| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franz Fazekas, Christian Enzinger, Stefan Ropele, Helena Schmidt, Reinhold Schmidt, Siegrid Strasser-Fuch. The impact of our genes: consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis. Journal of the neurological sciences. vol 245. issue 1-2. 2006-08-25. PMID:16631796. |
apolipoprotein e (apoe) polymorphism has been considered a candidate for impacting on ms because of its numerous functions related to brain tissue and evidence for an association with a variety of cerebral disorders, specifically alzheimer's disease (ad). |
2006-08-25 |
2023-08-12 |
Not clear |
| Alfred Rapp, Bernhard Gmeiner, Manfred Hüttinge. Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes. Biochimie. vol 88. issue 5. 2006-08-24. PMID:16376010. |
apolipoprotein e (apoe) has been genetically linked to late-onset alzheimer's disease. |
2006-08-24 |
2023-08-12 |
rat |
| Mitchell K P Lai, Shirley W Y Tsang, Monica Garcia-Alloza, Stephen L Minger, James A R Nicoll, Margaret M Esiri, Peter T-H Wong, Christopher P L-H Chen, María J Ramírez, Paul T Franci. Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16473016. |
selective effects of the apoe epsilon4 allele on presynaptic cholinergic markers in the neocortex of alzheimer's disease. |
2006-08-24 |
2023-08-12 |
Not clear |
| Mitchell K P Lai, Shirley W Y Tsang, Monica Garcia-Alloza, Stephen L Minger, James A R Nicoll, Margaret M Esiri, Peter T-H Wong, Christopher P L-H Chen, María J Ramírez, Paul T Franci. Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16473016. |
the effects of the apoe epsilon4 allele on a range of pre- and postsynaptic cholinergic markers were studied in a cohort of community-based alzheimer's disease (ad) patients. |
2006-08-24 |
2023-08-12 |
Not clear |
| Edward D Huey, Nadeem Mirza, Karen T Putnam, Holly Soares, Gyorgy Csako, James A Levy, Brittany Copenhaver, Robert M Cohen, Trey Sunderlan. Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dementia and geriatric cognitive disorders. vol 22. issue 1. 2006-08-18. PMID:16682793. |
stability of csf beta-amyloid(1-42) and tau levels by apoe genotype in alzheimer patients. |
2006-08-18 |
2023-08-12 |
Not clear |
| Timothy Kleiman, Kristina Zdanys, Benjamin Black, Tracy Rightmer, Monique Grey, Katherine Garman, Martha Macavoy, Joel Gelernter, Christopher van Dyc. Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis. Dementia and geriatric cognitive disorders. vol 22. issue 1. 2006-08-18. PMID:16699282. |
the apolipoprotein e (apoe) epsilon4 allele is a well-documented genetic risk factor for alzheimer's disease (ad). |
2006-08-18 |
2023-08-12 |
human |
| Jonathan Savitz, Mark Solms, Rajkumar Ramesa. Apolipoprotein E variants and cognition in healthy individuals: a critical opinion. Brain research reviews. vol 51. issue 1. 2006-08-10. PMID:16378640. |
the epsilon4 allele of apolipoprotein e (apoe) is a well-established risk factor for late onset alzheimer's disease (ad). |
2006-08-10 |
2023-08-12 |
Not clear |
| Elaine R Peskind, Ge Li, Jane Shofer, Joseph F Quinn, Jeffrey A Kaye, Chris M Clark, Martin R Farlow, Charles DeCarli, Murray A Raskind, Gerard D Schellenberg, Virginia M-Y Lee, Douglas R Galask. Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition. Archives of neurology. vol 63. issue 7. 2006-08-07. PMID:16831961. |
normal aging and the presence of the apolipoprotein e (apoe*4) allele are the most important known risk factors for alzheimer disease. |
2006-08-07 |
2023-08-12 |
Not clear |
| Seth Love, L Khai Siew, David Dawbarn, Gordon K Wilcock, Yoav Ben-Shlomo, Shelley J Alle. Premorbid effects of APOE on synaptic proteins in human temporal neocortex. Neurobiology of aging. vol 27. issue 6. 2006-07-26. PMID:15979210. |
apoe affects the risk of alzheimer's disease (ad) and course of several other neurologic diseases. |
2006-07-26 |
2023-08-12 |
human |
| E R Martin, P G Bronson, Y-J Li, N Wall, R-H Chung, D E Schmechel, G Small, P-T Xu, J Bartlett, N Schnetz-Boutaud, J L Haines, J R Gilbert, M A Pericak-Vanc. Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. Journal of medical genetics. vol 42. issue 10. 2006-07-24. PMID:16199552. |
interaction between the alpha-t catenin gene (vr22) and apoe in alzheimer's disease. |
2006-07-24 |
2023-08-12 |
Not clear |
| E R Martin, P G Bronson, Y-J Li, N Wall, R-H Chung, D E Schmechel, G Small, P-T Xu, J Bartlett, N Schnetz-Boutaud, J L Haines, J R Gilbert, M A Pericak-Vanc. Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. Journal of medical genetics. vol 42. issue 10. 2006-07-24. PMID:16199552. |
