| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric M Reiman, Jennifer A Webster, Amanda J Myers, John Hardy, Travis Dunckley, Victoria L Zismann, Keta D Joshipura, John V Pearson, Diane Hu-Lince, Matthew J Huentelman, David W Craig, Keith D Coon, Winnie S Liang, RiLee H Herbert, Thomas Beach, Kristen C Rohrer, Alice S Zhao, Doris Leung, Leslie Bryden, Lauren Marlowe, Mona Kaleem, Diego Mastroeni, Andrew Grover, Christopher B Heward, Rivka Ravid, Joseph Rogers, Michael L Hutton, Stacey Melquist, Ron C Petersen, Gene E Alexander, Richard J Caselli, Walter Kukull, Andreas Papassotiropoulos, Dietrich A Stepha. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. vol 54. issue 5. 2007-07-31. PMID:17553421. |
gab2 alleles modify alzheimer's risk in apoe epsilon4 carriers. |
2007-07-31 |
2023-08-12 |
Not clear |
| Eric M Reiman, Jennifer A Webster, Amanda J Myers, John Hardy, Travis Dunckley, Victoria L Zismann, Keta D Joshipura, John V Pearson, Diane Hu-Lince, Matthew J Huentelman, David W Craig, Keith D Coon, Winnie S Liang, RiLee H Herbert, Thomas Beach, Kristen C Rohrer, Alice S Zhao, Doris Leung, Leslie Bryden, Lauren Marlowe, Mona Kaleem, Diego Mastroeni, Andrew Grover, Christopher B Heward, Rivka Ravid, Joseph Rogers, Michael L Hutton, Stacey Melquist, Ron C Petersen, Gene E Alexander, Richard J Caselli, Walter Kukull, Andreas Papassotiropoulos, Dietrich A Stepha. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. vol 54. issue 5. 2007-07-31. PMID:17553421. |
the apolipoprotein e (apoe) epsilon4 allele is the best established genetic risk factor for late-onset alzheimer's disease (load). |
2007-07-31 |
2023-08-12 |
Not clear |
| Eric M Reiman, Jennifer A Webster, Amanda J Myers, John Hardy, Travis Dunckley, Victoria L Zismann, Keta D Joshipura, John V Pearson, Diane Hu-Lince, Matthew J Huentelman, David W Craig, Keith D Coon, Winnie S Liang, RiLee H Herbert, Thomas Beach, Kristen C Rohrer, Alice S Zhao, Doris Leung, Leslie Bryden, Lauren Marlowe, Mona Kaleem, Diego Mastroeni, Andrew Grover, Christopher B Heward, Rivka Ravid, Joseph Rogers, Michael L Hutton, Stacey Melquist, Ron C Petersen, Gene E Alexander, Richard J Caselli, Walter Kukull, Andreas Papassotiropoulos, Dietrich A Stepha. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. vol 54. issue 5. 2007-07-31. PMID:17553421. |
our findings suggest that gab2 modifies load risk in apoe epsilon4 carriers and influences alzheimer's neuropathology. |
2007-07-31 |
2023-08-12 |
Not clear |
| Izumi Maezawa, Nobuyo Maeda, Thomas J Montine, Kathleen S Montin. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. Journal of neuroinflammation. vol 3. 2007-07-20. PMID:16603079. |
apoe isoform-specific modulation of several pathogenic processes, in addition to amyloid beta metabolism in alzheimer's disease, have been proposed: one of these is innate immune response by glia. |
2007-07-20 |
2023-08-12 |
mouse |
| Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah, Todd E Gold. Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Molecular neurodegeneration. vol 1. 2007-07-20. PMID:16930450. |
sorla has been shown to be down regulated in alzheimer's disease brains, interact with apoe, and modulate abeta production. |
2007-07-20 |
2023-08-12 |
Not clear |
| Hyung-Doo Park, Kyoung Un Park, Ki-Woong Kim, Junghan Song, Ho Eun Chang, Se Ran Heo, Hyun Jung Lee, Jin Q Ki. Real-time multiplex PCR assay for genotyping of three apolipoprotein E alleles and two choline acetyltransferase alleles with three hybridization probes. Clinical chemistry and laboratory medicine. vol 45. issue 3. 2007-07-19. PMID:17378730. |
apolipoprotein e (apoe) and choline acetyltransferase (chat) have been suggested as candidate genes for determining the risk of late-onset alzheimer's disease. |
2007-07-19 |
2023-08-12 |
Not clear |
| Philip Shaw, Jason P Lerch, Jens C Pruessner, Kristin N Taylor, A Blythe Rose, Deanna Greenstein, Liv Clasen, Alan Evans, Judith L Rapoport, Jay N Gied. Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. The Lancet. Neurology. vol 6. issue 6. 2007-07-17. PMID:17509484. |
alleles of the apolipoprotein e (apoe) gene modulate risk for alzheimer's disease, with carriers of the epsilon4 allele being at increased risk and carriers of the epsilon2 allele possibly at decreased risk compared with non-carriers. |
2007-07-17 |
2023-08-12 |
Not clear |
| Chen K Cha. The genetics of Alzheimer's disease. American journal of Alzheimer's disease and other dementias. vol 22. issue 1. 2007-07-16. PMID:17534000. |
the genetics of alzheimer's disease is produced by 3 essentially interactive gene groups: (1) app and presenilin 1 and 2; (2) apoe e2, e3, and e4; (3) genes on chromosomes 9, 10, 12, etc. |
2007-07-16 |
2023-08-12 |
Not clear |
| James M Hill, Partha S Bhattacharjee, Donna M Neuman. Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease. Experimental eye research. vol 84. issue 5. 2007-07-11. PMID:17007837. |
