| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katrin Beyer, José I Lao, Milagros Gómez, Nadal Riutort, Pilar Latorre, José L Mate, Aurelio Ariz. The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095653. |
in the present study we have investigated both polymorphisms in a series of 183 alzheimer disease (ad) patients and 169 controls divided into age at onset/age dependent subgroups and the data obtained have been corrected for the presence of both expression-changing alleles in apoe homozygous individuals. |
2003-06-05 |
2023-08-12 |
Not clear |
| Makoto Michikaw. The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol. Molecular neurobiology. vol 27. issue 1. 2003-05-30. PMID:12668899. |
the implication that cholesterol plays an essential role in the pathogenesis of alzheimer's disease (ad) is based on the 1993 finding that the presence of apolipoprotein e (apoe) allele epsilon;4 is a strong risk factor for developing ad. |
2003-05-30 |
2023-08-12 |
Not clear |
| Francesco Panza, Vincenzo Solfrizzi, Anna M Colacicco, Anna M Basile, Alessia D'Introno, Cristiano Capurso, Maria Sabba, Sabrina Capurso, Antonio Capurs. Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians. Neuroreport. vol 14. issue 4. 2003-05-29. PMID:12657895. |
apolipoprotein e (apoe) polymorphism influences serum apoe levels in alzheimer's disease patients and centenarians. |
2003-05-29 |
2023-08-12 |
Not clear |
| Francesco Panza, Vincenzo Solfrizzi, Anna M Colacicco, Anna M Basile, Alessia D'Introno, Cristiano Capurso, Maria Sabba, Sabrina Capurso, Antonio Capurs. Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians. Neuroreport. vol 14. issue 4. 2003-05-29. PMID:12657895. |
vascular factors may play a role in the etiology of alzheimer's disease (ad) and increased serum apolipoprotein e (apoe) levels in ad could be of interest, as apoe concentration is associated with vascular disease. |
2003-05-29 |
2023-08-12 |
Not clear |
| M C Ljungberg, A Asuni, J Pearce, R Dayanandan, W März, M M Hoffmann, P Bertrand, G Siest, H T R Rupniak, B H Anderton, M Huettinger, S Loveston. Apolipoprotein E (apoE) uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells. Neuroscience letters. vol 341. issue 1. 2003-05-20. PMID:12676346. |
as part of investigations of the cellular uptake of apolipoprotein e (apoe) relevant to alzheimer's disease we have found that different preparations of apoe are handled differently by cells expressing the ldl-receptor. |
2003-05-20 |
2023-08-12 |
Not clear |
| Shigeki Sakamoto, Hiroshi Matsuda, Takashi Asada, Takashi Ohnishi, Seigo Nakano, Hidekazu Kanetaka, Masaru Takasak. Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 13. issue 2. 2003-05-20. PMID:12722493. |
to determine the association of the apolipoprotein e (apoe) genotype and longitudinal changes of regional cerebral blood flow (rcbf) in alzheimer's disease (ad). |
2003-05-20 |
2023-08-12 |
Not clear |
| Maite Alvarez-Alvarez, Luis Galdos, Manuel Fernández-Martínez, Fernando Gómez-Busto, Victoria García-Centeno, Caridad Arias-Arias, Carmen Sánchez-Salazar, Ana Belén Rodríguez-Martínez, Juan José Zarranz, Marian M de Pancorb. 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country. Neuroscience letters. vol 339. issue 1. 2003-05-19. PMID:12618306. |
5-hydroxytryptamine 6 receptor (5-ht(6)) receptor and apolipoprotein e (apoe) polymorphisms in patients with alzheimer's disease in the basque country. |
2003-05-19 |
2023-08-12 |
Not clear |
| Maite Alvarez-Alvarez, Luis Galdos, Manuel Fernández-Martínez, Fernando Gómez-Busto, Victoria García-Centeno, Caridad Arias-Arias, Carmen Sánchez-Salazar, Ana Belén Rodríguez-Martínez, Juan José Zarranz, Marian M de Pancorb. 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country. Neuroscience letters. vol 339. issue 1. 2003-05-19. PMID:12618306. |
although there is considerable evidence implicating apolipoprotein e (apoe) epsilon4 in the development of the alzheimer's disease (ad), additional factors are also known to be involved. |
2003-05-19 |
2023-08-12 |
Not clear |
| Gal Ophir, Sigal Meilin, Margalit Efrati, Joab Chapman, Dimitri Karussis, Allen Roses, Daniel M Michaelso. Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. Neurobiology of disease. vol 12. issue 1. 2003-05-09. PMID:12609489. |
the allele e4 of apolipoprotein e (apoe) is an important risk factor for alzheimer's disease (ad) and the chronic brain inflammation which is associated with ad is more pronounced in subjects who carry this allele. |
2003-05-09 |
2023-08-12 |
mouse |
| Xianlin Han, Hua Cheng, John D Fryer, Anne M Fagan, David M Holtzma. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. The Journal of biological chemistry. vol 278. issue 10. 2003-04-23. PMID:12501252. |
