| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Cosme Dodart, Kelly R Bales, Edward M Johnstone, Sheila P Little, Steven M Pau. Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419536. |
we have recently reported a critical role for apolipoprotein e (apoe) in the process of amyloid deposition and neuritic plaque formation in app(v717f) transgenic (tg) mice, an animal model of alzheimer's disease (ad). |
2003-01-31 |
2023-08-12 |
mouse |
| Jochen Brich, Feng-Shiun Shie, Brian W Howell, Renhua Li, Katalin Tus, Edward K Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, Jonathan A Coope. Genetic modulation of tau phosphorylation in the mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 1. 2003-01-27. PMID:12514215. |
dab1 mutant mice provide an animal model for studying the relationships between apoe receptors, tau hyperphosphorylation, and alzheimer's disease. |
2003-01-27 |
2023-08-12 |
mouse |
| Barry W McColl, David I Graham, Christopher J Weir, Fiona White, Karen Horsburg. Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype. The American journal of pathology. vol 162. issue 1. 2003-01-24. PMID:12507910. |
apolipoprotein epsilon4 (apoe, protein; apoe, gene) allele is the most important genetic risk factor for development of alzheimer's disease and is also associated with poor outcome after brain injury. |
2003-01-24 |
2023-08-12 |
human |
| A Frank, E Díez-Tejedor, M J Bullido, F Valdivieso, P Barreir. APOE genotype in cerebrovascular disease and vascular dementia. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417379. |
the fact that the allele epsilon 4 of the apolipoprotein e (apoe) gene could act like a risk factor not only in late-onset familial and sporadic alzheimer's disease (ad) but also in cerebrovascular disease (cvd) and vascular dementia (vad) is still controversial. |
2003-01-23 |
2023-08-12 |
Not clear |
| S Salloway, T Gur, T Berzin, R Tavares, B Zipser, S Correia, V Hovanesian, J Fallon, V Kuo-Leblanc, D Glass, C Hulette, C Rosenberg, M Vitek, E Stop. Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417381. |
effect of apoe genotype on microvascular basement membrane in alzheimer's disease. |
2003-01-23 |
2023-08-12 |
Not clear |
| G R Chandak, M Uma Sridevi, C J Vas, D M Panikker, L Sing. Apolipoprotein E and presenilin-1 allelic variation and Alzheimer's disease in India. Human biology. vol 74. issue 5. 2003-01-23. PMID:12495082. |
of these, 49 alzheimer's disease (ad) cases were analyzed for risk association with apoe e*4 allele at apolipoprotein e gene (apoe) and presenilin-1 (ps-1) intron-8 polymorphism and were compared with 100 age- and sex-matched nondemented controls. |
2003-01-23 |
2023-08-12 |
Not clear |
| H-M Huang, Y-M Kuo, H-C Ou, C-C Lin, L-J Chu. Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 11. 2003-01-22. PMID:12454737. |
to verify the association between apoe4 frequency and various dementias in taiwan chinese individuals, apoe genotypes were determined in patients with dementia of alzheimer's type (ad), vascular dementia (vd), dementias due to other general medical conditions (od), and dementia of alzheimer's type with cerebral vascular disease (mixed type dementia; md). |
2003-01-22 |
2023-08-12 |
Not clear |
| F Glöckner, V Meske, T G Oh. Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer's disease. Neuroscience. vol 114. issue 4. 2003-01-10. PMID:12379263. |
inheritance of the epsilon4 allele of apolipoprotein e (apoe, gene; apoe, protein) represents the most common genetic risk factor for developing alzheimer's disease (ad), but the role of apoe in ad pathogenesis is yet to be clarified. |
2003-01-10 |
2023-08-12 |
Not clear |
| Richard E Hartman, Helmut Laurer, Luca Longhi, Kelly R Bales, Steven M Paul, Tracy K McIntosh, David M Holtzma. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451108. |
the epsilon4 allele of apolipoprotein e (apoe) and traumatic brain injury (tbi) are both risk factors for the development of alzheimer's disease (ad). |
2002-12-23 |
2023-08-12 |
mouse |
| Edwin J Weeber, Uwe Beffert, Chris Jones, Jill M Christian, Eckart Forster, J David Sweatt, Joachim Her. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. The Journal of biological chemistry. vol 277. issue 42. 2002-12-19. PMID:12167620. |
apoe receptors have been indirectly implicated in memory and neurodegenerative disorders because their ligand, apoe, is genetically associated with alzheimer disease. |
2002-12-19 |
2023-08-12 |
mouse |
