| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Yoshida, Y Iwabuchi, Y Numachi, H Saito, H Yamazaki, H Sakai, M Kimura, H Matsuoka, M Sat. Clinical features and alterations in the inferior horn sizes in lateral ventricle in Alzheimer's patients with different ApoE genotype in Japanese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 7. 2002-01-15. PMID:11513353. |
e4 allele of apolipoprotein e (apoe) is considered to be not only a risk factor for alzheimer's disease (ad) but also a determinant of clinical features in ad. |
2002-01-15 |
2023-08-12 |
Not clear |
| H R Morris, A Schrag, U Nath, D Burn, N P Quinn, S Daniel, N W Wood, A J Lee. Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy. Neuroscience letters. vol 312. issue 2. 2002-01-15. PMID:11595348. |
the apoe epsilon4 allele is associated with an earlier age of onset of sporadic and familial alzheimer's disease. |
2002-01-15 |
2023-08-12 |
Not clear |
| K Urakami, Y Wakutani, K Wada-Isoe, K Yamagata, Y Adachi, K Nakashim. [Analysis of causative genes and genetic risk factor in Alzheimer's disease]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 38. issue 6. 2002-01-14. PMID:11774719. |
many reports have established that apoe genotype distribution for the epsilon 4 allele is a susceptibility factor for the earlier onset and more rapid progression of alzheimer's disease (ad). |
2002-01-14 |
2023-08-12 |
Not clear |
| C Russ, J F Powell, J Zhao, M Baker, M Hutton, F Crawford, M Mullan, G Roks, M Cruts, S Loveston. The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698154. |
several studies have suggested an association between polymorphisms and an extended haplotype of the microtubule associated protein tau gene and alzheimer's disease (ad) in synergy with apolipoprotein e (apoe) epsilon 4 status. |
2002-01-07 |
2023-08-12 |
Not clear |
| R B DeMattos, R P Brendza, J E Heuser, M Kierson, J R Cirrito, J Fryer, P M Sullivan, A M Fagan, X Han, D M Holtzma. Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578777. |
the varepsilon4 allele of apolipoprotein e (apoe) is a genetic risk factor for alzheimer's disease (ad). |
2001-12-28 |
2023-08-12 |
mouse |
| G I Korovaĭtseva, T V Shcherbatykh, N V Selezneva, S I Gavrilova, V E Golimbet, N I Voskresenskaia, E I Rogae. [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika. vol 37. issue 4. 2001-12-21. PMID:11421127. |
[genetic association between the apolipoprotein e (apoe) gene alleles and various forms of alzheimer's disease]. |
2001-12-21 |
2023-08-12 |
Not clear |
| G I Korovaĭtseva, T V Shcherbatykh, N V Selezneva, S I Gavrilova, V E Golimbet, N I Voskresenskaia, E I Rogae. [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika. vol 37. issue 4. 2001-12-21. PMID:11421127. |
allele epsilon 4 of the apolipoprotein e (apoe) gene is associated with higher risk of alzheimer's disease (ad) in many, though not all, ethnic groups. |
2001-12-21 |
2023-08-12 |
Not clear |
| A S Rigaud, L Traykov, L Caputo, J Coste, F Latour, R Couderc, F Moulin, F Boller, F Forett. Association of the apolipoprotein E epsilon4 allele with late-onset depression. Neuroepidemiology. vol 20. issue 4. 2001-12-19. PMID:11684904. |
apolipoprotein e (apoe) phenotyping was determined in 42 subjects with alzheimer's disease (ad), 49 with depression, including 26 with early-onset depression (eod) and 23 with late-onset depression (lod), and 49 controls. |
2001-12-19 |
2023-08-12 |
human |
| W J Strittmatte. Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447826. |
the three common apolipoprotein e (apoe) alleles differentially contribute to the risk of alzheimer's disease (ad). |
2001-12-14 |
2023-08-12 |
Not clear |
| S Lovestone, B Anderton, J Betts, R Dayanandan, G Gibb, C Ljungberg, J Pearc. Apolipoprotein E gene and Alzheimer's disease: is tau the link? Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447827. |
the finding that apoe (the gene encoding apolipoprotein e) polymorphic variation was associated with an altered risk of developing alzheimer's disease (ad) was a significant advance and immediately prompted a search for the mechanisms responsible for this alteration. |
2001-12-14 |
2023-08-12 |
Not clear |
