| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R S Souza, M R de Godoy, J Hotta, E H Tajara, A C Brandão, S Pinheiro Júnior, W A Tognola, J E dos Santo. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 7. 2004-01-20. PMID:12845379. |
the distribution of alleles and genotypes of the apoe gene in late-onset alzheimer's disease (n = 68), other late-life dementias (n = 39), and in cognitively normal controls (n = 58) was determined, as also was the risk for alzheimer's disease associated with the epsilon4 allele. |
2004-01-20 |
2023-08-12 |
Not clear |
| D R S Souza, M R de Godoy, J Hotta, E H Tajara, A C Brandão, S Pinheiro Júnior, W A Tognola, J E dos Santo. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 7. 2004-01-20. PMID:12845379. |
apoe epsilon2 frequency was considerably lower in the alzheimer's disease group (1%), and the epsilon3 allele and epsilon3/epsilon3 genotype frequencies were higher in the controls (84 and 72%, respectively) as were the epsilon4 allele and epsilon3/epsilon4 genotype frequencies in alzheimer's disease (25 and 41%, respectively). |
2004-01-20 |
2023-08-12 |
Not clear |
| Lars Ulrik Gerde. The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations. Clinical chemistry and laboratory medicine. vol 41. issue 5. 2004-01-12. PMID:12812258. |
the common apoe polymorphism is associated with varying risk of cardiovascular disease and alzheimer's disease, but other interesting aspects may emerge in the future. |
2004-01-12 |
2023-08-12 |
Not clear |
| Kazuko Aoki, Toshiki Uchihara, Ayako Nakamura, Takashi Komori, Nobutaka Arai, Toshio Mizutan. Expression of apolipoprotein E in ballooned neurons-comparative immunohistochemical study on neurodegenerative disorders and infarction. Acta neuropathologica. vol 106. issue 5. 2004-01-09. PMID:12898155. |
we used antibodies against apoe and phosphorylated neurofilament (pnf) to investigate the immunohistochemical features of ballooned neurons (bns) in infarction and in various chronic degenerative disorders, including pick body disease, corticobasal degeneration/progressive supranuclear palsy, alzheimer's disease, and frontotemporal dementia. |
2004-01-09 |
2023-08-12 |
Not clear |
| Marcos A Marques, Keith A Crutche. Apolipoprotein E-related neurotoxicity as a therapeutic target for Alzheimer's disease. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501016. |
apolipoprotein e (apoe) remains the most important genetic risk factor for the development of alzheimer's disease (ad). |
2003-12-23 |
2023-08-12 |
Not clear |
| Suzana S Petanceska, Steven DeRosa, Ali Sharma, Nichole Diaz, Karen Duff, Steven G Tint, Lorenzo M Refolo, Miguel Pappoll. Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501024. |
apolipoprotein e (apoe) influences the risk of late onset alzheimer's disease (ad) in an isoform-dependent manner, such that the presence of the apoe epsilon4 allele increases the risk of ad while the presence of the apoe epsilon2 allele appears to be protective. |
2003-12-23 |
2023-08-12 |
mouse |
| Suzana S Petanceska, Steven DeRosa, Ali Sharma, Nichole Diaz, Karen Duff, Steven G Tint, Lorenzo M Refolo, Miguel Pappoll. Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501024. |
here, we used a transgenic mouse model of alzheimer's amyloidosis to examine whether the diet-induced or pharmacologically induced changes in plasma cholesterol that result in altered brain amyloidosis also affect apoe content in liver and in brain. |
2003-12-23 |
2023-08-12 |
mouse |
| Z Hawi, K Sheehan, A Lynch, I Evans, N Lowe, B Lawlor, M Gil. Late onset Alzheimer's disease and apolipoprotein association in the Irish population: relative risk and attributable fraction. Irish journal of medical science. vol 172. issue 2. 2003-12-11. PMID:12930057. |
familial and sporadic late onset alzheimer's disease (load) shows a consistent genetic association with apoe epsilon4. |
2003-12-11 |
2023-08-12 |
Not clear |
| Leslie C Baxter, Richard J Caselli, Sterling C Johnson, Eric Reiman, David Osborn. Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease. Neurobiology of aging. vol 24. issue 7. 2003-12-09. PMID:12928055. |
the apolipoprotein e (apoe) epsilon 4 allele is an important risk factor for alzheimer's disease (ad). |
2003-12-09 |
2023-08-12 |
human |
| Glenda Parra-Bonilla, Gonzalo Arboleda, Juan Yunis, Eugenia Solano, Rodrigo Pardo, Gabriel Arango, Daniel Hedmont, Humberto Arboled. Haplogroup analysis of the risk associated with APOE promoter polymorphisms (-219T/G, -491A/T and -427T/C) in Colombian Alzheimer's disease patients. Neuroscience letters. vol 349. issue 3. 2003-12-04. PMID:12951193. |
haplogroup analysis of the risk associated with apoe promoter polymorphisms (-219t/g, -491a/t and -427t/c) in colombian alzheimer's disease patients. |
2003-12-04 |
2023-08-12 |
Not clear |
