| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Zill, R Engel, H Hampel, S Behrens, K Bürger, F Padberg, S Stübner, H J Möller, M Ackenheil, B Bond. Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients. European archives of psychiatry and clinical neuroscience. vol 251. issue 1. 2001-08-09. PMID:11315514. |
we studied the association between the apoe epsilon 4 polymorphism and the -491a/t and th1e47cst/g polymorphisms in a sample of 118 healthy, non-demented controls and 239 consecutively recruited gerontopsychiatric patients diagnosed as: alzheimer's disease (n = 89), age mild cognitive impairment (n = 32), memory complainers without any cognitive deficit (n = 54) and depression/other psychiatric disorders (n = 64), to test whether the investigated polymorphisms have a high enough selectivity and specificity to distinguish between the different gerontopsychiatric disorders or to differentiate ad genetically from other forms of dementia, respectively. |
2001-08-09 |
2023-08-12 |
Not clear |
| P Zill, R Engel, H Hampel, S Behrens, K Bürger, F Padberg, S Stübner, H J Möller, M Ackenheil, B Bond. Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients. European archives of psychiatry and clinical neuroscience. vol 251. issue 1. 2001-08-09. PMID:11315514. |
we found a statistically significant association between the apoe epsilon 4 allele and alzheimer's disease (p = 0.0001) and age associated memory impairment (p = 0.006). |
2001-08-09 |
2023-08-12 |
Not clear |
| R Stewart, C Russ, M Richards, C Brayne, S Lovestone, A Man. Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population. Dementia and geriatric cognitive disorders. vol 12. issue 4. 2001-08-09. PMID:11351136. |
a reduced risk of alzheimer's disease (ad) associated with the apolipoprotein e (apoe) epsilon4 allele is reported in populations of african origin. |
2001-08-09 |
2023-08-12 |
human |
| J A Nicoll, L Martin, J Stewart, L S Murray, S Love, P G Kenned. Involvement of apolipoprotein E in herpes simplex encephalitis. Neuroreport. vol 12. issue 4. 2001-08-02. PMID:11277566. |
apoe polymorphism may influence risk for cold sores and, by interacting with latent hsv-1, risk for alzheimer's disease (ad). |
2001-08-02 |
2023-08-12 |
Not clear |
| V M Moceri, W A Kukull, I Emanual, G van Belle, J R Starr, G D Schellenberg, W C McCormick, J D Bowen, L Teri, E B Larso. Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's disease. Epidemiology (Cambridge, Mass.). vol 12. issue 4. 2001-08-02. PMID:11416775. |
we also evaluated whether subjects with the apolipoprotein epsilon 4 allele (apoe epsilon 4), a strong genetic risk factor that is not a necessary cause or a sufficient cause by itself for the development of alzheimer's disease, were at higher risk than subjects who did not carry this allele. |
2001-08-02 |
2023-08-12 |
human |
| V M Moceri, W A Kukull, I Emanual, G van Belle, J R Starr, G D Schellenberg, W C McCormick, J D Bowen, L Teri, E B Larso. Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's disease. Epidemiology (Cambridge, Mass.). vol 12. issue 4. 2001-08-02. PMID:11416775. |
among subjects with the apoe epsilon 4 allele whose fathers held lower-socioeconomic level occupations, the odds of developing alzheimer's disease were higher (odds ratio = 2.35, 95% confidence interval = 1.07--5.16) compared with subjects without the allele (odds ratio = 1.40, 95% confidence interval = 0.78--2.52). |
2001-08-02 |
2023-08-12 |
human |
| V M Moceri, W A Kukull, I Emanual, G van Belle, J R Starr, G D Schellenberg, W C McCormick, J D Bowen, L Teri, E B Larso. Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's disease. Epidemiology (Cambridge, Mass.). vol 12. issue 4. 2001-08-02. PMID:11416775. |
subjects carrying the apoe epsilon 4 allele alone have a threefold increased risk of alzheimer's disease (odds ratio = 3.17, 95% confidence interval = 1.99--5.04). |
2001-08-02 |
2023-08-12 |
human |
| V M Moceri, W A Kukull, I Emanual, G van Belle, J R Starr, G D Schellenberg, W C McCormick, J D Bowen, L Teri, E B Larso. Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's disease. Epidemiology (Cambridge, Mass.). vol 12. issue 4. 2001-08-02. PMID:11416775. |
the data suggest that apoe epsilon 4 may modify the associations between father's occupation, other early-life environmental factors, and development of alzheimer's disease in late life. |
2001-08-02 |
2023-08-12 |
human |
| M Mulder, A Blokland, D J van den Berg, H Schulten, A H Bakker, D Terwel, W Honig, E R de Kloet, L M Havekes, H W Steinbusch, E C de Lang. Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Laboratory investigation; a journal of technical methods and pathology. vol 81. issue 7. 2001-08-02. PMID:11454984. |
