| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fumiko Irie, Annette L Fitzpatrick, Oscar L Lopez, Lewis H Kuller, Rita Peila, Anne B Newman, Lenore J Laune. Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Archives of neurology. vol 65. issue 1. 2008-02-14. PMID:18195144. |
enhanced risk for alzheimer disease in persons with type 2 diabetes and apoe epsilon4: the cardiovascular health study cognition study. |
2008-02-14 |
2023-08-12 |
Not clear |
| Fumiko Irie, Annette L Fitzpatrick, Oscar L Lopez, Lewis H Kuller, Rita Peila, Anne B Newman, Lenore J Laune. Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Archives of neurology. vol 65. issue 1. 2008-02-14. PMID:18195144. |
diabetes and the apolipoprotein e epsilon4 allele (apoe epsilon4) increase the risk for alzheimer disease (ad). |
2008-02-14 |
2023-08-12 |
Not clear |
| Derek Gordon, Chad Haynes, Yaning Yang, Patricia L Kramer, Stephen J Finc. Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error. Genetic epidemiology. vol 31. issue 8. 2008-02-05. PMID:17565750. |
finally, we apply ltt ae and a method without double-sample information (ltt std) to double-sampled phenotype data for an actual alzheimer's disease (ad) case-control study with apoe genotypes. |
2008-02-05 |
2023-08-12 |
Not clear |
| Maria Cándida Déniz-Naranjo, Carmen Muñoz-Fernández, Maria Jesús Alemany-Rodríguez, Maria del Carmen Pérez-Vieitez, Yolanda Aladro-Benito, Juncal Irurita-Latasa, Florentino Sánchez-Garcí. Butyrylcholinesterase, ApoE and Alzheimer's disease in a population from the Canary Islands (Spain). Neuroscience letters. vol 427. issue 1. 2008-01-25. PMID:17923322. |
butyrylcholinesterase, apoe and alzheimer's disease in a population from the canary islands (spain). |
2008-01-25 |
2023-08-12 |
Not clear |
| Menachem J Gunzburg, Matthew A Perugini, Geoffrey J Howlet. Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E. The Journal of biological chemistry. vol 282. issue 49. 2008-01-17. PMID:17916554. |
a genetic link between a common isoform of apoe, apoe4, and the incidence of late onset alzheimer disease has drawn considerable attention to the potential roles of apoe in amyloid-related disease. |
2008-01-17 |
2023-08-12 |
human |
| Menachem J Gunzburg, Matthew A Perugini, Geoffrey J Howlet. Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E. The Journal of biological chemistry. vol 282. issue 49. 2008-01-17. PMID:17916554. |
aggregates of apoe with abeta and apoc-ii are found in alzheimer and atherosclerotic plaques, respectively. |
2008-01-17 |
2023-08-12 |
human |
| Olivia Belbin, Janette L Dunn, Yan Ling, Linda Morgan, Sally Chappell, Helen Beaumont, Donald Warden, David A Smith, Noor Kalsheker, Kevin Morga. Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease. Human molecular genetics. vol 16. issue 18. 2008-01-10. PMID:17613540. |
the aim of this study was to investigate whether single nucleotide polymorphisms (snps) in the regulatory regions of the apolipoprotein e (apoe) gene modify the well-established epsilon4-associated risk for alzheimer's disease (ad). |
2008-01-10 |
2023-08-12 |
Not clear |
| Nicolas Cherbuin, Liana S Leach, Helen Christensen, Kaarin J Anste. Neuroimaging and APOE genotype: a systematic qualitative review. Dementia and geriatric cognitive disorders. vol 24. issue 5. 2008-01-10. PMID:17911980. |
apolipoprotein e (apoe) is the major genetic risk factor for late-onset alzheimer's disease (ad) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. |
2008-01-10 |
2023-08-12 |
Not clear |
| Qiang Liu, Celina V Zerbinatti, Juan Zhang, Hyang-Sook Hoe, Baiping Wang, Sarah L Cole, Joachim Herz, Louis Muglia, Guojun B. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron. vol 56. issue 1. 2008-01-08. PMID:17920016. |
mutations in the amyloid precursor protein (app) cause early-onset alzheimer's disease (ad), but the only genetic risk factor for late-onset ad is the varepsilon4 allele of apolipoprotein e (apoe), a major cholesterol carrier. |
2008-01-08 |
2023-08-12 |
mouse |
| Alejandro Arias-Vásquez, Aaron Isaacs, Yurii S Aulchenko, Albert Hofman, Ben A Oostra, Monique Breteler, Cornelia M van Duij. The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease. Neurogenetics. vol 8. issue 3. 2008-01-07. PMID:17503098. |
like the apolipoprotein e (apoe) gene, the most common genetic determinant for alzheimer's disease (ad), the cholesteryl ester transfer protein (cetp) is involved in lipid metabolism. |
2008-01-07 |
2023-08-12 |
Not clear |
