| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Hamanaka, Y Katoh-Fukui, K Suzuki, M Kobayashi, R Suzuki, Y Motegi, Y Nakahara, A Takeshita, M Kawai, K Ishiguro, M Yokoyama, S C Fujit. Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Human molecular genetics. vol 9. issue 3. 2000-05-04. PMID:10655544. |
thevarepsilon4 allele of apolipoprotein e (apoe) is associated with an increased risk of developing alzheimer's disease (ad). |
2000-05-04 |
2023-08-12 |
mouse |
| M Bonarek, P Barberger-Gateau, L Letenneur, V Deschamps, A Iron, B Dubroca, J F Dartigue. Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study. Neuroepidemiology. vol 19. issue 3. 2000-05-04. PMID:10705232. |
elevated high-density lipoprotein cholesterol was associated with a significantly decreased risk of dementia, independent of apoe status and other potential confounding variables, suggesting that cholesterol fractions could be involved in both alzheimer's disease and vascular dementia. |
2000-05-04 |
2023-08-12 |
human |
| Apolipoprotein E epsilon 4 allele (APOE epsilon 4) and Alzheimer's disease: role of genetic testing for diagnosis and risk assessment. Tecnologica. MAP supplement. Blue Cross and Blue Shield Association. Medical Advisory Panel. 2000-05-04. PMID:10848162. |
apolipoprotein e epsilon 4 allele (apoe epsilon 4) and alzheimer's disease: role of genetic testing for diagnosis and risk assessment. |
2000-05-04 |
2023-08-12 |
Not clear |
| D M Holtzman, K R Bales, T Tenkova, A M Fagan, M Parsadanian, L J Sartorius, B Mackey, J Olney, D McKeel, D Wozniak, S M Pau. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10694577. |
apolipoprotein e (apoe) alleles determine the age-adjusted relative risk (epsilon4 > epsilon3) for alzheimer's disease (ad). |
2000-04-25 |
2023-08-12 |
mouse |
| W K Scott, J M Grubber, P M Conneally, G W Small, C M Hulette, C K Rosenberg, A M Saunders, A D Roses, J L Haines, M A Pericak-Vanc. Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. American journal of human genetics. vol 66. issue 3. 2000-04-20. PMID:10712207. |
apolipoprotein e (apoe) is the only confirmed susceptibility gene for late-onset alzheimer disease (ad). |
2000-04-20 |
2023-08-12 |
Not clear |
| R M Corbo, R Scacch. Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele? Annals of human genetics. vol 63. issue Pt 4. 2000-04-18. PMID:10738542. |
in particular, the apoe*4 allele is a risk factor for susceptibility to coronary artery disease (cad) and alzheimer's disease (ad). |
2000-04-18 |
2023-08-12 |
human |
| W K Scott, L H Yamaoka, M P Bass, P C Gaskell, P M Conneally, G W Small, L A Farrer, S A Auerbach, A M Saunders, A D Roses, J L Haines, M A Pericak-Vanc. No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. Neurogenetics. vol 1. issue 3. 2000-04-13. PMID:10737120. |
the low-density lipoprotein receptor-related protein gene (lrp1) is often mentioned as a candidate gene for alzheimer disease (ad) because of its role as a receptor for apolipoprotein e (apoe), a major genetic risk factor for late-onset familial and sporadic ad. |
2000-04-13 |
2023-08-12 |
Not clear |
| T Siddique, M A Pericak-Vance, J Caliendo, S T Hong, W Y Hung, J Kaplan, D McKenna-Yasek, J B Rimmler, P Sapp, A M Saunders, W K Scott, N Siddique, J L Haines, R H Brow. Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis. Neurogenetics. vol 1. issue 3. 2000-04-13. PMID:10737125. |
the apolipoprotein e (apoe) gene is a known genetic risk factor for alzheimer disease (ad), another neuro-degenerative disease. |
2000-04-13 |
2023-08-12 |
human |
| M B Graeber, S Kösel, E Grasbon-Frodl, H J Möller, P Mehraei. Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. Neurogenetics. vol 1. issue 3. 2000-04-13. PMID:10737127. |
histopathology and apoe genotype of the first alzheimer disease patient, auguste d. alois alzheimer published two papers on the disease which was named after him by emil kraepelin in 1910. |
2000-04-13 |
2023-08-12 |
Not clear |
| M B Graeber, S Kösel, E Grasbon-Frodl, H J Möller, P Mehraei. Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D. Neurogenetics. vol 1. issue 3. 2000-04-13. PMID:10737127. |
here, we describe the histopathology and apoe genotype of alois alzheimer's first patient, auguste d. as in the case of johann f., a large number of tissue sections belonging to alzheimer's laboratory, which was later headed by spielmeyer, were found among material kept at the institute of neuropathology of the university of munich. |
2000-04-13 |
2023-08-12 |
Not clear |
