| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Fallin, A Cohen, L Essioux, I Chumakov, M Blumenfeld, D Cohen, N J Schor. Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome research. vol 11. issue 1. 2001-03-01. PMID:11156623. |
genetic analysis of case/control data using estimated haplotype frequencies: application to apoe locus variation and alzheimer's disease. |
2001-03-01 |
2023-08-12 |
Not clear |
| D Fallin, A Cohen, L Essioux, I Chumakov, M Blumenfeld, D Cohen, N J Schor. Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome research. vol 11. issue 1. 2001-03-01. PMID:11156623. |
we applied the proposed methods in a study of the relationship between polymorphisms within the apoe gene region and alzheimer's disease. |
2001-03-01 |
2023-08-12 |
Not clear |
| D Fallin, A Cohen, L Essioux, I Chumakov, M Blumenfeld, D Cohen, N J Schor. Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome research. vol 11. issue 1. 2001-03-01. PMID:11156623. |
our results confirm the known association between the apoe locus and alzheimer's disease, even when the epsilon 4 polymorphism is not contained in the tested haplotypes. |
2001-03-01 |
2023-08-12 |
Not clear |
| T Tomiyama, E H Corder, H Mor. Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 56. issue 3-4. 2001-03-01. PMID:11212354. |
apolipoprotein e (apoe) epsilon4 allele is a genetic risk factor for late-onset familial and sporadic alzheimer's disease (ad). |
2001-03-01 |
2023-08-12 |
mouse |
| Y Ihara, T Hayabara, K Sasaki, R Kawada, Y Nakashima, S Kurod. Relationship between oxidative stress and apoE phenotype in Alzheimer's disease. Acta neurologica Scandinavica. vol 102. issue 6. 2001-02-15. PMID:11125747. |
relationship between oxidative stress and apoe phenotype in alzheimer's disease. |
2001-02-15 |
2023-08-12 |
Not clear |
| Y Ihara, T Hayabara, K Sasaki, R Kawada, Y Nakashima, S Kurod. Relationship between oxidative stress and apoE phenotype in Alzheimer's disease. Acta neurologica Scandinavica. vol 102. issue 6. 2001-02-15. PMID:11125747. |
to investigate the relationship between oxidative stress and apoe phenotype in dementia of alzheimer type (dat). |
2001-02-15 |
2023-08-12 |
Not clear |
| A Alvarez-Arcaya, O Combarros, J Llorca, M Sánchez-Guerra, J Berciano, C Fernández-Viadero, N Peñ. The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women. Acta neurologica Scandinavica. vol 102. issue 6. 2001-02-15. PMID:11125748. |
recent reports indicate that the k variant of the butyrylcholinesterase (bche) gene may act in synergism with the epsilon4 allele of apolipoprotein e (apoe) to increase the risk of alzheimer's disease (ad), but this is controversial. |
2001-02-15 |
2023-08-12 |
Not clear |
| W R Lin, M A Wozniak, M M Esiri, P Klenerman, R F Itzhak. Herpes simplex encephalitis: involvement of apolipoprotein E genotype. Journal of neurology, neurosurgery, and psychiatry. vol 70. issue 1. 2001-02-08. PMID:11118260. |
it was previously found that herpes simplex type 1 virus (hsv1) when present in the brain, is a risk factor for alzheimer's disease in carriers of the type 4 allele of the gene for apolipoprotein e (apoe epsilon4), and apoe epsilon4 is a risk factor for herpes labialis. |
2001-02-08 |
2023-08-12 |
human |
| T Asada, T Motonaga, T Kinoshit. Predictors of severity of behavioral disturbance among community-dwelling elderly individuals with Alzheimer's disease: a 6-year follow-up study. Psychiatry and clinical neurosciences. vol 54. issue 6. 2001-02-08. PMID:11145467. |
to clarify which baseline factors, including apolipoprotein e (apoe) genotyping and caregiver characteristics, predict the future severity of behavioral disturbance among community-dwelling elderly with alzheimer's disease (ad), we conducted a longitudinal study for up to 6 years. |
2001-02-08 |
2023-08-12 |
human |
| B Drouet, A Fifre, M Pinçon-Raymond, J Vandekerckhove, M Rosseneu, J L Guéant, J Chambaz, T Pillo. ApoE protects cortical neurones against neurotoxicity induced by the non-fibrillar C-terminal domain of the amyloid-beta peptide. Journal of neurochemistry. vol 76. issue 1. 2001-02-08. PMID:11145984. |
although the genetic link between the epsilon 4 allele of apolipoprotein e (apoe) and alzheimer's disease (ad) is well established, the apoe isoform-specific activity underlying this correlation remains unclear. |
2001-02-08 |
2023-08-12 |
rat |
| M C Irizarry, G W Rebeck, B Cheung, K Bales, S M Paul, D Holzman, B T Hyma. Modulation of A beta deposition in APP transgenic mice by an apolipoprotein E null background. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193147. |
