| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A G Yip, A C McKee, R C Green, J Wells, H Young, L A Cupples, L A Farre. APOE, vascular pathology, and the AD brain. Neurology. vol 65. issue 2. 2006-01-04. PMID:16043796. |
to use neuropathologic data to examine the association between apoe genotype and cerebrovascular lesions commonly found in alzheimer disease (ad), as well as neuritic senile plaque (sp) and neurofibrillary tangle (nft) burden. |
2006-01-04 |
2023-08-12 |
Not clear |
| Nancy C Stratman, Christine K Castle, Bruce M Taylor, Dennis E Epps, George W Melchior, Donald B Carte. Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide. Chemistry and physics of lipids. vol 137. issue 1-2. 2005-12-07. PMID:16140289. |
brain plaque deposits of amyloid-beta peptide (abeta) is a pathological hallmark of alzheimer's disease (ad) and apolipoprotein e (apoe) is thought to be involved in its deposition. |
2005-12-07 |
2023-08-12 |
human |
| A Bizzarro, C Marra, A Acciarri, A Valenza, F D Tiziano, C Brahe, C Masull. Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 20. issue 4. 2005-12-01. PMID:16103669. |
the existence of an association between apolipoprotein e (apoe) and alzheimer's disease (ad) has been reported in several studies. |
2005-12-01 |
2023-08-12 |
Not clear |
| Jennifer D Klages, John D Fisk, Kenneth Rockwoo. APOE genotype, vascular risk factors, memory test performance and the five-year risk of vascular cognitive impairment or Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 20. issue 5. 2005-12-01. PMID:16166776. |
apoe genotype, vascular risk factors, memory test performance and the five-year risk of vascular cognitive impairment or alzheimer's disease. |
2005-12-01 |
2023-08-12 |
Not clear |
| Jennifer D Klages, John D Fisk, Kenneth Rockwoo. APOE genotype, vascular risk factors, memory test performance and the five-year risk of vascular cognitive impairment or Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 20. issue 5. 2005-12-01. PMID:16166776. |
we examined the multivariate effects of apoe genotype, memory test performance and vascular risk factors in predicting incident alzheimer's disease (ad) and vascular cognitive impairment (vci) in the canadian study of health and aging. |
2005-12-01 |
2023-08-12 |
Not clear |
| E Hone, I J Martins, M Jeoung, T H Ji, S E Gandy, R N Martin. Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding. Journal of Alzheimer's disease : JAD. vol 7. issue 4. 2005-11-10. PMID:16131732. |
this also suggests that abeta may also compromise apoe function in the alzheimer disease affected brain. |
2005-11-10 |
2023-08-12 |
Not clear |
| Anna Juhász, András Palotás, Zoltán Janka, Agnes Rimanóczy, Miklós Palotás, Nikoletta Bódi, Krisztina Boda, Marianna Zana, Gábor Vincze, János Kálmá. ApoE -491A/T promoter polymorphism is not an independent risk factor, but associated with the epsilon4 allele in Hungarian Alzheimer's dementia population. Neurochemical research. vol 30. issue 5. 2005-10-31. PMID:16176061. |
apoe -491a/t promoter polymorphism is not an independent risk factor, but associated with the epsilon4 allele in hungarian alzheimer's dementia population. |
2005-10-31 |
2023-08-12 |
Not clear |
| Trey Sunderland, Raquel E Gur, Steven E Arnol. The use of biomarkers in the elderly: current and future challenges. Biological psychiatry. vol 58. issue 4. 2005-10-27. PMID:16018985. |
potential biomarkers with pathophysiologic significance have been studied in the field of alzheimer disease research with some success, especially in the area of genetic markers (apolipoprotein e [apoe] epsilon4 allele), neuroimaging, and cerebrospinal fluid markers (beta-amyloid and tau). |
2005-10-27 |
2023-08-12 |
Not clear |
| C E Shepherd, G C Gregory, J C Vickers, G M Hallida. Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease. Neuropathology and applied neurobiology. vol 31. issue 5. 2005-10-27. PMID:16150121. |
these 'inflammatory plaques' consisted of a dense cresyl violet-, silver-, and thioflavin s-positive, but abeta-, tau-, apolipoprotein e (apoe)-, non-abeta component of alzheimer's disease amyloid (nac)- and ps-1-negative core. |
2005-10-27 |
2023-08-12 |
Not clear |
| G Malek, L V Johnson, B E Mace, P Saloupis, D E Schmechel, D W Rickman, C A Toth, P M Sullivan, C Bowes Rickma. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 33. 2005-10-25. PMID:16079201. |
our findings in this model implicate the human apoe e4 allele as a susceptibility gene for amd and support the hypothesis that common pathogenic mechanisms may underlie amd and alzheimer's disease. |
