| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolas Cherbuin, Kaarin J Anstey, Perminder S Sachdev, Jerome J Maller, Chantal Meslin, Holly A Mack, Wei Wen, Simon Eastea. Total and regional gray matter volume is not related to APOE*E4 status in a community sample of middle-aged individuals. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 63. issue 5. 2008-07-15. PMID:18511754. |
the apoe*e4 allele has been associated with greater gray matter atrophy and with alzheimer's disease. |
2008-07-15 |
2023-08-12 |
Not clear |
| Piotr Lewczuk, Johannes Kornhuber, Hugo Vanderstichele, Eugeen Vanmechelen, Hermann Esselmann, Mirko Bibl, Stefanie Wolf, Markus Otto, Udo Reulbach, Heike Kölsch, Frank Jessen, Johannes Schröder, Peter Schönknecht, Harald Hampel, Oliver Peters, Erik Weimer, Robert Perneczky, Holger Jahn, Christian Luckhaus, Ulrich Lamla, Tillmann Supprian, Juan Manuel Maler, Jens Wiltfan. Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study. Neurobiology of aging. vol 29. issue 6. 2008-06-20. PMID:17239996. |
concentration of biomarkers of alzheimer's disease in cerebrospinal fluid (csf) was measured with multiplexing technology (n=223), and compared to the results of elisa assays in patients with early dementias or mild cognitive impairment (mci) collected at 12 gerontopsychiatric university departments, and apoe genotyping was performed. |
2008-06-20 |
2023-08-12 |
human |
| Paul R Borghesani, L Clark Johnson, Amy L Shelton, Elaine R Peskind, Elizabeth H Aylward, Gerard D Schellenberg, Monique M Cherrie. Altered medial temporal lobe responses during visuospatial encoding in healthy APOE*4 carriers. Neurobiology of aging. vol 29. issue 7. 2008-06-20. PMID:17350142. |
the apolipoprotein varepsilon4 allele (apoe*4) is a major genetic risk factor for alzheimer's disease (ad) and has been associated with altered cortical activation as assessed by functional neuroimaging in cognitively normal younger and older carriers. |
2008-06-20 |
2023-08-12 |
human |
| Feng Xu, Michael P Vitek, Carol A Colton, Mary Lou Previti, Nastaran Gharkholonarehe, Judianne Davis, William E Van Nostran. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 20. 2008-06-19. PMID:18480287. |
human apolipoprotein (apoe) genotype influences the development of alzheimer's disease and cerebral amyloid angiopathy (caa). |
2008-06-19 |
2023-08-12 |
mouse |
| Claudia Giannattasio, Anna Poleggi, Maria Puopolo, Maurizio Pocchiari, Piero Antuono, Gloria Dal Forno, David R Wekstein, Maria G Matera, Davide Seripa, Adele Acciarri, Alessandra Bizzarro, Alessandra Lauria, Carlo Masull. Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. Dementia and geriatric cognitive disorders. vol 25. issue 4. 2008-06-17. PMID:18332630. |
survival in alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the prnp gene and no apoe epsilon 4 allele. |
2008-06-17 |
2023-08-12 |
Not clear |
| Claudia Giannattasio, Anna Poleggi, Maria Puopolo, Maurizio Pocchiari, Piero Antuono, Gloria Dal Forno, David R Wekstein, Maria G Matera, Davide Seripa, Adele Acciarri, Alessandra Bizzarro, Alessandra Lauria, Carlo Masull. Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. Dementia and geriatric cognitive disorders. vol 25. issue 4. 2008-06-17. PMID:18332630. |
we assessed the role of the apoe genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic alzheimer's disease patients. |
2008-06-17 |
2023-08-12 |
Not clear |
| Lilian Calderón-Garcidueñas, Anna C Solt, Carlos Henríquez-Roldán, Ricardo Torres-Jardón, Bryan Nuse, Lou Herritt, Rafael Villarreal-Calderón, Norma Osnaya, Ida Stone, Raquel García, Diane M Brooks, Angelica González-Maciel, Rafael Reynoso-Robles, Ricardo Delgado-Chávez, William Ree. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicologic pathology. vol 36. issue 2. 2008-06-17. PMID:18349428. |
exposure to air pollution should be considered a risk factor for alzheimer's and parkinson's diseases, and carriers of the apoe 4 allele could have a higher risk of developing alzheimer's disease if they reside in a polluted environment. |
2008-06-17 |
2023-08-12 |
human |
| Seong Hye Choi, Sang Yun Kim, Hae Ri Na, Byung-Kun Kim, Dong Won Yang, Jay C Kwon, Mee Young Par. Effect of ApoE genotype on response to donepezil in patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 25. issue 5. 2008-06-17. PMID:18401173. |
effect of apoe genotype on response to donepezil in patients with alzheimer's disease. |
2008-06-17 |
2023-08-12 |
Not clear |
| Seong Hye Choi, Sang Yun Kim, Hae Ri Na, Byung-Kun Kim, Dong Won Yang, Jay C Kwon, Mee Young Par. Effect of ApoE genotype on response to donepezil in patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 25. issue 5. 2008-06-17. PMID:18401173. |
the possible influence of apolipoprotein e (apoe) genotype on the response to acetylcholinesterase inhibitor therapy in patients with alzheimer's disease (ad) remains a matter of controversy. |
2008-06-17 |
2023-08-12 |
Not clear |
| Gilbert Gallardo, Oliver M Schlüter, Thomas C Südho. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nature neuroscience. vol 11. issue 3. 2008-06-16. PMID:18297066. |
