| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yvonne Davidson, Linda Gibbons, Antonia Pritchard, Jayne Hardicre, Joanne Wren, Cheryl Stopford, Camille Julien, Jennifer Thompson, Antony Payton, Stuart M Pickering-Brown, Neil Pendleton, Michael A Horan, Alistair Burns, Nitin Purandare, Corinne L Lendon, David Neary, Julie S Snowden, David M A Man. Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 23. issue 1. 2007-02-27. PMID:17108687. |
the age distribution of the epsilon4 allelic form of the apolipoprotein e gene (apoe) was investigated in 630 patients with alzheimer's disease (ad) with onset age ranging from 35 to 90 years. |
2007-02-27 |
2023-08-12 |
Not clear |
| Z-W Sun, Y-X Zhu, H-Y Liu, J Liu, X-Q Zhu, J-N Zhou, R-Y Li. Decreased cerebral blood flow velocity in apolipoprotein E epsilon4 allele carriers with mild cognitive impairment. European journal of neurology. vol 14. issue 2. 2007-02-23. PMID:17250722. |
our findings, the decreased cbfv in apoe epsilon4 allele carriers with mci, suggest that a large sample and longitudinal study in cbfv and cognitive changes may have the implications on early diagnosis of alzheimer's disease. |
2007-02-23 |
2023-08-12 |
Not clear |
| Lars Bertram, Matthew B McQueen, Kristina Mullin, Deborah Blacker, Rudolph E Tanz. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature genetics. vol 39. issue 1. 2007-02-21. PMID:17192785. |
in addition to identifying the epsilon4 allele of apoe and related effects, we pinpointed over a dozen potential alzheimer disease susceptibility genes (ace, chrnb2, cst3, esr1, gapdhs, ide, mthfr, ncstn, prnp, psen1, tf, tfam and tnf) with statistically significant allelic summary odds ratios (ranging from 1.11-1.38 for risk alleles and 0.92-0.67 for protective alleles). |
2007-02-21 |
2023-08-12 |
Not clear |
| Daria Pasalić, Goran Ferencak, Branka Grsković, Ana Stavljenic-Rukavin. [The frequencies of apolipoprotein E genotypes in health and disease in the Croatian population--an overview of expectations and real results]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 60. issue 5. 2007-02-13. PMID:17217095. |
the apoe genotype frequencies in patients with alzheimer's disease were significantly different from those in the control group. |
2007-02-13 |
2023-08-12 |
human |
| Daria Pasalić, Goran Ferencak, Branka Grsković, Ana Stavljenic-Rukavin. [The frequencies of apolipoprotein E genotypes in health and disease in the Croatian population--an overview of expectations and real results]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 60. issue 5. 2007-02-13. PMID:17217095. |
it is concluded that the frequencies of apoe genotypes yielded no statistically significant result to confirm the association between apoe genotypes and any specific disease with the exception of alzheimer's disease; apo-epsilon4 allell has become one of the important biomarkers in diagnosis of alzheimer's dementia. |
2007-02-13 |
2023-08-12 |
human |
| Kristina F Zdanys, Timothy G Kleiman, Martha G MacAvoy, Benjamin T Black, Tracy E Rightmer, Monique Grey, Katherine S Garman, Rajesh R Tampi, Joel Gelernter, Christopher H van Dyc. Apolipoprotein E epsilon4 allele increases risk for psychotic symptoms in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 1. 2007-02-09. PMID:16841077. |
the apolipoprotein e (apoe) epsilon4 allele is a well-documented genetic risk factor for sporadic alzheimer's disease (ad). |
2007-02-09 |
2023-08-12 |
human |
| Alexander I Tröster, Julie A Fields, Anthony M Paolo, William C Kolle. Absence of the apolipoprotein E epsilon4 allele is associated with working memory impairment in Parkinson's disease. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16769085. |
the apolipoprotein e (apoe) epsilon4 allele has been associated with an increased risk of alzheimer's disease (ad) and weaker episodic memory among elderly. |
2007-01-23 |
2023-08-12 |
human |
| T Darreh-Shori, S Brimijoin, A Kadir, O Almkvist, A Nordber. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Neurobiology of disease. vol 24. issue 2. 2007-01-23. PMID:16973370. |
differential csf butyrylcholinesterase levels in alzheimer's disease patients with the apoe epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. |
2007-01-23 |
2023-08-12 |
Not clear |
| T Darreh-Shori, S Brimijoin, A Kadir, O Almkvist, A Nordber. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Neurobiology of disease. vol 24. issue 2. 2007-01-23. PMID:16973370. |
butyrylcholinesterase (buche) is increased in the cerebral cortex of alzheimer's disease (ad) patients, particularly those carrying epsilon4 allele of the apolipoprotein e gene (apoe) and certain buche variants that predict increased ad risk and poor response to anticholinesterase therapy. |
2007-01-23 |
2023-08-12 |
Not clear |
