| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Licastro, I L Campbell, C Kincaid, I Veinbergs, E Van Uden, E Rockenstein, M Mallory, J R Gilbert, E Maslia. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487844. |
a role for apoe in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in alzheimer's disease. |
1999-10-07 |
2023-08-12 |
mouse |
| F Licastro, I L Campbell, C Kincaid, I Veinbergs, E Van Uden, E Rockenstein, M Mallory, J R Gilbert, E Maslia. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487844. |
this study was designed to explore the possible functional relationships between apolipoprotein e (apoe) and the protease inhibitor alpha-1-antichymotrypsin in the aging mouse brain and in alzheimer's disease. |
1999-10-07 |
2023-08-12 |
mouse |
| F Licastro, S Pedrini, M Govoni, A Pession, C Ferri, G Annoni, V Casadei, F Veglia, S Bertolini, L M Grimald. Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease. Neuroscience letters. vol 270. issue 3. 1999-09-30. PMID:10462111. |
alzheimer disease (ad) patients with both sporadic and familial forms of ad and non-demented controls were genotyped for common polymorphisms in the signal peptide for alpha-1-antichymotrypsin (act) gene and in two different regions of apolipoprotein e (apoe) gene. |
1999-09-30 |
2023-08-12 |
human |
| J A Cauley, J M Zmuda, K Yaffe, L H Kuller, R E Ferrell, S R Wisniewski, S R Cumming. Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk--The Study of Osteoporotic Fractures. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 7. 1999-09-28. PMID:10404018. |
the apolipoprotein e*4 (apoe) allele, associated with alzheimer's disease, has also been associated with osteoporosis in hemodialysis patients. |
1999-09-28 |
2023-08-12 |
Not clear |
| L Terrisse, D Séguin, P Bertrand, J Poirier, R Milne, E Rassar. Modulation of apolipoprotein D and apolipoprotein E expression in rat hippocampus after entorhinal cortex lesion. Brain research. Molecular brain research. vol 70. issue 1. 1999-09-21. PMID:10381540. |
a second apolipoprotein, apoe is known to play an important role in lipid transport, and apoe genetic polymorphism has been shown to be associated with susceptibility to alzheimer's disease. |
1999-09-21 |
2023-08-12 |
mouse |
| J C Breitner, B W Wyse, J C Anthony, K A Welsh-Bohmer, D C Steffens, M C Norton, J T Tschanz, B L Plassman, M R Meyer, I Skoog, A Khachaturia. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430421. |
to examine the prevalence of alzheimer's disease (ad) and other dementias in relation to age, education, sex, and genotype at apoe. |
1999-09-21 |
2023-08-12 |
Not clear |
| F Lai, E Kammann, G W Rebeck, A Anderson, Y Chen, R A Nixo. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430422. |
apoe genotype and gender effects on alzheimer disease in 100 adults with down syndrome. |
1999-09-21 |
2023-08-12 |
Not clear |
| Y Zhou, A Cheshire, L A Howell, D H Ryan, R B Harri. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain research bulletin. vol 49. issue 3. 1999-09-20. PMID:10435780. |
progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with alzheimer's disease and in mice lacking apolipoprotein e (apoe). |
1999-09-20 |
2023-08-12 |
mouse |
| T J Montine, K S Montine, S J Olson, D G Graham, L J Roberts, J D Morrow, M F Linton, S Fazio, L L Swif. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Experimental neurology. vol 158. issue 1. 1999-09-09. PMID:10448437. |
aged homozygous apolipoprotein e gene-deficient (apoe -/-) mice have been proposed as an experimental model for the role of human apoe isoforms in alzheimer's disease (ad). |
1999-09-09 |
2023-08-12 |
mouse |
| A J Slooter, J J Houwing-Duistermaat, F van Harskamp, M Cruts, C Van Broeckhoven, M M Breteler, A Hofman, T Stijnen, C M van Duij. Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study. Journal of neurology. vol 246. issue 4. 1999-09-08. PMID:10367700. |