| Glenda Parra-Bonilla, Gonzalo Arboleda, Juan Yunis, Eugenia Solano, Rodrigo Pardo, Gabriel Arango, Daniel Hedmont, Humberto Arboled. Haplogroup analysis of the risk associated with APOE promoter polymorphisms (-219T/G, -491A/T and -427T/C) in Colombian Alzheimer's disease patients. Neuroscience letters. vol 349. issue 3. 2003-12-04. PMID:12951193. |
results analyzing the association between polymorphisms in the promoter region of the apolipoprotein e (apoe) gene and alzheimer's disease (ad) are contradictory. |
2003-12-04 |
2023-08-12 |
Not clear |
| Peng Zhang, Ze Yang, Chuanfang Zhang, Zeping Lu, Xiaohong Shi, Weidong Zheng, Chunling Wan, Duanyang Zhang, Chenguang Zheng, Shu Li, Feng Jin, Li Wan. Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese. Neuroscience letters. vol 349. issue 3. 2003-12-04. PMID:12951205. |
to investigate the possible involvement of the transferrin (tf) gene polymorphism in the manifestation of alzheimer's disease (ad), we analyzed the tf and apolipoprotein e (apoe) genotypes of 67 sporadic late-onset ad patients and 131 normal elderly controls in the chinese population. |
2003-12-04 |
2023-08-12 |
human |
| Seth Love, James A R Nicoll, Anthony Hughes, Gordon K Wilcoc. APOE and cerebral amyloid angiopathy in the elderly. Neuroreport. vol 14. issue 11. 2003-11-20. PMID:12960780. |
possession of apoe epsilon4 is associated with increased prevalence and severity of caa in alzheimer's disease (ad) and in cerebral haemorrhage. |
2003-11-20 |
2023-08-12 |
Not clear |
| János Kálmán, Anna Juhász, Agnes Rimanóczy, András Palotás, Miklós Palotás, Zoltán Szabó, Krisztina Boda, János Márki-Zay, Zoltán Jank. Lack of influence of the apolipoprotein E genotype on the outcome of selegiline treatment in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 16. issue 1. 2003-11-10. PMID:12714797. |
the objective of our study was to investigate whether an interaction exists between apolipoprotein e (apoe) genotype and the response of patients with alzheimer's disease (ad) to selegiline treatment, and whether apoe genotype independently affects the rate of ad progression. |
2003-11-10 |
2023-08-12 |
Not clear |
| J D Yang, G Y Feng, J Zhang, J Cheung, D St Clair, L He, Keiichi Ichimur. Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population. Neuroscience letters. vol 350. issue 1. 2003-11-10. PMID:12962909. |
polymorphisms at positions -491, -427 and -219 in the promoter region of the apolipoprotein e apoe gene have been variously reported to confer an increased risk of developing alzheimer's disease (ad) independent of the effect of epsilon 2, 3 or 4 alleles in exon 4. |
2003-11-10 |
2023-08-12 |
Not clear |
| Benyan Luo, Zhi Chen, Yanyan Zhang, Xiaoping Pan, Xia Li, Feng Che. Apolipoprotein E genotype in patients with Alzheimer's disease. Chinese medical journal. vol 116. issue 8. 2003-11-07. PMID:12935416. |
to explore the frequency and significance of apoe gene polymorphisms in patients with sporadic alzheimer's disease (ad). |
2003-11-07 |
2023-08-12 |
Not clear |
| Erin D Bigler, Christopher M Lowry, Burton Kerr, David F Tate, Cory D Hessel, Heath D Earl, Michael J Miller, Sara A Rice, Kay H Smith, JoAnn T Tschanz, Kathleen Welsh-Bohmer, Brenda Plassman, Jeff Victorof. Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. Neuropsychology. vol 17. issue 3. 2003-10-31. PMID:12959500. |
neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with alzheimer's disease (ad), non-ad dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein e (apoe) genotype. |
2003-10-31 |
2023-08-12 |
human |
| David C Steffens, William T Trost, Martha E Payne, Celia F Hybels, James R MacFal. Apolipoprotein E genotype and subcortical vascular lesions in older depressed patients and control subjects. Biological psychiatry. vol 54. issue 7. 2003-10-23. PMID:14512206. |
the apolipoprotein e gene (apoe) epsilon 4 allele has been associated with a variety of late-life neuropsychiatric disorders, including alzheimer's disease, vascular dementia, and depression. |
2003-10-23 |
2023-08-12 |
human |
| J Carbonell, R Allen, G Kalsi, A McQuillin, G Livingston, C Katona, Z Walker, A Katz, G Rands, T Stevens, I Crossan, D Curtis, H Gurlin. Variation in the DCP1 gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer's disease. Psychiatric genetics. vol 13. issue 1. 2003-10-21. PMID:12605101. |
to attempt to replicate previous reports that polymorphic variation in the dcp1 gene causes increased susceptibility to the development of alzheimer's disease, either on its own or in interaction with the effects of the gene for apolipoprotein e (apoe). |
2003-10-21 |
2023-08-12 |
Not clear |
| S Lai, Y Chen, Z We. [Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. vol 22. issue 3. 2003-10-02. PMID:11860878. |
to investigate the distribution of apolipoprotein e (apoe) genotype of patients with alzheimer's disease (ad) in the population aged 75 and older in guangzhou and to determine whether there was an association between ad and apoe epsilon4 allele. |
2003-10-02 |
2023-08-12 |
Not clear |