| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S C Fujita, K Sakuta, R Tsuchiya, H Hamanak. Apolipoprotein E is found in astrocytes but not in microglia in the normal mouse brain. Neuroscience research. vol 35. issue 2. 2000-01-21. PMID:10616916. |
apolipoprotein e (apoe) is a known risk factor for alzheimer's disease, but neither its roles in the pathogenesis nor its exact physiological functions in the brain is known. |
2000-01-21 |
2023-08-12 |
mouse |
| P M Bretsky, J G Buckwalter, T E Seeman, C A Miller, J Poirier, G D Schellenberg, C E Finch, V W Henderso. Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer disease and associated disorders. vol 13. issue 4. 2000-01-18. PMID:10609670. |
carriers of the apolipoprotein e (apoe) epsilon4 allele show significantly higher risk of alzheimer disease (ad). |
2000-01-18 |
2023-08-12 |
human |
| K Yamauchi, M Tozuka, T Nakabayashi, M Sugano, H Hidaka, Y Kondo, T Katsuyam. Higher avidity binding of apolipoprotein (E-AII) complex than of apolipoprotein E monomer to beta-amyloid. Journal of neuroscience research. vol 58. issue 2. 2000-01-12. PMID:10502286. |
apolipoprotein e (apoe) is believed to be closely involved in the pathogenesis of alzheimer's disease (ad) because of its ability to bind to beta-amyloid (abeta), the primary component of senile plaques. |
2000-01-12 |
2023-08-12 |
Not clear |
| C E Finch, R M Sapolsk. The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms. Neurobiology of aging. vol 20. issue 4. 2000-01-12. PMID:10604433. |
the evolution of alzheimer disease, the reproductive schedule, and apoe isoforms. |
2000-01-12 |
2023-08-12 |
human |
| C B Dobson, R F Itzhak. Herpes simplex virus type 1 and Alzheimer's disease. Neurobiology of aging. vol 20. issue 4. 2000-01-12. PMID:10604441. |
the present review describes 1) the search for hsv1 in human brain; 2) hsv1 infection of the peripheral nervous system; 3) hsv1 infection of the central nervous system; 4) how apoe genotype might influence hsv1 infection; 5) possible apoe genotype effect on viral latency and its reactivation; 6) interactions of viruses with lipoproteins, their components, and lipoprotein receptors; 7) the role of apoe in repair; 8) pathological processes in ad and their relationship to prior damage; and 9) implications for the prevention or treatment of alzheimer's disease. |
2000-01-12 |
2023-08-12 |
human |
| N Bon. The evolution of Alzheimer's disease and ApoE isoforms. Neurobiology of aging. vol 20. issue 4. 2000-01-12. PMID:10604440. |
the evolution of alzheimer's disease and apoe isoforms. |
2000-01-12 |
2023-08-12 |
Not clear |
| K Nishida, A J Quantock, A Dota, N H Choi-Miura, S Kinoshit. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies. The British journal of ophthalmology. vol 83. issue 10. 2000-01-11. PMID:10502582. |
apolipoprotein j (apoj) and apolipoprotein e (apoe) are thought to contribute to amyloid formation in patients with alzheimer's disease. |
2000-01-11 |
2023-08-12 |
Not clear |
| R Camicioli, J Kaye, H Payami, M J Ball, G Murdoc. Apolipoprotein E epsilon4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 10. issue 6. 2000-01-11. PMID:10559556. |
apolipoprotein e epsilon4 (apoe epsilon4) is associated with an earlier age at onset of alzheimer's (ad) and possibly parkinson's disease, suggesting a general role for apoe epsilon4 in neuronal plasticity. |
2000-01-11 |
2023-08-12 |
human |
| C Hesse, N Bogdanovic, P Davidsson, K Blenno. A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 10. issue 6. 2000-01-11. PMID:10559559. |
apoliprotein e (apoe) has been implicated in the pathogenesis of alzheimer's disease (ad). |
2000-01-11 |
2023-08-12 |
human |
| S G Schwab, M Bagli, A Papassotiropoulos, F Jessen, W Maier, M L Rao, R Heu. Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population. Dementia and geriatric cognitive disorders. vol 10. issue 6. 2000-01-11. PMID:10559561. |
the a allele of a common a-t polymorphism in the signal peptide of alpha(1)-antichymotrypsin gene (act) has been reported to contribute a two- to threefold increased risk to alzheimer's disease (ad) patients who carry the apolipoprotein e epsilon4 (apoe epsilon4) genotype. |
2000-01-11 |
2023-08-12 |
Not clear |
