
| L Oron, M Efrati, D M Michaelso. Secretion of the amyloid precursor protein is elevated isoform specifically by apolipoprotein E4. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961428. |
genetic studies suggest that the neuropathology and etiology of alzheimer's disease (ad) are associated with several genotypes including mutations in the amyloid precursor protein (app) gene and the allele e4 of apolipoprotein e (apoe). |
2000-12-22 |
2023-08-12 |
Not clear |
| T Asada, T Motonaga, Z Yamagata, M Uno, K Takahash. Associations between retrospectively recalled napping behavior and later development of Alzheimer's disease: association with APOE genotypes. Sleep. vol 23. issue 5. 2000-12-14. PMID:10947030. |
associations between retrospectively recalled napping behavior and later development of alzheimer's disease: association with apoe genotypes. |
2000-12-14 |
2023-08-12 |
human |
| L C Walker, J Pahnke, M Madauss, S Vogelgesang, A Pahnke, E W Herbst, D Stausske, R Walther, C Kessler, R W Warzo. Apolipoprotein E4 promotes the early deposition of Abeta42 and then Abeta40 in the elderly. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912918. |
we found that: (1) the number of both abeta42- and abeta40-positive senile plaques increase with age; (2) abeta42 appears at younger ages, and in more amyloid deposits, than does abeta40 in all apoe groups; (3) when compared at similar ages, older persons with apoeepsilon4 are more likely to have abeta42- and abeta40-immunoreactive deposits than are persons without apoeepsilon4; (4) abeta40-containing plaques arise at least a decade later than do abeta42 plaques, and are seldom found in the medial temporal lobe of older persons lacking apoeepsilon4; and (5) in the absence of overt alzheimer's disease, cerebral amyloid angiopathy is rare in the elderly, but in our sample was significantly augmented in apoeepsilon4 homozygotes. |
2000-12-07 |
2023-08-12 |
Not clear |
| I Tesseur, J Van Dorpe, K Bruynseels, F Bronfman, R Sciot, A Van Lommel, F Van Leuve. Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. The American journal of pathology. vol 157. issue 5. 2000-12-07. PMID:11073810. |
the hypothesis that the expression pattern of human apoe might be important for the pathogenesis of alzheimer's disease was tested by generating transgenic mice that express human apoe4 in neurons or in astrocytes of the central nervous system. |
2000-12-07 |
2023-08-12 |
mouse |
| R S Bedlack, W J Strittmatter, J C Morgenlande. Apolipoprotein E and neuromuscular disease: a critical review of the literature. Archives of neurology. vol 57. issue 11. 2000-11-30. PMID:11074787. |
several recent studies have asked whether apolipoprotein e (apoe for the protein, apoe for the gene) influences these aspects of specific neuromuscular disorders, as it does in central nervous system disorders such as alzheimer disease. |
2000-11-30 |
2023-08-12 |
human |
| D Blacke. New insights into genetic aspects of Alzheimer's disease. Does genetic information make a difference in clinical practice? Postgraduate medicine. vol 108. issue 5. 2000-11-22. PMID:11043085. |
in patients who have a family history of late-onset alzheimer's disease, while apoe's contribution to increased risk is indisputable, its potential use as a genetic test is very limited. |
2000-11-22 |
2023-08-12 |
Not clear |
| F Panza, V Solfrizzi, F Torres, F Mastroianni, A M Colacicco, A M Basile, C Capurso, A D'Introno, A Del Parigi, A Capurs. Apolipoprotein E in Southern Italy: protective effect of epsilon 2 allele in early- and late-onset sporadic Alzheimer's disease. Neuroscience letters. vol 292. issue 2. 2000-11-07. PMID:10998553. |
apolipoprotein e (apoe) polymorphism was evaluated in 81 sporadic late onset alzheimer's disease (load) patients, 28 sporadic early-onset alzheimer's disease (eoad) and 92 sex- and age-matched healthy controls from apulia, southern italy. |
2000-11-07 |
2023-08-12 |
human |
| S M Fullerton, A G Clark, K M Weiss, D A Nickerson, S L Taylor, J H Stengârd, V Salomaa, E Vartiainen, M Perola, E Boerwinkle, C F Sin. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. American journal of human genetics. vol 67. issue 4. 2000-10-31. PMID:10986041. |
three common protein isoforms of apolipoprotein e (apoe), encoded by the epsilon2, epsilon3, and epsilon4 alleles of the apoe gene, differ in their association with cardiovascular and alzheimer's disease risk. |
2000-10-31 |
2023-08-12 |
human |
| M G Dik, D J Deeg, L M Bouter, E H Corder, A Kok, C Jonke. Stroke and apolipoprotein E epsilon4 are independent risk factors for cognitive decline: A population-based study. Stroke. vol 31. issue 10. 2000-10-26. PMID:11022076. |
stroke and apolipoprotein e epsilon4 (apoe epsilon4) are individually important risk factors for cognitive decline, including alzheimer disease. |
2000-10-26 |
2023-08-12 |
Not clear |
| J W Kardaun, L White, H E Resnick, H Petrovitch, S M Marcovina, A M Saunders, D J Foley, R J Havli. Genotypes and phenotypes for apolipoprotein E and Alzheimer disease in the Honolulu-Asia aging study. Clinical chemistry. vol 46. issue 10. 2000-10-25. PMID:11017931. |
the utility of apolipoprotein e (apoe) type as an indicator of genetic susceptibility to alzheimer disease (ad) depends on the reliability of typing. |
2000-10-25 |
2023-08-12 |
Not clear |
| M Schiefermeier, H Kollegger, C Madl, C Schwarz, M Holzer, J Kofler, F Ster. Apolipoprotein E polymorphism: survival and neurological outcome after cardiopulmonary resuscitation. Stroke. vol 31. issue 9. 2000-10-17. PMID:10978031. |
the apolipoprotein e 3/3 (apoe 3/3) genotype is associated with a reduced risk of developing alzheimer's disease and with a favorable neurological outcome after traumatic head injury. |
2000-10-17 |
2023-08-12 |
Not clear |
| L Zurutuza, P Verpillat, G Raux, D Hannequin, M Puel, S Belliard, A Michon, Y Pothin, A Camuzat, C Penet, C Martin, A Brice, D Campion, F Clerget-Darpoux, T Frebour. APOE promoter polymorphisms do not confer independent risk for Alzheimer's disease in a French population. European journal of human genetics : EJHG. vol 8. issue 9. 2000-10-12. PMID:10980578. |
apoe promoter polymorphisms do not confer independent risk for alzheimer's disease in a french population. |
2000-10-12 |
2023-08-12 |
Not clear |