| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroaki Fukumoto, Martin Ingelsson, Nina Gårevik, Lars Olof Wahlund, Nobuyuki Nukina, Yoshio Yaguchi, Masao Shibata, Bradley T Hyman, G William Rebeck, Michael C Irizarr. APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. Experimental neurology. vol 183. issue 1. 2003-10-02. PMID:12957508. |
apoe epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein e4 in cerebrospinal fluid relative to plasma, independent of alzheimer's disease diagnosis. |
2003-10-02 |
2023-08-12 |
human |
| Hiroaki Fukumoto, Martin Ingelsson, Nina Gårevik, Lars Olof Wahlund, Nobuyuki Nukina, Yoshio Yaguchi, Masao Shibata, Bradley T Hyman, G William Rebeck, Michael C Irizarr. APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. Experimental neurology. vol 183. issue 1. 2003-10-02. PMID:12957508. |
inheritance of the apolipoprotein e (apoe) epsilon 4 allele is associated with an increased risk of alzheimer's disease (ad). |
2003-10-02 |
2023-08-12 |
human |
| J Vidal, C Bruce Verchere, S Andrikopoulos, F Wang, R L Hull, M Cnop, K L Olin, R C LeBoeuf, K D O'Brien, A Chait, S E Kah. The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice. Diabetologia. vol 46. issue 1. 2003-10-01. PMID:12637985. |
as apolipoprotein e (apoe), another component of islet amyloid deposits, plays a critical role in amyloid formation in alzheimer's disease, we hypothesised that apoe could play an important role in islet amyloid formation. |
2003-10-01 |
2023-08-12 |
mouse |
| Nobutsugu Hirono, Mamoru Hashimoto, Minoru Yasuda, Hirokazu Kazui, Etsuro Mor. Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele. The Journal of neuropsychiatry and clinical neurosciences. vol 15. issue 3. 2003-09-24. PMID:12928512. |
to investigate a possible effect of the apolipoprotein (apoe) epsilon4 allele on memory decline in alzheimer's disease (ad), we examined 64 ad patients with the apoe epsilon3/3, epsilon3/4, or epsilon4/4 allele using the alzheimer disease assessment scale-cognitive subscale (adas-cog) and its subtests at the initial examination and at the 1-year follow-up visit. |
2003-09-24 |
2023-08-12 |
Not clear |
| Michael J Finton, John A Lucas, Julie D Rippeth, Daryl L Bohac, Glenn E Smith, Robert J Ivnik, Ronald C Petersen, Neill R Graff-Radfor. Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease. Journal of the International Neuropsychological Society : JINS. vol 9. issue 5. 2003-09-23. PMID:12901781. |
the relationship between apolipoprotein e (apoe) genotype and cognitive performance was examined in 200 patients with probable alzheimer's disease (ad). |
2003-09-23 |
2023-08-12 |
human |
| Mark W Bondi, Wes S Houston, David P Salmon, Jody Corey-Bloom, Robert Katzman, Leon J Thal, Dean C Deli. Neuropsychological deficits associated with Alzheimer's disease in the very-old: discrepancies in raw vs. standardized scores. Journal of the International Neuropsychological Society : JINS. vol 9. issue 5. 2003-09-23. PMID:12901784. |
the profiles of neuropsychological deficits associated with alzheimer's disease (ad) in young-old (m age and 70) and very-old (m age > 80) patients were compared, along with possible modifying effects of apolipoprotein e (apoe) genotype on these profiles. |
2003-09-23 |
2023-08-12 |
Not clear |
| Annette Skraep Nielsen, Rivka Ravid, Wouter Kamphorst, Ole Steen Jørgense. Apolipoprotein E epsilon 4 in an autopsy series of various dementing disorders. Journal of Alzheimer's disease : JAD. vol 5. issue 2. 2003-09-16. PMID:12719629. |
apolipoprotein e (apoe) allele epsilon 4 is a risk factor for alzheimer's disease (ad) and has also been associated with impaired recovery from brain injury. |
2003-09-16 |
2023-08-12 |
human |
| K Millar, J A R Nicoll, S Thornhill, G D Murray, G M Teasdal. Long term neuropsychological outcome after head injury: relation to APOE genotype. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 8. 2003-09-09. PMID:12876232. |
existing evidence suggests that some patients who sustain a head injury suffer cognitive decline many years later, and that head injury and possession of the apoe epsilon 4 allele are each risk factors for alzheimer's disease. |
2003-09-09 |
2023-08-12 |
Not clear |
| Masami Nishio, Eiji Kohmura, Takamichi Yuguchi, Yoshikazu Nakajima, Toshiyuki Fujinaka, Chihiro Akiyama, Akira Iwata, Toshiki Yoshimin. Neuronal apolipoprotein E is not synthesized in neuron after focal ischemia in rat brain. Neurological research. vol 25. issue 4. 2003-09-04. PMID:12870266. |
apolipoprotein e (apoe) is a major apolipoprotein in the central nervous system (cns) that plays an important role in alzheimer's disease. |
2003-09-04 |
2023-08-12 |
rat |
| K Chalmers, G K Wilcock, S Lov. APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein. Neuropathology and applied neurobiology. vol 29. issue 3. 2003-07-31. PMID:12787320. |
