| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Vincent, J D Smit. Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner. The European journal of neuroscience. vol 14. issue 2. 2001-10-11. PMID:11553277. |
thus, apoe and astrocytic factor(s) may modulate the pathogenesis of alzheimer's disease. |
2001-10-11 |
2023-08-12 |
mouse |
| T Niskakangas, J Ohman, M Niemelä, E Ilveskoski, T A Kunnas, P J Karhune. Association of apolipoprotein E polymorphism with outcome after aneurysmal subarachnoid hemorrhage: a preliminary study. Stroke. vol 32. issue 5. 2001-09-27. PMID:11340230. |
apoe genotype is the most important genetic determinant of susceptibility to alzheimer's disease, and it is also shown to be associated with the outcome after traumatic brain injury. |
2001-09-27 |
2023-08-12 |
Not clear |
| K Yanagisaw. [Risk factors for Alzheimer's disease]. Rinsho shinkeigaku = Clinical neurology. vol 40. issue 12. 2001-09-27. PMID:11464462. |
apolipoprotein e (apoe) is the major risk factor, besides aging, for alzheimer's disease (ad). |
2001-09-27 |
2023-08-12 |
Not clear |
| F White, J A Nicoll, A D Roses, K Horsburg. Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion. Neurobiology of disease. vol 8. issue 4. 2001-09-27. PMID:11493026. |
the apolipoprotein e (apoe) epsilon 4 allele is a major risk factor for late-onset familial and sporadic alzheimer's disease (ad) and is associated with a poor outcome after brain injury. |
2001-09-27 |
2023-08-12 |
mouse |
| A E Molero, G Pino-Ramírez, G E Maestr. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neuroscience letters. vol 307. issue 1. 2001-09-27. PMID:11516561. |
an ongoing longitudinal study in maracaibo, venezuela, examined the interaction between apolipoprotein e (apoe) genotypes and alzheimer's disease (ad) and vascular dementia (vd), evaluating age and gender as potential modifiers of risk. |
2001-09-27 |
2023-08-12 |
human |
| J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harli. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet (London, England). vol 357. issue 9256. 2001-09-27. PMID:11558492. |
effect of the apoe promoter polymorphisms on cerebral amyloid peptide deposition in alzheimer's disease. |
2001-09-27 |
2023-08-12 |
Not clear |
| J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harli. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet (London, England). vol 357. issue 9256. 2001-09-27. PMID:11558492. |
polymorphisms in the promoter region of the apolipoprotein e gene (apoe) affect the amount of amyloid peptide (abeta) in the brains of patients with alzheimer's disease. |
2001-09-27 |
2023-08-12 |
Not clear |
| J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harli. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet (London, England). vol 357. issue 9256. 2001-09-27. PMID:11558492. |
these findings in patients with confirmed alzheimer's disease are consistent with the hypothesis that variation in apoe expression directly affects alzheimer's disease pathology. |
2001-09-27 |
2023-08-12 |
Not clear |
| D J Brat, M Gearing, P T Goldthwaite, B H Wainer, P C Burge. Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype. Neuropathology and applied neurobiology. vol 27. issue 3. 2001-09-20. PMID:11489139. |
the frequency and spectrum of degenerative pathology in these lesions have not been defined, nor has their relation to patient age or factors such as apolipoprotein e (apoe) genotype that predispose to alzheimer's disease. |
2001-09-20 |
2023-08-12 |
Not clear |
| A Naidu, R Catalano, K Bales, S Wu, S M Paul, B Cordel. Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease. Neuroreport. vol 12. issue 6. 2001-09-13. PMID:11338204. |
a beta deposition in the appv717f transgenic model of alzheimer's pathology involves apolipoprotein e (apoe). |
2001-09-13 |
2023-08-12 |
mouse |
| K W Kim, J H Jhoo, J H Lee, D Y Lee, K U Lee, J Y Youn, J I Wo. Transferrin C2 variant does not confer a risk for Alzheimer's disease in Koreans. Neuroscience letters. vol 308. issue 1. 2001-09-13. PMID:11445282. |
