| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J G Dubelaar, R W H Verwer, M A Hofman, J J Van Heerikhuize, R Ravid, D E Swaa. ApoE epsilon4 genotype is accompanied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. Journal of neuropathology and experimental neurology. vol 63. issue 2. 2004-03-24. PMID:14989602. |
we previously found apolipoprotein (apoe) epsilon4-dependent lower metabolic activity in nucleus basalis of meynert (nbm) neurons in alzheimer disease (ad). |
2004-03-24 |
2023-08-12 |
human |
| L Mosconi, B Nacmias, S Sorbi, M T R De Cristofaro, M Fayazz, A Tedde, L Bracco, K Herholz, A Pup. Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 3. 2004-03-23. PMID:14966149. |
brain metabolic decreases related to the dose of the apoe e4 allele in alzheimer's disease. |
2004-03-23 |
2023-08-12 |
Not clear |
| Kohji Mori, Akiko Yokoyama, Lihua Yang, Limin Yang, Nobuji Maeda, Noriaki Mitsuda, Junya Tanak. L-serine-mediated release of apolipoprotein E and lipids from microglial cells. Experimental neurology. vol 185. issue 2. 2004-03-02. PMID:14736503. |
apolipoprotein e (apoe), one of the genetic risk factors for alzheimer's disease, is considered to have a critical role in transporting lipids in the brain. |
2004-03-02 |
2023-08-12 |
rat |
| Z Qiu, K A Crutcher, B T Hyman, G W Rebec. ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes. Neuroscience. vol 122. issue 2. 2004-03-01. PMID:14614897. |
apolipoprotein e (apoe) alters the pathophysiology of alzheimer's disease, but its mechanism is not fully understood. |
2004-03-01 |
2023-08-12 |
human |
| Douglas C Ewban. The APOE gene and differences in life expectancy in Europe. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 59. issue 1. 2004-02-26. PMID:14718482. |
common alleles of the apolipoprotein-e gene (apoe) are associated with different risks of ischemic heart disease, alzheimer's disease, and other chronic conditions in european populations. |
2004-02-26 |
2023-08-12 |
Not clear |
| Yu Liang, Suizhen Lin, Thomas P Beyer, Youyan Zhang, Xin Wu, Kelly R Bales, Ronald B DeMattos, Patrick C May, Shuyu Dan Li, Xian-Cheng Jiang, Patrick I Eacho, Guoqing Cao, Steven M Pau. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. Journal of neurochemistry. vol 88. issue 3. 2004-02-24. PMID:14720212. |
apoe is abundantly expressed in astrocytes in the brain and is closely linked to the pathogenesis of alzheimer's disease (ad). |
2004-02-24 |
2023-08-12 |
mouse |
| R John Davenpor. Plaque attack. Mice without ApoE and related protein unexpectedly accumulate beta-amyloid deposits. Science of aging knowledge environment : SAGE KE. vol 2004. issue 4. 2004-02-23. PMID:14749520. |
new work establishes that apoe, a protein connected to alzheimer's disease (ad), makes a similar choice. |
2004-02-23 |
2023-08-12 |
mouse |
| J-C Lambert, N Coyle, C Lendo. The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease. Journal of medical genetics. vol 41. issue 2. 2004-02-23. PMID:14757857. |
the epsilon4 allele of the apolipoprotein e (apoe) gene is a major genetic risk factor for alzheimer's disease but appears to be associated with greater risk in women than in men. |
2004-02-23 |
2023-08-12 |
Not clear |
| J-C Lambert, N Coyle, C Lendo. The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease. Journal of medical genetics. vol 41. issue 2. 2004-02-23. PMID:14757857. |
some studies suggest that the level of apoe may of its own modulate the risk for alzheimer's disease. |
2004-02-23 |
2023-08-12 |
Not clear |
| J-C Lambert, N Coyle, C Lendo. The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease. Journal of medical genetics. vol 41. issue 2. 2004-02-23. PMID:14757857. |
these findings suggest an interaction between oestrogen and apoe in the alzheimer's disease process. |
2004-02-23 |
2023-08-12 |
Not clear |
| M Baron, A Jimenez-Escrig, L Orensanz, J Simon, J Perez-Tu. Apolipoprotein E Pittsburgh variant is not associated with the risk of late-onset Alzheimer's disease in a Spanish population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 120B. issue 1. 2004-02-19. PMID:12815750. |
