| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Fukuyama, T Mizuno, S Mori, K Yanagisawa, K Nakajima, S Fushik. Age-dependent decline in the apolipoprotein E level in cerebrospinal fluid from control subjects and its increase in cerebrospinal fluid from patients with Alzheimer's disease. European neurology. vol 43. issue 3. 2000-06-06. PMID:10765057. |
in order to address the significance of apolipoprotein e (apoe) in the pathogenesis as well as the clinical diagnosis of alzheimer's disease (ad), we measured its level in cerebrospinal fluid (csf) from randomly selected japanese control subjects at various ages (n = 36), which included 14 age-matched controls, and from ad patients including early-onset (n = 11, eoad) and late-onset (n = 14, load) cases. |
2000-06-06 |
2023-08-12 |
human |
| P Grammas, U Reimann-Philipp, P H Weige. Cerebrovasculature-mediated neuronal cell death. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818489. |
the presence of significant vascular disease in patients with alzheimer's disease (ad) and the recognition of the apoe genotype as a risk factor for both coronary disease and ad support an association between ad and vascular disease. |
2000-06-02 |
2023-08-12 |
human |
| J M Olichney, L A Hansen, J H Lee, C R Hofstetter, R Katzman, L J Tha. Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818499. |
in this brief review, we aim to describe the complex relationship between cerebral amyloid angiopathy (caa), apolipoprotein e (apoe), and cerebrovascular lesions in alzheimer's disease (ad). |
2000-06-02 |
2023-08-12 |
Not clear |
| M O McCarron, J A Nicol. Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818505. |
following the identification of the role of the apolipoprotein e (apoe) gene polymorphism in alzheimer's disease (ad), this gene was examined in cerebral amyloid angiopathy (caa). |
2000-06-02 |
2023-08-12 |
Not clear |
| M M Verbeek, W E Van Nostrand, I Otte-Höller, P Wesseling, R M De Waa. Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818507. |
the results of this study are in line with the observations that inheritance of the apoe epsilon 4 allele increases the risk of developing alzheimer's disease, and that the apoe epsilon 2 allele has a relatively protective effect. |
2000-06-02 |
2023-08-12 |
human |
| S Craft, S Asthana, G Schellenberg, L Baker, M Cherrier, A A Boyt, R N Martins, M Raskind, E Peskind, S Plymat. Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818510. |
higher fasting plasma insulin levels and reduced csf-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with alzheimer's disease (ad) who do not possess an apolipoprotein e (apoe)-epsilon 4 allele. |
2000-06-02 |
2023-08-12 |
human |
| I Alafuzoff, S Helisalmi, A Mannermaa, H Soinine. Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818513. |
our results demonstrate that apoe epsilon 4 allele, a known risk factor for dementia, indeed influences the extent of alzheimer's lesions seen in the brain tissue of demented patients and asymptomatic controls. |
2000-06-02 |
2023-08-12 |
Not clear |
| S H Han, S Y Chun. Marked hippocampal neuronal damage without motor deficits after mild concussive-like brain injury in apolipoprotein E-deficient mice. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818526. |
of various biological factors, only allele epsilon 4 of apolipoprotein e (apoe, protein; apoe4, gene) has been thus far suggested as a major determinant of genetic risk for sporadic and late-onset familial alzheimer's disease (ad). |
2000-06-02 |
2023-08-12 |
mouse |
| F van Leuve. Single and multiple transgenic mice as models for Alzheimer's disease. Progress in neurobiology. vol 61. issue 3. 2000-05-31. PMID:10727777. |
mice overexpressing human presenilin 1, apoe 4 and protein tau to generate "multiple" transgenic mice, offer additional potential to define the pathological interactions of these genetic factors, known to be involved, directly or indirectly, in dementia of the alzheimer type. |
2000-05-31 |
2023-08-12 |
mouse |
| H Sawada, F Udaka, Y Izumi, K Nishinaka, H Kawakami, S Nakamura, M Kameyam. Cerebral white matter lesions are not associated with apoE genotype but with age and female sex in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 68. issue 5. 2000-05-30. PMID:10766901. |
cerebral white matter lesions are not associated with apoe genotype but with age and female sex in alzheimer's disease. |
2000-05-30 |
2023-08-12 |
Not clear |
| H Sawada, F Udaka, Y Izumi, K Nishinaka, H Kawakami, S Nakamura, M Kameyam. Cerebral white matter lesions are not associated with apoE genotype but with age and female sex in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 68. issue 5. 2000-05-30. PMID:10766901. |