we analyzed the transferrin (tf) and apolipoprotein e (apoe) genotypes of 164 probable alzheimer's disease (ad) patients and 239 cognitively normal elderly controls in koreans. |
2001-09-13 |
2023-08-12 |
human |
| S Hass, A Weidemann, G Utermann, G Baie. Intracellular apolipoprotein E affects Amyloid Precursor Protein processing and amyloid Abeta production in COS-1 cells. Molecular genetics and genomics : MGG. vol 265. issue 5. 2001-09-13. PMID:11523796. |
the apoe gene has been identified as a major susceptibility locus for late-onset alzheimer's disease (load). |
2001-09-13 |
2023-08-12 |
Not clear |
| S P McIlroy, K B Dynan, D J Vahidassr, J T Lawson, C C Patterson, P Passmor. Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern Ireland. American journal of medical genetics. vol 105. issue 6. 2001-09-06. PMID:11496365. |
genetic variation in one of the major apoe receptors in the brain has been associated with increased risk for alzheimer disease (ad). |
2001-09-06 |
2023-08-12 |
Not clear |
| A Alvarez-Arcaya, O Combarros, J Llorca, M Sánchez-Guerra, J Berciano, J L Fernández-Lun. The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease. Neuroscience letters. vol 304. issue 3. 2001-08-30. PMID:11343837. |
homozygosity for the a allele of the -491 a/t apolipoprotein e (apoe) promoter polymorphism has recently been reported to be associated with sporadic alzheimer's disease (ad). |
2001-08-30 |
2023-08-12 |
Not clear |
| S Matsushita, H Arai, T Yuzuriha, M Kato, T Matsui, K Urakami, S Higuch. No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. Neurobiology of aging. vol 22. issue 4. 2001-08-30. PMID:11445257. |
among many candidate genes for the genetically heterogeneous alzheimer's disease (ad), only apolipoprotein e (apoe) has been confirmed. |
2001-08-30 |
2023-08-12 |
human |
| H C Kim, D K Kim, I J Choi, K H Kang, S D Yi, J Park, Y N Par. Relation of apolipoprotein E polymorphism to clinically diagnosed Alzheimer's disease in the Korean population. Psychiatry and clinical neurosciences. vol 55. issue 2. 2001-08-23. PMID:11285089. |
the apoe epsilon4 allele is overrepresented in alzheimer's disease (ad) and is accepted as a genetic risk factor. |
2001-08-23 |
2023-08-12 |
human |
| M Kimura, S Matsushita, H Arai, T Matsui, T Yuzuriha, S Higuch. No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer's disease in Japanese. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 12. 2001-08-23. PMID:11458997. |
the reported association between -491 a/t polymorphism in the regulatory region of the apolipoprotein e gene (apoe) and increased risk for alzheimer's disease (ad) is controversial: studies of different racial and ethnic populations have found both positive and negative associations. |
2001-08-23 |
2023-08-12 |
human |
| Y C Yen, C K Liu, F W Lung, M Y Chon. Apolipoprotein E polymorphism and Alzheimer's disease. The Kaohsiung journal of medical sciences. vol 17. issue 4. 2001-08-23. PMID:11482130. |
we aimed to determine the association and related factors of the apolipoprotein e (apoe) genotype and alzheimer's disease (ad) in taiwan. |
2001-08-23 |
2023-08-12 |
Not clear |
| M Ingelson, S F Fabre, L Lilius, C Andersen, M Viitanen, O Almkvist, L O Wahlund, L Lannfel. Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4. Neuroreport. vol 12. issue 5. 2001-08-09. PMID:11303757. |
furthermore, a certain extended tau haplotype has been shown to increase the risk for progressive supranuclear palsy, corticobasal degeneration, parkinson's disease and, in interaction with the apolipoprotein e (apoe) epsilon4 allele, alzheimer's disease. |
2001-08-09 |
2023-08-12 |
Not clear |
| P Zill, R Engel, H Hampel, S Behrens, K Bürger, F Padberg, S Stübner, H J Möller, M Ackenheil, B Bond. Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients. European archives of psychiatry and clinical neuroscience. vol 251. issue 1. 2001-08-09. PMID:11315514. |
two recently described polymorphisms in the promoter region of the apolipoprotein e (apoe), the -491a/t and th1/e47cst/g polymorphism, have been suggested to be associated with an increased risk for alzheimer's disease (ad) independent from the apoe epsilon 4 carrier status. |
2001-08-09 |
2023-08-12 |
Not clear |