the objective of this study was to assess whether the apoe(pittsburgh) variant (apoe*4p) is associated to alzheimer's disease (ad) in a population from madrid (spain). |
2004-02-19 |
2023-08-12 |
human |
| Hamdi K Hamdi, Cristina Kenne. Age-related macular degeneration: a new viewpoint. Frontiers in bioscience : a journal and virtual library. vol 8. 2004-02-11. PMID:12700041. |
apoe is not specific to the retina, and has been more intriguingly associated with alzheimer's, another disease of age. |
2004-02-11 |
2023-08-12 |
human |
| Hamdi K Hamdi, Cristina Kenne. Age-related macular degeneration: a new viewpoint. Frontiers in bioscience : a journal and virtual library. vol 8. 2004-02-11. PMID:12700041. |
the apoe 4 allele and the ace alu+/+ genotype have both been shown to be a risk for alzheimer's and protective for amd. |
2004-02-11 |
2023-08-12 |
human |
| Franck Schürhoff, Marie-Odile Krebs, Andrei Szöke, Jean-Yves Loze, Céline Goldberger, Valérie Quignon, Jean Tignol, Frédéric Rouillon, Jean-Louis Laplanche, Marion Leboye. Apolipoprotein E in schizophrenia: a French association study and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 119B. issue 1. 2004-02-06. PMID:12707932. |
apolipoprotein e (apoe) gene variants are associated with alterations in brain function and an increased risk of alzheimer's disease (ad). |
2004-02-06 |
2023-08-12 |
Not clear |
| Gabriel Gold, Jean-Louis Blouin, François R Herrmann, Agnès Michon, Reinhild Mulligan, Geneviève Duriaux Saïl, Constantin Bouras, Panteleimon Giannakopoulos, Stylianos E Antonaraki. Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 119B. issue 1. 2004-02-06. PMID:12707937. |
specific bace1 genotypes provide additional risk for late-onset alzheimer disease in apoe epsilon 4 carriers. |
2004-02-06 |
2023-08-12 |
Not clear |
| Gabriel Gold, Jean-Louis Blouin, François R Herrmann, Agnès Michon, Reinhild Mulligan, Geneviève Duriaux Saïl, Constantin Bouras, Panteleimon Giannakopoulos, Stylianos E Antonaraki. Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 119B. issue 1. 2004-02-06. PMID:12707937. |
we conclude that sequence variation in the bace1 or bace 2 gene is not a significant risk factor for ad; however, a combination of a specific bace1 allele and apoe epsilon 4 may increase the risk for alzheimer disease over and above that attributed to apoe epsilon 4 alone. |
2004-02-06 |
2023-08-12 |
Not clear |
| Joseph F Pulliam, C Darrell Jennings, Richard J Kryscio, Daron G Davis, Dianne Wilson, Thomas J Montine, Frederick A Schmitt, William R Markesber. Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 119B. issue 1. 2004-02-06. PMID:12707938. |
association of hfe mutations with neurodegeneration and oxidative stress in alzheimer's disease and correlation with apoe. |
2004-02-06 |
2023-08-12 |
human |
| Patrick G Kehoe, Hagit Katzov, Lars Feuk, Anna M Bennet, Boo Johansson, Björn Wiman, Ulf de Faire, Nigel J Cairns, Gordon K Wilcock, Anthony J Brookes, Kaj Blennow, Jonathan A Princ. Haplotypes extending across ACE are associated with Alzheimer's disease. Human molecular genetics. vol 12. issue 8. 2004-01-23. PMID:12668609. |
numerous genes have been implicated in alzheimer's disease (ad), but, with the exception of a demonstrated association with the epsilon 4 allele of apoe, findings have not been consistently replicated across populations. |
2004-01-23 |
2023-08-12 |
Not clear |
| Noriko Tanaka, Toru Kinoshita, Takashi Asada, Yasuo Ohash. Log-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein E (apoE) gene in Alzheimer's disease. Journal of human genetics. vol 48. issue 10. 2004-01-23. PMID:14505229. |
log-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein e (apoe) gene in alzheimer's disease. |
2004-01-23 |
2023-08-12 |
human |
| D R S Souza, M R de Godoy, J Hotta, E H Tajara, A C Brandão, S Pinheiro Júnior, W A Tognola, J E dos Santo. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 7. 2004-01-20. PMID:12845379. |
a common polymorphism in the apolipoprotein e (apoe) gene is considered to be the major risk factor in families with sporadic and late-onset alzheimer's disease as well as in the general population. |
2004-01-20 |
2023-08-12 |
Not clear |