| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eloy Rodríguez-Rodríguez, Ignacio Mateo, Javier Llorca, Coro Sánchez-Quintana, Jon Infante, Inés García-Gorostiaga, Pascual Sánchez-Juan, José Berciano, Onofre Combarro. Association of genetic variants of ABCA1 with Alzheimer's disease risk. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17510946. |
to evaluate the relationship between abca1 genetic variants and alzheimer's disease (ad), independently or in concert with the apoe epsilon4 allele, we examined three abca1 polymorphisms located in the coding region (r219k, i883m, and r1587k) and two abca1 polymorphisms in the promoter region (c-14t and c-477t) in a group of 372 spanish ad patients and 440 controls. |
2007-12-06 |
2023-08-12 |
Not clear |
| Larry A Tupler, K Ranga R Krishnan, Daniel L Greenberg, Santica M Marcovina, Martha E Payne, James R MacFall, H Cecil Charles, P Murali Doraiswam. Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve. Neurobiology of aging. vol 28. issue 11. 2007-11-30. PMID:16916565. |
major predictors of alzheimer's disease (ad) include apolipoprotein e (apoe)-epsilon4, hippocampal atrophy on magnetic resonance imaging (mri), and memory dysfunction prior to diagnosis. |
2007-11-30 |
2023-08-12 |
human |
| Federico Licastro, Elisa Porcellini, Calogero Caruso, Domenico Lio, Elizabeth H Corde. Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation. Neurobiology of aging. vol 28. issue 11. 2007-11-30. PMID:16930778. |
genetic risk profiles for alzheimer's disease: integration of apoe genotype and variants that up-regulate inflammation. |
2007-11-30 |
2023-08-12 |
Not clear |
| Federico Licastro, Elisa Porcellini, Calogero Caruso, Domenico Lio, Elizabeth H Corde. Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation. Neurobiology of aging. vol 28. issue 11. 2007-11-30. PMID:16930778. |
a number of studies associate alzheimer's disease with apoe polymorphism and alleles which favor the increased expression of immunological mediators such as cytokines or acute phase proteins. |
2007-11-30 |
2023-08-12 |
Not clear |
| Cristina Osorio, Patrick M Sullivan, Dong Ning He, Brian E Mace, John F Ervin, Warren J Strittmatter, Oscar Alzat. Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice. Neurobiology of aging. vol 28. issue 12. 2007-11-20. PMID:17050040. |
human apoe targeted replacement (tr) mice have been used to elucidate the role of apoe4 in alzheimer's disease (ad), since these animals express the apoe4 gene without the classical pathological signatures of ad. |
2007-11-20 |
2023-08-12 |
mouse |
| Xueying Liang, Eden R Martin, Nathalie Schnetz-Boutaud, Jackie Bartlett, Brent Anderson, Stephan Züchner, Harry Gwirtsman, Don Schmechel, Regina Carney, John R Gilbert, Margaret A Pericak-Vance, Jonathan L Haine. Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease. Human mutation. vol 28. issue 11. 2007-11-13. PMID:17573676. |
with the exception of apoe (apoe), no universally accepted genetic association has been identified with late-onset alzheimer disease (ad). |
2007-11-13 |
2023-08-12 |
Not clear |
| Yonghong Zhang, Sheeja Vasudevan, Radiya Sojitrawala, Wentao Zhao, Chunxian Cui, Chao Xu, Daping Fan, Yvonne Newhouse, Reeny Balestra, W Gray Jerome, Karl Weisgraber, Qianqian Li, Jianjun Wan. A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry. vol 46. issue 37. 2007-11-06. PMID:17715945. |
recent evidence indicates that apoe is also critical in several other important biological processes, including alzheimer's disease, cognitive function, immunoregulation, cell signaling, and infectious diseases. |
2007-11-06 |
2023-08-12 |
human |
| Sebastiaan Engelborghs, Kristel Sleegers, Patrick Cras, Nathalie Brouwers, Sally Serneels, Evelyn De Leenheir, Jean-Jacques Martin, Eugeen Vanmechelen, Christine Van Broeckhoven, Peter Paul De Dey. No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease. Brain : a journal of neurology. vol 130. issue Pt 9. 2007-11-01. PMID:17586559. |
the csf biomarkers beta-amyloid peptide (abeta(1-42)), total tau protein (t-tau) and tau phosphorylated at threonine 181 (p-tau(181p)) were determined in autopsy-confirmed alzheimer's disease patients in order to study possible associations with the epsilon4 allele of apoe and density and spread of plaques (sp) and tangles (nft). |
2007-11-01 |
2023-08-12 |
Not clear |
| Annelies E van der Vlies, Yolande A L Pijnenburg, Teddy Koene, Martin Klein, Astrid Kok, Philip Scheltens, Wiesje M van der Flie. Cognitive impairment in Alzheimer's disease is modified by APOE genotype. Dementia and geriatric cognitive disorders. vol 24. issue 2. 2007-10-31. PMID:17596691. |
cognitive impairment in alzheimer's disease is modified by apoe genotype. |
2007-10-31 |
2023-08-12 |
Not clear |
