| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Mosconi, D Perani, S Sorbi, K Herholz, B Nacmias, V Holthoff, E Salmon, J-C Baron, M T R De Cristofaro, A Padovani, B Borroni, M Franceschi, L Bracco, A Pup. MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET. Neurology. vol 63. issue 12. 2005-08-15. PMID:15623696. |
to investigate whether the combination of fluoro-2-deoxy-d-glucose (fdg) pet measures with the apoe genotype would improve prediction of the conversion from mild cognitive impairment (mci) to alzheimer disease (ad). |
2005-08-15 |
2023-08-12 |
Not clear |
| R Pulido, A Jiménez-Escrig, L Orensanz, F Saura-Calixto, A Jiménez-Escri. Study of plasma antioxidant status in Alzheimer's disease. European journal of neurology. vol 12. issue 7. 2005-08-11. PMID:15958093. |
to examine the plasma antioxidant status of alzheimer's disease (ad) patients and to evaluate the influence of apolipoprotein e (apoe) genotype. |
2005-08-11 |
2023-08-12 |
human |
| Maura Poli, Luisa Benerini Gatta, Roberto Dominici, Carlo Lovati, Claudio Mariani, Alberto Albertini, Dario Finazz. Apolipoprotein E haplotyping by denaturing high-performance liquid chromatography. Clinical chemistry and laboratory medicine. vol 43. issue 5. 2005-08-08. PMID:15899673. |
numerous studies have shown an important association between the epsilon4 variant and an increased risk of alzheimer's disease; other data suggest a possible linkage of apoe genetic heterogeneity with lipid profile and an increased risk of atherothrombotic stroke and coronary heart disease. |
2005-08-08 |
2023-08-12 |
Not clear |
| Yansheng Du, Xianming Chen, Xing Wei, Kelly R Bales, David T Berg, Steven M Paul, Martin R Farlow, Bryan Maloney, Yuan-Wen Ge, Debomoy K Lahir. NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells. Brain research. Molecular brain research. vol 136. issue 1-2. 2005-08-02. PMID:15893602. |
the apolipoprotein e gene (apoe) plays an important role in the pathogenesis of alzheimer's disease (ad), and amyloid plaque comprised mostly of the amyloid-beta peptide (a(beta)) is one of the major hallmarks of ad. |
2005-08-02 |
2023-08-12 |
human |
| Eric M Reiman, Kewei Chen, Gene E Alexander, Richard J Caselli, Daniel Bandy, David Osborne, Ann M Saunders, John Hard. Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 23. 2005-07-27. PMID:15932949. |
we previously found that cognitively normal late-middle-aged apoe epsilon4 carriers have abnormally low cmrgl in the same brain regions as patients with probable alzheimer's dementia. |
2005-07-27 |
2023-08-12 |
human |
| Simona Vuletic, Elaine R Peskind, Santica M Marcovina, Joseph F Quinn, Marian C Cheung, Hal Kennedy, Jeffrey A Kaye, Lee-Way Jin, John J Alber. Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15795933. |
reduced csf pltp activity in alzheimer's disease and other neurologic diseases; pltp induces apoe secretion in primary human astrocytes in vitro. |
2005-07-26 |
2023-08-12 |
human |
| Simona Vuletic, Elaine R Peskind, Santica M Marcovina, Joseph F Quinn, Marian C Cheung, Hal Kennedy, Jeffrey A Kaye, Lee-Way Jin, John J Alber. Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15795933. |
the aims of this study were to test the hypothesis that patients with alzheimer's disease (ad) have altered pltp-mediated phospholipid transfer activity in csf, and to examine the potential relationship between pltp activity and apolipoprotein e (apoe) levels in csf. |
2005-07-26 |
2023-08-12 |
human |
| Mark Raftery, Ross Campbell, Elias N Glaros, Kerry-Anne Rye, Glenda M Halliday, Wendy Jessup, Brett Garne. Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD/E site in vitro. Biochemistry. vol 44. issue 19. 2005-07-26. PMID:15882073. |
apoe is also associated with insoluble amyloid detected in alzheimer disease brain lesions. |
2005-07-26 |
2023-08-12 |
human |
| Celina V Zerbinatti, Guojun B. LRP and Alzheimer's disease. Reviews in the neurosciences. vol 16. issue 2. 2005-07-25. PMID:15959937. |
apoe is the major cholesterol transporter in the brain and human carriers of one or two copies of the e4 allele of apoe are at a higher risk of developing alzheimer's disease (ad). |
2005-07-25 |
2023-08-12 |
mouse |
| Nai-Wen Chang, Dar-Ren Chen, Chen-Ten Wu, Bradley E Aouizerat, Fei-Na Chen, Shin-Jer Hung, Shiuan-Huei Wang, Ming-Feng Wei, Cheng-Shyong Chan. Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. Breast cancer research and treatment. vol 90. issue 3. 2005-07-20. PMID:15830139. |
preliminary evidence suggests that apoe genotype appears to be a risk factor for not only cardiovascular disease, but also alzheimer's disease and cancer. |
2005-07-20 |
2023-08-12 |
Not clear |