| Edwin J Weeber, Uwe Beffert, Chris Jones, Jill M Christian, Eckart Forster, J David Sweatt, Joachim Her. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. The Journal of biological chemistry. vol 277. issue 42. 2002-12-19. PMID:12167620. |
thus, the impairment of apoe receptor-dependent neuromodulation may contribute to cognitive impairment and synaptic loss in alzheimer disease. |
2002-12-19 |
2023-08-12 |
mouse |
| Zhi-Xing Yao, Vassilios Papadopoulo. Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 12. 2002-12-17. PMID:12206998. |
amyloid beta-peptide (abeta), abeta precursor protein (app), apolipoprotein e (apoe), and elevated cholesterol levels have been linked to alzheimer's disease (ad) pathology. |
2002-12-17 |
2023-08-12 |
human |
| Richard J Caselli, Eric M Reiman, Joseph G Hentz, David Osborne, Gene E Alexander, Bradley F Boev. A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes. Sleep. vol 25. issue 4. 2002-12-12. PMID:12071547. |
to correlate memory measures with a trait measure of chronic daytime somnolence in cognitively normal individuals with different gene doses of the apolipoprotein e (apoe) e4 allele, a common alzheimer's disease susceptibility gene. |
2002-12-12 |
2023-08-12 |
Not clear |
| Candice M Brown, Elizabeth Wright, Carol A Colton, Patrick M Sullivan, Daniel T Laskowitz, Michael P Vite. Apolipoprotein E isoform mediated regulation of nitric oxide release. Free radical biology & medicine. vol 32. issue 11. 2002-12-02. PMID:12031891. |
these data suggest a potentially novel mechanism for gender-dependent and apoe isoform-dependent immune responses that parallel the genetic susceptibility of apoe4 carriers for the development of alzheimer's disease. |
2002-12-02 |
2023-08-12 |
mouse |
| Qing-Song Wang, Lin Tian, Yong-Lu Huang, Song Qin, Long-Quan He, Jiang-Ning Zho. Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment. Brain research. vol 951. issue 1. 2002-11-26. PMID:12231459. |
these results suggested that the decreased olfactory identification in mci may be a marker for the early diagnosis of alzheimer's disease, and apoe genotype may be part of the basis of olfactory identification decline. |
2002-11-26 |
2023-08-12 |
human |
| Erin D Bigler, David F Tate, Michael J Miller, Sara A Rice, Cory D Hessel, Heath D Earl, Joann T Tschanz, Brenda Plassman, Kathleen A Welsh-Bohme. Dementia, asymmetry of temporal lobe structures, and apolipoprotein E genotype: relationships to cerebral atrophy and neuropsychological impairment. Journal of the International Neuropsychological Society : JINS. vol 8. issue 7. 2002-11-26. PMID:12405544. |
we examined asymmetry of hippocampal volume as well as other temporal lobe structures (temporal lobe, temporal horn of the lateral ventricular system, parahippocampal and fusiform gyri) in 194 subjects from the cache county, utah study, with varying disorders [85 with alzheimer's disease (ad), 59 with some cognitive or neuropsychiatric disorder-referenced as a mixed neuropsychiatric group, 30 with mild ambiguous/mild cognitive impairment (ma/mci) and 20 controls] and apoe genotypes. |
2002-11-26 |
2023-08-12 |
human |
| Kelly L Lange, Mark W Bondi, David P Salmon, Douglas Galasko, Dean C Delis, Ronald G Thomas, Leon J Tha. Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype. Journal of the International Neuropsychological Society : JINS. vol 8. issue 7. 2002-11-26. PMID:12405546. |
decline in verbal memory during preclinical alzheimer's disease: examination of the effect of apoe genotype. |
2002-11-26 |
2023-08-12 |
human |
| T Masterman, Z Zhang, D Hellgren, H Salter, M Anvret, L Lilius, L Lannfelt, J Hiller. APOE genotypes and disease severity in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 8. issue 2. 2002-11-18. PMID:11990879. |
the apoe epsilon4 allele confers susceptibility to both familial and sporadic alzheimer's disease (ad). |
2002-11-18 |
2023-08-12 |
Not clear |
| A G Yip, C Brayne, D Easton, D C Rubinsztei. Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. Journal of medical genetics. vol 39. issue 9. 2002-11-12. PMID:12205106. |
apolipoprotein e (apoe) polymorphisms are unequivocally associated with risk for alzheimer's disease (ad). |
2002-11-12 |
2023-08-12 |
Not clear |
| Raja Parasuraman, Pamela M Greenwood, Trey Sunderlan. The apolipoprotein E gene, attention, and brain function. Neuropsychology. vol 16. issue 2. 2002-10-29. PMID:11949718. |
the epsilon4 allele of the apolipoprotein e (apoe) gene is associated with alterations in brain function and is a risk factor for alzheimer's disease (ad). |
2002-10-29 |
2023-08-12 |
Not clear |