| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Aerssens, P Raeymaekers, S Lilienfeld, H Geerts, F Konings, W Pary. APOE genotype: no influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173877. |
apolipoprotein e (apoe) has been extensively demonstrated to be a genetic risk factor for alzheimer's disease (ad). |
2001-07-12 |
2023-08-12 |
human |
| P Høgh, G M Knudsen, K H Kjaer, O S Jørgensen, O B Paulson, G Waldema. Single photon emission computed tomography and apolipoprotein E in Alzheimer's disease: impact of the epsilon4 allele on regional cerebral blood flow. Journal of geriatric psychiatry and neurology. vol 14. issue 1. 2001-07-12. PMID:11281316. |
the aim of this study was to examine the impact of the apolipoprotein e (apoe) epsilon4 allele on semiquantitative regional cerebral blood flow (rcbf) in alzheimer's disease. |
2001-07-12 |
2023-08-12 |
Not clear |
| P Høgh, G M Knudsen, K H Kjaer, O S Jørgensen, O B Paulson, G Waldema. Single photon emission computed tomography and apolipoprotein E in Alzheimer's disease: impact of the epsilon4 allele on regional cerebral blood flow. Journal of geriatric psychiatry and neurology. vol 14. issue 1. 2001-07-12. PMID:11281316. |
the results of this study suggest that the apoe genotype in itself may have an impact on the pattern of rcbf deficits in alzheimer's disease. |
2001-07-12 |
2023-08-12 |
Not clear |
| D M Dreon, S J Peroutka. Medical utility of apoe allele determination in assessing the need for antioxidant therapy. Medical hypotheses. vol 56. issue 3. 2001-07-12. PMID:11359359. |
the apoe varepsilon4 allele is associated with a variety of conditions such as alzheimer's disease, coronary artery disease, stroke and postoperative cognitive dysfunction. |
2001-07-12 |
2023-08-12 |
Not clear |
| H Kadotani, T Kadotani, T Young, P E Peppard, L Finn, I M Colrain, G M Murphy, E Migno. Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. JAMA. vol 285. issue 22. 2001-07-05. PMID:11401610. |
apolipoprotein e epsilon4(apoe epsilon4) is a well-known risk factor for alzheimer disease and cardiovascular disease. |
2001-07-05 |
2023-08-12 |
Not clear |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
the authors examined the impact of the apolipoprotein e (apoe)(*)epsilon4 allele on alzheimer's disease incidence in relation to use of antihypertensive medication. |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
compared with (*)epsilon3/(*)epsilon3, the apoe(*)epsilon4 allele increased the risk of developing dementia (relative risk (rr) = 1.5, 95% confidence interval (ci): 1.1, 2.1) and alzheimer's disease (rr = 1.7, 95% ci: 1.2, 2.5). |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
subjects using antihypertensive medication at baseline (n = 432, 80% used diuretics) had a decreased risk of dementia (rr = 0.6, 95% ci: 0.5, 0.9) and alzheimer's disease (rr = 0.5, 95% ci: 0.3, 0.8) after adjustment for several variables, including apoe. |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
the apoe(*)epsilon4 allele is an important predictor of dementia and alzheimer's disease incidence. |
2001-06-28 |
2023-08-12 |
human |
| R M Corbo, R Scacchi, T Vilardo, M Rugger. Polymorphisms in the apolipoprotein E gene regulatory region in relation to coronary heart disease and their effect on plasma apolipoprotein E. Clinical chemistry and laboratory medicine. vol 39. issue 1. 2001-06-28. PMID:11256794. |
studies carried out on patients with alzheimer's disease demonstrated that -491a/t and -427t/c polymorphisms affect the level of plasma apoe. |
2001-06-28 |
2023-08-12 |
human |
| C Masullo, A Daniele, V M Fazio, D Seripa, C Gravina, V Filippini, D Grossi, N Fragassi, P Nichelli, M Leone, G Gainott. The Apolipoprotein E genotype in patients affected by syndromes with focal cortical atrophy. Neuroscience letters. vol 303. issue 2. 2001-06-28. PMID:11311499. |
