| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R J Caselli, E M Reiman, D Osborne, J G Hentz, L C Baxter, J L Hernandez, G G Alexande. Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele. Neurology. vol 62. issue 11. 2004-12-20. PMID:15184602. |
to determine whether memory loss is detectable before the symptomatic presentation of mild cognitive impairment (mci) in those at greater genetic risk for alzheimer disease (ad) based upon presence or absence of the e4 allele of apoe. |
2004-12-20 |
2023-08-12 |
Not clear |
| Y J Li, M A Hauser, W K Scott, E R Martin, M W Booze, X J Qin, J W Walter, M A Nance, J P Hubble, W C Koller, R Pahwa, M B Stern, B C Hiner, J Jankovic, C G Goetz, G W Small, F Mastaglia, J L Haines, M A Pericak-Vance, J M Vanc. Apolipoprotein E controls the risk and age at onset of Parkinson disease. Neurology. vol 62. issue 11. 2004-12-20. PMID:15184605. |
similarities between alzheimer disease (ad) and parkinson disease (pd) suggest a possible role for apolipoprotein e (apoe) in pd. |
2004-12-20 |
2023-08-12 |
Not clear |
| J A Prince, H Zetterberg, N Andreasen, J Marcusson, K Blenno. APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42. Neurology. vol 62. issue 11. 2004-12-20. PMID:15184629. |
the epsilon4 allele of apoe is a risk factor for alzheimer disease (ad). |
2004-12-20 |
2023-08-12 |
human |
| Benedetta Nacmias, Carolina Piccini, Silvia Bagnoli, Andrea Tedde, Elena Cellini, Laura Bracco, Sandro Sorb. Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer's disease. Neuroscience letters. vol 367. issue 3. 2004-12-17. PMID:15337270. |
to investigate the effect of bdnf and apoe polymorphisms on the cognitive profile of mild-moderate alzheimer's disease (ad) cases, ad patients, genotyped for apoe and bdnf polymorphisms, underwent extensive neuropsychological investigation. |
2004-12-17 |
2023-08-12 |
Not clear |
| Paul E Gilbert, Claire Murph. The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls. Journal of clinical and experimental neuropsychology. vol 26. issue 6. 2004-12-02. PMID:15370375. |
the effect of the apoe epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed alzheimer's disease, probable alzheimer's disease, and healthy elderly controls. |
2004-12-02 |
2023-08-12 |
Not clear |
| Xuemei Huang, Peter C Chen, Charles Pool. APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease. Neurology. vol 62. issue 12. 2004-12-01. PMID:15210882. |
the link of the apolipoprotein (apoe) -epsilon4 allele to alzheimer disease (ad) has led to studies investigating the role of apoe polymorphisms in parkinson disease (pd). |
2004-12-01 |
2023-08-12 |
Not clear |
| Blanca Hernández-Charro, Sira Moreno, Alberto Valiente, José María Manubens, María Dolores Villar, María Antonia Ramos-Arroy. [ACT/AA polymorphism could duplicate the APOE*epsilon4-associated Alzheimer's disease risk]. Medicina clinica. vol 123. issue 7. 2004-11-23. PMID:15482730. |
[act/aa polymorphism could duplicate the apoe*epsilon4-associated alzheimer's disease risk]. |
2004-11-23 |
2023-08-12 |
Not clear |
| Blanca Hernández-Charro, Sira Moreno, Alberto Valiente, José María Manubens, María Dolores Villar, María Antonia Ramos-Arroy. [ACT/AA polymorphism could duplicate the APOE*epsilon4-associated Alzheimer's disease risk]. Medicina clinica. vol 123. issue 7. 2004-11-23. PMID:15482730. |
the association between the presence of the allele apoe*epsilon4 (apolipoprotein e) and sporadic alzheimer disease (ad) has been long established. |
2004-11-23 |
2023-08-12 |
Not clear |
| Uwe Beffert, Peggy C Stolt, Joachim Her. Functions of lipoprotein receptors in neurons. Journal of lipid research. vol 45. issue 3. 2004-11-10. PMID:14657206. |
one ligand common to all ldlr family members is apolipoprotein e (apoe), a lipid transport protein that also plays a central role in the pathogenesis of neurodegeneration in alzheimer's disease. |
2004-11-10 |
2023-08-12 |
Not clear |
| Ging-Yuek R Hsiung, A Dessa Sadovnick, Howard Feldma. Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. vol 171. issue 8. 2004-11-02. PMID:15477624. |
apolipoprotein e (apoe) epsilon4 genotype is a well-established risk factor for alzheimer's disease (ad). |
2004-11-02 |
2023-08-12 |
Not clear |
| Jun Yao, Suzana S Petanceska, Thomas J Montine, David M Holtzman, Stephen D Schmidt, Carolyn A Parker, Michael J Callahan, William J Lipinski, Charles L Bisgaier, Brian A Turner, Ralph A Nixon, Ralph N Martins, Charles Ouimet, Jonathan D Smith, Peter Davies, Eugene Laska, Michelle E Ehrlich, Lary C Walker, Paul M Mathews, Sam Gand. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287908. |
aging, gender and apoe isotype modulate metabolism of alzheimer's abeta peptides and f-isoprostanes in the absence of detectable amyloid deposits. |
