| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L F Lue, Y M Kuo, A E Roher, L Brachova, Y Shen, L Sue, T Beach, J H Kurth, R E Rydel, J Roger. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487842. |
we have characterized amyloid beta peptide (abeta) concentration, abeta deposition, paired helical filament formation, cerebrovascular amyloid angiopathy, apolipoprotein e (apoe) allotype, and synaptophysin concentration in entorhinal cortex and superior frontal gyrus of normal elderly control (nd) patients, alzheimer's disease (ad) patients, and high pathology control (hpc) patients who meet pathological criteria for ad but show no synapse loss or overt antemortem symptoms of dementia. |
1999-10-07 |
2023-08-12 |
Not clear |
| T J Montine, W R Markesbery, W Zackert, S C Sanchez, L J Roberts, J D Morro. The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487843. |
the magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with apoe genotype in alzheimer's disease patients. |
1999-10-07 |
2023-08-12 |
Not clear |
| F Licastro, I L Campbell, C Kincaid, I Veinbergs, E Van Uden, E Rockenstein, M Mallory, J R Gilbert, E Maslia. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487844. |
a role for apoe in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in alzheimer's disease. |
1999-10-07 |
2023-08-12 |
mouse |
| F Licastro, I L Campbell, C Kincaid, I Veinbergs, E Van Uden, E Rockenstein, M Mallory, J R Gilbert, E Maslia. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487844. |
this study was designed to explore the possible functional relationships between apolipoprotein e (apoe) and the protease inhibitor alpha-1-antichymotrypsin in the aging mouse brain and in alzheimer's disease. |
1999-10-07 |
2023-08-12 |
mouse |
| F Licastro, S Pedrini, M Govoni, A Pession, C Ferri, G Annoni, V Casadei, F Veglia, S Bertolini, L M Grimald. Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease. Neuroscience letters. vol 270. issue 3. 1999-09-30. PMID:10462111. |
alzheimer disease (ad) patients with both sporadic and familial forms of ad and non-demented controls were genotyped for common polymorphisms in the signal peptide for alpha-1-antichymotrypsin (act) gene and in two different regions of apolipoprotein e (apoe) gene. |
1999-09-30 |
2023-08-12 |
human |
| J A Cauley, J M Zmuda, K Yaffe, L H Kuller, R E Ferrell, S R Wisniewski, S R Cumming. Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk--The Study of Osteoporotic Fractures. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 7. 1999-09-28. PMID:10404018. |
the apolipoprotein e*4 (apoe) allele, associated with alzheimer's disease, has also been associated with osteoporosis in hemodialysis patients. |
1999-09-28 |
2023-08-12 |
Not clear |
| L Terrisse, D Séguin, P Bertrand, J Poirier, R Milne, E Rassar. Modulation of apolipoprotein D and apolipoprotein E expression in rat hippocampus after entorhinal cortex lesion. Brain research. Molecular brain research. vol 70. issue 1. 1999-09-21. PMID:10381540. |
a second apolipoprotein, apoe is known to play an important role in lipid transport, and apoe genetic polymorphism has been shown to be associated with susceptibility to alzheimer's disease. |
1999-09-21 |
2023-08-12 |
mouse |
| J C Breitner, B W Wyse, J C Anthony, K A Welsh-Bohmer, D C Steffens, M C Norton, J T Tschanz, B L Plassman, M R Meyer, I Skoog, A Khachaturia. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430421. |
to examine the prevalence of alzheimer's disease (ad) and other dementias in relation to age, education, sex, and genotype at apoe. |
1999-09-21 |
2023-08-12 |
Not clear |
| F Lai, E Kammann, G W Rebeck, A Anderson, Y Chen, R A Nixo. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430422. |
apoe genotype and gender effects on alzheimer disease in 100 adults with down syndrome. |
1999-09-21 |
2023-08-12 |
Not clear |
| Y Zhou, A Cheshire, L A Howell, D H Ryan, R B Harri. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain research bulletin. vol 49. issue 3. 1999-09-20. PMID:10435780. |
progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with alzheimer's disease and in mice lacking apolipoprotein e (apoe). |
1999-09-20 |
2023-08-12 |
mouse |
| T J Montine, K S Montine, S J Olson, D G Graham, L J Roberts, J D Morrow, M F Linton, S Fazio, L L Swif. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Experimental neurology. vol 158. issue 1. 1999-09-09. PMID:10448437. |
aged homozygous apolipoprotein e gene-deficient (apoe -/-) mice have been proposed as an experimental model for the role of human apoe isoforms in alzheimer's disease (ad). |
1999-09-09 |
2023-08-12 |
mouse |
| A J Slooter, J J Houwing-Duistermaat, F van Harskamp, M Cruts, C Van Broeckhoven, M M Breteler, A Hofman, T Stijnen, C M van Duij. Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study. Journal of neurology. vol 246. issue 4. 1999-09-08. PMID:10367700. |
the apoe*4 allele of the apolipoprotein e gene increases the risk of alzheimer's disease (ad), but whether it also affects the course of the disease is controversial. |
1999-09-08 |
2023-08-12 |
Not clear |
| X Wei, Y Zhang, J Zho. Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse. Neuroscience letters. vol 268. issue 3. 1999-09-01. PMID:10406024. |
the levels of alzheimer's disease (ad)-related genes, including beta-amyloid precursor protein(app), presenilin-1 (ps-1), ps-2, apoe, tau, c-fos, neural cell adhesion molecular 180 (ncam-180), tgf-beta 1, il-1 alpha/beta, il-6, tnf-alpha/beta, alpha-2-macroglobulin (alpha 2m), class ii major histocompatibility antigen la (mhcii la), bcl-2 alpha, glucocorticoid receptor-alpha (gr alpha) and mineralocorticoid receptor (mr) mrnas were determined by reverse transcription polymerase chain reaction (rt-pcr) in the hippocampus and cerebral cortex of senescence accelerated mouse (sam). |
1999-09-01 |
2023-08-12 |
mouse |
| M Tolar, J N Keller, S Chan, M P Mattson, M A Marques, K A Crutche. Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436064. |
such findings strengthen the hypothesis that apoe plays a direct role in the pathology of alzheimer's disease. |
1999-09-01 |
2023-08-12 |
rat |
| M W Bondi, D P Salmon, D Galasko, R G Thomas, L J Tha. Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology and aging. vol 14. issue 2. 1999-08-26. PMID:10403716. |
significantly more apoe-epsilon4 participants developed probable or questionable alzheimer's disease (ad) compared with non-epsilon4 participants, suggesting that the group differences resulted from a preponderance of preclinical ad cases within the epsilon4 group and not from a direct influence of apoe genotype on cognition. |
1999-08-26 |
2023-08-12 |
human |
| P K Panegyres, C D Mamotte, S D Vasikaran, S Wilton, V Fabian, B A Kakula. Butyrycholinesterase K variant and Alzheimer's disease. Journal of neurology. vol 246. issue 5. 1999-08-24. PMID:10399868. |
when related to apoe epsilon4 typing the association was specific but not sensitive for the diagnosis of alzheimer's disease. |
1999-08-24 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
to confirm a synergistic effect between the polymorphic k variant of the butyrylcholinesterase (bche-k) gene and the epsilon4 allele of the apolipoprotein e (apoe) gene in alzheimer's disease, the frequency of the bche-k allele was re-examined in a large series of japanese patients with alzheimer's disease and controls. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
two hundred and three patients with alzheimer's disease and 288 age and sex matched controls were genotyped by polymerase chain reaction and restriction fragment length polymorphism for bche-k and apoe. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
the study failed to confirm the findings of a previous study which found a significantly higher incidence of bche-k in patients with alzheimer's disease with apoe epsilon4 allele than in controls. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
in the japanese population studied here, there was no association between bche-k and alzheimer's disease, nor an interaction between bche-k and apoe epsilon4 allele. |
1999-08-19 |
2023-08-12 |
Not clear |