| Annelies E van der Vlies, Yolande A L Pijnenburg, Teddy Koene, Martin Klein, Astrid Kok, Philip Scheltens, Wiesje M van der Flie. Cognitive impairment in Alzheimer's disease is modified by APOE genotype. Dementia and geriatric cognitive disorders. vol 24. issue 2. 2007-10-31. PMID:17596691. |
we examined whether impairment in specific cognitive domains in alzheimer's disease (ad) differed according to apoe genotype and age at onset. |
2007-10-31 |
2023-08-12 |
Not clear |
| Dimitri Trembath, John F Ervin, Lucy Broom, Mari Szymanski, Kathleen Welsh-Bohmer, Carl Pieper, Christine M Hulett. The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype. Acta neuropathologica. vol 113. issue 1. 2007-10-26. PMID:17089130. |
the distribution of cerebrovascular amyloid in alzheimer's disease varies with apoe genotype. |
2007-10-26 |
2023-08-12 |
human |
| Dimitri Trembath, John F Ervin, Lucy Broom, Mari Szymanski, Kathleen Welsh-Bohmer, Carl Pieper, Christine M Hulett. The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype. Acta neuropathologica. vol 113. issue 1. 2007-10-26. PMID:17089130. |
we performed a comparative study to assess cerebral amyloid angiopathy and apoe genotype in cases of alzheimer's disease (ad). |
2007-10-26 |
2023-08-12 |
human |
| Grace J Petot, Ursula Vega, Fatoumata Traore, Thomas Fritsch, Sara M Debanne, Robert P Friedland, Alan J Lerne. Height and Alzheimer's disease: findings from a case-control study. Journal of Alzheimer's disease : JAD. vol 11. issue 3. 2007-10-11. PMID:17851184. |
the purpose of this study is to examine the relationship of height, apolipoprotein e genotype (apoe) and alzheimer's disease (ad). |
2007-10-11 |
2023-08-12 |
human |
| Paolo Bosco, Filippo Caraci, Agata Copani, Rosario S Spada, Maria Angela Sortino, Roberto Salluzzo, Michele Salemi, Ferdinando Nicoletti, Raffaele Ferr. The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neuroscience letters. vol 419. issue 3. 2007-09-28. PMID:17498878. |
the cdc2 i-g-t haplotype associated with the apoe epsilon4 allele increases the risk of sporadic alzheimer's disease in sicily. |
2007-09-28 |
2023-08-12 |
human |
| D M Alexander, L M Williams, J M Gatt, C Dobson-Stone, S A Kuan, E G Todd, P R Schofield, N J Cooper, E Gordo. The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades. Biological psychology. vol 75. issue 3. 2007-09-26. PMID:17433528. |
neuroimaging shows brain-functional differences due to apolipoprotein e (apoe) polymorphisms may exist decades before the increased risk period for alzheimer's disease, but little is known about their effect on cognition and brain function in children and young adults. |
2007-09-26 |
2023-08-12 |
human |
| Daniel J Berlau, Kristin Kahle-Wrobleski, Elizabeth Head, Matthew Goodus, Ronald Kim, Claudia Kawa. Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Archives of neurology. vol 64. issue 8. 2007-09-18. PMID:17698712. |
the apolipoprotein e (apoe) epsilon2 allele has been suggested as having a protective effect and delaying the age at onset of alzheimer disease. |
2007-09-18 |
2023-08-12 |
Not clear |
| Christian R A Mondadori, Dominique J-F de Quervain, Andreas Buchmann, Henrietta Mustovic, M Axel Wollmer, Conny F Schmidt, Peter Boesiger, Christoph Hock, Roger M Nitsch, Andreas Papassotiropoulos, Katharina Henk. Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 8. 2007-09-11. PMID:17077159. |
the apolipoprotein e (apoe) epsilon4 allele is the major genetic risk factor for alzheimer's disease, but an apoe effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown. |
2007-09-11 |
2023-08-12 |
human |
| L F M Scint. ApoE allelic variability influences pupil response to cholinergic challenge and cognitive impairment. Genes, brain, and behavior. vol 6. issue 3. 2007-08-29. PMID:16764677. |
the current study links apolipoprotein e (apoe) allelic variability to the magnitude of pupil response in a sample of community-dwelling elderly without a diagnosis of alzheimer's disease or dementia. |
2007-08-29 |
2023-08-12 |
Not clear |
| Suzanne E Wahrle, Aarti R Shah, Anne M Fagan, Scott Smemo, John S K Kauwe, Andrew Grupe, Anthony Hinrichs, Kevin Mayo, Hong Jiang, Leon J Thal, Alison M Goate, David M Holtzma. Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Molecular neurodegeneration. vol 2. 2007-08-13. PMID:17430597. |
animal studies suggest that brain apolipoprotein e (apoe) levels influence amyloid-beta (abeta) deposition and thus risk for alzheimer's disease (ad). |
2007-08-13 |
2023-08-12 |
mouse |
| Hyang-Sook Hoe, Jacob Freeman, G William Rebec. Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons. Molecular neurodegeneration. vol 1. 2007-07-31. PMID:17166269. |
since apoe is important in the pathogenesis of alzheimer's disease (ad), we tested whether apoe treatment of neurons affected molecules important to phosphorylation of tau, such as gsk 3beta, p35, and cdk5, and the phosphorylation of tau itself. |
2007-07-31 |
2023-08-12 |
Not clear |