| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D I Graham, K Horsburgh, J A Nicoll, G M Teasdal. Apolipoprotein E and the response of the brain to injury. Acta neurochirurgica. Supplement. vol 73. 1999-10-20. PMID:10494348. |
after the demonstration of an association between the apoe epsilon 4 and increased risk of subsequent development of both sporadic and late-onset form alzheimer's disease, recent studies have provided additional evidence for the possibility that apoe may play an isoform-specific role in determining both the initial response and the subsequent consequences to acute brain injury. |
1999-10-20 |
2023-08-12 |
Not clear |
| C Ramassamy, D Averill, U Beffert, S Bastianetto, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, J Davignon, R Quirion, J Poirie. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free radical biology & medicine. vol 27. issue 5-6. 1999-10-19. PMID:10490274. |
a great number of epidemiological studies have demonstrated that the frequency of the epsilon4 allele of the apolipoprotein e gene (apoe) is markedly higher in sporadic and in familial late onset alzheimer disease (ad). |
1999-10-19 |
2023-08-12 |
human |
| C Ramassamy, D Averill, U Beffert, S Bastianetto, L Theroux, S Lussier-Cacan, J S Cohn, Y Christen, J Davignon, R Quirion, J Poirie. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free radical biology & medicine. vol 27. issue 5-6. 1999-10-19. PMID:10490274. |
lpo levels were significantly elevated in tissues from alzheimer's cases which are homozygous for the epsilon4 allele of apoe, compared to ad epsilon3/epsilon3 cases and controls. |
1999-10-19 |
2023-08-12 |
human |
| L F Lue, Y M Kuo, A E Roher, L Brachova, Y Shen, L Sue, T Beach, J H Kurth, R E Rydel, J Roger. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487842. |
we have characterized amyloid beta peptide (abeta) concentration, abeta deposition, paired helical filament formation, cerebrovascular amyloid angiopathy, apolipoprotein e (apoe) allotype, and synaptophysin concentration in entorhinal cortex and superior frontal gyrus of normal elderly control (nd) patients, alzheimer's disease (ad) patients, and high pathology control (hpc) patients who meet pathological criteria for ad but show no synapse loss or overt antemortem symptoms of dementia. |
1999-10-07 |
2023-08-12 |
Not clear |
| T J Montine, W R Markesbery, W Zackert, S C Sanchez, L J Roberts, J D Morro. The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487843. |
the magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with apoe genotype in alzheimer's disease patients. |
1999-10-07 |
2023-08-12 |
Not clear |
| F Licastro, I L Campbell, C Kincaid, I Veinbergs, E Van Uden, E Rockenstein, M Mallory, J R Gilbert, E Maslia. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487844. |
a role for apoe in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in alzheimer's disease. |
1999-10-07 |
2023-08-12 |
mouse |
| F Licastro, I L Campbell, C Kincaid, I Veinbergs, E Van Uden, E Rockenstein, M Mallory, J R Gilbert, E Maslia. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487844. |
this study was designed to explore the possible functional relationships between apolipoprotein e (apoe) and the protease inhibitor alpha-1-antichymotrypsin in the aging mouse brain and in alzheimer's disease. |
1999-10-07 |
2023-08-12 |
mouse |
| F Licastro, S Pedrini, M Govoni, A Pession, C Ferri, G Annoni, V Casadei, F Veglia, S Bertolini, L M Grimald. Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease. Neuroscience letters. vol 270. issue 3. 1999-09-30. PMID:10462111. |
alzheimer disease (ad) patients with both sporadic and familial forms of ad and non-demented controls were genotyped for common polymorphisms in the signal peptide for alpha-1-antichymotrypsin (act) gene and in two different regions of apolipoprotein e (apoe) gene. |
1999-09-30 |
2023-08-12 |
human |
| J A Cauley, J M Zmuda, K Yaffe, L H Kuller, R E Ferrell, S R Wisniewski, S R Cumming. Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk--The Study of Osteoporotic Fractures. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 7. 1999-09-28. PMID:10404018. |
the apolipoprotein e*4 (apoe) allele, associated with alzheimer's disease, has also been associated with osteoporosis in hemodialysis patients. |
1999-09-28 |
2023-08-12 |
Not clear |
| L Terrisse, D Séguin, P Bertrand, J Poirier, R Milne, E Rassar. Modulation of apolipoprotein D and apolipoprotein E expression in rat hippocampus after entorhinal cortex lesion. Brain research. Molecular brain research. vol 70. issue 1. 1999-09-21. PMID:10381540. |
