| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M DeKroon, P J Armat. The endosomal trafficking of apolipoprotein E3 and E4 in cultured human brain neurons and astrocytes. Neurobiology of disease. vol 8. issue 1. 2001-05-24. PMID:11162242. |
the association of the e4 isoform of apolipoprotein e (apoe) as a genetic risk factor for late onset alzheimer's disease (ad) has been well established. |
2001-05-24 |
2023-08-12 |
human |
| J H Jhoo, K W Kim, D Y Lee, K U Lee, J H Lee, S Y Kim, J Y Youn, J C Youn, J I Wo. Association of alpha-2-macroglobulin deletion polymorphism with sporadic Alzheimer's disease in Koreans. Journal of the neurological sciences. vol 184. issue 1. 2001-05-24. PMID:11231028. |
alpha-2-macroglobulin (a2m) deletion polymorphism was recently reported to be associated with alzheimer's disease (ad) in a way comparable to apolipoprotein e (apoe) polymorphism in a family-based study. |
2001-05-24 |
2023-08-12 |
human |
| K Urakami, Y Wakutani, K Wada-Isoe, K Yamagata, Y Adachi, K Nakashim. [Causative genes in Alzheimer's disease]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 38. issue 2. 2001-05-24. PMID:11305015. |
third, apoe mrna level in the brains of patients with alzheimer's disease (27 cases) and down's syndrome (11 cases) was determined by reverse transcriptase-polymerase chain reaction (rt-pcr). |
2001-05-24 |
2023-08-12 |
Not clear |
| K Urakami, Y Wakutani, K Wada-Isoe, K Yamagata, Y Adachi, K Nakashim. [Causative genes in Alzheimer's disease]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 38. issue 2. 2001-05-24. PMID:11305015. |
high levels of apoe mrna in ad and ds may play an important role in the development of alzheimer pathology. |
2001-05-24 |
2023-08-12 |
Not clear |
| K Czyzewski, M M Lalowski, A Pfeffer, M Barcikowsk. Lipid metabolism parameters in patients with Alzheimer's disease and their first degree relatives. Acta neurobiologiae experimentalis. vol 61. issue 1. 2001-05-21. PMID:11315318. |
recently, it was suggested that the presence of total cholesterol (tc), age and sex interaction in alzheimer's type dementia (ad) is linked with the apolipoprotein e (apoe) genotype. |
2001-05-21 |
2023-08-12 |
Not clear |
| V Senanarong, K Harnphadungkit, P Lertrit, C Mitrpant, S Udompunthurak, C Limwong, N Prayoonwiwat, N Poungvari. Experience of ApoE study in Thai elderly. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 84. issue 2. 2001-05-21. PMID:11336076. |
the association between apoe e4 and dementia is reported in alzheimer's disease and other dementia such as in multi-infarct dementia. |
2001-05-21 |
2023-08-12 |
Not clear |
| P Bonay, J Avil. Apolipoprotein E4 stimulates sulfation of glycosaminoglycans in neural cells. Biochimica et biophysica acta. vol 1535. issue 3. 2001-05-17. PMID:11278162. |
since the presence of apoe is a risk factor for alzheimer's disease (ad) and the presence of sgag could facilitate the assembly of the main components, beta-amyloid and tau proteins, of the aberrant structures found in ad, the present study indicates a possible relation between those factors. |
2001-05-17 |
2023-08-12 |
Not clear |
| C Ramassamy, P Krzywkowski, D Averill, S Lussier-Cacan, L Theroux, Y Christen, J Davignon, J Poirie. Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain. Brain research. Molecular brain research. vol 86. issue 1-2. 2001-05-10. PMID:11165374. |
apolipoprotein e (apoe) is a lipid transport molecule, which has been linked to the pathogenesis of alzheimer's disease. |
2001-05-10 |
2023-08-12 |
mouse |
| J Dong, C A Peters-Libeu, K H Weisgraber, B W Segelke, B Rupp, I Capila, M J Hernáiz, L A LeBrun, R J Linhard. Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry. vol 40. issue 9. 2001-05-10. PMID:11258893. |
apoe is a major genetic risk factor in heart disease and in neurodegenerative disease, including alzheimer's disease. |
2001-05-10 |
2023-08-12 |
human |
| J Dong, C A Peters-Libeu, K H Weisgraber, B W Segelke, B Rupp, I Capila, M J Hernáiz, L A LeBrun, R J Linhard. Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry. vol 40. issue 9. 2001-05-10. PMID:11258893. |
the interaction of apoe with heparan sulfate proteoglycans plays an important role in lipoprotein remnant uptake and likely in atherogenesis and alzheimer's disease. |
2001-05-10 |
