| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Tian, J Shi, K Bailey, C L Lendon, S M Pickering-Brown, D M A Man. Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 5. 2004-06-08. PMID:15090562. |
to investigate the association between white matter damage, as evidenced by myelin loss (ml), the extent of cerebral amyloid angiopathy (caa), or arteriosclerosis (art), and apolipoprotein e (apoe) e4 allele in alzheimer's disease (ad), in order to understand the causes of damage to white matter in ad and its contribution to the pathogenesis of the disorder. |
2004-06-08 |
2023-08-12 |
Not clear |
| Patrick G Kehoe, Hagit Katzov, Niels Andreasen, Maragaret Gatz, Gordon K Wilcock, Nigel J Cairns, Juni Palmgren, Ulf de Faire, Anthony J Brookes, Nancy L Pedersen, Kaj Blennow, Jonathan A Princ. Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease. Human genetics. vol 114. issue 5. 2004-06-04. PMID:14986105. |
an excellent example of this can be found for the epsilon4 allele of apoe in relation to alzheimer's disease (ad) for which association with both risk and age-at-onset (aao) is evident. |
2004-06-04 |
2023-08-12 |
human |
| Xuan Feng, Fernette F Eide, Hong Jiang, Anthony T Rede. Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity. Frontiers in bioscience : a journal and virtual library. vol 9. 2004-06-02. PMID:14977565. |
adeno-associated viral vector-mediated apoe expression in alzheimer's disease mice: low cns immune response, long-term expression, and astrocyte specificity. |
2004-06-02 |
2023-08-12 |
mouse |
| Xuan Feng, Fernette F Eide, Hong Jiang, Anthony T Rede. Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity. Frontiers in bioscience : a journal and virtual library. vol 9. 2004-06-02. PMID:14977565. |
to study the roles of human apolipoprotein e (apoe) alleles in the pathogenesis of alzheimer's disease and other cns diseases, we generated recombinant aav-apoe alleles driven by the gfap promoter and expressed them in the mouse brain of alzheimer's disease mouse. |
2004-06-02 |
2023-08-12 |
mouse |
| Walter J Brecht, Faith M Harris, Shengjun Chang, Ina Tesseur, Gui-Qiu Yu, Qin Xu, Jo Dee Fish, Tony Wyss-Coray, Manuel Buttini, Lennart Mucke, Robert W Mahley, Yadong Huan. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 10. 2004-05-28. PMID:15014128. |
apolipoprotein e (apoe) is found in amyloid plaques and neurofibrillary tangles (nfts) in alzheimer's disease (ad) brains, but its role in their pathogenesis is unclear. |
2004-05-28 |
2023-08-12 |
mouse |
| Guido Anello, Rosa-Maria Guéant-Rodríguez, Paolo Bosco, Jean-Louis Guéant, Antonino Romano, Bernard Namour, Rosario Spada, Filippo Caraci, Gregory Pourié, Jean-Luc Daval, Raffaele Ferr. Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease. Neuroreport. vol 15. issue 5. 2004-05-28. PMID:15073531. |
we evaluated the association of homocysteine with alzheimer's disease (ad) and the influence of related polymorphisms and apoe, in 180 cases and 181 controls from southern italy. |
2004-05-28 |
2023-08-12 |
Not clear |
| Katy A Chalmers, Doris Culpan, Patrick G Kehoe, Gordon K Wilcock, Anthony Hughes, Seth Lov. APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease. Neuroreport. vol 15. issue 1. 2004-05-27. PMID:15106838. |
apoe promoter, ace1 and cyp46 polymorphisms and beta-amyloid in alzheimer's disease. |
2004-05-27 |
2023-08-12 |
Not clear |
| Katy A Chalmers, Doris Culpan, Patrick G Kehoe, Gordon K Wilcock, Anthony Hughes, Seth Lov. APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease. Neuroreport. vol 15. issue 1. 2004-05-27. PMID:15106838. |
polymorphisms in the apoe promoter, ace1 and cyp46 genes have all been reported to be associated with alzheimer's disease (ad). |
2004-05-27 |
2023-08-12 |
Not clear |
| Ara S Khachaturian, Christopher D Corcoran, Lawrence S Mayer, Peter P Zandi, John C S Breitne. Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Archives of general psychiatry. vol 61. issue 5. 2004-05-25. PMID:15123497. |
the incidence of alzheimer disease (ad) increases strongly with age, but little is known about the cumulative incidence of ad over a lifetime of 100 years, or its relationship to the polymorphic apoe locus that encodes apolipoprotein e. apoe is a strong genetic risk factor for ad. |
2004-05-25 |
2023-08-12 |
Not clear |
| Yuko Saito, Kinuko Suzuki, Christine M Hulette, Shigeo Murayam. Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease. Journal of neuropathology and experimental neurology. vol 63. issue 4. 2004-05-12. PMID:15099022. |