| B Teter, P T Xu, J R Gilbert, A D Roses, D Galasko, G M Col. Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture. Journal of neurochemistry. vol 73. issue 6. 1999-12-27. PMID:10582625. |
the apolipoprotein e (apoe) epsilon4 allele is a major risk factor for neurodegenerative conditions, including alzheimer's disease. |
1999-12-27 |
2023-08-12 |
mouse |
| B Teter, P T Xu, J R Gilbert, A D Roses, D Galasko, G M Col. Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture. Journal of neurochemistry. vol 73. issue 6. 1999-12-27. PMID:10582625. |
these data indicate that apoe isoform-specific effects on neuroregeneration may contribute to its genetic risk for alzheimer's disease. |
1999-12-27 |
2023-08-12 |
mouse |
| M Mulder, D Terwe. Possible link between lipid metabolism and cerebral amyloid angiopathy in Alzheimer's disease: A role for high-density lipoproteins? Haemostasis. vol 28. issue 3-4. 1999-12-22. PMID:10420065. |
although apolipoprotein e4 (apoe4) is a well-established risk factor for the development of alzheimer's disease (ad), it is unclear how apoe affects the progression of the disease. |
1999-12-22 |
2023-08-12 |
human |
| P de Knijff, C M van Duij. Role of APOE in dementia: A critical reappraisal. Haemostasis. vol 28. issue 3-4. 1999-12-22. PMID:10420066. |
the apolipoprotein e (apoe) gene is strongly associated to the risk of alzheimer's disease (ad). |
1999-12-22 |
2023-08-12 |
Not clear |
| D Tsuang, E B Larson, J Bowen, W McCormick, L Teri, D Nochlin, J B Leverenz, E R Peskind, A Lim, M A Raskind, M L Thompson, S S Mirra, M Gearing, G D Schellenberg, W Kukul. The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series. Archives of neurology. vol 56. issue 12. 1999-12-16. PMID:10593304. |
a recent collaborative study found that apolipoprotein e (apoe) genotype, in conjunction with the clinical diagnosis of alzheimer disease (ad), was useful in improving diagnostic specificity (correctly not diagnosing ad) relative to the clinical diagnosis alone. |
1999-12-16 |
2023-08-12 |
Not clear |
| G W Small, W K Scott, S Komo, L H Yamaoka, L A Farrer, S H Auerbach, A M Saunders, A D Roses, J L Haines, M A Pericak-Vanc. No association between the HLA-A2 allele and Alzheimer disease. Neurogenetics. vol 2. issue 3. 1999-12-10. PMID:10541592. |
the apolipoprotein e (apoe)-4 allele is a major risk factor for late-onset alzheimer disease (ad), but it does not account for all the genetic variation in late-onset ad; thus, other genetic markers must be examined. |
1999-12-10 |
2023-08-12 |
human |
| M Kanai, M Shizuka, K Urakami, E Matsubara, Y Harigaya, K Okamoto, M Shoj. Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease. Neuroscience letters. vol 267. issue 1. 1999-12-06. PMID:10400250. |
to examine the effect of apolipoprotein e (apoe) 4 on the progression of alzheimer's disease (ad), the clinical course of 33 ad patients (17 cases with apoe epsilon4 and 16 cases without apoe epsilon4) was evaluated with the mini-mental state examination (mmse) and cerebrospinal fluid (csf) biological markers. |
1999-12-06 |
2023-08-12 |
Not clear |
| G W Rebeck, B S Cheung, W B Growdon, A Deng, P Akuthota, J Locascio, S M Greenberg, B T Hyma. Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease. Neuroscience letters. vol 272. issue 3. 1999-12-02. PMID:10505604. |
several studies have demonstrated genetic associations between alzheimer's disease (ad) and polymorphisms in the promoter/enhancer regions of the apolipoprotein e (apoe) gene. |
1999-12-02 |
2023-08-12 |
Not clear |
| S Helisalmi, M Hiltunen, P Valonen, A Mannermaa, A M Koivisto, M Lehtovirta, M Ryynänen, H Soinine. Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals. Journal of neurology. vol 246. issue 9. 1999-12-02. PMID:10525981. |
promoter polymorphism (-491a/t) in the apoe gene of finnish alzheimer's disease patients and control individuals. |
1999-12-02 |
2023-08-12 |
Not clear |
| S Helisalmi, M Hiltunen, P Valonen, A Mannermaa, A M Koivisto, M Lehtovirta, M Ryynänen, H Soinine. Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals. Journal of neurology. vol 246. issue 9. 1999-12-02. PMID:10525981. |
apolipoprotein e (apoe) epsilon4 allele is a major risk factor for the development of alzheimer's disease (ad). |
1999-12-02 |
2023-08-12 |
Not clear |