| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Gómez-Ramos, E J Mufson, M A Morá. Apolipoprotein E immunoreactivity in neurons and neurofibrillary degeneration of aged non-demented and Alzheimer's disease patients. Microscopy research and technique. vol 55. issue 1. 2001-12-04. PMID:11596149. |
apolipoprotein e (apoe) genotype is a risk factor for alzheimer's disease (ad) but its relationship with neurofibrillary degeneration remains obscure. |
2001-12-04 |
2023-08-12 |
Not clear |
| A E Taylor, A Yip, C Brayne, D Easton, J G Evans, J Xuereb, N Cairns, M M Esiri, D C Rubinsztei. Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease. Journal of medical genetics. vol 38. issue 4. 2001-10-25. PMID:11283204. |
the only locus unequivocally associated with late onset alzheimer's disease (ad) risk is apoe. |
2001-10-25 |
2023-08-12 |
Not clear |
| L Sánchez, V Alvarez, P González, I González, R Alvarez, E Cot. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. American journal of medical genetics. vol 105. issue 1. 2001-10-25. PMID:11425005. |
genetic variation at the apoe, a2m, and lrp genes has been associated with the risk of developing late-onset alzheimer disease (load). |
2001-10-25 |
2023-08-12 |
Not clear |
| Y T Chang, S F Tsai, W J Wang, C J Hong, C Y Huang, C K Won. A study of apolipoproteins E and A-I in cutaneous amyloids. The British journal of dermatology. vol 145. issue 3. 2001-10-25. PMID:11531831. |
apolipoprotein e (apoe) is present in a variety of biochemically different amyloid deposits, including alzheimer's disease, systemic amyloidosis and primary cutaneous amyloidosis (pca). |
2001-10-25 |
2023-08-12 |
Not clear |
| Y T Chang, S F Tsai, W J Wang, C J Hong, C Y Huang, C K Won. A study of apolipoproteins E and A-I in cutaneous amyloids. The British journal of dermatology. vol 145. issue 3. 2001-10-25. PMID:11531831. |
among the three closely related alleleic forms of apoe, the epsilon4 allele is linked to alzheimer's disease. |
2001-10-25 |
2023-08-12 |
Not clear |
| B Vincent, J D Smit. Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner. The European journal of neuroscience. vol 14. issue 2. 2001-10-11. PMID:11553277. |
thus, apoe and astrocytic factor(s) may modulate the pathogenesis of alzheimer's disease. |
2001-10-11 |
2023-08-12 |
mouse |
| T Niskakangas, J Ohman, M Niemelä, E Ilveskoski, T A Kunnas, P J Karhune. Association of apolipoprotein E polymorphism with outcome after aneurysmal subarachnoid hemorrhage: a preliminary study. Stroke. vol 32. issue 5. 2001-09-27. PMID:11340230. |
apoe genotype is the most important genetic determinant of susceptibility to alzheimer's disease, and it is also shown to be associated with the outcome after traumatic brain injury. |
2001-09-27 |
2023-08-12 |
Not clear |
| K Yanagisaw. [Risk factors for Alzheimer's disease]. Rinsho shinkeigaku = Clinical neurology. vol 40. issue 12. 2001-09-27. PMID:11464462. |
apolipoprotein e (apoe) is the major risk factor, besides aging, for alzheimer's disease (ad). |
2001-09-27 |
2023-08-12 |
Not clear |
| F White, J A Nicoll, A D Roses, K Horsburg. Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion. Neurobiology of disease. vol 8. issue 4. 2001-09-27. PMID:11493026. |
the apolipoprotein e (apoe) epsilon 4 allele is a major risk factor for late-onset familial and sporadic alzheimer's disease (ad) and is associated with a poor outcome after brain injury. |
2001-09-27 |
2023-08-12 |
mouse |
| A E Molero, G Pino-Ramírez, G E Maestr. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neuroscience letters. vol 307. issue 1. 2001-09-27. PMID:11516561. |
an ongoing longitudinal study in maracaibo, venezuela, examined the interaction between apolipoprotein e (apoe) genotypes and alzheimer's disease (ad) and vascular dementia (vd), evaluating age and gender as potential modifiers of risk. |
2001-09-27 |
2023-08-12 |
human |
