| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roger Lane, Howard H Feldman, Joanne Meyer, Yunsheng He, Steven H Ferris, Agneta Nordberg, Taher Darreh-Shori, Hilkka Soininen, Tuula Pirttilä, Martin R Farlow, Nikolaos Sfikas, Clive Ballard, Nigel H Grei. Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease. Pharmacogenetics and genomics. vol 18. issue 4. 2008-05-01. PMID:18334913. |
to evaluate the synergistic effects of the apolipoprotein e (apoe) epsilon4 and butyrylcholinesterase k-variant (bche-k) alleles on progression to alzheimer's disease (ad) in individuals with mild cognitive impairment (mci). |
2008-05-01 |
2023-08-12 |
Not clear |
| Juan Manuel Villalpando-Berumen, Silvia Mejia-Arango, Carlos Alberto Aguilar-Salinas, Maria Luisa Ordonez-Sanchez, Luis Miguel Gutierrez-Robled. Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos. Journal of the American Geriatrics Society. vol 56. issue 4. 2008-04-24. PMID:18205760. |
to determine the relationship between apolipoprotein e (apoe) epsilon4 and alzheimer's disease (ad) in the mexican mestizo population, as well as its effects on the cognitive profile of ad and elderly mestizos without dementia. |
2008-04-24 |
2023-08-12 |
Not clear |
| Fanggeng Zou, Rangaraj K Gopalraj, Johann Lok, Haiyan Zhu, I-Fang Ling, James F Simpson, H Michael Tucker, Jeremiah F Kelly, Samuel G Younkin, Dennis W Dickson, Ronald C Petersen, Neill R Graff-Radford, David A Bennett, Julia E Crook, Steven G Younkin, Steven Estu. Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease. Human molecular genetics. vol 17. issue 7. 2008-04-17. PMID:18065781. |
since apoe allele status is the predominant alzheimer's disease (ad) genetic risk factor, functional single nucleotide polymorphisms (snps) in brain apoe receptors represent excellent candidates for association with ad. |
2008-04-17 |
2023-08-12 |
human |
| Lisa Mosconi, Susan De Santi, Miroslaw Brys, Wai H Tsui, Elizabeth Pirraglia, Lidia Glodzik-Sobanska, Kenneth E Rich, Remigius Switalski, Pankaj D Mehta, Domenico Pratico, Ray Zinkowski, Kay Blennow, Mony J de Leo. Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints. Biological psychiatry. vol 63. issue 6. 2008-04-14. PMID:17720148. |
we examined whether cerebral metabolic rates for glucose (cmrglc) on 2-[(18)f]fluoro-2-deoxy-d-glucose (fdg)-positron emission tomography (pet) and cerebrospinal fluid (csf) markers of alzheimer's disease (ad) are altered in cognitively normal apolipoprotein e (apoe) e4 carriers with subjective memory complaints (smc). |
2008-04-14 |
2023-08-12 |
Not clear |
| Ramón Cacabelo. Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease. Molecular diagnosis & therapy. vol 11. issue 6. 2008-04-14. PMID:18078356. |
mutations in genes directly associated with the amyloid cascade (app, psen1, psen2) are present in less than 5% of the alzheimer's disease population; however, the presence of the epsilon4 allele of the apolipoprotein e gene (apoe) represents a major risk factor for more than 40% of patients with dementia. |
2008-04-14 |
2023-08-12 |
human |
| Alexander M Kulminski, Svetlana V Ukraintseva, Konstantin G Arbeev, Kenneth G Manton, Junko Oshima, George M Martin, Dora Il'yasova, Anatoli I Yashi. Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men. Journal of the American Geriatrics Society. vol 56. issue 3. 2008-04-10. PMID:18179501. |