| Erin E Sundermann, Paul E Gilbert, Claire Murph. Apolipoprotein E epsilon4 genotype and gender: effects on memory. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 15. issue 10. 2008-01-02. PMID:17911364. |
episodic recognition memory for odors and visual was assessed in apolipoprotein e (apoe) epsilon4-positive and epsilon4-negative men and women diagnosed with alzheimer disease (ad) and a healthy age- and gender-matched comparison group. |
2008-01-02 |
2023-08-12 |
Not clear |
| Kuo-Liang Su, Ta-Hsiang Wen, Chi-Yuan Chou, Gu-Gang Chang, Guang-Yaw Liu, Hui-Chih Hun. Structural variation manipulates the differential oxidative susceptibility and conformational stability of apolipoprotein E isoforms. Proteins. vol 68. issue 1. 2007-12-31. PMID:17410580. |
a growing amount of evidence implicates the involvement of apolipoprotein e (apoe) in the development of late-onset and sporadic forms of alzheimer's disease (ad). |
2007-12-31 |
2023-08-12 |
Not clear |
| Ofir Levi, Iftach Dolev, Haim Belinson, Daniel M Michaelso. Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17666042. |
importantly, we found that exposure of mice transgenic for either apoe4, or the alzheimer's disease benign allele apoe3, to an enriched environment elevates similarly the hippocampal levels of amyloid-beta peptide (abeta) and apoe of these mice, but that the degree of aggregation and spatial distribution of abeta in these mice are markedly affected by the apoe genotype. |
2007-12-21 |
2023-08-12 |
mouse |
| Bryan Maloney, Yuan-Wen Ge, George M Alley, Debomoy K Lahir. Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17854398. |
important differences between human and mouse apoe gene promoters: limitation of mouse apoe model in studying alzheimer's disease. |
2007-12-21 |
2023-08-12 |
mouse |
| Bryan Maloney, Yuan-Wen Ge, George M Alley, Debomoy K Lahir. Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17854398. |
apolipoprotein e (apoe), encoded by the apolipoprotein e gene (apoe), plays an important role in the pathogenesis of alzheimer's disease (ad). |
2007-12-21 |
2023-08-12 |
mouse |
| Marjan Shafaati, Alina Solomon, Miia Kivipelto, Ingemar Björkhem, Valerio Leon. Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. Neuroscience letters. vol 425. issue 2. 2007-12-14. PMID:17822846. |
consistent with this mechanism, a significant correlation is demonstrated here between levels of apoe and 24s-hydroxycholesterol in cerebrospinal fluid from patients with alzheimer's disease and patients with mild cognitive impairment. |
2007-12-14 |
2023-08-12 |
Not clear |
| A Cagnin, A Zambon, G Zarantonello, D Vianello, M Marchiori, D Mercurio, F Miccichè, M Ermani, A Leon, L Battisti. Serum lipoprotein profile and APOE genotype in Alzheimer's disease. Journal of neural transmission. Supplementum. issue 72. 2007-12-10. PMID:17982892. |
serum lipoprotein profile and apoe genotype in alzheimer's disease. |
2007-12-10 |
2023-08-12 |
human |
| P Barberger-Gateau, C Raffaitin, L Letenneur, C Berr, C Tzourio, J F Dartigues, A Alpérovitc. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology. vol 69. issue 20. 2007-12-07. PMID:17998483. |
the aim of our study was to analyze the relationship between dietary patterns and risk of dementia or alzheimer disease (ad), adjusting for sociodemographic and vascular risk factors, and taking into account the apoe genotype. |
2007-12-07 |
2023-08-12 |
Not clear |
| Eloy Rodríguez-Rodríguez, Ignacio Mateo, Javier Llorca, Coro Sánchez-Quintana, Jon Infante, Inés García-Gorostiaga, Pascual Sánchez-Juan, José Berciano, Onofre Combarro. Association of genetic variants of ABCA1 with Alzheimer's disease risk. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17510946. |
to evaluate the relationship between abca1 genetic variants and alzheimer's disease (ad), independently or in concert with the apoe epsilon4 allele, we examined three abca1 polymorphisms located in the coding region (r219k, i883m, and r1587k) and two abca1 polymorphisms in the promoter region (c-14t and c-477t) in a group of 372 spanish ad patients and 440 controls. |
2007-12-06 |
2023-08-12 |
Not clear |
| Larry A Tupler, K Ranga R Krishnan, Daniel L Greenberg, Santica M Marcovina, Martha E Payne, James R MacFall, H Cecil Charles, P Murali Doraiswam. Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve. Neurobiology of aging. vol 28. issue 11. 2007-11-30. PMID:16916565. |
major predictors of alzheimer's disease (ad) include apolipoprotein e (apoe)-epsilon4, hippocampal atrophy on magnetic resonance imaging (mri), and memory dysfunction prior to diagnosis. |
2007-11-30 |
2023-08-12 |
human |