2004-10-28 |
2023-08-12 |
mouse |
| Jun Yao, Suzana S Petanceska, Thomas J Montine, David M Holtzman, Stephen D Schmidt, Carolyn A Parker, Michael J Callahan, William J Lipinski, Charles L Bisgaier, Brian A Turner, Ralph A Nixon, Ralph N Martins, Charles Ouimet, Jonathan D Smith, Peter Davies, Eugene Laska, Michelle E Ehrlich, Lary C Walker, Paul M Mathews, Sam Gand. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287908. |
aging and apolipoprotein e (apoe) isoform are among the most consistent risks for the development of alzheimer's disease (ad). |
2004-10-28 |
2023-08-12 |
mouse |
| R M Evans, S Hui, A Perkins, D K Lahiri, J Poirier, M R Farlo. Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology. vol 62. issue 10. 2004-10-26. PMID:15159498. |
cholesterol and apoe genotype interact to influence alzheimer disease progression. |
2004-10-26 |
2023-08-12 |
Not clear |
| Suzanne E Wahrle, Hong Jiang, Maia Parsadanian, Justin Legleiter, Xianlin Han, John D Fryer, Tomasz Kowalewski, David M Holtzma. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. The Journal of biological chemistry. vol 279. issue 39. 2004-10-26. PMID:15269217. |
since apoe isoforms and levels strongly influence alzheimer's disease pathology and risk, these data suggest that abca1 may be a novel therapeutic target. |
2004-10-26 |
2023-08-12 |
mouse |
| F Licastro, M Chiappelli, L J Thal, E Maslia. alpha-1-Antichymotrypsin polymorphism in the gene promoter region affects survival and synapsis loss in Alzheimer's disease. Archives of gerontology and geriatrics. Supplement. issue 9. 2004-10-21. PMID:15207421. |
one-hundred-thirty-tree patients with neuropathologically confirmed alzheimer's disease (ad) were genotyped for the polymorphic regions in the apolipoprotein eepsilon (apoe)and a new polymorphism in the promoter region of the alpha-1-antichymotrypsin (act) gene. |
2004-10-21 |
2023-08-12 |
Not clear |
| David A Hosford, Eric H Lai, John H Riley, Chun-Fang Xu, Theodore M Danoff, Allen D Rose. Pharmacogenetics to predict drug-related adverse events. Toxicologic pathology. vol 32 Suppl 1. 2004-10-21. PMID:15209398. |
three studies exemplify the principles of using polymorphisms to identify associations in progressively larger genomic regions: polymorphic repeats within the udp-glucuronysltransferase i (ugt1a1) gene in patients experiencing hyperbilirubinemia after administration of tranilast, an experimental drug to prevent re-stenosis following coronary revascularization; high linkage disequilibrium within the apolipoprotein e (apoe) gene in patients with alzheimer disease (ad); and the polymorphic variant hla-b57 in patients with hypersensitivity reaction after administration of abacavir, a nucleoside reverse transcriptase inhibitor for the treatment of hiv. |
2004-10-21 |
2023-08-12 |
human |
| Francesco Panza, Alessia D'Introno, Anna M Colacicco, Cristiano Capurso, Anna M Basile, Sabrina Capurso, Antonio Capurso, Vincenzo Solfrizz. Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 126B. issue 1. 2004-10-19. PMID:15048651. |
the low density lipoprotein receptor-related protein 1 (lrp1 gene) is a candidate gene for alzheimer's disease (ad), because it is a ligand for proteins involved in ad pathogenesis, such as apolipoprotein e (apoe), alpha2-macroglobulin (a2m), amyloid precursor protein (app), and is located on chromosome 12, within a region linked with ad. |
2004-10-19 |
2023-08-12 |
Not clear |
| R C Klein, J L Yake. Inhibition of nicotinic acetylcholine receptors by apolipoprotein E-derived peptides in rat hippocampal slices. Neuroscience. vol 127. issue 3. 2004-10-18. PMID:15283956. |
apolipoprotein e (apoe) is a well-known genetic risk factor for alzheimer's disease (ad). |
2004-10-18 |
2023-08-12 |
rat |
| Benjamin Tycko, Joseph H Lee, Alejandra Ciappa, Anjana Saxena, Chi-Ming Li, Lin Feng, Alex Arriaga, Yaakov Stern, Rafael Lantigua, Neil Shachter, Richard Mayeu. APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals. Archives of neurology. vol 61. issue 9. 2004-10-07. PMID:15364690. |
apoe and apoc1 promoter polymorphisms and the risk of alzheimer disease in african american and caribbean hispanic individuals. |
2004-10-07 |
2023-08-12 |
Not clear |
| Benjamin Tycko, Joseph H Lee, Alejandra Ciappa, Anjana Saxena, Chi-Ming Li, Lin Feng, Alex Arriaga, Yaakov Stern, Rafael Lantigua, Neil Shachter, Richard Mayeu. APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals. Archives of neurology. vol 61. issue 9. 2004-10-07. PMID:15364690. |
the apoe epsilon4 allele is a genetic risk factor for alzheimer disease (ad), though the strength of the association varies by ethnic group. |
2004-10-07 |
2023-08-12 |
Not clear |