| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer D Klages, John D Fisk, Kenneth Rockwoo. APOE genotype, memory test performance, and the risk of Alzheimer's disease in the Canadian Study of Health and Aging. Dementia and geriatric cognitive disorders. vol 15. issue 1. 2003-03-28. PMID:12457072. |
apoe genotype, memory test performance, and the risk of alzheimer's disease in the canadian study of health and aging. |
2003-03-28 |
2023-08-12 |
Not clear |
| Jennifer D Klages, John D Fisk, Kenneth Rockwoo. APOE genotype, memory test performance, and the risk of Alzheimer's disease in the Canadian Study of Health and Aging. Dementia and geriatric cognitive disorders. vol 15. issue 1. 2003-03-28. PMID:12457072. |
this study examined the relation between two risks for alzheimer's disease (ad): the apolipoprotein (apoe) epsilon4 allele and poor memory test performance. |
2003-03-28 |
2023-08-12 |
Not clear |
| Simon M Laws, Eugene Hone, Sam Gandy, Ralph N Martin. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of neurochemistry. vol 84. issue 6. 2003-03-28. PMID:12614323. |
expanding the association between the apoe gene and the risk of alzheimer's disease: possible roles for apoe promoter polymorphisms and alterations in apoe transcription. |
2003-03-28 |
2023-08-12 |
Not clear |
| Karen H Gylys, Jeffrey A Fein, Aiko M Tan, Gregory M Col. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals. Journal of neurochemistry. vol 84. issue 6. 2003-03-28. PMID:12614344. |
the cellular mechanism by which apolipoprotein e (apoe) affects the pathogenesis of alzheimer's disease (ad) is not understood. |
2003-03-28 |
2023-08-12 |
rat |
| Paola Castelli, Ana Luisa Sosa, Carlos Campillo, Humberto Nicolini, Carlos Cruz-Fuente. Apolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City. International psychogeriatrics. vol 14. issue 3. 2003-03-26. PMID:12475089. |
the association between the apoe gene and alzheimer's disease and other forms of dementia has been widely documented, but its relevance as a genetic risk factor in specific ethnic groups other than caucasians in the united states and europe is limited. |
2003-03-26 |
2023-08-12 |
human |
| A Law, S Gauthier, R Quirio. Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493565. |
impairments in cognitive performance have been observed in aged apolipoprotein e (apoe)-deficient mice, and apoe epsilon 4 allele is a risk factor in alzheimer's disease (ad). |
2003-03-26 |
2023-08-12 |
mouse |
| R Scacchi, G Gambina, G Ferrari, R M Corb. Screening of two mutations at exon 3 of the apolipoprotein E gene (sites 28 and 42) in a sample of patients with sporadic late-onset Alzheimer's disease. Neurobiology of aging. vol 24. issue 2. 2003-03-26. PMID:12498968. |
the search for further variation at the apoe gene in a sample of patients with sporadic late-onset alzheimer's disease (ad) and related controls revealed two different mutations in the exon 3 of the gene. |
2003-03-26 |
2023-08-12 |
Not clear |
| E Ronald de Kloet, Jeannette Grootendorst, Adriaan M Karssen, Melly S Oitz. Gene x environment interaction and cognitive performance: animal studies on the role of corticosterone. Neurobiology of learning and memory. vol 78. issue 3. 2003-03-21. PMID:12559836. |
using apolipoprotein e knockout (apoe0/0) mice we show that apoe (apoe4 is a genetic risk factor for alzheimer's disease) is a candidate gene with an important function in shaping the cognitive outcome (genotype x environment interaction). |
2003-03-21 |
2023-08-12 |
mouse |
| Anne-Sophie Rigaud, Latchezar Traykov, Florence Latour, Rémy Couderc, Florence Moulin, Françoise Forett. Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease. Pharmacogenetics. vol 12. issue 5. 2003-03-13. PMID:12142731. |
the objective was to evaluate the effects of the apolipoprotein e (apoe) genotype and gender on the response to donepezil treatment in alzheimer's disease. |
2003-03-13 |
2023-08-12 |
Not clear |
| Anne-Sophie Rigaud, Latchezar Traykov, Florence Latour, Rémy Couderc, Florence Moulin, Françoise Forett. Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease. Pharmacogenetics. vol 12. issue 5. 2003-03-13. PMID:12142731. |
apoe genotyping was performed on 117 patients with mild to moderate alzheimer's disease who were included in a 36-week open label trial of donepezil therapy. |