| T G Ohm, U Hamker, A Cedazo-Minguez, W Röckl, H Scharnagl, W März, R Cowburn, W Müller, V Mesk. Apolipoprotein E and beta A4-amyloid: signals and effects. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447828. |
apart from age, the apoe epsilon 4 allele represents the most important risk factor in sporadic alzheimer's disease (ad). |
2001-12-14 |
2023-08-12 |
Not clear |
| S Jiang, S Lin, G Tan. [The association between microsatellite polymorphism of alpha 1-antichymotrypsin gene and Alzheimer's disease]. Zhonghua yi xue za zhi. vol 79. issue 8. 2001-12-14. PMID:11715411. |
to examine the relation between the microsatellite polymorphism of alpha 1-antichymotrypsin (aact) gene and alzheimer's disease (ad) in han population of shanghai area, and to detect the influences of apolipoprotein e (apoe) gene epsilon 4 allele on this relation. |
2001-12-14 |
2023-08-12 |
Not clear |
| M Sjögren, C Hesse, H Basun, G Köl, H Thostrup, L Kilander, J Marcusson, A Edman, A Wallin, I Karlsson, M Troell, G Wachtmaister, A Ekdahl, H Olofsson, A Sandström, N Andreasen, L Minthon, K Blenno. Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 4. 2001-12-12. PMID:11475012. |
tacrine and rate of progression in alzheimer's disease--relation to apoe allele genotype. |
2001-12-12 |
2023-08-12 |
Not clear |
| E M Reiman, R J Caselli, K Chen, G E Alexander, D Bandy, J Fros. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 6. 2001-12-04. PMID:11248079. |
cross-sectional positron emission tomography (pet) studies find that cognitively normal carriers of the apolipoprotein e (apoe) epsilon4 allele, a common alzheimer's susceptibility gene, have abnormally low measurements of the cerebral metabolic rate for glucose (cmrgl) in the same regions as patients with alzheimer's dementia. |
2001-12-04 |
2023-08-12 |
human |
| C Hesse, C L Nilsson, K Blennow, P Davidsso. Identification of the apolipoprotein E4 isoform in cerebrospinal fluid with preparative two-dimensional electrophoresis and matrix assisted laser desorption/ionization-time of flight-mass spectrometry. Electrophoresis. vol 22. issue 9. 2001-12-04. PMID:11425239. |
apolipoprotein e (apoe) was isolated from human cerebrospinal fluid (csf) from control individuals and patients with alzheimer's disease (ad). |
2001-12-04 |
2023-08-12 |
human |
| C P Libeu, S Lund-Katz, M C Phillips, S Wehrli, M J Hernáiz, I Capila, R J Linhardt, R L Raffaï, Y M Newhouse, F Zhou, K H Weisgrabe. New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11500500. |
the interaction of apoe with hspgs has also been implicated in the pathogenesis of alzheimer's disease and may play a role in neuronal repair. |
2001-12-04 |
2023-08-12 |
Not clear |
| C Lendon, N Craddoc. Susceptibility gene(s) for Alzheimer's disease on chromosome 10. Trends in neurosciences. vol 24. issue 10. 2001-12-04. PMID:11576650. |
one of these genes is apolipoprotein e where the polymorphic allele (apoe epsilon 4) has been robustly shown to modify risk and the course of alzheimer's disease. |
2001-12-04 |
2023-08-12 |
Not clear |
| P Gómez-Ramos, E J Mufson, M A Morá. Apolipoprotein E immunoreactivity in neurons and neurofibrillary degeneration of aged non-demented and Alzheimer's disease patients. Microscopy research and technique. vol 55. issue 1. 2001-12-04. PMID:11596149. |
apolipoprotein e (apoe) genotype is a risk factor for alzheimer's disease (ad) but its relationship with neurofibrillary degeneration remains obscure. |
2001-12-04 |
2023-08-12 |
Not clear |
| A E Taylor, A Yip, C Brayne, D Easton, J G Evans, J Xuereb, N Cairns, M M Esiri, D C Rubinsztei. Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease. Journal of medical genetics. vol 38. issue 4. 2001-10-25. PMID:11283204. |
the only locus unequivocally associated with late onset alzheimer's disease (ad) risk is apoe. |
2001-10-25 |
2023-08-12 |
Not clear |
| L Sánchez, V Alvarez, P González, I González, R Alvarez, E Cot. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. American journal of medical genetics. vol 105. issue 1. 2001-10-25. PMID:11425005. |
genetic variation at the apoe, a2m, and lrp genes has been associated with the risk of developing late-onset alzheimer disease (load). |
2001-10-25 |
2023-08-12 |
Not clear |