a second apolipoprotein, apoe is known to play an important role in lipid transport, and apoe genetic polymorphism has been shown to be associated with susceptibility to alzheimer's disease. |
1999-09-21 |
2023-08-12 |
mouse |
| J C Breitner, B W Wyse, J C Anthony, K A Welsh-Bohmer, D C Steffens, M C Norton, J T Tschanz, B L Plassman, M R Meyer, I Skoog, A Khachaturia. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430421. |
to examine the prevalence of alzheimer's disease (ad) and other dementias in relation to age, education, sex, and genotype at apoe. |
1999-09-21 |
2023-08-12 |
Not clear |
| F Lai, E Kammann, G W Rebeck, A Anderson, Y Chen, R A Nixo. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430422. |
apoe genotype and gender effects on alzheimer disease in 100 adults with down syndrome. |
1999-09-21 |
2023-08-12 |
Not clear |
| Y Zhou, A Cheshire, L A Howell, D H Ryan, R B Harri. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain research bulletin. vol 49. issue 3. 1999-09-20. PMID:10435780. |
progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with alzheimer's disease and in mice lacking apolipoprotein e (apoe). |
1999-09-20 |
2023-08-12 |
mouse |
| T J Montine, K S Montine, S J Olson, D G Graham, L J Roberts, J D Morrow, M F Linton, S Fazio, L L Swif. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Experimental neurology. vol 158. issue 1. 1999-09-09. PMID:10448437. |
aged homozygous apolipoprotein e gene-deficient (apoe -/-) mice have been proposed as an experimental model for the role of human apoe isoforms in alzheimer's disease (ad). |
1999-09-09 |
2023-08-12 |
mouse |
| A J Slooter, J J Houwing-Duistermaat, F van Harskamp, M Cruts, C Van Broeckhoven, M M Breteler, A Hofman, T Stijnen, C M van Duij. Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study. Journal of neurology. vol 246. issue 4. 1999-09-08. PMID:10367700. |
the apoe*4 allele of the apolipoprotein e gene increases the risk of alzheimer's disease (ad), but whether it also affects the course of the disease is controversial. |
1999-09-08 |
2023-08-12 |
Not clear |
| X Wei, Y Zhang, J Zho. Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse. Neuroscience letters. vol 268. issue 3. 1999-09-01. PMID:10406024. |
the levels of alzheimer's disease (ad)-related genes, including beta-amyloid precursor protein(app), presenilin-1 (ps-1), ps-2, apoe, tau, c-fos, neural cell adhesion molecular 180 (ncam-180), tgf-beta 1, il-1 alpha/beta, il-6, tnf-alpha/beta, alpha-2-macroglobulin (alpha 2m), class ii major histocompatibility antigen la (mhcii la), bcl-2 alpha, glucocorticoid receptor-alpha (gr alpha) and mineralocorticoid receptor (mr) mrnas were determined by reverse transcription polymerase chain reaction (rt-pcr) in the hippocampus and cerebral cortex of senescence accelerated mouse (sam). |
1999-09-01 |
2023-08-12 |
mouse |
| M Tolar, J N Keller, S Chan, M P Mattson, M A Marques, K A Crutche. Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436064. |
such findings strengthen the hypothesis that apoe plays a direct role in the pathology of alzheimer's disease. |
1999-09-01 |
2023-08-12 |
rat |
| M W Bondi, D P Salmon, D Galasko, R G Thomas, L J Tha. Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology and aging. vol 14. issue 2. 1999-08-26. PMID:10403716. |
significantly more apoe-epsilon4 participants developed probable or questionable alzheimer's disease (ad) compared with non-epsilon4 participants, suggesting that the group differences resulted from a preponderance of preclinical ad cases within the epsilon4 group and not from a direct influence of apoe genotype on cognition. |
1999-08-26 |
2023-08-12 |
human |
| P K Panegyres, C D Mamotte, S D Vasikaran, S Wilton, V Fabian, B A Kakula. Butyrycholinesterase K variant and Alzheimer's disease. Journal of neurology. vol 246. issue 5. 1999-08-24. PMID:10399868. |
when related to apoe epsilon4 typing the association was specific but not sensitive for the diagnosis of alzheimer's disease. |
1999-08-24 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
to confirm a synergistic effect between the polymorphic k variant of the butyrylcholinesterase (bche-k) gene and the epsilon4 allele of the apolipoprotein e (apoe) gene in alzheimer's disease, the frequency of the bche-k allele was re-examined in a large series of japanese patients with alzheimer's disease and controls. |
1999-08-19 |
2023-08-12 |
Not clear |