| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Gao, Yan-Jun Lei, Jun Han, Qi Shi, Lan Chen, Yan Guo, Yong-Jun Gao, Jian-Ming Chen, Hui-Ying Jiang, Wei Zhou, Xiao-Ping Don. Recombinant neural protein PrP can bind with both recombinant and native apolipoprotein E in vitro. Acta biochimica et biophysica Sinica. vol 38. issue 9. 2006-12-12. PMID:16953297. |
apolipoprotein e (apoe) is an apolipoprotein which is considered to play an important role in the development of alzheimer's disease and other neurodegenerative diseases by forming protein complex through binding to the receptor located in the clathrin-coated pits of the cell surface. |
2006-12-12 |
2023-08-12 |
human |
| Lucia Olarte, Nicole Schupf, Joseph H Lee, Ming-Xin Tang, Vincent Santana, Jennifer Williamson, Prashanthi Maramreddy, Benjamin Tycko, Richard Mayeu. Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics. Archives of neurology. vol 63. issue 11. 2006-12-12. PMID:17101827. |
the primary effect of the apolipoprotein e epsilon4 (apoe epsilon4) allele is on the age at onset of alzheimer disease (ad). |
2006-12-12 |
2023-08-12 |
Not clear |
| Jin-Hu Guo, Hai-Peng Cheng, Long Yu, Shouyuan Zha. Natural antisense transcripts of Alzheimer's disease associated genes. DNA sequence : the journal of DNA sequencing and mapping. vol 17. issue 2. 2006-11-28. PMID:17076261. |
present work investigated the presence of nats of alzheimer's disease associated genes including presenilin1, presenilin2, bace1, bace2, app, apoe, tau (mapt), prion, alpha-synuclein (snca), nicastrin, pen2, aph1a, aph1b as well as cd147 (basigin), and the results revealed that app, bace2, aph1a, tau, cd147 and alpha-synuclein contain natural antisense transcripts. |
2006-11-28 |
2023-08-12 |
Not clear |
| H M Wen, L Baum, W S Cheung, V Mok, W W M Lam, B Tomlinson, K S Wong, H K N. Apolipoprotein E epsilon4 allele is associated with the volume of white matter changes in patients with lacunar infarcts. European journal of neurology. vol 13. issue 11. 2006-11-09. PMID:17038035. |
the relationship between the apolipoprotein e (apoe) exon 4 polymorphism and white matter changes (wmc) in elderly subjects or patients with alzheimer's disease is controversial. |
2006-11-09 |
2023-08-12 |
human |
| B Borroni, M Grassi, C Agosti, C Costanzi, S Archetti, S Franzoni, C Caltagirone, M Di Luca, L Caimi, A Padovan. Genetic correlates of behavioral endophenotypes in Alzheimer disease: role of COMT, 5-HTTLPR and APOE polymorphisms. Neurobiology of aging. vol 27. issue 11. 2006-10-26. PMID:16257094. |
genetic correlates of behavioral endophenotypes in alzheimer disease: role of comt, 5-httlpr and apoe polymorphisms. |
2006-10-26 |
2023-08-12 |
Not clear |
| Marcella Folin, Silvia Baiguera, Diego Guidolin, Rosa Di Liddo, Claudio Grandi, Eugenio De Carlo, Gastone G Nussdorfer, Pier Paolo Parnigott. Apolipoprotein-E modulates the cytotoxic effect of beta-amyloid on rat brain endothelium in an isoform-dependent specific manner. International journal of molecular medicine. vol 17. issue 5. 2006-10-24. PMID:16596266. |
collectively, our findings confirm the view that apoe plays a relevant role in the pathogenesis of alzheimer's disease. |
2006-10-24 |
2023-08-12 |
rat |
| Paul Hollingworth, Marian L Hamshere, Valentina Moskvina, Kimberley Dowzell, Pamela J Moore, Catherine Foy, Nicola Archer, Aoibhinn Lynch, Simon Lovestone, Carol Brayne, David C Rubinsztein, Brian Lawlor, Mike Gill, Michael J Owen, Julie William. Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease. Journal of the American Geriatrics Society. vol 54. issue 9. 2006-10-20. PMID:16970641. |
to investigate behavioral components of alzheimer's disease (ad) and to analyze behavioral components in relation to disease severity, apolipoprotein e genotype (apoe), sex, years of education, age at onset, and cognitive impairment. |
2006-10-20 |
2023-08-12 |
Not clear |
| Allen D Rose. On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease. Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914873. |
after sequencing this "impurity" band, several tryptic peptide sequences were found to be identical for apoe which, at that time, had no known association with alzheimer's disease. |
2006-10-19 |
2023-08-12 |
human |
| Barbara Borroni, Daniela Perani, Silvana Archetti, Chiara Agosti, Barbara Paghera, Giuseppe Bellelli, Monica Di Luca, Alessandro Padovan. Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration. BMC neurology. vol 6. 2006-10-12. PMID:16930470. |
apolipoprotein e (apoe) genotype, the major genetic risk factor in sporadic late-onset alzheimer disease (ad), modulates cerebral perfusion in late middle-age cognitively normal subjects. |
2006-10-12 |
2023-08-12 |
human |