this novel role for apoe in the cns may provide new insights into the connection of apoe with alzheimer's disease and poor recovery after brain injury. |
2003-04-23 |
2023-08-12 |
mouse |
| E Stefanova, K Blennow, O Almkvist, E Hellström-Lindahl, A Nordber. Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients. Neuroscience letters. vol 338. issue 2. 2003-04-18. PMID:12566177. |
we evaluated cerebral glucose metabolism (cmrglc) and cerebrospinal fluid (csf) levels of tau and beta-amyloid(1-42) (abeta42), in relation to apolipoprotein e (apoe) genotype, in patients with mild alzheimer disease (ad) treated with rivastigmine (n=11) and tacrine (n=16) for 1 year; and two untreated ad groups. |
2003-04-18 |
2023-08-12 |
human |
| Kang U Lee, Jae S Lee, Ki W Kim, Jin H Jhoo, Dong Y Lee, Jong C Yoon, Jung H Lee, Dong S Lee, Myung C Lee, Jong I Wo. Influence of the apolipoprotein E type 4 allele on cerebral glucose metabolism in Alzheimer's disease patients. The Journal of neuropsychiatry and clinical neurosciences. vol 15. issue 1. 2003-04-17. PMID:12556576. |
it is still unclear whether apolipoprotein e epsilon 4 (apoe e4) influences the cerebral glucose metabolism abnormalities found in alzheimer's disease (ad), although apoe e4 is a well-known risk factor for ad. |
2003-04-17 |
2023-08-12 |
Not clear |
| Zhongmin Zhou, Norman Relkin, Jorge Ghiso, Jonathan D Smith, Sam Gand. Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro. Molecular medicine (Cambridge, Mass.). vol 8. issue 7. 2003-04-16. PMID:12393935. |
we have previously reported the isoform-specific interaction of native human apolipoprotein e (apoe, gene; apoe, protein) epsilon 3 with the amyloid-ss peptide, ass(1-40), the major component of the cerebral amyloid deposits that appear to cause alzheimer's disease. |
2003-04-16 |
2023-08-12 |
human |
| Gerwin Rok. [Alzheimer's disease. Present and future role of genetics]. Tijdschrift voor gerontologie en geriatrie. vol 34. issue 1. 2003-04-08. PMID:12629906. |
the fourth gene involved in alzheimer's disease is the apolipoprotein e gene (apoe). |
2003-04-08 |
2023-08-12 |
Not clear |
| Gerwin Rok. [Alzheimer's disease. Present and future role of genetics]. Tijdschrift voor gerontologie en geriatrie. vol 34. issue 1. 2003-04-08. PMID:12629906. |
carriers of the e4 variant of apoe have an increased risk of alzheimer's disease. |
2003-04-08 |
2023-08-12 |
Not clear |
| Thomas B Shea, Eugene Rogers, David Ashline, Daniela Ortiz, Min-Shyan She. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free radical biology & medicine. vol 33. issue 8. 2003-04-04. PMID:12374623. |
the epsilon 4 allele of the apolipoprotein e gene (apoe) is associated with alzheimer's disease (ad). |
2003-04-04 |
2023-08-12 |
mouse |
| George Lee, Harvey B Pollard, Nelson Arisp. Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site. Peptides. vol 23. issue 7. 2003-04-03. PMID:12128082. |
these results also provide a biochemical mechanism by which the apoe varepsilon2 allele, but not apoe varepsilon4, can be protective towards the incidence and progression of alzheimer's disease. |
2003-04-03 |
2023-08-12 |
Not clear |
| J Pahnke, L C Walker, E Schroeder, S Vogelgesang, D Stausske, R Walther, R W Warzo. Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele. Acta neuropathologica. vol 105. issue 1. 2003-04-03. PMID:12471457. |
the apolipoprotein e epsilon4 allele (apoe, gene; apoe, protein) is widely accepted as a risk factor for alzheimer's disease (ad). |
2003-04-03 |
2023-08-12 |
Not clear |
| T Gabryelewicz, D Religa, M Styczynska, B Peplonska, A Pfeffer, B Wasiak, E Luczywek, M Golebiowski, W Androsiuk, K Czyzewski, I Przekop, M Barcikowsk. Behavioural pathology in Alzheimer's disease with special reference to apolipoprotein E genotype. Dementia and geriatric cognitive disorders. vol 14. issue 4. 2003-03-28. PMID:12411763. |
the aim of this study was to define the co-occurrence of behavioural symptoms and alzheimer's disease (ad) in relation to apolipoprotein e (apoe) genotype. |
2003-03-28 |
2023-08-12 |
Not clear |
| T Gabryelewicz, D Religa, M Styczynska, B Peplonska, A Pfeffer, B Wasiak, E Luczywek, M Golebiowski, W Androsiuk, K Czyzewski, I Przekop, M Barcikowsk. Behavioural pathology in Alzheimer's disease with special reference to apolipoprotein E genotype. Dementia and geriatric cognitive disorders. vol 14. issue 4. 2003-03-28. PMID:12411763. |
probable ad patients from the alzheimer's day clinic (n = 139) were assessed with the 'behavioural pathology in alzheimer's disease' rating scale, and their apoe genotype was determined. |
2003-03-28 |
2023-08-12 |
Not clear |