| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Holmans, Marian Hamshere, Paul Hollingworth, Frances Rice, Nigel Tunstall, Sue Jones, Pamela Moore, Fabienne Wavrant DeVrieze, Amanda Myers, Richard Crook, Danielle Compton, Helen Marshall, David Meyer, Shantia Shears, Jeremy Booth, Dzanan Ramic, Nigel Williams, Nadine Norton, Richard Abraham, Pat Kehoe, Hywel Williams, Varuni Rudrasingham, Mick O'Donovan, Lesley Jones, John Hardy, Alison Goate, Simon Lovestone, Michael Owen, Julie William. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 135B. issue 1. 2005-05-31. PMID:15729734. |
we performed an affected sib-pair (asp) linkage analysis to test for the effects of age at onset (aao), rate of decline (rod), and apolipoprotein e (apoe) genotype on linkage to late-onset alzheimer's disease (ad) in a sample comprising 428 sib-pairs. |
2005-05-31 |
2023-08-12 |
Not clear |
| Neelum T Aggarwal, Robert S Wilson, Todd L Beck, Julia L Bienias, Elizabeth Berry-Kravis, David A Bennet. The apolipoprotein E epsilon4 allele and incident Alzheimer's disease in persons with mild cognitive impairment. Neurocase. vol 11. issue 1. 2005-05-27. PMID:15804918. |
possession of one or more copies of the apolipoprotein e (apoe) epsilon4 allele is a known risk factor for alzheimer's disease (ad), but it is uncertain whether the epsilon4 allele is associated with disease incidence among persons with mild cognitive impairment (mci). |
2005-05-27 |
2023-08-12 |
human |
| Reinaldo B Oriá, Peter D Patrick, Hong Zhang, Breyette Lorntz, Carlos Maurício de Castro Costa, Gerly A C Brito, Leah J Barrett, Aldo A M Lima, Richard L Guerran. APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil. Pediatric research. vol 57. issue 2. 2005-05-24. PMID:15611352. |
polymorphisms in the apolipoprotein e (apoe) have constituted the major rationale to identify potential risk groups for developing late-onset alzheimer's disease and help to predict recovery of cognitive function after brain injury. |
2005-05-24 |
2023-08-12 |
Not clear |
| Barbara L Trommer, Chirag Shah, Sung Hwan Yun, Georgi Gamkrelidze, Emily S Pasternak, Gui Lan Ye, Michelle Sotak, Patrick M Sullivan, Joseph F Pasternak, Mary Jo LaD. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport. vol 15. issue 17. 2005-05-16. PMID:15570172. |
inheritance of the epsilon4 allele for apolipoprotein e (apoe) increases the risk of alzheimer disease and memory impairment, whereas epsilon2 decreases these risks compared with the most common epsilon3 allele, but the mechanism for these effects is unknown. |
2005-05-16 |
2023-08-12 |
mouse |
| Hyang-Sook Hoe, D Christopher Harris, G William Rebec. Multiple pathways of apolipoprotein E signaling in primary neurons. Journal of neurochemistry. vol 93. issue 1. 2005-05-16. PMID:15773914. |
apolipoprotein e is a genetic risk factor for alzheimer's disease, and the apoe protein is associated with beta-amyloid deposits in alzheimer's disease brain. |
2005-05-16 |
2023-08-12 |
Not clear |
| Ellen M Wijsman, E Warwick Daw, Xuesong Yu, Ellen J Steinbart, David Nochlin, Thomas D Bird, Gerard D Schellenber. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15389756. |
apoe and other loci affect age-at-onset in alzheimer's disease families with ps2 mutation. |
2005-05-12 |
2023-08-12 |
Not clear |
| Chunsheng Wang, Wilkie A Wilson, Scott D Moore, Brian E Mace, Nobuyo Maeda, Donald E Schmechel, Patrick M Sulliva. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiology of disease. vol 18. issue 2. 2005-05-12. PMID:15686968. |
the human apoe*4 allele is associated with an early age of onset and increased risk of alzheimer's disease (ad). |
2005-05-12 |
2023-08-12 |
mouse |
| Cathleen D Zick, Charles J Mathews, J Scott Roberts, Robert Cook-Deegan, Robert J Pokorski, Robert C Gree. Genetic testing for Alzheimer's disease and its impact on insurance purchasing behavior. Health affairs (Project Hope). vol 24. issue 2. 2005-05-05. PMID:15757934. |
to test for this behavior, we followed 148 cognitively normal people participating in a randomized clinical trial of genetic testing for alzheimer's disease for one year after risk assessment and apolipoprotein e (apoe) genotype disclosure. |
2005-05-05 |
2023-08-12 |
Not clear |
| U Igbavboa, G P Eckert, T M Malo, A E Studniski, L N A Johnson, N Yamamoto, M Kobayashi, S C Fujita, T R Appel, W E Müller, W G Wood, K Yanagisaw. Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age. Journal of the neurological sciences. vol 229-230. 2005-05-03. PMID:15760644. |
apolipoprotein e (apoe) 4 and aging are risk factors for alzheimer's disease (ad). |
2005-05-03 |
2023-08-12 |
mouse |
| Ofir Levi, Ana L Jongen-Relo, Joram Feldon, Daniel M Michaelso. Brain area- and isoform-specific inhibition of synaptic plasticity by apoE4. Journal of the neurological sciences. vol 229-230. 2005-05-03. PMID:15760646. |