| S Craft, S Asthana, G Schellenberg, M Cherrier, L D Baker, J Newcomer, S Plymate, S Latendresse, A Petrova, M Raskind, E Peskind, C Lofgreen, K Grimwoo. Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology. vol 70. issue 2. 2000-04-11. PMID:10461029. |
higher fasting plasma insulin levels and reduced csf-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with alzheimer's disease (ad) who do not possess an apolipoprotein e (apoe)-epsilon4 allele. |
2000-04-11 |
2023-08-12 |
human |
| E R Martin, J R Gilbert, E H Lai, J Riley, A R Rogala, B D Slotterbeck, C A Sipe, J M Grubber, L L Warren, P M Conneally, A M Saunders, D E Schmechel, I Purvis, M A Pericak-Vance, A D Roses, J M Vanc. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics. vol 63. issue 1. 2000-04-11. PMID:10662539. |
to begin to examine the practical issues surrounding this methodology, we identified 10 snps in the region immediately surrounding the apolipoprotein e locus (apoe), an established susceptibility gene for alzheimer disease. |
2000-04-11 |
2023-08-12 |
Not clear |
| A D Rose. A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease. Neurogenetics. vol 1. issue 1. 2000-04-11. PMID:10735268. |
apolipoprotein e (apoe) polymorphisms are associated with variable risk and age of onset distributions for the common form of alzheimer disease. |
2000-04-11 |
2023-08-12 |
Not clear |
| W A Pedersen, S L Chan, M P Mattso. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737598. |
inheritance of the apolipoprotein e (apoe) epsilon4 allele increases the risk for alzheimer's disease and may also influence the pathogenesis of other neurodegenerative diseases such as amyotrophic lateral sclerosis (als). |
2000-04-11 |
2023-08-12 |
mouse |
| C Ramassamy, D Averill, U Beffert, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, A Schoofs, J Davignon, J Poirie. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain. Neurobiology of disease. vol 7. issue 1. 2000-03-29. PMID:10671320. |
the epsilon4 allele of the apolipoprotein e gene (apoe) is associated with sporadic and familial late-onset alzheimer's disease (ad). |
2000-03-29 |
2023-08-12 |
mouse |
| V Mooser, N Helbecque, J Miklossy, S M Marcovina, P Nicod, P Amouye. Interactions between apolipoprotein E and apolipoprotein(a) in patients with late-onset Alzheimer disease. Annals of internal medicine. vol 132. issue 7. 2000-03-29. PMID:10744589. |
apolipoprotein(a) [apo(a)], the distinctive, highly polymorphic glycoprotein of lipoprotein(a), shares a series of common features with apolipoprotein e (apoe), which is implicated in the development of alzheimer disease. |
2000-03-29 |
2023-08-12 |
Not clear |
| I Tesseur, J Van Dorpe, K Spittaels, C Van den Haute, D Moechars, F Van Leuve. Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. The American journal of pathology. vol 156. issue 3. 2000-03-23. PMID:10702411. |
epidemiological studies have established that the epsilon 4 allele of the apoe gene (apoe4) constitutes an important risk factor for alzheimer's disease and might influence the outcome of central nervous system injury. |
2000-03-23 |
2023-08-12 |
mouse |
| V N Trieu, F M Ucku. Apolipoprotein E and apolipoprotein D expression in a murine model of singlet oxygen-induced cerebral stroke. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679292. |
apolipoprotein e (apoe)-deficient mice exhibit neuronal abnormalities similar to those in alzheimer's disease and enhanced sensitivity to stroke-associated injuries. |
2000-03-22 |
2023-08-12 |
mouse |
| V N Trieu, F M Ucku. Apolipoprotein E and apolipoprotein D expression in a murine model of singlet oxygen-induced cerebral stroke. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679292. |
the insights gained from this study should facilitate the elucidation of the role of apoe in neurological disorders such as dementia with stroke and alzheimer's disease. |
2000-03-22 |
2023-08-12 |
mouse |
| M Schiefermeier, H Kollegger, C Madl, C Polli, W Oder, H Kühn, F Berr, P Ferenc. The impact of apolipoprotein E genotypes on age at onset of symptoms and phenotypic expression in Wilson's disease. Brain : a journal of neurology. vol 123 Pt 3. 2000-03-16. PMID:10686180. |
in neurological disorders, such as alzheimer's disease, temporal lobe epilepsy and cerebral trauma, the presence of the apolipoprotein e (apoe) allele epsilon4 is associated with an increased vulnerability of the brain to the effects of the disease, whereas the presence of the apoe genotype epsilon3/3 appears to provide moderate neuroprotection. |
2000-03-16 |
2023-08-12 |
human |