to reexamine a health-protective role of the common apolipoprotein e (apoe) polymorphism focusing on connections between the apoe epsilon2-containing genotypes and impairments in instrumental activities of daily living (iadls) in older (> or = 65) men and women and to examine how diagnosed coronary heart disease (chd), alzheimer's disease, colorectal cancer, macular degeneration, and atherosclerosis may mediate these connections. |
2008-04-10 |
2023-08-12 |
Not clear |
| Masao Kanek. [Genomic approaches to bone and joint diseases. New insights into molecular mechanisms underlying protective effects of vitamin K on bone health]. Clinical calcium. vol 18. issue 2. 2008-04-01. PMID:18245893. |
the impact of genotype of apoe, a major vitamin k transporter, on ostepporosis as well as alzheimer disease and atherosclerosis, raises a question whether vitamin k is involved in the pathogenesis of these diseases. |
2008-04-01 |
2023-08-12 |
Not clear |
| C Petit-Turcotte, N Aumont, J-F Blain, J Poirie. Apolipoprotein E receptors and amyloid expression are modulated in an apolipoprotein E-dependent fashion in response to hippocampal deafferentation in rodent. Neuroscience. vol 150. issue 1. 2008-03-28. PMID:17935896. |
this approach has been used successfully to contrast the profile of reactivity from various proteins associated with alzheimer's disease pathophysiology in wild-type and apolipoprotein e (apoe)-deficient (apoe ko) mice. |
2008-03-28 |
2023-08-12 |
mouse |
| Thomas Espeseth, Lars T Westlye, Anders M Fjell, Kristine B Walhovd, Helge Rootwelt, Ivar Reinvan. Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4. Neurobiology of aging. vol 29. issue 3. 2008-03-27. PMID:17161508. |
upon comparison of the epsilon 4-specific age-related thinning with previously published patterns of thinning in normal aging and alzheimer's disease (ad), we conclude that apoe epsilon 4 may function to accelerate thinning in areas found to decline in aging (medial prefrontal and pericentral cortex), but also to initiate thinning in areas associated with ad and amyloid-beta aggregation (occipitotemporal and basal temporal cortex). |
2008-03-27 |
2023-08-12 |
human |
| Suzanne E Wahrle, Hong Jiang, Maia Parsadanian, Jungsu Kim, Aimin Li, Amanda Knoten, Sanjay Jain, Veronica Hirsch-Reinshagen, Cheryl L Wellington, Kelly R Bales, Steven M Paul, David M Holtzma. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. The Journal of clinical investigation. vol 118. issue 2. 2008-03-27. PMID:18202749. |
apoe genotype is a major genetic risk factor for late-onset alzheimer disease (ad). |
2008-03-27 |
2023-08-12 |
mouse |
| Ji-Ping Qi, He Wu, Yi Yang, Dan-Dan Wang, Yan-Xi Chen, Yun-He Gu, Tao Li. Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198420. |
we investigated the expression and distribution of abeta1-40, beta1-42 and apoe in human hippocampus after cerebral ischemia in this study to determine the role of cerebral ischemia in alzheimer's disease. |
2008-03-25 |
2023-08-12 |
human |
| Yang Zeng, Fei Miao, Liang Li, De-Hua Sun, Xiang-Min X. A rapid and accurate DHPLC assay for determination of apolipoprotein E genotypes. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198422. |
the variants of apolipoprotein e (apoe) are closely related to hyperlipidemia iii, alzheimer's disease (ad), coronary artery disease (cad) and many other human lipid metabolism-related problems. |
2008-03-25 |
2023-08-12 |
human |
| Da-Wei Chen, Jing-Fang Yang, Zhe Tang, Xiu-Min Dong, Xiu-Li Feng, Shun Yu, Piu Cha. Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese. Brain research. vol 1187. 2008-03-17. PMID:18036514. |
cholesteryl ester transfer protein polymorphism d442g associated with a potential decreased risk for alzheimer's disease as a modifier for apoe epsilon4 in chinese. |