our data reveal a molecular link between central pathogenic mechanisms implicated in parkinson's disease and alzheimer's disease and suggest that intracellular alpha-synuclein is pathogenic, at least in part, by activation of extracellular signaling pathways involving apoe. |
2008-06-16 |
2023-08-12 |
mouse |
| Michael Ewers, Zhenyu Zhong, Katharina Bürger, Anders Wallin, Kaj Blennow, Stefan J Teipel, Yong Shen, Harald Hampe. Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease. Brain : a journal of neurology. vol 131. issue Pt 5. 2008-06-16. PMID:18334538. |
the apolipoprotein (apoe) epsilon 4 allele is a major genetic risk factor of alzheimer's disease, and may affect the production of amyloid beta (a beta(1-42)). |
2008-06-16 |
2023-08-12 |
human |
| Michael Ewers, Zhenyu Zhong, Katharina Bürger, Anders Wallin, Kaj Blennow, Stefan J Teipel, Yong Shen, Harald Hampe. Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease. Brain : a journal of neurology. vol 131. issue Pt 5. 2008-06-16. PMID:18334538. |
here, we have examined an association between the apoe genotype and csf-levels of bace 1 activity in alzheimer's disease and mild cognitive impairment (mci). |
2008-06-16 |
2023-08-12 |
human |
| Cristiano Capurso, Vincenzo Solfrizzi, Alessia D'Introno, Anna M Colacicco, Sabrina A Capurso, Luigia Bifaro, Roberta Menga, Andrea Santamato, Davide Seripa, Alberto Pilotto, Antonio Capurso, Francesco Panz. Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms. Neuroscience letters. vol 432. issue 3. 2008-06-12. PMID:18248894. |
catalase (cat) -262 c/t promoter (rs1001179), cathepsin d (ctsd) exon 2 (rs17571), and apolipoprotein e (apoe) gene polymorphisms were studied in 242 patients with sporadic alzheimer's disease (ad) and 421 unrelated age-, sex-, and ethnically matched control subjects from apulia (southern italy). |
2008-06-12 |
2023-08-12 |
human |
| S Cosentino, N Scarmeas, E Helzner, M M Glymour, J Brandt, M Albert, D Blacker, Y Ster. APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology. vol 70. issue 19 Pt 2. 2008-06-06. PMID:18401023. |
apoe epsilon 4 allele predicts faster cognitive decline in mild alzheimer disease. |
2008-06-06 |
2023-08-12 |
Not clear |
| S Cosentino, N Scarmeas, E Helzner, M M Glymour, J Brandt, M Albert, D Blacker, Y Ster. APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology. vol 70. issue 19 Pt 2. 2008-06-06. PMID:18401023. |
to determine whether apoe epsilon 4 predicts rate of cognitive change in incident and prevalent alzheimer disease (ad). |
2008-06-06 |
2023-08-12 |
Not clear |
| Asad Vaisi-Raygani, Hadi Kharrazi, Zohreh Rahimi, Tayebeh Pourmotabbe. Frequencies of apolipoprotein E polymorphism in a healthy Kurdish population from Kermanshah, Iran. Human biology. vol 79. issue 5. 2008-06-05. PMID:18478972. |
the molecular polymorphism displayed by apolipoprotein e (apoe) has been listed as a risk factor for susceptibility to various disorders, such as those associated with lipid metabolism, arteriosclerosis, coronary artery disease (cad), and alzheimer disease. |
2008-06-05 |
2023-08-12 |
human |
| Asad Vaisi-Raygani, Hadi Kharrazi, Zohreh Rahimi, Tayebeh Pourmotabbe. Frequencies of apolipoprotein E polymorphism in a healthy Kurdish population from Kermanshah, Iran. Human biology. vol 79. issue 5. 2008-06-05. PMID:18478972. |
to evaluate the role of apoe genotypes as risk factors for alzheimer disease, cad, and atherosclerosis in the kurdish population of kermanshah, iran, we studied the frequencies of apoe alleles *2, *3, and *4 and genotypes in 914 healthy kurdish subjects (514 men and 400 women). |
2008-06-05 |
2023-08-12 |
human |
| Ryan J Haasl, M Reza Ahmadi, Sivan Vadakkadath Meethal, Carey E Gleason, Sterling C Johnson, Sanjay Asthana, Richard L Bowen, Craig S Atwoo. A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele. BMC medical genetics. vol 9. 2008-05-28. PMID:18439297. |
genetic and biochemical studies support the apolipoprotein e (apoe) epsilon4 allele as a major risk factor for late-onset alzheimer's disease (ad), though ~50% of ad patients do not carry the allele. |
2008-05-28 |
2023-08-12 |
Not clear |
| Valéria Santoro Bahia, Fernando Kok, Suely Nagahashi Marie, Sueli Oba Shinjo, Paulo Caramelli, Ricardo Nitrin. Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. Alzheimer disease and associated disorders. vol 22. issue 1. 2008-05-20. PMID:18317248. |
polymorphisms of apoe and lrp genes in brazilian individuals with alzheimer disease. |
2008-05-20 |
2023-08-12 |
human |
| Julien Chapuis, Didier Hannequin, Florence Pasquier, Peter Bentham, Alexis Brice, Isabelle Leber, Thierry Frebourg, Jean-François Deleuze, Emmanuelle Cousin, Uma Thaker, Philippe Amouyel, David Mann, Corinne Lendon, Dominique Campion, Jean-Charles Lamber. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiology of disease. vol 30. issue 1. 2008-05-19. PMID:18272374. |
the first genome-wide association in alzheimer's disease (ad) suggested that the gab2 gene rs2373115 polymorphism may be a strong risk factor in apoe varepsilon4-carriers. |
2008-05-19 |
2023-08-12 |
Not clear |