| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael C Irizarry, Amy Deng, Alberto Lleo, Oksana Berezovska, Christine A F Von Arnim, Matthew Martin-Rehrmann, Arlene Manelli, Mary Jo LaDu, Bradley T Hyman, G William Rebec. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312168. |
polymorphisms in the apolipoprotein e (apoe) gene affect the risk of alzheimer disease and the amount of amyloid beta-protein (abeta) deposited in the brain. |
2004-09-30 |
2023-08-12 |
Not clear |
| Michael C Irizarry, Amy Deng, Alberto Lleo, Oksana Berezovska, Christine A F Von Arnim, Matthew Martin-Rehrmann, Arlene Manelli, Mary Jo LaDu, Bradley T Hyman, G William Rebec. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312168. |
the apoe modulation of abeta production and app signaling is a potential mechanism affecting alzheimer disease risk. |
2004-09-30 |
2023-08-12 |
Not clear |
| Katrina A B Goddard, Jane M Olson, Haydeh Payami, Monique van der Voet, Helena Kuivaniemi, Gerard Trom. Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease. Neurogenetics. vol 5. issue 2. 2004-09-24. PMID:15034766. |
recently, we reported evidence of linkage on chromosome 20 for alzheimer disease (ad) using a novel statistical approach to incorporate covariates (e.g., age, apoe genotype) into the analysis. |
2004-09-24 |
2023-08-12 |
human |
| M Rosich-Estragó, L Figuera-Terré, B Mulet-Pérez, M T Arrufat-Cardús, A Pascual San Emeterio, I Arbeola-Rigau, A Labad-Alquézar, E Vilella-Cuadrad. [Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene]. Revista de neurologia. vol 38. issue 9. 2004-09-24. PMID:15152345. |
the apoe epsilon4 allele is a well-established risk factor for alzheimer's disease. |
2004-09-24 |
2023-08-12 |
Not clear |
| Ellen M Wijsman, E Warwick Daw, Change-En Yu, Haydeh Payami, Ellen J Steinbart, David Nochlin, Erin M Conlon, Thomas D Bird, Gerard D Schellenber. Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. American journal of human genetics. vol 75. issue 3. 2004-09-17. PMID:15248153. |
late-onset familial alzheimer disease (lofad) is a genetically heterogeneous and complex disease for which only one locus, apoe, has been definitively identified. |
2004-09-17 |
2023-08-12 |
Not clear |
| D Craig, D J Hart, K McCool, S P McIlroy, A P Passmor. Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 9. 2004-09-14. PMID:15314125. |
aggressive change may result from known genetic risk factors for alzheimer's disease (ad) and therefore accompany conventional markers such as apolipoprotein e (apoe). |
2004-09-14 |
2023-08-12 |
human |
| Barbara Borroni, Silvana Archetti, Chiara Agosti, Nabil Akkawi, Cristina Brambilla, Luigi Caimi, Carlo Caltagirone, Monica Di Luca, Alessandro Padovan. Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators. Neurobiology of aging. vol 25. issue 6. 2004-09-07. PMID:15165699. |
intronic cyp46 polymorphism along with apoe genotype in sporadic alzheimer disease: from risk factors to disease modulators. |
2004-09-07 |
2023-08-12 |
Not clear |
| K Sleegers, G Roks, J Theuns, Y S Aulchenko, R Rademakers, M Cruts, W A van Gool, C Van Broeckhoven, P Heutink, B A Oostra, J C van Swieten, C M van Duij. Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. Brain : a journal of neurology. vol 127. issue Pt 7. 2004-08-27. PMID:15130954. |
a high percentage of late-onset alzheimer's disease could be explained by apoe*4, but 55% of its origin is still unknown. |
2004-08-27 |
2023-08-12 |
Not clear |
| J Wesson Ashfor. APOE genotype effects on Alzheimer's disease onset and epidemiology. Journal of molecular neuroscience : MN. vol 23. issue 3. 2004-08-26. PMID:15181244. |
apoe genotype effects on alzheimer's disease onset and epidemiology. |
2004-08-26 |
2023-08-12 |
Not clear |
| Bruce Tete. ApoE-dependent plasticity in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 23. issue 3. 2004-08-26. PMID:15181245. |
the contribution of neuroplasticity to alzheimer's disease (ad) is supported by important effects of apoe on both the pathology of ad and the environmental and developmental factors influencing its etiologies. |
2004-08-26 |
2023-08-12 |
Not clear |
| Keith A Crutche. Apolipoprotein E is a prime suspect, not just an accomplice, in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 23. issue 3. 2004-08-26. PMID:15181246. |
