| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iwo J Boh. Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease? Lipids in health and disease. vol 4. 2006-05-25. PMID:15949039. |
the relationship between alzheimer's disease (ad) and progressive degeneration of the forebrain cholinergic system is very well established, whereas mechanisms linking this disease with cholesterol, apolipoprotein e (apoe) phenotype, and amyloid precursor protein (app) metabolism have not been fully elucidated even though there is a plethora of publications separately on each of these issues. |
2006-05-25 |
2023-08-12 |
Not clear |
| Derek Gordon, Yaning Yang, Chad Haynes, Stephen J Finch, Nancy R Mendell, Abraham M Brown, Vahram Haroutunia. Increasing power for tests of genetic association in the presence of phenotype and/or genotype error by use of double-sampling. Statistical applications in genetics and molecular biology. vol 3. 2006-05-18. PMID:16646805. |
we also consider case/control apoe genotype data for an actual alzheimer's study. |
2006-05-18 |
2023-08-12 |
Not clear |
| Dong Young Lee, Jong Choul Youn, Il Han Choo, Ki Woong Kim, Jin Hyeong Jhoo, Yong Su Pak, Kwon Woo Suh, Jong Inn Wo. Combination of clinical and neuropsychologic information as a better predictor of the progression to Alzheimer disease in questionable dementia individuals. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 14. issue 2. 2006-05-11. PMID:16473977. |
this study aimed to examine the clinical outcomes of questionable dementia (qd) elderly subjects after three years of follow-up and to compare the ability of a standardized clinical assessment, neuropsychologic tests, the apoe genotyping, and possible combinations of these methods to predict their progression to alzheimer disease (ad). |
2006-05-11 |
2023-08-12 |
human |
| Valentina Fernández Del Pozo, Maite Alvarez Alvarez, Manuel Fernández Martínez, Luis Galdós Alcelay, Fernando Gómez Busto, Jose A Peña, Miguel A Alfonso-Sánchez, Juan José Zarranz Imirizaldu, Marian M de Pancorb. Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 21. issue 2. 2006-05-09. PMID:16340204. |
late-onset alzheimer's disease (load) is associated with changes in certain proteins, such as apoe and cyp46a1, of the elimination route for cerebral cholesterol. |
2006-05-09 |
2023-08-12 |
Not clear |
| R Monastero, E Mariani, C Camarda, T Ingegni, M R Averna, U Senin, R Camarda, P Mecocc. Association between apolipoprotein E epsilon4 allele and apathy in probable Alzheimer's disease. Acta psychiatrica Scandinavica. vol 113. issue 1. 2006-05-09. PMID:16390371. |
there have been inconclusive results to date on the association between the apolipoprotein e (apoe) genotype and neuropsychiatric symptoms (nps) in alzheimer's disease (ad). |
2006-05-09 |
2023-08-12 |
Not clear |
| G Spalletta, S Bernardini, L Bellincampi, G Federici, A Trequattrini, C Caltagiron. Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset. European journal of neurology. vol 13. issue 2. 2006-05-09. PMID:16490049. |
delusion symptoms are associated with apoe epsilon4 allelic variant at the early stage of alzheimer's disease with late onset. |
2006-05-09 |
2023-08-12 |
Not clear |
| Johanna Lind, Anne Larsson, Jonas Persson, Martin Ingvar, Lars-Göran Nilsson, Lars Bäckman, Rolf Adolfsson, Marc Cruts, Kristel Sleegers, Christine Van Broeckhoven, Lars Nyber. Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory. Neuroscience letters. vol 396. issue 1. 2006-04-28. PMID:16406347. |
apolipoprotein e epsilon4 (apoe epsilon4) is the main known genetic risk factor for alzheimer's disease (ad). |
2006-04-28 |
2023-08-12 |
Not clear |
| G A Rippon, M X Tang, J H Lee, R Lantigua, M Medrano, R Mayeu. Familial Alzheimer disease in Latinos: interaction between APOE, stroke, and estrogen replacement. Neurology. vol 66. issue 1. 2006-04-20. PMID:16401842. |
familial alzheimer disease in latinos: interaction between apoe, stroke, and estrogen replacement. |
2006-04-20 |
2023-08-12 |
Not clear |
| M Kaur, P P Balgi. APOE2 and consanguinity: a risky combination for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 8. issue 3. 2006-04-14. PMID:16340087. |
to investigate the association between apoe genotypes and alzheimer's disease (ad) in elderly indian subjects. |
2006-04-14 |
2023-08-12 |
human |
| Richard Camicioli, Richard Krysci. Nature throws curveballs: APOE and nonlinear decline in Alzheimer disease. Neurology. vol 65. issue 12. 2006-04-14. PMID:16380605. |