| J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harli. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet (London, England). vol 357. issue 9256. 2001-09-27. PMID:11558492. |
effect of the apoe promoter polymorphisms on cerebral amyloid peptide deposition in alzheimer's disease. |
2001-09-27 |
2023-08-12 |
Not clear |
| J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harli. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet (London, England). vol 357. issue 9256. 2001-09-27. PMID:11558492. |
polymorphisms in the promoter region of the apolipoprotein e gene (apoe) affect the amount of amyloid peptide (abeta) in the brains of patients with alzheimer's disease. |
2001-09-27 |
2023-08-12 |
Not clear |
| J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harli. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet (London, England). vol 357. issue 9256. 2001-09-27. PMID:11558492. |
these findings in patients with confirmed alzheimer's disease are consistent with the hypothesis that variation in apoe expression directly affects alzheimer's disease pathology. |
2001-09-27 |
2023-08-12 |
Not clear |
| D J Brat, M Gearing, P T Goldthwaite, B H Wainer, P C Burge. Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype. Neuropathology and applied neurobiology. vol 27. issue 3. 2001-09-20. PMID:11489139. |
the frequency and spectrum of degenerative pathology in these lesions have not been defined, nor has their relation to patient age or factors such as apolipoprotein e (apoe) genotype that predispose to alzheimer's disease. |
2001-09-20 |
2023-08-12 |
Not clear |
| A Naidu, R Catalano, K Bales, S Wu, S M Paul, B Cordel. Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease. Neuroreport. vol 12. issue 6. 2001-09-13. PMID:11338204. |
a beta deposition in the appv717f transgenic model of alzheimer's pathology involves apolipoprotein e (apoe). |
2001-09-13 |
2023-08-12 |
mouse |
| K W Kim, J H Jhoo, J H Lee, D Y Lee, K U Lee, J Y Youn, J I Wo. Transferrin C2 variant does not confer a risk for Alzheimer's disease in Koreans. Neuroscience letters. vol 308. issue 1. 2001-09-13. PMID:11445282. |
we analyzed the transferrin (tf) and apolipoprotein e (apoe) genotypes of 164 probable alzheimer's disease (ad) patients and 239 cognitively normal elderly controls in koreans. |
2001-09-13 |
2023-08-12 |
human |
| S Hass, A Weidemann, G Utermann, G Baie. Intracellular apolipoprotein E affects Amyloid Precursor Protein processing and amyloid Abeta production in COS-1 cells. Molecular genetics and genomics : MGG. vol 265. issue 5. 2001-09-13. PMID:11523796. |
the apoe gene has been identified as a major susceptibility locus for late-onset alzheimer's disease (load). |
2001-09-13 |
2023-08-12 |
Not clear |
| S P McIlroy, K B Dynan, D J Vahidassr, J T Lawson, C C Patterson, P Passmor. Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern Ireland. American journal of medical genetics. vol 105. issue 6. 2001-09-06. PMID:11496365. |
genetic variation in one of the major apoe receptors in the brain has been associated with increased risk for alzheimer disease (ad). |
2001-09-06 |
2023-08-12 |
Not clear |
| A Alvarez-Arcaya, O Combarros, J Llorca, M Sánchez-Guerra, J Berciano, J L Fernández-Lun. The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease. Neuroscience letters. vol 304. issue 3. 2001-08-30. PMID:11343837. |
homozygosity for the a allele of the -491 a/t apolipoprotein e (apoe) promoter polymorphism has recently been reported to be associated with sporadic alzheimer's disease (ad). |
2001-08-30 |
2023-08-12 |
Not clear |
| S Matsushita, H Arai, T Yuzuriha, M Kato, T Matsui, K Urakami, S Higuch. No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. Neurobiology of aging. vol 22. issue 4. 2001-08-30. PMID:11445257. |
among many candidate genes for the genetically heterogeneous alzheimer's disease (ad), only apolipoprotein e (apoe) has been confirmed. |
2001-08-30 |
2023-08-12 |
human |