the apoe*4 allele of the apolipoprotein e gene increases the risk of alzheimer's disease (ad), but whether it also affects the course of the disease is controversial. |
1999-09-08 |
2023-08-12 |
Not clear |
| X Wei, Y Zhang, J Zho. Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse. Neuroscience letters. vol 268. issue 3. 1999-09-01. PMID:10406024. |
the levels of alzheimer's disease (ad)-related genes, including beta-amyloid precursor protein(app), presenilin-1 (ps-1), ps-2, apoe, tau, c-fos, neural cell adhesion molecular 180 (ncam-180), tgf-beta 1, il-1 alpha/beta, il-6, tnf-alpha/beta, alpha-2-macroglobulin (alpha 2m), class ii major histocompatibility antigen la (mhcii la), bcl-2 alpha, glucocorticoid receptor-alpha (gr alpha) and mineralocorticoid receptor (mr) mrnas were determined by reverse transcription polymerase chain reaction (rt-pcr) in the hippocampus and cerebral cortex of senescence accelerated mouse (sam). |
1999-09-01 |
2023-08-12 |
mouse |
| M Tolar, J N Keller, S Chan, M P Mattson, M A Marques, K A Crutche. Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436064. |
such findings strengthen the hypothesis that apoe plays a direct role in the pathology of alzheimer's disease. |
1999-09-01 |
2023-08-12 |
rat |
| M W Bondi, D P Salmon, D Galasko, R G Thomas, L J Tha. Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology and aging. vol 14. issue 2. 1999-08-26. PMID:10403716. |
significantly more apoe-epsilon4 participants developed probable or questionable alzheimer's disease (ad) compared with non-epsilon4 participants, suggesting that the group differences resulted from a preponderance of preclinical ad cases within the epsilon4 group and not from a direct influence of apoe genotype on cognition. |
1999-08-26 |
2023-08-12 |
human |
| P K Panegyres, C D Mamotte, S D Vasikaran, S Wilton, V Fabian, B A Kakula. Butyrycholinesterase K variant and Alzheimer's disease. Journal of neurology. vol 246. issue 5. 1999-08-24. PMID:10399868. |
when related to apoe epsilon4 typing the association was specific but not sensitive for the diagnosis of alzheimer's disease. |
1999-08-24 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
to confirm a synergistic effect between the polymorphic k variant of the butyrylcholinesterase (bche-k) gene and the epsilon4 allele of the apolipoprotein e (apoe) gene in alzheimer's disease, the frequency of the bche-k allele was re-examined in a large series of japanese patients with alzheimer's disease and controls. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
two hundred and three patients with alzheimer's disease and 288 age and sex matched controls were genotyped by polymerase chain reaction and restriction fragment length polymorphism for bche-k and apoe. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
the study failed to confirm the findings of a previous study which found a significantly higher incidence of bche-k in patients with alzheimer's disease with apoe epsilon4 allele than in controls. |
1999-08-19 |
2023-08-12 |
Not clear |
| Y Yamamoto, M Yasuda, E Mori, K Maed. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369830. |
in the japanese population studied here, there was no association between bche-k and alzheimer's disease, nor an interaction between bche-k and apoe epsilon4 allele. |
1999-08-19 |
2023-08-12 |
Not clear |
| D Praticò, J Rokach, R K Tangiral. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428071. |
differential expression of apoe isoforms has been linked to longevity and to the pathogenesis of alzheimer's disease. |
1999-08-13 |
2023-08-12 |
mouse |
| M F Weiner, G Vega, R C Risser, L S Honig, C M Cullum, D Crumpacker, R N Rosenber. Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimer's disease. Biological psychiatry. vol 45. issue 5. 1999-08-10. PMID:10088051. |
the epsilon 4 allele of apolipoprotein e (apoe epsilon 4) is associated with late-onset alzheimer's disease (ad), but its relationship to various aspects of ad has become increasingly unclear. |
1999-08-10 |
2023-08-12 |
Not clear |