2005-10-25 |
2023-08-12 |
mouse |
| Jin Li, Wei-hong Kuang, Jing Li, Xue Wang, Ming-sheng Huang, Ding-ping W. [Study of relationship between ApoE epsilon4 allele and hippocampal atrophy in Alzheimer disease]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 36. issue 1. 2005-10-18. PMID:15702779. |
[study of relationship between apoe epsilon4 allele and hippocampal atrophy in alzheimer disease]. |
2005-10-18 |
2023-08-12 |
Not clear |
| Lei Cai, Guomei Tang, Lishan Chen, Bosheng Zhang, Sanduo Jiang, Daming Re. Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients. Neuroreport. vol 16. issue 9. 2005-09-30. PMID:15931081. |
we investigated insertion (ins)/deletion(del) polymorphism in alpha-2-macroglobulin (a2m), g/c variant in the beta-site amyloid precursor protein-cleaving enzyme 1 (bace1) and apolipoprotein e (apoe) gene epsilon2/epsilon3/epsilon4 polymorphism in 387 chinese han ethnic patients with alzheimer's disease and healthy study participants. |
2005-09-30 |
2023-08-12 |
human |
| María C Ramos, Salomón Matías, María J Artiga, Julio Pozueta, Isabel Sastre, Fernando Valdivieso, María J Bullid. Neuronal specific regulatory elements in apolipoprotein E gene proximal promoter. Neuroreport. vol 16. issue 9. 2005-09-30. PMID:15931082. |
systemic and local changes in apolipoprotein e (apoe) quantity have been related with alzheimer's and other neurodegenerative diseases, showing the relevance of maintaining physiological apoe levels. |
2005-09-30 |
2023-08-12 |
human |
| Hervé C Gérard, Kristin L Wildt, Judith A Whittum-Hudson, Zongshan Lai, Joel Ager, Alan P Hudso. The load of Chlamydia pneumoniae in the Alzheimer's brain varies with APOE genotype. Microbial pathogenesis. vol 39. issue 1-2. 2005-09-29. PMID:15998578. |
the load of chlamydia pneumoniae in the alzheimer's brain varies with apoe genotype. |
2005-09-29 |
2023-08-12 |
Not clear |
| A Drzezga, M Riemenschneider, B Strassner, T Grimmer, M Peller, A Knoll, S Wagenpfeil, S Minoshima, M Schwaiger, A Kur. Cerebral glucose metabolism in patients with AD and different APOE genotypes. Neurology. vol 64. issue 1. 2005-09-27. PMID:15642911. |
to examine the influence of the apoe epsilon4 allele on cerebral glucose metabolism in a large series of patients with alzheimer disease (ad). |
2005-09-27 |
2023-08-12 |
Not clear |
| Sabine Wellnitz, Arno Friedlein, Corinne Bonanni, Vivianne Anquez, Fabienne Goepfert, Hansruedi Loetscher, Celine Adessi, Christian Czec. A 13 kDa carboxy-terminal fragment of ApoE stabilizes Abeta hexamers. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:16011742. |
the pathological role of apoe4 in alzheimer's disease (ad) is not fully elucidated yet but there is strong evidence that apoe is involved in abeta deposition, which is an early hallmark of ad neuropathology. |
2005-09-22 |
2023-08-12 |
Not clear |
| D W Tsuang, R K Wilson, O L Lopez, E K Luedecking-Zimmer, J B Leverenz, S T DeKosky, M I Kamboh, R L Hamilto. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology. vol 64. issue 3. 2005-09-19. PMID:15699383. |
genetic association between the apoe*4 allele and lewy bodies in alzheimer disease. |
2005-09-19 |
2023-08-12 |
Not clear |
| D W Tsuang, R K Wilson, O L Lopez, E K Luedecking-Zimmer, J B Leverenz, S T DeKosky, M I Kamboh, R L Hamilto. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology. vol 64. issue 3. 2005-09-19. PMID:15699383. |
to explore the association between apoe*4 and pathologically confirmed cases of the lewy body (lb) variant of alzheimer disease (ad). |
2005-09-19 |
2023-08-12 |
Not clear |
| Donald J Lehmann, Mario Cortina-Borja, Donald R Warden, A David Smith, Kristel Sleegers, Jonathan A Prince, Cornelia M van Duijn, Patrick G Keho. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. American journal of epidemiology. vol 162. issue 4. 2005-08-30. PMID:16033878. |
apolipoprotein e epsilon4 (apoe*4) is the only fully established susceptibility allele for alzheimer's disease. |
2005-08-30 |
2023-08-12 |
Not clear |
| H Asita de Silva, Saman B Gunatilake, Carole Johnston, Donald Warden, A David Smit. Medial temporal lobe atrophy, apolipoprotein genotype, and plasma homocysteine in Sri Lankan patients with Alzheimer's disease. Experimental aging research. vol 31. issue 3. 2005-08-30. PMID:16036726. |
the authors studied the association of alzheimer's disease (ad) with total plasma homocysteine (thcy) and apolipoprotein e (apoe) genotype, and the usefulness of measuring medial temporal lobe thickness (mtl) thickness for the diagnosis of ad in sri lankan patients. |
2005-08-30 |
2023-08-12 |
human |