the allele e4 of apolipoprotein e4 (apoe4), the most prevalent genetic risk factor of alzheimer's disease (ad), inhibits the improvements in learning and memory which result from exposure of apoe transgenic mice to environmental stimulation (es). |
2005-05-03 |
2023-08-12 |
mouse |
| San-Duo Jiang, Guo-Mei Tang, Ming-Yuan Zhang, Da-Ming Ren, Yi-Ping Qian, Ye Zhang, Si-Cui Lin, Fei Li, Dong-Xiang Wan. [Expression variation and mutation analysis of exon 9 and 10 in amyloid precursor protein gene in Alzheimer's disease]. Yi chuan = Hereditas. vol 25. issue 5. 2005-05-02. PMID:15639925. |
to explore the expression differences of exon 9 and 10 in amyloid precursor protein gene(app9 approximately 10) in alzheimer's disease,and detect the probable point mutation appeared in cdna fragment of app9 approximately 10 in the shanghai han people.semi-quantitative competitive rt-pcr technique was performed to detect the expression of app9 approximately 10 in peripheral lymphocyte, and the apolipoprotein e gene(apoe) and presenilin 1(ps1)gene were genotyped with pcr-rflp method. |
2005-05-02 |
2023-08-12 |
Not clear |
| Kristin K Nicodemus, Judith E Stenger, Donald E Schmechel, Kathleen A Welsh-Bohmer, Ann M Saunders, Allen D Roses, John R Gilbert, Jeffery M Vance, Jonathan L Haines, Margaret A Pericak-Vance, Eden R Marti. Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. Neurogenetics. vol 5. issue 4. 2005-04-29. PMID:15455263. |
comprehensive association analysis of apoe regulatory region polymorphisms in alzheimer disease. |
2005-04-29 |
2023-08-12 |
Not clear |
| Kristin K Nicodemus, Judith E Stenger, Donald E Schmechel, Kathleen A Welsh-Bohmer, Ann M Saunders, Allen D Roses, John R Gilbert, Jeffery M Vance, Jonathan L Haines, Margaret A Pericak-Vance, Eden R Marti. Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. Neurogenetics. vol 5. issue 4. 2005-04-29. PMID:15455263. |
several recent case-control studies have examined the association between single nucleotide polymorphisms (snps) in the promoter region of the apolipoprotein e gene (apoe) and risk of alzheimer disease (ad), with conflicting results. |
2005-04-29 |
2023-08-12 |
Not clear |
| Yi-Ju Li, Margaret A Pericak-Vance, Jonathan L Haines, Nailah Siddique, Diane McKenna-Yasek, Wu-Yen Hung, Peter Sapp, Coy I Allen, Wenjie Chen, Betsy Hosler, Ann M Saunders, Lisa M Dellefave, Robert H Brown, Teepu Siddiqu. Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis. Neurogenetics. vol 5. issue 4. 2005-04-29. PMID:15657798. |
apolipoprotein e (apoe) is a confirmed risk factor for alzheimer disease. |
2005-04-29 |
2023-08-12 |
Not clear |
| Tatjana Stojakovic, Hubert Scharnagl, Winfried Mär. ApoE: crossroads between Alzheimer's disease and atherosclerosis. Seminars in vascular medicine. vol 4. issue 3. 2005-04-28. PMID:15630629. |
apoe: crossroads between alzheimer's disease and atherosclerosis. |
2005-04-28 |
2023-08-12 |
Not clear |
| Tatjana Stojakovic, Hubert Scharnagl, Winfried Mär. ApoE: crossroads between Alzheimer's disease and atherosclerosis. Seminars in vascular medicine. vol 4. issue 3. 2005-04-28. PMID:15630629. |
the genetic polymorphism of apoe is among the strongest determinants of the risk and mean age of onset of alzheimer's disease. |
2005-04-28 |
2023-08-12 |
Not clear |
| Jae Hee Kang, Giancarlo Logroscino, Immaculata De Vivo, David Hunter, Francine Grodstei. Apolipoprotein E, cardiovascular disease and cognitive function in aging women. Neurobiology of aging. vol 26. issue 4. 2005-04-25. PMID:15653176. |
the apolipoprotein e (apoe) e4 allele increases risk of alzheimer disease and cardiovascular diseases. |
2005-04-25 |
2023-08-12 |
human |
| Virginia M Rosen, Trey Sunderland, James Levy, Angela Harwell, Lori McGee, Christopher Hammond, Deepa Bhupali, Karen Putnam, Judy Bergeson, Charlene Lefkowit. Apolipoprotein E and category fluency: evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease. Neuropsychologia. vol 43. issue 4. 2005-04-12. PMID:15716154. |
two groups of non-demented individuals, who differed on genetic risk for alzheimer's disease (ad) based on their apolipoprotein e (apoe) genotype, were tested on a category fluency task. |
2005-04-12 |
2023-08-12 |
Not clear |
| D Bunce, L Fratiglioni, B J Small, B Winblad, L Bäckma. APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging. Neurology. vol 63. issue 5. 2005-04-08. PMID:15365129. |
apoe and cognitive decline in preclinical alzheimer disease and non-demented aging. |
2005-04-08 |
2023-08-12 |
Not clear |
| D Bunce, L Fratiglioni, B J Small, B Winblad, L Bäckma. APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging. Neurology. vol 63. issue 5. 2005-04-08. PMID:15365129. |
to investigate whether presence of the apoe epsilon4 allele is related to the pathologic progression of preclinical alzheimer disease (ad), as reflected by change in mini-mental state examination (mmse) scores among persons in the preclinical phase of ad, and cognitively intact adults confirmed as dementia-free during the 6-year assessment period. |
2005-04-08 |
2023-08-12 |
Not clear |