apoe is the only gene that has been consistently replicated as a risk factor for late onset alzheimer's disease. |
2006-07-24 |
2023-08-12 |
Not clear |
| J-C Becher, J W Keeling, N McIntosh, B Wyatt, J Bel. The distribution of apolipoprotein E alleles in Scottish perinatal deaths. Journal of medical genetics. vol 43. issue 5. 2006-07-17. PMID:16183800. |
the apolipoprotein e (apoe) polymorphism has been well studied in the adult human population, in part because the e4 allele is a known risk factor for alzheimer's disease. |
2006-07-17 |
2023-08-12 |
human |
| J I Lao, C Montoriol, I Morer, K Beye. Genetic contribution to aging: deleterious and helpful genes define life expectancy. Annals of the New York Academy of Sciences. vol 1057. 2006-07-10. PMID:16399887. |
examples of deleterious genes affecting aging (predisposition to early-life pathology and disease) are those that confer risk for developing vascular disease in the heart, brain, or peripheral vessels (apoe, ace, mtfhr, and mutation at factor ii and factor v genes), a gene associated with sporadic late-onset alzheimer's disease (apoe e4), a polymorphism (colia1 sp1) associated with an increased fracture risk, and several genetic polymorphisms involved in hormonal metabolism that affect adverse reactions to estrogen replacement in postmenopausal women. |
2006-07-10 |
2023-08-12 |
Not clear |
| E Rodríguez, I Mateo, J Infante, J Llorca, J Berciano, O Combarro. Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon4 allele. Journal of neurology. vol 253. issue 2. 2006-06-28. PMID:16096813. |
cholesteryl ester transfer protein (cetp) polymorphism modifies the alzheimer's disease risk associated with apoe epsilon4 allele. |
2006-06-28 |
2023-08-12 |
Not clear |
| Karlygash Abildayeva, Paula J Jansen, Veronica Hirsch-Reinshagen, Vincent W Bloks, Arjen H F Bakker, Frans C S Ramaekers, Jan de Vente, Albert K Groen, Cheryl L Wellington, Folkert Kuipers, Monique Mulde. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. The Journal of biological chemistry. vol 281. issue 18. 2006-06-28. PMID:16524875. |
both apolipoprotein e (apoe) and 24(s)-hydroxycholesterol are involved in the pathogenesis of alzheimer disease (ad). |
2006-06-28 |
2023-08-12 |
Not clear |
| Stuart Macgregor, Nick Craddock, Peter A Holman. Use of phenotypic covariates in association analysis by sequential addition of cases. European journal of human genetics : EJHG. vol 14. issue 5. 2006-06-23. PMID:16538225. |
we demonstrate proof of principle, using an example of incorporation of age-at-onset data into a study of a small sample for association between apoe and late-onset alzheimer's disease. |
2006-06-23 |
2023-08-12 |
Not clear |
| Robert W Mahley, Karl H Weisgraber, Yadong Huan. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 15. 2006-06-09. PMID:16567625. |
in multiple pathways affecting neuropathology, including alzheimer's disease, apoe acts directly or in concert with age, head injury, oxidative stress, ischemia, inflammation, and excess amyloid beta peptide production to cause neurological disorders, accelerating progression, altering prognosis, or lowering age of onset. |
2006-06-09 |
2023-08-12 |
Not clear |
| Melanie S Burkhardt, Jonathan K Foster, Roger M Clarnette, S A Paul Chubb, David G Bruce, Peter D Drummond, Ralph N Martins, Bu B Yea. Interaction between testosterone and apolipoprotein E epsilon4 status on cognition in healthy older men. The Journal of clinical endocrinology and metabolism. vol 91. issue 3. 2006-06-07. PMID:16368754. |
men who possess the apolipoprotein e (apoe) epsilon4 allele have an increased risk of developing alzheimer's disease; however, no studies have examined whether the influence of testosterone on cognition in healthy older men may be modulated by this genetic predisposition. |
2006-06-07 |
2023-08-12 |
Not clear |
| Sara M Marian. ApoE and Alzheimer's disease--10 years later. MedGenMed : Medscape general medicine. vol 6. issue 3. 2006-05-31. PMID:15520671. |
apoe and alzheimer's disease--10 years later. |
2006-05-31 |
2023-08-12 |
Not clear |
| Johanna Lind, Jonas Persson, Martin Ingvar, Anne Larsson, Marc Cruts, Christine Van Broeckhoven, Rolf Adolfsson, Lars Bäckman, Lars-Göran Nilsson, Karl Magnus Petersson, Lars Nyber. Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers. Brain : a journal of neurology. vol 129. issue Pt 5. 2006-05-31. PMID:16537568. |
the apolipoprotein e epsilon4 (apoe epsilon4) is the main known genetic risk factor for alzheimer's disease. |
2006-05-31 |
2023-08-12 |
Not clear |