| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Milla Koistinaho, Suizhen Lin, Xin Wu, Michail Esterman, Deanna Koger, Jeffrey Hanson, Richard Higgs, Feng Liu, Seema Malkani, Kelly R Bales, Steven M Pau. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nature medicine. vol 10. issue 7. 2004-08-19. PMID:15195085. |
thus, apoe seems to be important in the degradation and clearance of deposited abeta species by astrocytes, a process that may be impaired in alzheimer disease. |
2004-08-19 |
2023-08-12 |
mouse |
| J Cervilla, M Prince, S Joels, S Lovestone, A Man. Premorbid cognitive testing predicts the onset of dementia and Alzheimer's disease better than and independently of APOE genotype. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 8. 2004-08-18. PMID:15258208. |
premorbid cognitive testing predicts the onset of dementia and alzheimer's disease better than and independently of apoe genotype. |
2004-08-18 |
2023-08-12 |
Not clear |
| Jerome A Yesavage, Leah Friedman, Helena Kraemer, Jared R Tinklenberg, Ahmad Salehi, Art Noda, Joy L Taylor, Ruth O'Hara, Greer Murph. Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course. Journal of geriatric psychiatry and neurology. vol 17. issue 1. 2004-08-10. PMID:15018693. |
sleep/wake disruption in alzheimer's disease: apoe status and longitudinal course. |
2004-08-10 |
2023-08-12 |
human |
| Lisa Mosconi, Sandro Sorbi, Benedetta Nacmias, Maria Teresa R De Cristofaro, Mozhgan Fayyaz, Laura Bracco, Karl Herholz, Alberto Pup. Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study. Psychiatry research. vol 130. issue 2. 2004-08-10. PMID:15033184. |
age and apoe genotype interaction in alzheimer's disease: an fdg-pet study. |
2004-08-10 |
2023-08-12 |
Not clear |
| Gysèle S Bleumink, Cornelia M van Duijn, J Herre Kingma, Jacqueline C M Witteman, Albert Hofman, Bruno H Ch Stricke. Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. American heart journal. vol 147. issue 4. 2004-08-09. PMID:15077085. |
apolipoprotein (apoe) epsilon4 allele has been associated with cardiac dysfunction in alzheimer's disease and beta-thalassemia. |
2004-08-09 |
2023-08-12 |
human |
| Yuko Saito, Nyoka N Ruberu, Mieko Harada, Tomio Arai, Motoji Sawabe, Nobuyuki Nukina, Shigeo Murayam. In situ detection of apolipoprotein E epsilon 4 in archival human brain. Neuroreport. vol 15. issue 7. 2004-07-27. PMID:15129156. |
this method will allow in situ detection of apoe epsilon4 and contribute to studies of the effect of epsilon4 on alzheimer's disease. |
2004-07-27 |
2023-08-12 |
human |
| M C Déniz Naranjo, C Muñoz Fernández, M J Alemany Rodríguez, M C Pérez Viéitez, J Irurita Latasa, R Suárez Armas, M P Suárez Valentín, F Sánchez Garcí. [Gender has a strong modulating effect on the risk of Alzheimer's disease conferred by the apolipoprotein E gene in the population of the Canary Islands, Spain]. Revista de neurologia. vol 38. issue 7. 2004-07-23. PMID:15098180. |
apolipoprotein e (apoe) gen has been found to confer risk for alzheimer disease in every population studied. |
2004-07-23 |
2023-08-12 |
Not clear |
| Caleb E Finch, Craig B Stanfor. Meat-adaptive genes and the evolution of slower aging in humans. The Quarterly review of biology. vol 79. issue 1. 2004-07-13. PMID:15101252. |
one candidate gene is apolipoprotein e (apoe), with the e3 allele evolved in the genus homo that reduces the risks for alzheimer's and vascular disease, as well as influencing inflammation, infection, and neuronal growth. |
2004-07-13 |
2023-08-12 |
human |
| Laurence Mabile, Chantal Lefebvre, Jacques Lavigne, Lucie Boulet, Jean Davignon, Suzanne Lussier-Cacan, Lise Bernie. Secreted apolipoprotein E reduces macrophage-mediated LDL oxidation in an isoform-dependent way. Journal of cellular biochemistry. vol 90. issue 4. 2004-07-09. PMID:14587032. |
such is the case for apolipoprotein e (apoe), which has been shown to exert antioxidant properties in some studies, mostly in relation to alzheimer's disease. |
2004-07-09 |
2023-08-12 |
Not clear |
| Annica Johansson, Hagit Katzov, Henrik Zetterberg, Lars Feuk, Boo Johansson, Nenad Bogdanovic, Niels Andreasen, Boris Lenhard, Anthony J Brookes, Nancy L Pedersen, Kaj Blennow, Jonathan A Princ. Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease. Human genetics. vol 114. issue 6. 2004-06-29. PMID:15034781. |
variants of cyp46a1 may interact with age and apoe to influence csf abeta42 levels in alzheimer's disease. |
2004-06-29 |
2023-08-12 |
Not clear |
