| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Casey N Bassett, Larry L Swift, Kathleen S Montine, William R Markesbery, Thomas J Montin. Cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in Alzheimer's disease and is dependent on apoE monomer concentration. Journal of Alzheimer's disease : JAD. vol 4. issue 1. 2002-10-29. PMID:12214015. |
cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in alzheimer's disease and is dependent on apoe monomer concentration. |
2002-10-29 |
2023-08-12 |
human |
| Kartrin Beyer, José I Lao, Milagros Gómez, Nadal Riutort, Pilar Latorre, José L Mate, Aurelio Ariz. Identification of a protective allele against Alzheimer disease in the APOE gene promoter. Neuroreport. vol 13. issue 11. 2002-10-18. PMID:12167762. |
identification of a protective allele against alzheimer disease in the apoe gene promoter. |
2002-10-18 |
2023-08-12 |
Not clear |
| Nicholas M Bentley, Mary Jo Ladu, Chandrika Rajan, Godfrey S Getz, Catherine A Reardo. Apolipoprotein E structural requirements for the formation of SDS-stable complexes with beta-amyloid-(1-40): the role of salt bridges. The Biochemical journal. vol 366. issue Pt 1. 2002-10-08. PMID:12015813. |
of the three major isoforms of human apolipoprotein e (apoe), apoe4 is a risk factor for the development of alzheimer's disease. |
2002-10-08 |
2023-08-12 |
human |
| G Roks, M Cruts, J J Houwing-Duistermaat, B Dermaut, S Serneels, L M Havekes, A Hofman, M M B Breteler, C Van Broeckhoven, C M van Duij. Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study. American journal of medical genetics. vol 114. issue 5. 2002-10-01. PMID:12116196. |
besides its role in lipid transport, the apoe*4 allele is a genetic risk factor for alzheimer disease (ad). |
2002-10-01 |
2023-08-12 |
Not clear |
| Ian J Deary, Martha C Whiteman, Alison Pattie, John M Starr, Caroline Hayward, Alan F Wright, Andrew Carothers, Lawrence J Whalle. Cognitive change and the APOE epsilon 4 allele. Nature. vol 418. issue 6901. 2002-09-27. PMID:12198535. |
this effect of the apoe epsilon 4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards alzheimer's disease. |
2002-09-27 |
2023-08-12 |
human |
| Thomas Müller-Thomsen, Sönke Arlt, Stefanie Ganzer, Ulrike Mann, Reinhard Mass, Dieter Naber, Ulrike Beisiege. Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. Dementia and geriatric cognitive disorders. vol 14. issue 2. 2002-09-26. PMID:12145452. |
the association between depression and apolipoprotein e (apoe) was investigated in 137 out-patients with alzheimer's disease. |
2002-09-26 |
2023-08-12 |
Not clear |
| Jonathan D Smit. Apolipoproteins and aging: emerging mechanisms. Ageing research reviews. vol 1. issue 3. 2002-09-09. PMID:12067591. |
one variant of apoe (e4) is associated with increased risk for heart disease, stroke and alzheimer's disease (ad). |
2002-09-09 |
2023-08-12 |
Not clear |
| Matthew A Wozniak, Ruth F Itzhaki, E Brian Faragher, Martin W James, Steven D Ryder, William L Irvin. Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Hepatology (Baltimore, Md.). vol 36. issue 2. 2002-08-27. PMID:12143056. |
apoe genotypes can affect the extent of damage in diseases caused by 2 other viruses--herpes simplex virus type 1 (hsv1; in alzheimer's disease and herpes labialis) and human immunodeficiency virus (hiv). |
2002-08-27 |
2023-08-12 |
human |
| A M Colacicco, F Panza, A M Basile, V Solfrizzi, C Capurso, A D'Introno, F Torres, S Capurso, S Cozza, R Flora, A Capurs. F175S change and a novel polymorphism in presenilin-1 gene in late-onset familial Alzheimer's disease. European neurology. vol 47. issue 4. 2002-08-22. PMID:12037434. |
we analyzed at the molecular level with presenilin-1 (ps-1) and apolipoprotein e (apoe) genotyping the affected subjects and asymptomatic relatives of an italian family with several members affected by late-onset familial alzheimer's disease (ad). |
2002-08-22 |
2023-08-12 |
human |
| Spiros Georgopoulos, Ann McKee, Horng-Yuan Kan, Vassilis I Zanni. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry. vol 41. issue 30. 2002-08-22. PMID:12135350. |
apolipoprotein e (apoe) isoforms are key determinants of susceptibility to late-onset alzheimer's disease (ad). |
2002-08-22 |
2023-08-12 |
mouse |
| B Teter, P-T Xu, J R Gilbert, A D Roses, D Galasko, G M Col. Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. Journal of neuroscience research. vol 68. issue 3. 2002-08-21. PMID:12111863. |