nature throws curveballs: apoe and nonlinear decline in alzheimer disease. |
2006-04-14 |
2023-08-12 |
Not clear |
| C A R Martins, A Oulhaj, C A de Jager, J H William. APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model. Neurology. vol 65. issue 12. 2006-04-14. PMID:16380608. |
apoe alleles predict the rate of cognitive decline in alzheimer disease: a nonlinear model. |
2006-04-14 |
2023-08-12 |
Not clear |
| C A R Martins, A Oulhaj, C A de Jager, J H William. APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model. Neurology. vol 65. issue 12. 2006-04-14. PMID:16380608. |
the apoe genotype predicts the age at onset of alzheimer disease (ad) and neuropathologic progression. |
2006-04-14 |
2023-08-12 |
Not clear |
| T L Huang, P P Zandi, K L Tucker, A L Fitzpatrick, L H Kuller, L P Fried, G L Burke, M C Carlso. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology. vol 65. issue 9. 2006-04-12. PMID:16275829. |
to compare associations of lean fish vs fatty fish (tuna or other fish) intake with dementia, alzheimer disease (ad), and vascular dementia (vad) and in relation to apoe epsilon4 status in the cardiovascular health cognition study (chcs). |
2006-04-12 |
2023-08-12 |
Not clear |
| Elaine A Gay, Rebecca C Klein, Jerrel L Yake. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16249370. |
the most significant genetic risk factor for the development of alzheimer's disease is inheritance of the epsilon4 allele of apolipoprotein e (apoe). |
2006-04-04 |
2023-08-12 |
rat |
| Wes S Houston, Dean C Delis, Amy Lansing, Mark W Jacobson, Krystal R Cobell, David P Salmon, Mark W Bond. Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluency. Journal of the International Neuropsychological Society : JINS. vol 11. issue 7. 2006-03-29. PMID:16519265. |
recent studies have reported cognitive asymmetries in patients with alzheimer's disease (ad) and in individuals with apolipoprotein e epsilon4 (apoe epsilon4) genotype who are in the preclinical phase of ad. |
2006-03-29 |
2023-08-12 |
human |
| Oye Gureje, Adesola Ogunniyi, Olusegun Baiyewu, Brandon Price, Frederick W Unverzagt, Rebecca M Evans, Valerie Smith-Gamble, Kathleen A Lane, Sujuan Gao, Kathleen S Hall, Hugh C Hendrie, Jill R Murrel. APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians. Annals of neurology. vol 59. issue 1. 2006-03-23. PMID:16278853. |
apoe epsilon4 is not associated with alzheimer's disease in elderly nigerians. |
2006-03-23 |
2023-08-12 |
Not clear |
| Oye Gureje, Adesola Ogunniyi, Olusegun Baiyewu, Brandon Price, Frederick W Unverzagt, Rebecca M Evans, Valerie Smith-Gamble, Kathleen A Lane, Sujuan Gao, Kathleen S Hall, Hugh C Hendrie, Jill R Murrel. APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians. Annals of neurology. vol 59. issue 1. 2006-03-23. PMID:16278853. |
in contrast with other populations, the apoe epsilon4 allele was not significantly associated with alzheimer's disease or dementia. |
2006-03-23 |
2023-08-12 |
Not clear |
| Tuomo Polvikoski, Raimo Sulkava, Sari Rastas, Annamaija Sutela, Leena Niinistö, Irma-Leena Notkola, Auli Verkkoniemi, Petteri Viramo, Kati Juva, Matti Halti. Incidence of dementia in very elderly individuals: a clinical, neuropathological and molecular genetic study. Neuroepidemiology. vol 26. issue 2. 2006-03-21. PMID:16352910. |
to evaluate the effect of medical record use on figures for the incidence of dementia and the effect of apolipoprotein e (apoe) polymorphism on this incidence and neuropathologically defined alzheimer's disease (ad) in very elderly individuals. |
2006-03-21 |
2023-08-12 |
Not clear |
| Mehul A Trivedi, Taylor W Schmitz, Michele L Ries, Britta M Torgerson, Mark A Sager, Bruce P Hermann, Sanjay Asthana, Sterling C Johnso. Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study. BMC medicine. vol 4. 2006-03-15. PMID:16412236. |
the presence of the apolipoprotein e (apoe) epsilon4 allele is a major risk factor for the development of alzheimer's disease (ad), and has been associated with metabolic brain changes several years before the onset of typical ad symptoms. |
2006-03-15 |
2023-08-12 |
Not clear |
| K Hall, J Murrell, A Ogunniyi, M Deeg, O Baiyewu, S Gao, O Gureje, J Dickens, R Evans, V Smith-Gamble, F W Unverzagt, J Shen, H Hendri. Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology. vol 66. issue 2. 2006-03-14. PMID:16434658. |
cholesterol, apoe genotype, and alzheimer disease: an epidemiologic study of nigerian yoruba. |
2006-03-14 |
2023-08-12 |
Not clear |