several lines of evidence implicate apolipoprotein e (apoe) and its receptor--the low density lipoprotein receptor related protein (lrp)--in alzheimer's disease (ad) pathogenesis, including increased amyloid deposition in human ad brains of people containing the apoe epsilon 4 allele, presence of apoe and lrp in amyloid plaques, and in vitro uptake of amyloid precursor protein (app) and amyloid beta protein (a beta) by lrp. |
2001-02-08 |
2023-08-12 |
mouse |
| S Nakamura, F Ono, M Hamano, K Odagiri, M Kubo, K Komatsuzaki, K Terao, M Shinagawa, K Takahashi, Y Yoshikaw. Immunohistochemical detection of apolipoprotein E within prion-associated lesions in squirrel monkey brains. Acta neuropathologica. vol 100. issue 4. 2001-02-01. PMID:10985693. |
as for cerebral amyloidoses, although the correlation between amyloid beta protein (abeta) and apoe in alzheimer's disease (ad) has been clarified, the interaction of prion protein isoform (prpsc) and apoe in several types of prion diseases (pds) has not been examined in detail. |
2001-02-01 |
2023-08-12 |
mouse |
| M C Irizarry, B S Cheung, G W Rebeck, S M Paul, K R Bales, B T Hyma. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice. Acta neuropathologica. vol 100. issue 5. 2001-02-01. PMID:11045665. |
apolipoprotein e (apoe) has been implicated as a risk factor for alzheimer's disease and in the deposition, fibrillogenesis, and clearance of the amyloid beta-peptide (abeta). |
2001-02-01 |
2023-08-12 |
mouse |
| J Poirie. Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism. Annals of the New York Academy of Sciences. vol 924. 2001-02-01. PMID:11193807. |
the convergence of the so-called amyloid cascade hypothesis (hardy et al., 1992) and of the apoe/lipid recycling cascade model (poirier, 1994) is consistent with the notion that alterations in lipid homeostasis could serve as the common denominator for apoe and beta amyloid dysfunctions in alzheimer's disease. |
2001-02-01 |
2023-08-12 |
mouse |
| N Durany, P Riederer, F F Cruz-Sánche. Apolipoprotein E genotype in Spanish schizophrenic patients. Psychiatric genetics. vol 10. issue 2. 2001-01-26. PMID:10994644. |
schizophrenia is in some cases associated with cognitive impairment similar to that of alzheimer patients; therefore, one may postulate that the apoe gene, whose role in the dementia of alzheimer's type has been clearly demonstrated, may also be involved in schizophrenia. |
2001-01-26 |
2023-08-12 |
Not clear |
| N Durany, P Riederer, F F Cruz-Sánche. Apolipoprotein E genotype in Spanish schizophrenic patients. Psychiatric genetics. vol 10. issue 2. 2001-01-26. PMID:10994644. |
our negative data do not support an involvement of apoe in schizophrenia, and suggest that the underlying mechanism for the cognitive impairment found in schizophrenic patients is not related to that of alzheimer's patients nor to a higher prevalence of the apoe allele 4. |
2001-01-26 |
2023-08-12 |
Not clear |
| T Tapiola, T Pirttilä, P D Mehta, I Alafuzofff, M Lehtovirta, H Soinine. Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease. Neurobiology of aging. vol 21. issue 5. 2001-01-18. PMID:11016543. |
relationship between apoe genotype and csf beta-amyloid (1-42) and tau in patients with probable and definite alzheimer's disease. |
2001-01-18 |
2023-08-12 |
Not clear |
| D M Maraganore, M J Farrer, J A Hardy, S K McDonnell, D J Schaid, W A Rocc. Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 15. issue 4. 2001-01-11. PMID:10928584. |
we investigated the association of parkinson's disease (pd) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (cyp2d6) and n-acetyltransferase 2 (nat2), and with one gene related to alzheimer's disease, apolipoprotein e (apoe). |
2001-01-11 |
2023-08-12 |
human |
| J C Wang, J M Kwon, P Shah, J C Morris, A Goat. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease. Neurology. vol 55. issue 11. 2001-01-11. PMID:11113217. |
effect of apoe genotype and promoter polymorphism on risk of alzheimer's disease. |
2001-01-11 |
2023-08-12 |
Not clear |
| J D Yang, G Feng, J Zhang, Z X Lin, T Shen, G Breen, D St Clair, L H. Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. Neuroscience letters. vol 295. issue 1-2. 2001-01-09. PMID:11078932. |
there is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (apoe) gene is a major risk factor for late-onset alzheimer's disease (ad). |
2001-01-09 |
2023-08-12 |
Not clear |