apoe epsilon 4 influences the pathological phenotype of alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of a beta protein. |
2003-07-31 |
2023-08-12 |
Not clear |
| Mariko Kobayashi, Koichi Ishiguro, Yuko Katoh-Fukui, Minesuke Yokoyama, Shinobu C Fujit. Phosphorylation state of tau in the hippocampus of apolipoprotein E4 and E3 knock-in mice. Neuroreport. vol 14. issue 5. 2003-07-23. PMID:12692466. |
the apolipoprotein e (apoe) epsilon 4 allele is associated with an increased risk of sporadic as well as late-onset familial alzheimer's disease (ad). |
2003-07-23 |
2023-08-12 |
mouse |
| S D Edland, F Wavrant-De Vriesé, D Compton, G E Smith, R Ivnik, B F Boeve, E G Tangalos, R C Peterse. Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). Neuroscience letters. vol 345. issue 1. 2003-07-10. PMID:12809979. |
insulin degrading enzyme (ide) genetic variants and risk of alzheimer's disease: evidence of effect modification by apolipoprotein e (apoe). |
2003-07-10 |
2023-08-12 |
human |
| Onofre Combarros, Marisa García-Román, Ana Fontalba, José L Fernández-Luna, Javier Llorca, Jon Infante, José Bercian. Interaction of the H63D mutation in the hemochromatosis gene with the apolipoprotein E epsilon 4 allele modulates age at onset of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 15. issue 3. 2003-07-03. PMID:12584430. |
the h63d mutation in the hemochromatosis gene (hfe) has recently been considered as a risk factor in alzheimer's disease (ad) with advancing age at onset of the disease, independently of the apolipoprotein e (apoe) epsilon4 allele effect. |
2003-07-03 |
2023-08-12 |
Not clear |
| Mónica Campillos, José Ramón Lamas, Miguel Angel García, María Jesús Bullido, Fernando Valdivieso, Jesús Vázque. Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity. Nucleic acids research. vol 31. issue 12. 2003-07-03. PMID:12799433. |
the polymorphic -219t/g variant in the apoe promoter has been associated with variations in basal transcriptional activity as well as with the risk of developing alzheimer's disease, myocardial infarction and early-onset coronary heart disease. |
2003-07-03 |
2023-08-12 |
human |
| Ramon Diaz-Arrastia, Yunhua Gong, Suzette Fair, Kristin D Scott, Maria C Garcia, Mary C Carlile, Mark A Agostini, Paul C Van Nes. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele. Archives of neurology. vol 60. issue 6. 2003-07-02. PMID:12810485. |
inheritance of the apolipoprotein e (apoe) epsilon4 allele is associated with increased risk of alzheimer disease, progression to disability in multiple sclerosis, and poor outcome after traumatic brain injury. |
2003-07-02 |
2023-08-12 |
Not clear |
| Eric E Niederkofler, Kemmons A Tubbs, Urban A Kiernan, Dobrin Nedelkov, Randall W Nelso. Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins. Journal of lipid research. vol 44. issue 3. 2003-06-18. PMID:12562854. |
additionally, the apoe phenotype of e3/e3 was observed in three of the individuals, and e2/e3 and e3/e4 observed in the remaining two individuals, the latter of whom suffers from alzheimer's disease. |
2003-06-18 |
2023-08-12 |
Not clear |
| Makoto Michikaw. Cholesterol paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease? Journal of neuroscience research. vol 72. issue 2. 2003-06-12. PMID:12671988. |
the discovery that possession of apolipoprotein e (apoe), allele epsilon4 is a strong risk factor for alzheimer's disease (ad) leads us to focus on the role of cholesterol in the pathogenesis of ad. |
2003-06-12 |
2023-08-12 |
Not clear |
| Suzanne L Tyas, Lon R White, Helen Petrovitch, G Webster Ross, Daniel J Foley, Harley K Heimovitz, Lenore J Laune. Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study. Neurobiology of aging. vol 24. issue 4. 2003-06-11. PMID:12714116. |
adjusting for age, education and apolipoprotein e (apoe) genotype, the risk of alzheimer's disease (ad) in smokers increased with pack-years of smoking at medium (odds ratio (or)=2.18, 95% confidence interval (ci)=1.07-4.69) and heavy (or=2.40; 95% ci=1.16-5.17) smoking levels. |
2003-06-11 |
2023-08-12 |
Not clear |
| Wami Marui, Eizo Iseki, Naoya Sugiyama, Takehiko Matsumura, Kyoko Suzuki, Toshinari Odawara, Hiroaki Hino, Kenji Kosak. [A Japanese family with familial Alzheimer's disease associated with presenilin 1 mutation: relationship between younger age of onset and ApoE gene polymorphism]. No to shinkei = Brain and nerve. vol 55. issue 4. 2003-06-06. PMID:12755040. |
[a japanese family with familial alzheimer's disease associated with presenilin 1 mutation: relationship between younger age of onset and apoe gene polymorphism]. |
2003-06-06 |
2023-08-12 |
Not clear |
| Katrin Beyer, José I Lao, Milagros Gómez, Nadal Riutort, Pilar Latorre, José L Mate, Aurelio Ariz. The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095653. |
the th1/e47cs-g apolipoprotein e (apoe) promoter allele is a risk factor for alzheimer disease of very later onset. |
2003-06-05 |
2023-08-12 |
Not clear |