| Chandra A Reynolds, Jonathan A Prince, Lars Feuk, Anthony J Brookes, Margaret Gatz, Nancy L Pederse. Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes. Behavior genetics. vol 36. issue 2. 2006-10-11. PMID:16402284. |
longitudinal memory performance during normal aging: twin association models of apoe and other alzheimer candidate genes. |
2006-10-11 |
2023-08-12 |
Not clear |
| Chandra A Reynolds, Jonathan A Prince, Lars Feuk, Anthony J Brookes, Margaret Gatz, Nancy L Pederse. Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes. Behavior genetics. vol 36. issue 2. 2006-10-11. PMID:16402284. |
the apoe gene (apolipoprotein e) is a major risk factor for alzheimer's disease (ad) but has been inconsistently associated with memory in nondemented adults. |
2006-10-11 |
2023-08-12 |
Not clear |
| Nikolaos Scarmeas, Yaakov Ster. Imaging studies and APOE genotype in persons at risk for Alzheimer's disease. Current psychiatry reports. vol 8. issue 1. 2006-10-11. PMID:16513038. |
imaging studies and apoe genotype in persons at risk for alzheimer's disease. |
2006-10-11 |
2023-08-12 |
human |
| M Michikaw. Role of cholesterol in amyloid cascade: cholesterol-dependent modulation of tau phosphorylation and mitochondrial function. Acta neurologica Scandinavica. Supplementum. vol 185. 2006-10-02. PMID:16866907. |
apolipoprotein e (apoe) alleles are important genetic risk factors for alzheimer's disease (ad), with the epsilon4 allele increasing and the epsilon2 allele decreasing the risk of developing ad. |
2006-10-02 |
2023-08-12 |
Not clear |
| Gillian Hamilton, Farzana Samedi, Jo Knight, Nicola Archer, Catherine Foy, Sarah Walter, Dragana Turic, Luke Jehu, Pamela Moore, Paul Hollingworth, Michael C O'Donovan, Julie Williams, Michael J Owen, Simon Lovestone, John F Powel. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16574322. |
the varepsilon4 allele of the apoe locus is the only confirmed risk factor for late-onset alzheimer's disease (load). |
2006-09-28 |
2023-08-12 |
Not clear |
| Jonathan Halford, Gandis Mazeika, Susan Slifer, Marcy Speer, Ann M Saunders, Warren J Strittmatter, Joel C Morgenlande. APOE2 allele increased in tardive dyskinesia. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 4. 2006-09-26. PMID:16261623. |
apoe genotype-specific risks of both tardive dyskinesia and alzheimer's disease that vary across populations could be due to recruitment of patients or controls or could be due to modifying effects of differing genetic or environmental backgrounds. |
2006-09-26 |
2023-08-12 |
Not clear |
| Michael Basso, Joel Gelernter, John Yang, Martha G MacAvoy, Pradeep Varma, Richard A Bronen, Christopher H van Dyc. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease. Neurobiology of aging. vol 27. issue 10. 2006-09-18. PMID:16182410. |
although the apoe epsilon4 allele is well-established as the most important genetic risk factor for alzheimer's disease (ad), the effects of this allele on regional brain atrophy in ad patients remain controversial. |
2006-09-18 |
2023-08-12 |
human |
| Olivia J Handley, Catriona M Morrison, Christopher Miles, Antony J Baye. ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults. Neurobiology of aging. vol 27. issue 10. 2006-09-18. PMID:16202482. |
apoe gene and familial risk of alzheimer's disease as predictors of odour identification in older adults. |
2006-09-18 |
2023-08-12 |
human |
| Spencer R Wetter, Dean C Delis, Wes S Houston, Mark W Jacobson, Amy Lansing, Krystal Cobell, David P Salmon, Mark W Bond. Heterogeneity in verbal memory: a marker of preclinical Alzheimer's disease? Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. vol 13. issue 3-4. 2006-09-08. PMID:16887786. |
demonstrations of memory changes in those at risk for alzheimer's disease by the presence of the apoe e4 allele have been inconsistent to date. |
2006-09-08 |
2023-08-12 |
human |
| W M van der Flier, S N M Schoonenboom, Y A L Pijnenburg, N C Fox, P Schelten. The effect of APOE genotype on clinical phenotype in Alzheimer disease. Neurology. vol 67. issue 3. 2006-09-06. PMID:16894123. |
the effect of apoe genotype on clinical phenotype in alzheimer disease. |
2006-09-06 |
2023-08-12 |
Not clear |
| Ryozo Kuwano, Akinori Miyashita, Hiroyuki Arai, Takashi Asada, Masaki Imagawa, Mikio Shoji, Susumu Higuchi, Katsuya Urakami, Akiyoshi Kakita, Hitoshi Takahashi, Tamao Tsukie, Shinichi Toyabe, Kohei Akazawa, Ichiro Kanazawa, Yasuo Ihar. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Human molecular genetics. vol 15. issue 13. 2006-09-05. PMID:16740596. |
the apolipoprotein e (apoe) gene has been consistently shown to be a major genetic risk factor; however, all cases of alzheimer's disease (ad) cannot be attributed to the epsilon4 variant of apoe, because about half of ad patients have the apoe-epsilon3*3 genotype. |
2006-09-05 |
2023-08-12 |
human |