we studied the apoe allele distribution in 39 patients with clinically diagnosed syndromes associated with focal cerebral atrophy (fca), in 50 patients with early-onset probable alzheimer's disease (eoad), and in 60 patients with late-onset probable ad (load). |
2001-06-28 |
2023-08-12 |
Not clear |
| Z Qiu, D K Strickland, B T Hyman, G W Rebec. Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro. Journal of neuropathology and experimental neurology. vol 60. issue 5. 2001-06-28. PMID:11379818. |
the low-density lipoprotein (ldl) receptor-related protein (lrp) is a multifunctional receptor in the cns that binds both apolipoprotein e (apoe) and activated alpha2-macroglobulin (alpha2m*); all 3 proteins are genetically associated with alzheimer disease (ad). |
2001-06-28 |
2023-08-12 |
human |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
we have compared the apolipoprotein e (apoe) genotypes of han chinese with late-onset sporadic alzheimer's disease (load, n=191), and vascular dementia (vad, n=124) to controls (n=218) with a similar age distribution. |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
our findings support previous reports of a positive association between apoe epsilon4 and both alzheimer's disease and vascular dementia in han chinese. |
2001-06-21 |
2023-08-12 |
Not clear |
| S M Fullerton, G A Shirman, W J Strittmatter, W D Matthe. Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. Experimental neurology. vol 169. issue 1. 2001-06-07. PMID:11312553. |
recent studies implicating apoe in alzheimer's disease and successful recovery from neurological injury have stimulated much interest in the functions of apoe within the brain. |
2001-06-07 |
2023-08-12 |
mouse |
| M J Bullido, P Guallar-Castillón, M J Artiga, M C Ramos, I Sastre, J Aldudo, A Frank, F Coria, F Rodríguez-Artalejo, F Valdivies. Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by gender. Neuroscience letters. vol 289. issue 3. 2001-05-31. PMID:10961667. |
apolipoprotein e (apoe), the lipoprotein receptor related protein (lrp) and alpha-2 macroglobulin (alpha2m) have been proposed as a functional complex involved in amyloid clearance, a crucial event for alzheimer's disease development. |
2001-05-31 |
2023-08-12 |
human |
| G Halimi, L Duplan, C Bideau, D Iniesta, P Berthézène, C Oddoze, J M Verdier, B Michel, J L Bergé-Lefran. Association of APOE promoter but not A2M polymorphisms with risk of developing Alzheimer's disease. Neuroreport. vol 11. issue 16. 2001-05-31. PMID:11095526. |
association of apoe promoter but not a2m polymorphisms with risk of developing alzheimer's disease. |
2001-05-31 |
2023-08-12 |
Not clear |
| C M Lauderback, J M Hackett, J N Keller, S Varadarajan, L Szweda, M Kindy, W R Markesbery, D A Butterfiel. Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease. Biochemistry. vol 40. issue 8. 2001-05-31. PMID:11327877. |
vulnerability of synaptosomes from apoe knock-out mice to structural and oxidative modifications induced by a beta(1-40): implications for alzheimer's disease. |
2001-05-31 |
2023-08-12 |
mouse |
| C M Lauderback, J M Hackett, J N Keller, S Varadarajan, L Szweda, M Kindy, W R Markesbery, D A Butterfiel. Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease. Biochemistry. vol 40. issue 8. 2001-05-31. PMID:11327877. |
the e4 allele of apoe and amyloid beta-peptide (abeta) are associated with alzheimer's disease (ad) and may be central to the pathogenesis of this disorder. |
2001-05-31 |
2023-08-12 |
mouse |
| G Carrieri, M Bonafè, M De Luca, G Rose, O Varcasia, A Bruni, R Maletta, B Nacmias, S Sorbi, F Corsonello, E Feraco, K F Andreev, A I Yashin, C Franceschi, G De Benedicti. Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease. Human genetics. vol 108. issue 3. 2001-05-31. PMID:11354629. |
allele epsilon4 of the nuclear apoe gene is a leading genetic risk factor for sporadic alzheimer's disease (ad). |
2001-05-31 |
2023-08-12 |
human |