2003-03-13 |
2023-08-12 |
Not clear |
| Anne-Sophie Rigaud, Latchezar Traykov, Florence Latour, Rémy Couderc, Florence Moulin, Françoise Forett. Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease. Pharmacogenetics. vol 12. issue 5. 2003-03-13. PMID:12142731. |
consequently, these results do not support the hypothesis that the apoe phenotype and gender are predictors of the response to donepezil in alzheimer's disease patients. |
2003-03-13 |
2023-08-12 |
Not clear |
| N Bogdanovic, Elizabeth Corder, L Lannfelt, B Winbla. APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late-onset Alzheimer's disease. Journal of cellular and molecular medicine. vol 6. issue 2. 2003-03-06. PMID:12169205. |
apoe polymorphism and clinical duration determine regional neuropathology in swedish app(670, 671) mutation carriers: implications for late-onset alzheimer's disease. |
2003-03-06 |
2023-08-12 |
human |
| Elize D Haasdijk, Angela Vlug, Monique T Mulder, Dick Jaarsm. Increased apolipoprotein E expression correlates with the onset of neuronal degeneration in the spinal cord of G93A-SOD1 mice. Neuroscience letters. vol 335. issue 1. 2003-03-06. PMID:12457735. |
apolipoprotein e (apoe) genotype is well known as a risk factor for alzheimer's disease, but more recently also has been associated with the incidence or disease progression of other neurological diseases including amyotrophic lateral sclerosis (als). |
2003-03-06 |
2023-08-12 |
mouse |
| S M Laws, E Hone, K Taddei, C Harper, B Dean, C McClean, C Masters, N Lautenschlager, S E Gandy, R N Martin. Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E. Molecular psychiatry. vol 7. issue 8. 2003-02-25. PMID:12232782. |
variation at the apoe -491 promoter locus is associated with altered brain levels of apolipoprotein e. the apolipoprotein e (apoe, gene; apoe, protein) type 4 isoform is a well-established risk factor for late-onset alzheimer's disease (ad), and new data suggest that apoe promoter polymorphisms might also modulate ad risk, perhaps by altering transcription of the apoe gene. |
2003-02-25 |
2023-08-12 |
human |
| Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordel. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468034. |
apolipoprotein e (apoe) genotype modulates the risk of alzheimer's disease. |
2003-02-25 |
2023-08-12 |
Not clear |
| Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordel. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468034. |
because apoe has been found necessary for plaque development in transgenic models of alzheimer's disease, suppressing apoe secretion by statins could reduce plaques and, in turn, improve cognitive function. |
2003-02-25 |
2023-08-12 |
Not clear |
| Suk Ling Ma, Ho Keung Ng, Larry Baum, Jesse Chung Sean Pang, Helen Fung Kum Chiu, Jean Woo, Nelson Leung Sang Tang, Linda Chiu Wa La. Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease. Neuroscience letters. vol 332. issue 3. 2003-02-21. PMID:12399018. |
apolipoprotein e (apoe) isoforms affect the risk of developing alzheimer's disease (ad). |
2003-02-21 |
2023-08-12 |
human |
| D K Lahiri, G M Alley, Y-W Ge, Y D. Functional characterization of the 5'-regulatory region of the murine apolipoprotein gene. Annals of the New York Academy of Sciences. vol 973. 2003-02-13. PMID:12485890. |
the apolipoprotein e (apoe) gene causes a major risk factor for the development of alzheimer's disease (ad). |
2003-02-13 |
2023-08-12 |
mouse |
| Susumu Goto, Aki Takahashi, Keiichi Kamisango, Koichi Matsubar. Single-nucleotide polymorphism analysis by hybridization protection assay on solid support. Analytical biochemistry. vol 307. issue 1. 2003-02-10. PMID:12137775. |
we also designed four probes to type the alzheimer's disease-related gene apoe, which has three genotypes (apoe2, 3, and 4) determined by two snp loci (c/t polymorphism). |
2003-02-10 |
2023-08-12 |
human |
| Yoshio Tsuboi, Keith A Josephs, Natalie Cookson, Dennis W Dickso. APOE E4 is a determinant for Alzheimer type pathology in progressive supranuclear palsy. Neurology. vol 60. issue 2. 2003-02-05. PMID:12552038. |
apoe e4 is a determinant for alzheimer type pathology in progressive supranuclear palsy. |
2003-02-05 |
2023-08-12 |
Not clear |