the association of apoe genotype, sex, age, and the presence of several vascular risk factors, with the presence of white matter lesions in 55 patients clinically diagnosed with alzheimer's disease was investigated. |
2000-05-30 |
2023-08-12 |
Not clear |
| H Sawada, F Udaka, Y Izumi, K Nishinaka, H Kawakami, S Nakamura, M Kameyam. Cerebral white matter lesions are not associated with apoE genotype but with age and female sex in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 68. issue 5. 2000-05-30. PMID:10766901. |
the apoe 4 genotype was strongly associated with alzheimer's disease (p=0.0001), but not associated with the presence or the degree of cerebral white matter lesions in alzheimer's disease (or=1.09, p>0.99). |
2000-05-30 |
2023-08-12 |
Not clear |
| D P Macfarlane, J A Nicoll, C Smith, D I Graha. APOE epsilon4 allele and amyloid beta-protein deposition in long term survivors of head injury. Neuroreport. vol 10. issue 18. 2000-05-23. PMID:10716238. |
head injury and apoe epsilon4 are risk factors for alzheimer's disease (ad). |
2000-05-23 |
2023-08-12 |
Not clear |
| K P Riley, D A Snowdon, A M Saunders, A D Roses, J A Mortimer, N Nanayakkar. Cognitive function and apolipoprotein E in very old adults: findings from the Nun Study. The journals of gerontology. Series B, Psychological sciences and social sciences. vol 55. issue 2. 2000-05-19. PMID:10794191. |
the epsilon4 allele of apolipoprotein e (apoe) has been associated with alzheimer' s disease and with milder forms of cognitive impairment. |
2000-05-19 |
2023-08-12 |
Not clear |
| G Tang, S Jiang, N Gu, T Jin, S Lin, Y Qian, D Wang, M Zhan. [The relation between alpha1-antichymotrypsin gene polymorphism and epsilon4 allele of apolipoprotein E gene in Alzheimer disease in Chinese]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 16. issue 2. 2000-05-18. PMID:10194255. |
to detect the relation between alpha1-antichymotrpsin(aact)gene polymorphism and epsilon4 allele of apolipoprotein e (apoe) gene in alzheimer disease (ad) in chinese. |
2000-05-18 |
2023-08-12 |
Not clear |
| J C Dodart, C Mathis, K R Bales, S M Paul, A Ungere. Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene. Neuroreport. vol 11. issue 3. 2000-05-18. PMID:10718322. |
both the beta-amyloid precursor protein (app) and the apoliprotein e (apoe) genes are involved in the pathogenesis of alzheimer's disease (ad). |
2000-05-18 |
2023-08-12 |
mouse |
| K W Kim, J H Jhoo, K U Lee, D Y Lee, J H Lee, J Y Youn, B J Lee, S H Han, J I Wo. No association between alpha-1-antichymotrypsin polymorphism and Alzheimer's disease in Koreans. American journal of medical genetics. vol 91. issue 5. 2000-05-12. PMID:10766998. |
to examine the possible involvement of the alpha-1-antichymotrypsin gene (act) polymorphism in the manifestation of alzheimer's disease (ad), we analyzed genotypes of the act and apolipoprotein e gene (apoe) among 110 korean patients with probable ad and 209 nondemented controls. |
2000-05-12 |
2023-08-12 |
human |
| J A Nicoll, R E Mrak, D I Graham, J Stewart, G Wilcock, S MacGowan, M M Esiri, L S Murray, D Dewar, S Love, T Moss, W S Griffi. Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Annals of neurology. vol 47. issue 3. 2000-05-08. PMID:10716257. |
we found the il-1a 2,2 genotype in 12.9% of 232 neuropathologically confirmed alzheimer's disease patients and 6.6% of 167 controls from four centers in the united kingdom and united states (odds ratio, 3.0; controlled for age and for apoe [apolipoprotein e] genotype). |
2000-05-08 |
2023-08-12 |
Not clear |
| H Hamanaka, Y Katoh-Fukui, K Suzuki, M Kobayashi, R Suzuki, Y Motegi, Y Nakahara, A Takeshita, M Kawai, K Ishiguro, M Yokoyama, S C Fujit. Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Human molecular genetics. vol 9. issue 3. 2000-05-04. PMID:10655544. |
thevarepsilon4 allele of apolipoprotein e (apoe) is associated with an increased risk of developing alzheimer's disease (ad). |
2000-05-04 |
2023-08-12 |
mouse |
| M Bonarek, P Barberger-Gateau, L Letenneur, V Deschamps, A Iron, B Dubroca, J F Dartigue. Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study. Neuroepidemiology. vol 19. issue 3. 2000-05-04. PMID:10705232. |
elevated high-density lipoprotein cholesterol was associated with a significantly decreased risk of dementia, independent of apoe status and other potential confounding variables, suggesting that cholesterol fractions could be involved in both alzheimer's disease and vascular dementia. |
2000-05-04 |
2023-08-12 |
human |