apolipoprotein e (apoe) alleles have been reported to affect the clinical outcome of numerous cardiovascular, neurodegenerative, and viral infectious diseases, including atherosclerosis, alzheimer's disease (ad), hepatitis c, and hiv. |
2007-07-11 |
2023-08-12 |
mouse |
| Chang-En Yu, Howard Seltman, Elaine R Peskind, Nichole Galloway, Peter X Zhou, Elisabeth Rosenthal, Ellen M Wijsman, Debby W Tsuang, Bernie Devlin, Gerard D Schellenber. Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. Genomics. vol 89. issue 6. 2007-07-11. PMID:17434289. |
comprehensive analysis of apoe and selected proximate markers for late-onset alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. |
2007-07-11 |
2023-08-12 |
Not clear |
| Chang-En Yu, Howard Seltman, Elaine R Peskind, Nichole Galloway, Peter X Zhou, Elisabeth Rosenthal, Ellen M Wijsman, Debby W Tsuang, Bernie Devlin, Gerard D Schellenber. Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. Genomics. vol 89. issue 6. 2007-07-11. PMID:17434289. |
the epsilon(4) allele of apoe confers a two- to fourfold increased risk for late-onset alzheimer's disease (load), but load pathology does not all fit neatly around apoe. |
2007-07-11 |
2023-08-12 |
Not clear |
| Arlene M Manelli, Lindsey C Bulfinch, Patrick M Sullivan, Mary Jo LaD. Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. Neurobiology of aging. vol 28. issue 8. 2007-07-10. PMID:16837105. |
autosomal dominant mutations that increase amyloid-beta(1-42) (abeta42) cause familial alzheimer's disease (ad), and the most common genetic risk factor for ad is the presence of the epsilon4 allele of apolipoprotein e (apoe). |
2007-07-10 |
2023-08-12 |
mouse |
| Caleb E Finch, Todd E Morga. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Current Alzheimer research. vol 4. issue 2. 2007-07-10. PMID:17430245. |
systemic inflammation, infection, apoe alleles, and alzheimer disease: a position paper. |
2007-07-10 |
2023-08-12 |
human |
| Madeleine Zetterberg, Gunnar Tasa, Mona Seibt Palmér, Erkki Juronen, Pait Teesalu, Kaj Blennow, Henrik Zetterber. Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma. American journal of ophthalmology. vol 143. issue 6. 2007-06-28. PMID:17524782. |
to investigate apolipoprotein e (apoe) polymorphisms, which are known to influence the risk of alzheimer disease (ad), in patients with primary open-angle glaucoma (poag). |
2007-06-28 |
2023-08-12 |
Not clear |
| Clare A Peters-Libeu, Yvonne Newhouse, Steven C Hall, H Ewa Witkowska, Karl H Weisgrabe. Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution. Journal of lipid research. vol 48. issue 5. 2007-06-22. PMID:17308333. |
polymorphisms of apoe are associated with cardiovascular disease and with a predisposition to alzheimer's disease and other forms of neurodegeneration. |
2007-06-22 |
2023-08-12 |
Not clear |
| Lingjun Zuo, Christopher H van Dyck, Xingguang Luo, Henry R Kranzler, Bao-zhu Yang, Joel Gelernte. Variation at APOE and STH loci and Alzheimer's disease. Behavioral and brain functions : BBF. vol 2. 2007-06-20. PMID:16603077. |
variation at apoe and sth loci and alzheimer's disease. |
2007-06-20 |
2023-08-12 |
Not clear |
| Lingjun Zuo, Christopher H van Dyck, Xingguang Luo, Henry R Kranzler, Bao-zhu Yang, Joel Gelernte. Variation at APOE and STH loci and Alzheimer's disease. Behavioral and brain functions : BBF. vol 2. 2007-06-20. PMID:16603077. |
the apolipoprotein e (apoe) and tau proteins play important roles in the pathological development of alzheimer's disease (ad). |
2007-06-20 |
2023-08-12 |
Not clear |
| Giuseppe Orsitto, Davide Seripa, Francesco Panza, Marilisa Franceschi, Leandro Cascavilla, Giuliana Placentino, Maria Giovanna Matera, Francesco Paris, Cristiano Capurso, Vincenzo Solfrizzi, Bruno Dallapiccola, Alberto Pilott. Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia. Dementia and geriatric cognitive disorders. vol 23. issue 5. 2007-06-20. PMID:17374951. |
polymorphism in the apolipoprotein e (apoe) gene is the major genetic risk factor associated with late-onset alzheimer's disease (ad). |
2007-06-20 |
2023-08-12 |
human |
| A P Grigorenko, E I Rogae. [Molecular basics of Alzheimer's disease]. Molekuliarnaia biologiia. vol 41. issue 2. 2007-06-19. PMID:17514900. |
first, genes with mutations causing alzheimer's disease (presenilin genes psi, ps2 and app) or bearing a risk factor polymorphism (apoe) for alzheimer's disease were described. |
2007-06-19 |
2023-08-12 |
Not clear |
| K A Jellinger, J Attem. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta neuropathologica. vol 113. issue 2. 2007-06-13. PMID:17089134. |
neurofibrillary tangle predominant dementia (nftpd) is a subset of late onset dementia, clinically different from traditional "plaque and tangle" alzheimer disease (ad): later onset, shorter duration, less severe cognitive impairment, and almost absence of apoe epsilon4. |
2007-06-13 |
2023-08-12 |
human |