| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brent J Small, Christopher B Rosnick, Laura Fratiglioni, Lars Bäckma. Apolipoprotein E and cognitive performance: a meta-analysis. Psychology and aging. vol 19. issue 4. 2005-04-08. PMID:15584785. |
the epsilon4 allele of the apolipoprotein e (apoe) gene is a known risk factor for alzheimer's disease and may also affect cognitive performance in normal aging. |
2005-04-08 |
2023-08-12 |
Not clear |
| Brian D Hoyt, Paul J Massman, Christopher Schatschneider, Norma Cooke, Rachelle S Dood. Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease. Archives of neurology. vol 62. issue 3. 2005-04-05. PMID:15767511. |
individual growth curve analysis of apoe epsilon 4-associated cognitive decline in alzheimer disease. |
2005-04-05 |
2023-08-12 |
Not clear |
| Brian D Hoyt, Paul J Massman, Christopher Schatschneider, Norma Cooke, Rachelle S Dood. Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease. Archives of neurology. vol 62. issue 3. 2005-04-05. PMID:15767511. |
the apolipoprotein e epsilon4 (apoe epsilon4) allele is associated with an increased risk of developing alzheimer disease (ad). |
2005-04-05 |
2023-08-12 |
Not clear |
| J M Hill, B M Gebhardt, A M Azcuy, K E Matthews, W J Lukiw, I Steiner, H W Thompson, M J Bal. Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease? Medical hypotheses. vol 64. issue 2. 2005-03-29. PMID:15607565. |
data from itzhaki's research suggests that hsv-1 in the brain and the carriage of an apolipoprotein e allele 4 (apoe e4) together confer risk for ad [j pathol 97 (2002) 395], [mol chem neuropathol 28 (1996) 135], [alzheimer's rep 1 (1998) 173], [biochem soc trans 26 (1998) 273]. |
2005-03-29 |
2023-08-12 |
Not clear |
| Ira Driscoll, Mark A McDaniel, Melissa J Guyn. Apolipoprotein E and prospective memory in normally aging adults. Neuropsychology. vol 19. issue 1. 2005-03-29. PMID:15656760. |
the epsilon4 allele of apolipoprotein e (apoe) is an established risk factor for alzheimer's disease, despite uncertainty as to its effect on cognitive function in normal aging. |
2005-03-29 |
2023-08-12 |
Not clear |
| David A Costa, Lars N G Nilsson, Kelly R Bales, Steven M Paul, Huntington Potte. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505373. |
to determine the role of apolipoprotein e (apoe) in the deposition of different forms of alzheimer amyloid deposit, we studied mice expressing both mutant human amyloid beta-protein precursor (abetapp) and presenilin 1 (ps1) that, in addition, were either normal or knocked-out for apoe. |
2005-03-21 |
2023-08-12 |
mouse |
| David A Costa, Lars N G Nilsson, Kelly R Bales, Steven M Paul, Huntington Potte. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505373. |
these and other behavior data indicate that the primary function of apoe in alzheimer's disease is to promote the polymerization of abeta into mature, beta pleated sheet filaments, a process that is necessary for inducing cognitive decline. |
2005-03-21 |
2023-08-12 |
mouse |
| Karen M Mann, Fayanne E Thorngate, Yuko Katoh-Fukui, Hiroki Hamanaka, David L Williams, Shinobu Fujita, Bruce T Lam. Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. Human molecular genetics. vol 13. issue 17. 2005-03-18. PMID:15229191. |
independent effects of apoe on cholesterol metabolism and brain abeta levels in an alzheimer disease mouse model. |
2005-03-18 |
2023-08-12 |
mouse |
| Karen M Mann, Fayanne E Thorngate, Yuko Katoh-Fukui, Hiroki Hamanaka, David L Williams, Shinobu Fujita, Bruce T Lam. Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. Human molecular genetics. vol 13. issue 17. 2005-03-18. PMID:15229191. |
the apoe epsilon4 allele is the most significant genetic risk factor associated with alzheimer's disease to date. |
2005-03-18 |
2023-08-12 |
mouse |
| Karen M Mann, Fayanne E Thorngate, Yuko Katoh-Fukui, Hiroki Hamanaka, David L Williams, Shinobu Fujita, Bruce T Lam. Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. Human molecular genetics. vol 13. issue 17. 2005-03-18. PMID:15229191. |
these data indicate an independent role for apoe in cholesterol metabolism in the periphery relative to the cns, and that the altered levels of cholesterol and apoe in these mice are insufficient to influence abeta metabolism in a mouse model of alzheimer's disease. |
2005-03-18 |
2023-08-12 |
mouse |
| M Christoforidis, R Schober, K Kroh. Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy. Neuropathology and applied neurobiology. vol 31. issue 1. 2005-03-16. PMID:15634227. |