2023-08-12 |
human |
| F Brahimi, P Bertrand, M Starck, M M Galteau, G Sies. Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2. Cell biochemistry and function. vol 19. issue 1. 2001-04-26. PMID:11223871. |
even though it is known that apolipoprotein e (apoe) is deeply involved in major age-related disorders such as atherosclerosis or alzheimer's disease (ad), the control of cell-specific apoe expression is still poorly understood. |
2001-04-26 |
2023-08-12 |
human |
| H S Cho, B T Hyman, S M Greenberg, G W Rebec. Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation. Journal of neuropathology and experimental neurology. vol 60. issue 4. 2001-04-19. PMID:11305869. |
quantitation of apoe domains in alzheimer disease brain suggests a role for apoe in abeta aggregation. |
2001-04-19 |
2023-08-12 |
Not clear |
| H S Cho, B T Hyman, S M Greenberg, G W Rebec. Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation. Journal of neuropathology and experimental neurology. vol 60. issue 4. 2001-04-19. PMID:11305869. |
apolipoprotein e (apoe) and apoe-derived proteolytic fragments are present in amyloid deposits in alzheimer disease (ad) and cerebral amyloid angiopathy (caa). |
2001-04-19 |
2023-08-12 |
Not clear |
| J R Lynch, D Morgan, J Mance, W D Matthew, D T Laskowit. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. Journal of neuroimmunology. vol 114. issue 1-2. 2001-04-12. PMID:11240021. |
apolipoprotein e (apoe) is a 299 amino acid protein that is associated with risk of developing alzheimer's disease (ad) and outcome after acute brain injury. |
2001-04-12 |
2023-08-12 |
human |
| X Wang, E K Luedecking, R L Minster, M Ganguli, S T DeKosky, M I Kambo. Lack of association between alpha2-macroglobulin polymorphisms and Alzheimer's disease. Human genetics. vol 108. issue 2. 2001-04-12. PMID:11281447. |
this study was undertaken to investigate the role of two alpha2-macroglobulin (a2m) polymorphisms, an intronic 5-bp deletion and ile1000val, in the development of alzheimer's disease (ad) and to evaluate the interaction between the apolipoprotein e (apoe) and a2m polymorphisms. |
2001-04-12 |
2023-08-12 |
Not clear |
| M A Pericak-Vance, J Grubber, L R Bailey, D Hedges, S West, L Santoro, B Kemmerer, J L Hall, A M Saunders, A D Roses, G W Small, W K Scott, P M Conneally, J M Vance, J L Haine. Identification of novel genes in late-onset Alzheimer's disease. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113612. |
four genes affecting alzheimer's disease (ad)(ap, ps1, ps2, and apoe) have been identified and a fifth potential gene localized to chromosome 12. |
2001-03-29 |
2023-08-12 |
Not clear |
| B Paradowski, M Szczepaniak, T Dobosz, M Sasiade. [Apolipoprotein E(ApoE)and tau protein in Alzheimer type dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 9. issue 53. 2001-03-08. PMID:11204323. |
[apolipoprotein e(apoe)and tau protein in alzheimer type dementia]. |
2001-03-08 |
2023-08-12 |
Not clear |
| B Paradowski, M Szczepaniak, T Dobosz, M Sasiade. [Apolipoprotein E(ApoE)and tau protein in Alzheimer type dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 9. issue 53. 2001-03-08. PMID:11204323. |
in 45 patients meeting nincds-ardra criteria for probably diagnosis of alzheimer disease (ad), apoe genotype and tau protein level in cerebro-spinal fluid (csf) were determined. |
2001-03-08 |
2023-08-12 |
Not clear |
| B Paradowski, M Szczepaniak, T Dobosz, M Sasiade. [Apolipoprotein E(ApoE)and tau protein in Alzheimer type dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 9. issue 53. 2001-03-08. PMID:11204323. |
the authors emphasize the usefulness of tau protein level measurement and determination of apoe allele in diagnosis of alzheimer disease. |
2001-03-08 |
2023-08-12 |
Not clear |
| Y Hatanaka, K Kamino, K Fukuo, N Mitsuda, Y Nishiwaki-Ueda, N Sato, T Satoh, H Yamamoto, H Yoneda, M Imagawa, T Miki, S Ohta, T Ogihar. Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clinical genetics. vol 58. issue 4. 2001-03-01. PMID:11076057. |
low density lipoprotein (ldl) receptor-related protein (lrp) gene polymorphisms located in the 5' region and in exon 3, and the apolipoprotein e (apoe) genotype were determined in 100 japanese patients affected by late-onset alzheimer's disease (ad). |
2001-03-01 |
2023-08-12 |
Not clear |