there is now a large body of evidence suggesting that apolipoprotein e (apoe) genotype is the single most important genetic risk factor for the most common (sporadic) form of alzheimer's disease. |
2004-08-26 |
2023-08-12 |
mouse |
| Arlene M Manelli, W Blaine Stine, Linda J Van Eldik, Mary Jo LaD. ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function. Journal of molecular neuroscience : MN. vol 23. issue 3. 2004-08-26. PMID:15181252. |
abnormalities in the processing of amyloid precursor protein to amyloid-beta (abeta) are causal factors, and the presence of the epsilon4 allele of apolipoprotein e (apoe) is the primary risk factor for alzheimer's disease (ad). |
2004-08-26 |
2023-08-12 |
Not clear |
| David M Holtzma. In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology. Journal of molecular neuroscience : MN. vol 23. issue 3. 2004-08-26. PMID:15181253. |
the epsilon4 allele of apolipoprotein e apoe is a risk factor for alzheimer's disease (ad) and cerebral amyloid angiopathy (caa), and the epsilon2 allele is associated with a decreased risk for ad. |
2004-08-26 |
2023-08-12 |
mouse |
| John F Ervin, Catherine Pannell, Mari Szymanski, Kathleen Welsh-Bohmer, Donald E Schmechel, Christine M Hulett. Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. Journal of neuropathology and experimental neurology. vol 63. issue 7. 2004-08-26. PMID:15290898. |
we analyzed smooth muscle actin (sma) immunoreactivity in brain blood vessels of 10 apoe 4,4 alzheimer disease (ad) patients and 10 apoe 3,3 ad patients matched for age, sex, and duration of dementia. |
2004-08-26 |
2023-08-12 |
Not clear |
| Ki-Woong Kim, Young-Ju Suh, Woong-Yang Park, Jin-Hyeong Jhoo, Dong-Young Lee, Jong-Chul Youn, Kwang-Hyuck Lee, Jeong-Sun Seo, Jong-Inn Wo. Choline acetyltransferase G +4 A polymorphism confers a risk for Alzheimer's disease in concert with Apolipoprotein E epsilon4. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276243. |
to examine whether the single nucleotide polymorphism at position +4 of the choline acetyltransferase (chat) confers a risk for alzheimer's disease (ad), we determined the chat and the apolipoprotein (apoe) genotypes of the 246 ad patients and 561 non-demented controls. |
2004-08-25 |
2023-08-12 |
Not clear |
| Jacob Raber, Yadong Huang, J Wesson Ashfor. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiology of aging. vol 25. issue 5. 2004-08-23. PMID:15172743. |
in this review, evidence is provided that apolipoprotein e (apoe) genotype accounts for the majority of alzheimer's disease (ad) risk and pathology. |
2004-08-23 |
2023-08-12 |
human |
| Debomoy K Lahiri, Kumar Sambamurti, David A Bennet. Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. Neurobiology of aging. vol 25. issue 5. 2004-08-23. PMID:15172744. |
herein we review the role of apolipoprotein e (apoe) in alzheimer's disease (ad) and how apoe interacts with various risk factors. |
2004-08-23 |
2023-08-12 |
Not clear |
| R F Itzhaki, C B Dobson, S J Shipley, M A Woznia. The role of viruses and of APOE in dementia. Annals of the New York Academy of Sciences. vol 1019. 2004-08-20. PMID:15246985. |
the virus, herpes simplex virus type 1 (hsv1), when present in brain, acts together with the type 4 allele of the apoe gene, a known susceptibility factor in alzheimer disease (ad), to confer a strong risk of ad; in carriers of the other two main alleles of the gene, the virus does not confer a risk. |
2004-08-20 |
2023-08-12 |
Not clear |
| D S Powell, H Maksoud, S B P Chargé, J H Moffitt, M Desai, R L Da Silva Fihlo, A T Hattersley, I M Stratton, D R Matthews, J C Levy, A Clar. Apolipoprotein E genotype, islet amyloid deposition and severity of Type 2 diabetes. Diabetes research and clinical practice. vol 60. issue 2. 2004-08-19. PMID:12706318. |
severity of cerebral amyloidosis in alzheimer's disease (ad) is increased in subjects with the apolipoprotein e (apoe) epsilon 4 allele. |
2004-08-19 |
2023-08-12 |
human |
| Milla Koistinaho, Suizhen Lin, Xin Wu, Michail Esterman, Deanna Koger, Jeffrey Hanson, Richard Higgs, Feng Liu, Seema Malkani, Kelly R Bales, Steven M Pau. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nature medicine. vol 10. issue 7. 2004-08-19. PMID:15195085. |
we have previously shown that apolipoprotein e (apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of apoe markedly affects the deposition of amyloid-beta peptides (abeta) in a mouse model of alzheimer disease. |
2004-08-19 |
2023-08-12 |
mouse |