the apolipoprotein e (apoe) epsilon 4 allele (apoe4) is a major risk factor for neurodegenerative conditions, including alzheimer's disease (ad). |
2002-08-21 |
2023-08-12 |
mouse |
| Anne M Fagan, Melanie Watson, Maia Parsadanian, Kelly R Bales, Steven M Paul, David M Holtzma. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 9. issue 3. 2002-08-13. PMID:11950276. |
human and murine apoe markedly alters a beta metabolism before and after plaque formation in a mouse model of alzheimer's disease. |
2002-08-13 |
2023-08-12 |
mouse |
| Anne M Fagan, Melanie Watson, Maia Parsadanian, Kelly R Bales, Steven M Paul, David M Holtzma. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 9. issue 3. 2002-08-13. PMID:11950276. |
the epsilon4 allele of apolipoprotein e (apoe) is a risk factor for alzheimer's disease (ad), perhaps through effects on amyloid-beta (abeta) metabolism. |
2002-08-13 |
2023-08-12 |
mouse |
| Lena Brong. Magnetic resonance imaging in dementia. A study of brain white matter changes. Acta radiologica. Supplementum. issue 428. 2002-08-09. PMID:12145969. |
in study iii the relation between wmc and apolipoprotein e (apoe) genotype was explored in patients with alzheimer's disease (ad). |
2002-08-09 |
2023-08-12 |
human |
| Miia Kivipelto, Eeva-Liisa Helkala, Mikko P Laakso, Tuomo Hänninen, Merja Hallikainen, Kari Alhainen, Susan Iivonen, Arto Mannermaa, Jaakko Tuomilehto, Aulikki Nissinen, Hilkka Soinine. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Annals of internal medicine. vol 137. issue 3. 2002-08-09. PMID:12160362. |
presence of the apolipoprotein e (apoe) epsilon4 allele, which is involved in cholesterol metabolism, is the most important genetic risk factor for alzheimer disease. |
2002-08-09 |
2023-08-12 |
Not clear |
| Kazuyoshi Yamauchi, Minoru Tozuka, Hiroya Hidaka, Tetsuo Nakabayashi, Mitsutoshi Sugano, Tsutomu Katsuyam. Isoform-specific effect of apolipoprotein E on endocytosis of beta-amyloid in cultures of neuroblastoma cells. Annals of clinical and laboratory science. vol 32. issue 1. 2002-08-06. PMID:11848621. |
investigation of the interactions of nerve cells with human apolipoprotein e (apoe), beta-amyloid (abeta), and their complex, which are known to be included in senile plaques, is necessary to clarify the functional role of apoe in the pathogenesis of alzheimer's disease. |
2002-08-06 |
2023-08-12 |
human |
| Kazuyoshi Yamauchi, Minoru Tozuka, Hiroya Hidaka, Tetsuo Nakabayashi, Mitsutoshi Sugano, Tsutomu Katsuyam. Isoform-specific effect of apolipoprotein E on endocytosis of beta-amyloid in cultures of neuroblastoma cells. Annals of clinical and laboratory science. vol 32. issue 1. 2002-08-06. PMID:11848621. |
the isoform-specific effects of apoe on the endocytosis of abeta may be implicated in the development of alzheimer's disease, and if so, each isoform of apoe would induce a different incidence of that disease. |
2002-08-06 |
2023-08-12 |
human |
| Milla Koistinaho, Mikko I Kettunen, David M Holtzman, Risto A Kauppinen, Linda S Higgins, Jari Koistinah. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Stroke. vol 33. issue 7. 2002-08-06. PMID:12105373. |
we studied whether the previously observed vulnerability in mice overexpressing the 751-amino-acid isoform of human amyloid precursor protein (app751) is regulated by human apolipoprotein e (apoe) alleles, which determine the relative risk for alzheimer's disease and the susceptibility to various forms of acute brain damage. |
2002-08-06 |
2023-08-12 |
mouse |
| J-C Lambert, L Araria-Goumidi, L Myllykangas, C Ellis, J C Wang, M J Bullido, J M Harris, M J Artiga, D Hernandez, J M Kwon, B Frigard, R C Petersen, A M Cumming, F Pasquier, I Sastre, P J Tienari, A Frank, R Sulkava, J C Morris, D St Clair, D M Mann, F Wavrant-DeVrièze, M Ezquerra-Trabalon, P Amouyel, J Hardy, M Haltia, F Valdivieso, A M Goate, J Pérez-Tur, C L Lendon, M-C Chartier-Harli. Contribution of APOE promoter polymorphisms to Alzheimer's disease risk. Neurology. vol 59. issue 1. 2002-07-25. PMID:12105308. |
contribution of apoe promoter polymorphisms to alzheimer's disease risk. |
2002-07-25 |
2023-08-12 |
Not clear |
| Barbara Borroni, Francesca Colciaghi, Lucia Pastorino, Silvana Archetti, Paola Corsini, Flaminio Cattabeni, Monica Di Luca, Alessandro Padovan. ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 3. 2002-07-16. PMID:12007670. |
apoe genotype influences the biological effect of donepezil on app metabolism in alzheimer disease: evidence from a peripheral model. |
2002-07-16 |
2023-08-12 |
human |