| Yan Sun, Jiajun Shi, Sizhong Zhang, Mouni Tang, Haiying Han, Yangbo Guo, Cui Ma, Xiehe Liu, Tao L. The APOC3 SstI polymorphism is weakly associated with sporadic Alzheimer's disease in a Chinese population. Neuroscience letters. vol 380. issue 3. 2005-07-20. PMID:15862889. |
in order to clarify the relationship of apolipoprotein ciii (apoc3) polymorphism and sporadic alzheimer's disease (ad) in chinese, 165 sporadic ad patients and 174 age-matched elderly individuals were genotyped for the apoc3 ssti and apolipoprotein e (apoe) hhai polymorphisms. |
2005-07-20 |
2023-08-12 |
Not clear |
| J-C Lambert, D Mann, F Richard, J Tian, J Shi, U Thaker, S Merrot, J Harris, B Frigard, T Iwatsubo, C Lendon, P Amouye. Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease? Journal of neurology, neurosurgery, and psychiatry. vol 76. issue 7. 2005-07-19. PMID:15965197. |
is there a relation between apoe expression and brain amyloid load in alzheimer's disease? |
2005-07-19 |
2023-08-12 |
Not clear |
| J-C Lambert, D Mann, F Richard, J Tian, J Shi, U Thaker, S Merrot, J Harris, B Frigard, T Iwatsubo, C Lendon, P Amouye. Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease? Journal of neurology, neurosurgery, and psychiatry. vol 76. issue 7. 2005-07-19. PMID:15965197. |
it has been proposed that, independent of the epsilon4 allele, apoe promoter polymorphisms (-491 a/t and -219 g/t) may be risks factor for alzheimer's disease by modulating apoe expression. |
2005-07-19 |
2023-08-12 |
Not clear |
| Jeannette Grootendorst, Alexandra Bour, Elise Vogel, Christian Kelche, Patrick M Sullivan, Jean-Cosme Dodart, Kelly Bales, Chantal Mathi. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behavioural brain research. vol 159. issue 1. 2005-07-12. PMID:15794991. |
apolipoprotein e4 (apoe4), one of the three most common human apoe (h-apoe) isoforms, is a major genetic risk factor for alzheimer's disease and for cognitive deficits associated with aging. |
2005-07-12 |
2023-08-12 |
mouse |
| Masayuki Morikawa, John D Fryer, Patrick M Sullivan, Erin A Christopher, Suzanne E Wahrle, Ronald B DeMattos, Mark A O'Dell, Anne M Fagan, Hilal A Lashuel, Thomas Walz, Kiyofumi Asai, David M Holtzma. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiology of disease. vol 19. issue 1-2. 2005-07-12. PMID:15837562. |
the apolipoprotein e (apoe) genotype is an important genetic risk factor for alzheimer's disease (ad). |
2005-07-12 |
2023-08-12 |
mouse |
| Adam Fleisher, Michael Grundman, Clifford R Jack, Ronald C Petersen, Curtis Taylor, Hyun T Kim, Denise H B Schiller, Victor Bagwell, Drahomira Sencakova, Myron F Weiner, Charles DeCarli, Steven T DeKosky, Christopher H van Dyck, Leon J Tha. Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment. Archives of neurology. vol 62. issue 6. 2005-06-30. PMID:15956166. |
the presence of the apolipoprotein e epsilon4 (apoe*e4) allele has been associated with greater hippocampal atrophy in women than in men with alzheimer disease. |
2005-06-30 |
2023-08-12 |
human |
| P N Wang, H C Liu, T Y Liu, A Chu, C J Hong, K N Lin, C W Ch. Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease. Dementia and geriatric cognitive disorders. vol 19. issue 2-3. 2005-06-24. PMID:15591802. |
estrogen-metabolizing gene comt polymorphism synergistic apoe epsilon4 allele increases the risk of alzheimer disease. |
2005-06-24 |
2023-08-12 |
human |
| Pieter Jelle Visser, Philip Scheltens, Esther Pelgrim, Frans R J Verhe. Medial temporal lobe atrophy and APOE genotype do not predict cognitive improvement upon treatment with rivastigmine in Alzheimer's disease patients. Dementia and geriatric cognitive disorders. vol 19. issue 2-3. 2005-06-24. PMID:15627759. |
medial temporal lobe atrophy and apoe genotype do not predict cognitive improvement upon treatment with rivastigmine in alzheimer's disease patients. |
2005-06-24 |
2023-08-12 |
human |
| A E Ashley-Koch, Y Shao, J B Rimmler, P C Gaskell, K A Welsh-Bohmer, C E Jackson, W K Scott, J L Haines, M A Pericak-Vanc. An autosomal genomic screen for dementia in an extended Amish family. Neuroscience letters. vol 379. issue 3. 2005-06-24. PMID:15843063. |
apolipoprotein e (apoe) is the only universally confirmed susceptibility gene for late-onset alzheimer disease (load), although many loci are believed to modulate load risk. |
2005-06-24 |
2023-08-12 |
Not clear |
| S I Gavrilova, I V Kolykhalov, G I Korovaĭtseva, G A Zharikov, Ia B Kalyn, N D Seleznev. [ApoE genotype and efficacy of neurotrophic and cholinergic therapy in Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 105. issue 4. 2005-06-09. PMID:15880838. |
[apoe genotype and efficacy of neurotrophic and cholinergic therapy in alzheimer's disease]. |
2005-06-09 |
2023-08-12 |
Not clear |