we therefore hypothesize that the role of apoe in the maintenance of the integrity of the bbb may be the mechanism by which apoe affects the progression of neurodegeneration, as seen in alzheimer's disease. |
2001-08-02 |
2023-08-12 |
mouse |
| K Terai, A Iwai, S Kawabata, M Sasamata, K Miyata, T Yamaguch. Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325345. |
in the present study, to understand more fully the amyloid deposition mechanism implicating alzheimer's disease pathogenesis, we examined immunohistochemically the distributions of apolipoprotein e (apoe) and abeta in amyloid plaques of aged tg2576 mouse brains. |
2001-07-26 |
2023-08-12 |
mouse |
| K Terai, A Iwai, S Kawabata, M Sasamata, K Miyata, T Yamaguch. Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325345. |
taken together, the characteristics of amyloid plaques in tg2576 mice are similar to those in alzheimer's disease with respect to apoe and astrogliosis. |
2001-07-26 |
2023-08-12 |
mouse |
| L Martorell, C Virgos, J Valero, G Coll, L Figuera, J Joven, M Pocoví, A Labad, E Vilell. Schizophrenic women with the APOE epsilon 4 allele have a worse prognosis than those without it. Molecular psychiatry. vol 6. issue 3. 2001-07-26. PMID:11326299. |
the epsilon 4 allele of apoe is generally accepted to be a risk factor in alzheimer's disease and it has been related to other neuropsychiatric disorders, including schizophrenia. |
2001-07-26 |
2023-08-12 |
Not clear |
| R Scacchi, M Ruggeri, G Gambina, M C Martini, G Ferrari, R M Corb. Plasma alpha1-antichymotrypsin in Alzheimer's disease; relationships with APOE genotypes. Neurobiology of aging. vol 22. issue 3. 2001-07-26. PMID:11378247. |
plasma alpha1-antichymotrypsin in alzheimer's disease; relationships with apoe genotypes. |
2001-07-26 |
2023-08-12 |
human |
| M H Baumann, J Kallijärvi, H Lankinen, C Soto, M Halti. Apolipoprotein E includes a binding site which is recognized by several amyloidogenic polypeptides. The Biochemical journal. vol 349. issue Pt 1. 2001-07-19. PMID:10861213. |
inheritance of the apolipoprotein e (apoe) epsilon 4 allele is a risk factor for late-onset alzheimer's disease (ad). |
2001-07-19 |
2023-08-12 |
Not clear |
| M Jacquier, D Arango, E Villareal, O Torres, M L Serrano, M Cruts, P Montañes, C Cano, M N Rodriguez, S Serneels, C Van Broeckhove. APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies. Arquivos de neuro-psiquiatria. vol 59. issue 1. 2001-07-19. PMID:11299424. |
apoe epsilon4 and alzheimer's disease: positive association in a colombian clinical series and review of the latin-american studies. |
2001-07-19 |
2023-08-12 |
Not clear |
| M Jacquier, D Arango, E Villareal, O Torres, M L Serrano, M Cruts, P Montañes, C Cano, M N Rodriguez, S Serneels, C Van Broeckhove. APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies. Arquivos de neuro-psiquiatria. vol 59. issue 1. 2001-07-19. PMID:11299424. |
as the strength of the association between the apoe epsilon4 allele and alzheimer's disease (ad) varies across ethnic groups, we studied if there was such an association in colombian patients. |
2001-07-19 |
2023-08-12 |
Not clear |
| H Yamaguchi, S Sugihara, A Ogawa, N Oshima, Y Ihar. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. Journal of neuropathology and experimental neurology. vol 60. issue 7. 2001-07-19. PMID:11444802. |
alzheimer beta amyloid deposition enhanced by apoe epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. |
2001-07-19 |
2023-08-12 |
human |
| H Yamaguchi, S Sugihara, A Ogawa, N Oshima, Y Ihar. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. Journal of neuropathology and experimental neurology. vol 60. issue 7. 2001-07-19. PMID:11444802. |
to clarify how alzheimer disease pathology develops in the brains of nondemented subjects, we examined the interrelations among the amounts and morphology of abeta deposition, neurofibrillary pathology, and apolipoprotein e (apoe) genotype in the frontal association cortex of 101 autopsy brains from patients aged between 40 to 83. |
2001-07-19 |
2023-08-12 |
human |
| K Yamagata, K Urakami, K Ikeda, Y Ji, Y Adachi, H Arai, H Sasaki, K Sato, K Nakashim. High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173875. |
in order to study progressive dementia in alzheimer's disease (ad) patients, we analyzed the gene expression of apolipoprotein e (apoe). |
2001-07-12 |
2023-08-12 |
Not clear |
| J Aerssens, P Raeymaekers, S Lilienfeld, H Geerts, F Konings, W Pary. APOE genotype: no influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173877. |
apoe genotype: no influence on galantamine treatment efficacy nor on rate of decline in alzheimer's disease. |
2001-07-12 |
2023-08-12 |
human |