in addition, in npc1 patients with apoe epsilon4 homozygosity, deposition of a beta occurs mimicking alzheimer disease (ad). |
2004-05-12 |
2023-08-12 |
human |
| M Boccardi, F Sabattoli, C Testa, A Beltramello, H Soininen, G B Frison. APOE and modulation of Alzheimer's and frontotemporal dementia. Neuroscience letters. vol 356. issue 3. 2004-05-10. PMID:15036621. |
apoe and modulation of alzheimer's and frontotemporal dementia. |
2004-05-10 |
2023-08-12 |
Not clear |
| M Boccardi, F Sabattoli, C Testa, A Beltramello, H Soininen, G B Frison. APOE and modulation of Alzheimer's and frontotemporal dementia. Neuroscience letters. vol 356. issue 3. 2004-05-10. PMID:15036621. |
to investigate the difference in the morphologic expression of frontotemporal dementia (ftd) and alzheimer's disease (ad) in patients carrying and not carrying the epsilon4 allele of apoe, mr images of 26 controls, 18 ad patients (11 carrying the epsilon4 allele, seven non-carriers), and eight ftd (two carriers, six non-carriers) were compared using voxel by voxel analysis. |
2004-05-10 |
2023-08-12 |
Not clear |
| Qiu-lan Ma, Jing-fang Yang, Ming Shao, Xiu-min Dong, Biao Che. [Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease]. Zhonghua yi xue za zhi. vol 83. issue 24. 2004-05-06. PMID:14720419. |
to assess the association between nad(p)h: quinone oxidoreductase 1 (nqo1) c609 t allele and apolipoprotein e (apoe) polymorphism and sporadic alzheimer disease (sad). |
2004-05-06 |
2023-08-12 |
Not clear |
| C Hesse, L Rosengren, E Vanmechelen, H Vanderstichele, C Jensen, P Davidsson, K Blenno. Cerebrospinal fluid markers for Alzheimer's disease evaluated after acute ischemic stroke. Journal of Alzheimer's disease : JAD. vol 2. issue 3-4. 2004-05-05. PMID:12214084. |
potential cerebrospinal fluid (csf) markers for alzheimer's disease (ad) include tau protein, the 42 amino-acid form of amyloid beta (amyloid beta(1-42)) and apolipoprotein e (apoe). |
2004-05-05 |
2023-08-12 |
Not clear |
| Kalpana Luthra, Manjari Tripathi, Rahul Grover, Manjari Dwivedi, Amit Kumar, A B De. Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 17. issue 3. 2004-05-03. PMID:14739533. |
the association of apolipoprotein e (apoe) gene polymorphism with alzheimer's disease (ad) has been reported in several populations including one from a rural community in north india. |
2004-05-03 |
2023-08-12 |
Not clear |
| Deng Chen, Jun-Wu Zhang, Zhen-Xin Zhang, Hua-Lu Zhao, Xiao-Qing Li, Ya-Ning Wu, Qiu-Ming Q. [Apolipoprotein E gene polymorphisms and Alzheimer disease]. Yi chuan xue bao = Acta genetica Sinica. vol 30. issue 12. 2004-04-22. PMID:14986436. |
pcr-rflp was used to investigate the distribution differences of apolipoprotein e (apoe) alleles and genotypes between sporadic alzheimer disease (ad) patients (n = 160) and healthy control individuals (n = 195) in chinese han population. |
2004-04-22 |
2023-08-12 |
human |
| Christos Ntais, Anastasia Polycarpou, John P A Ioannidi. Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review. American journal of epidemiology. vol 159. issue 6. 2004-04-09. PMID:15003956. |
the increased susceptibility to alzheimer's disease conferred by apoe*4 carriage tended to be more prominent in the presence of the t allele (random effects or = 6.07, 95% ci: 4.19, 8.79, and or = 4.09, 95% ci: 3.15, 5.31, in t carriers and noncarriers, respectively). |
2004-04-09 |
2023-08-12 |
human |
| Christos Ntais, Anastasia Polycarpou, John P A Ioannidi. Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review. American journal of epidemiology. vol 159. issue 6. 2004-04-09. PMID:15003956. |
the meta-analysis shows that the ctsd polymorphism is not a major risk factor for alzheimer's disease, although a small effect or an enhancement of the apoe*4 effect cannot be excluded. |
2004-04-09 |
2023-08-12 |
human |
| Jacob Rabe. Androgens, apoE, and Alzheimer's disease. Science of aging knowledge environment : SAGE KE. vol 2004. issue 11. 2004-04-09. PMID:15028864. |
androgens, apoe, and alzheimer's disease. |
2004-04-09 |
2023-08-12 |
human |
| Pamela Zambenedetti, GianLuca De Bellis, Ida Biunno, Massimo Musicco, Paolo Zatt. Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians. Journal of Alzheimer's disease : JAD. vol 5. issue 6. 2004-03-25. PMID:14757931. |
we have carried out a case-control study on the association between alzheimer's disease and transferrin c2 and apoe epsilon 4 alleles. |
2004-03-25 |
2023-08-12 |
human |