| James A Levy, Judy Bergeson, Karen Putnam, Virginia Rosen, Robert Cohen, Francois Lalonde, Nadeem Mirza, Gary Linker, Trey Sunderlan. Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease. Journal of the International Neuropsychological Society : JINS. vol 10. issue 3. 2004-06-21. PMID:15147594. |
context-specific memory and apolipoprotein e (apoe) epsilon 4: cognitive evidence from the nimh prospective study of risk for alzheimer's disease. |
2004-06-21 |
2023-08-12 |
Not clear |
| James A Levy, Judy Bergeson, Karen Putnam, Virginia Rosen, Robert Cohen, Francois Lalonde, Nadeem Mirza, Gary Linker, Trey Sunderlan. Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease. Journal of the International Neuropsychological Society : JINS. vol 10. issue 3. 2004-06-21. PMID:15147594. |
the aim of the study was to determine whether the epsilon 4 allele of the apolipoprotein e (apoe) gene was associated primarily with context-specific memory among individuals at genetic risk for developing alzheimer's disease. |
2004-06-21 |
2023-08-12 |
Not clear |
| James A Levy, Judy Bergeson, Karen Putnam, Virginia Rosen, Robert Cohen, Francois Lalonde, Nadeem Mirza, Gary Linker, Trey Sunderlan. Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease. Journal of the International Neuropsychological Society : JINS. vol 10. issue 3. 2004-06-21. PMID:15147594. |
the effect of apoe status on comprehensive neuropsychological results was examined in 176 healthy adults during baseline cognitive testing in the nimh prospective study of biomarkers for older controls at risk for alzheimer's disease (nimh prospective biocard study). |
2004-06-21 |
2023-08-12 |
Not clear |
| Mu-ni Tang, Zhen-xin Zhang, Hai-ying Han, Xie-he Liu, Yan She. [Analysis on association between the polymorphisms in apolipoprotein E, interleukin-1 alpha genes and Alzheimer's disease in Chengdu area]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 21. issue 2. 2004-06-15. PMID:15079806. |
to investigate the correlation between the polymorphisms of apolipoprotein e(apoe), the interleukin-1 alpha (il-1 alpha ) genes and the susceptibility to alzheimer's disease(ad). |
2004-06-15 |
2023-08-12 |
Not clear |
| C Qiu, M Kivipelto, H Agüero-Torres, B Winblad, L Fratiglion. Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 6. 2004-06-11. PMID:15145993. |
risk and protective effects of the apoe gene towards alzheimer's disease in the kungsholmen project: variation by age and sex. |
2004-06-11 |
2023-08-12 |
Not clear |
| C Qiu, M Kivipelto, H Agüero-Torres, B Winblad, L Fratiglion. Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 6. 2004-06-11. PMID:15145993. |
the risk effect of apoe epsilon 4 allele for alzheimer's disease is acknowledged, whereas the putative protective effect of epsilon 2 allele remains in debate. |
2004-06-11 |
2023-08-12 |
Not clear |
| K R Bales, J C Dodart, R B DeMattos, D M Holtzman, S M Pau. Apolipoprotein E, amyloid, and Alzheimer disease. Molecular interventions. vol 2. issue 6. 2004-06-09. PMID:14993413. |
the risk that specific isoforms of apoe pose with regard to alzheimer disease clearly varies, and so the roles that apoe plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies. |
2004-06-09 |
2023-08-12 |
Not clear |
| P M Sullivan, B E Mace, N Maeda, D E Schmeche. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience. vol 124. issue 4. 2004-06-08. PMID:15026113. |
finally, the differences in apoe levels we observed may explain the regional vulnerability of neuronal degeneration in alzheimer's disease. |
2004-06-08 |
2023-08-12 |
mouse |
| J Tian, J Shi, K Bailey, C L Lendon, S M Pickering-Brown, D M A Man. Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 5. 2004-06-08. PMID:15090562. |
to investigate the association between white matter damage, as evidenced by myelin loss (ml), the extent of cerebral amyloid angiopathy (caa), or arteriosclerosis (art), and apolipoprotein e (apoe) e4 allele in alzheimer's disease (ad), in order to understand the causes of damage to white matter in ad and its contribution to the pathogenesis of the disorder. |
2004-06-08 |
2023-08-12 |
Not clear |
| Patrick G Kehoe, Hagit Katzov, Niels Andreasen, Maragaret Gatz, Gordon K Wilcock, Nigel J Cairns, Juni Palmgren, Ulf de Faire, Anthony J Brookes, Nancy L Pedersen, Kaj Blennow, Jonathan A Princ. Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease. Human genetics. vol 114. issue 5. 2004-06-04. PMID:14986105. |
an excellent example of this can be found for the epsilon4 allele of apoe in relation to alzheimer's disease (ad) for which association with both risk and age-at-onset (aao) is evident. |
2004-06-04 |
2023-08-12 |
human |