2008-03-17 |
2023-08-12 |
human |
| Yonghong Li, Andrew Grupe, Charles Rowland, Peter Holmans, Ricardo Segurado, Richard Abraham, Lesley Jones, Joseph Catanese, David Ross, Kevin Mayo, Maribel Martinez, Paul Hollingworth, Alison Goate, Nigel J Cairns, Brad A Racette, Joel S Perlmutter, Michael C O'Donovan, John C Morris, Carol Brayne, David C Rubinsztein, Simon Lovestone, Leon J Thal, Michael J Owen, Julie William. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human molecular genetics. vol 17. issue 5. 2008-03-14. PMID:18063669. |
in exploring a potential mechanism for the association, we observed that expression of nedd9 and apoe show a strong inverse correlation in the hippocampus of alzheimer's cases. |
2008-03-14 |
2023-08-12 |
Not clear |
| Gloria Lena Vega, Myron F Weine. Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: effects of gender, CYP46, and ApoE polymorphisms. Journal of molecular neuroscience : MN. vol 33. issue 1. 2008-03-04. PMID:17901546. |
plasma 24s hydroxycholesterol response to statins in alzheimer's disease patients: effects of gender, cyp46, and apoe polymorphisms. |
2008-03-04 |
2023-08-12 |
human |
| Yonghong Li, Andrew Grup. Genetics of late-onset Alzheimer's disease: progress and prospect. Pharmacogenomics. vol 8. issue 12. 2008-02-26. PMID:18086004. |
genetic susceptibility factors for late-onset alzheimer's disease remain largely elusive, with the exception of apolipoprotein e4 (apoe e4) as the only confirmed genetic risk factor. |
2008-02-26 |
2023-08-12 |
Not clear |
| Yonghong Li, Andrew Grup. Genetics of late-onset Alzheimer's disease: progress and prospect. Pharmacogenomics. vol 8. issue 12. 2008-02-26. PMID:18086004. |
if we assume that multiple weak factors, together with apoe e4, account for the genetic contribution to late-onset alzheimer's disease risk, it will require the concerted efforts of the greater alzheimer's genetics community to pool existing genetic resources and/or data to identify novel genetic risk factors that are genuine. |
2008-02-26 |
2023-08-12 |
Not clear |
| Laura Bracco, Carolina Piccini, Michela Baccini, Valentina Bessi, Federica Biancucci, Benedetta Nacmias, Silvia Bagnoli, Sandro Sorb. Pattern and progression of cognitive decline in Alzheimer's disease: role of premorbid intelligence and ApoE genotype. Dementia and geriatric cognitive disorders. vol 24. issue 6. 2008-02-25. PMID:18025782. |
pattern and progression of cognitive decline in alzheimer's disease: role of premorbid intelligence and apoe genotype. |
2008-02-25 |
2023-08-12 |
Not clear |
| Laura Bracco, Carolina Piccini, Michela Baccini, Valentina Bessi, Federica Biancucci, Benedetta Nacmias, Silvia Bagnoli, Sandro Sorb. Pattern and progression of cognitive decline in Alzheimer's disease: role of premorbid intelligence and ApoE genotype. Dementia and geriatric cognitive disorders. vol 24. issue 6. 2008-02-25. PMID:18025782. |
because of controversial results across studies, we evaluated the predictive value of premorbid intelligence and the apolipoprotein e (apoe) genotype on baseline and progression of cognitive performance in alzheimer's disease (ad). |
2008-02-25 |
2023-08-12 |
Not clear |
| J Shi, C B Zhao, T L Vollmer, T M Tyry, S M Kuniyosh. APOE epsilon 4 allele is associated with cognitive impairment in patients with multiple sclerosis. Neurology. vol 70. issue 3. 2008-02-14. PMID:17460153. |
the role of apolipoprotein e (apoe) polymorphism has been well recognized in other cognitive neurodegenerative disorders, such as alzheimer disease. |
2008-02-14 |
2023-08-12 |
Not clear |