| Noriaki Mitsud. [Recent research progress in Alzheimer's disease: relationship with APOE genotype]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 43. issue 5. 2007-01-12. PMID:17073290. |
[recent research progress in alzheimer's disease: relationship with apoe genotype]. |
2007-01-12 |
2023-08-12 |
Not clear |
| Janet M Duchek, David A Balota, Michael Cortes. Prospective memory and apolipoprotein E in healthy aging and early stage Alzheimer's disease. Neuropsychology. vol 20. issue 6. 2007-01-10. PMID:17100508. |
the present study examined whether prospective memory performance discriminates healthy aging from very mild dementia of the alzheimer type (dat) and individuals at risk for dat because of the presence of the apolipoprotein e (apoe) epsilon4 allele. |
2007-01-10 |
2023-08-12 |
human |
| Rudi K Tannenberg, Heather L Scott, Anthony E G Tannenberg, Peter R Dod. Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE varepsilon4. Neurochemistry international. vol 49. issue 7. 2007-01-05. PMID:16814428. |
selective loss of synaptic proteins in alzheimer's disease: evidence for an increased severity with apoe varepsilon4. |
2007-01-05 |
2023-08-12 |
human |
| S I Gavrilov. [Pharmacological approaches to the therapy of Alzheimer's disease]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 9-10. 2007-01-05. PMID:17111921. |
the role of apolipoprotein e (apoe) genotype in the forming of response to various kinds of pathogenetic therapy of alzheimer's disease (ad) was studied in two samples of patients receiving cholinergic or neurotrophic therapy during four months. |
2007-01-05 |
2023-08-12 |
Not clear |
| Govind T Vatassery, Cornelius Lam, W Ed Smith, Hung T Quac. Apolipoprotein E exerts selective and differential control over vitamin E concentrations in different areas of mammalian brain. Journal of neuroscience research. vol 84. issue 6. 2007-01-04. PMID:16941498. |
apolipoprotein e (apoe) is known to be a risk factor for the incidence of alzheimer's disease (ad). |
2007-01-04 |
2023-08-12 |
mouse |
| P N Wang, J F Lirng, K N Lin, F C Chang, H C Li. Prediction of Alzheimer's disease in mild cognitive impairment: a prospective study in Taiwan. Neurobiology of aging. vol 27. issue 12. 2007-01-03. PMID:16321457. |
twenty normal elders, 58 mci, and 20 mild alzheimer's disease (ad) patients received neuropsychological, mri, and apoe genotype assessments at baseline. |
2007-01-03 |
2023-08-12 |
human |
| Rui-Sheng Duan, Zhiguo Chen, Ying-Chun Dou, Hernan Concha Quezada, Inger Nennesmo, Abdu Adem, Bengt Winblad, Jie Zh. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16919271. |
apolipoprotein e (apoe) down-regulates microglial activation and the secretion of inflammatory molecules in an isoform specific fashion (e2 > e3 > e4); the e4 isoform is over-represented in alzheimer cases while e2 is under-represented. |
2007-01-03 |
2023-08-12 |
mouse |
| Rui-Sheng Duan, Zhiguo Chen, Ying-Chun Dou, Hernan Concha Quezada, Inger Nennesmo, Abdu Adem, Bengt Winblad, Jie Zh. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16919271. |
taken together, these findings imply that apoe modulates hippocampal damage induced by ka and found early in the sequence of human alzheimer's brain changes, by modulating microglial activation. |
2007-01-03 |
2023-08-12 |
mouse |
| W C Eckelma. Imaging of muscarinic receptors in the central nervous system. Current pharmaceutical design. vol 12. issue 30. 2007-01-03. PMID:17073686. |
radioligands for the muscarinic receptor, for ach esterase, and to measure the concentration of acetylcholine have now been developed, a number of studies in small populations have identified changes in mild to moderate alzheimer's disease and, perhaps more importantly, changes in radioligand binding have been identified in clinically normal subjects genetically predisposed to alzheimer's disease by virtue of the epsilon 4+ variant of the apoe gene. |
2007-01-03 |
2023-08-12 |
human |
| Lars Bertram, Monica Hsiao, Matthew B McQueen, Michele Parkinson, Kristina Mullin, Deborah Blacker, Rudolph E Tanz. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiology of aging. vol 28. issue 1. 2006-12-28. PMID:16378661. |
genetic linkage studies suggest the presence of an alzheimer's disease (ad) risk gene on chromosome 19, acting independently of apolipoprotein e (apoe), a known ad risk factor on 19q13. |
2006-12-28 |
2023-08-12 |
Not clear |
| Rosa Maria Corbo, Martine Prévost, Vincent Raussens, Giuseppe Gambina, Giuseppe Moretto, Renato Scacch. Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation. Molecular genetics and metabolism. vol 89. issue 3. 2006-12-13. PMID:16621646. |
apolipoprotein e (apoe) is an important gene whose common polymorphism, and precisely the e *4 allele, has been reportedly associated with some disorders, including alzheimer's disease (ad) and coronary artery disease. |
2006-12-13 |
2023-08-12 |
human |