accumulating evidence suggests that genetic factors such as apolipoprotein e (apoe), can act in different ways in the pathogenesis of cerebral amyloid angiopathy (caa) and alzheimer's disease (ad). |
2005-03-16 |
2023-08-12 |
Not clear |
| A Algotsson, A Nordberg, L Lannfelt, O Almkvist, B Winbla. Apolipoprotein E epsilon4 allele, skin vessel reactivity and vascular risk factors in Alzheimer's disease. Archives of gerontology and geriatrics. vol 22. issue 3. 2005-03-15. PMID:15374172. |
the apolipoprotein e (apoe) epsilon4 allele is strongly associated with alzheimer's disease (ad), and is, at the same time, a risk factor for cardiovascular disease. |
2005-03-15 |
2023-08-12 |
Not clear |
| G Friedman, R Gabizon, A Ben-Yehud. Apolipoprotein Eepsilon4 allele, a risk factor for late onset nonfamilial Alzheimer's disease among Israeli Jews. Archives of gerontology and geriatrics. vol 24. issue 2. 2005-03-14. PMID:15374124. |
apolipoprotein (apoe) genotypes were determined in 90 israeli jews with late onset sporadic alzheimer's disease (ad) and in 90 age- and sex-matched non-demented controls. |
2005-03-14 |
2023-08-12 |
human |
| Rangaraj K Gopalraj, Haiyan Zhu, Jeremiah F Kelly, Marta Mendiondo, Joseph F Pulliam, David A Bennett, Steven Estu. Genetic association of low density lipoprotein receptor and Alzheimer's disease. Neurobiology of aging. vol 26. issue 1. 2005-03-14. PMID:15585340. |
the low density lipoprotein receptor (ldlr) is an attractive candidate gene for genetic association with alzheimer's disease (ad) because: (i) the ldlr is an apolipoprotein e (apoe) receptor, alleles of which have been associated with ad, (ii) ldlr resides at chromosome 19p13.3 within a region linked to ad, and (iii) ldlr modulates the homeostasis of cholesterol, which itself appears associated with ad. |
2005-03-14 |
2023-08-12 |
human |
| Raghda Lahdo, Laurence De La Fournière-Bessueill. Insertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein E. The Biochemical journal. vol 382. issue Pt 3. 2005-03-07. PMID:15202933. |
insertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein e. app (amyloid precursor protein), together with chol (cholesterol) and apoe (apolipoprotein e), has been linked to alzheimer's disease. |
2005-03-07 |
2023-08-12 |
Not clear |
| Jean-Cosme Dodart, Robert A Marr, Milla Koistinaho, Beth M Gregersen, Seema Malkani, Inder M Verma, Steven M Pau. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 4. 2005-03-01. PMID:15657137. |
apolipoprotein e (apoe) alleles are important genetic risk factors for alzheimer's disease (ad), with the epsilon4 allele increasing and the epsilon2 allele decreasing risk for developing ad. |
2005-03-01 |
2023-08-12 |
mouse |
| Nunzio Pomara, Lisa Willoughby, Keith Wesnes, David J Greenblatt, John J Sidti. Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults. Archives of general psychiatry. vol 62. issue 2. 2005-02-24. PMID:15699298. |
the apolipoprotein e (apoe) epsilon4 allele has been implicated as a significant risk factor in the development of late-onset alzheimer disease, but the evidence of cognitive sequelae in healthy individuals has been mixed. |
2005-02-24 |
2023-08-12 |
Not clear |
| Christian Spell, Heike Kölsch, Dieter Lütjohann, Anja Kerksiek, Frank Hentschel, Marinella Damian, Klaus von Bergmann, Marie Luise Rao, Wolfgang Maier, Reinhard Heu. SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele. Dementia and geriatric cognitive disorders. vol 18. issue 3-4. 2005-02-16. PMID:15286454. |
consequently the relationship between this srebp-1a gene polymorphism and alzheimer's disease (ad) alone and in combination with the apolipoprotein e (apoe) 4 allele was evaluated. |
2005-02-16 |
2023-08-12 |
Not clear |
| S Al-Shammari, H Fatania, R Al-Radwan, A O Akanj. Apolipoprotein E polymorphism and lipoprotein levels in a Gulf Arab population in Kuwait: a pilot study. Annals of Saudi medicine. vol 24. issue 5. 2005-02-15. PMID:15573849. |
apoe polymorphism is believed to confer susceptibility to coronary heart disease (chd) and alzheimer's disease. |
2005-02-15 |
2023-08-12 |
Not clear |
| M Farlow, R Lane, S Kudaravalli, Y H. Differential qualitative responses to rivastigmine in APOE epsilon 4 carriers and noncarriers. The pharmacogenomics journal. vol 4. issue 5. 2005-02-11. PMID:15289797. |
however, at 26 weeks, placebo-treated apoe epsilon4 patients declined 3.04 points below baseline on the cognitive subscale of the alzheimer's disease assessment scale (adas-cog), and rivastigmine-treated patients improved by 1.67 points. |
2005-02-11 |
2023-08-12 |
Not clear |