| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Slooter, P de Knijff, A Hofman, M Cruts, M M Breteler, C Van Broeckhoven, L M Havekes, C M van Duij. Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study. Neuroscience letters. vol 248. issue 1. 1999-03-30. PMID:9665654. |
our population-based study suggests that the differences in serum apoe level between alzheimer patients and controls are mainly the result of differences in the distribution of the apoe genotype. |
1999-03-30 |
2023-08-12 |
Not clear |
| P G Kehoe, H Williams, P Holmans, G Wilcock, N J Cairns, J Neal, M J Owe. The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. Journal of medical genetics. vol 35. issue 12. 1999-03-22. PMID:9863603. |
previous work has shown an association between the k variant of the butyrylcholinesterase (bche) gene and alzheimer's disease (ad) in patients carrying the epsilon4 allele of apoe. |
1999-03-22 |
2023-08-12 |
Not clear |
| M Kuriyam. [Lipoproteins in clinical laboratory medicine]. Rinsho byori. The Japanese journal of clinical pathology. vol 46. issue 12. 1999-03-22. PMID:9916507. |
a highly significant association between apolipoprotein e (apoe) epsilone 4 allele and late-onset familial and sporadic alzheimer's disease (ad) was reported. |
1999-03-22 |
2023-08-12 |
Not clear |
| N Hirono, E Mori, M Yasuda, K Ishii, Y Ikejiri, T Imamura, T Shimomura, M Hashimoto, H Yamashita, M Sasak. Lack of association of apolipoprotein E epsilon4 allele dose with cerebral glucose metabolism in Alzheimer disease. Alzheimer disease and associated disorders. vol 12. issue 4. 1999-03-18. PMID:9876966. |
parietal cerebral glucose metabolism is reduced before substantial impairments appeared in subjects carrying the apolipoprotein e (apoe) epsilon4 allele, but the effect of the apoe epsilon4 allele on cerebral metabolism in alzheimer disease (ad) is still undetermined. |
1999-03-18 |
2023-08-12 |
human |
| N Helbecque, F Richard, D Cottel, E Neuman, D Guez, P Amouye. The very low density lipoprotein (VLDL) receptor is a genetic susceptibility factor for Alzheimer disease in a European Caucasian population. Alzheimer disease and associated disorders. vol 12. issue 4. 1999-03-18. PMID:9876967. |
the epsilon4 allele of the apolipoprotein e gene (apoe) constitutes a major genetic susceptibility factor for alzheimer disease (ad). |
1999-03-18 |
2023-08-12 |
human |
| K L Moulder, M Narita, L K Chang, G Bu, E M Johnso. Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide. Journal of neurochemistry. vol 72. issue 3. 1999-03-18. PMID:10037478. |
the apolipoprotein e (apoe)-derived peptide (141-155)2 has a neurotoxic effect, implying that apoe itself could be a source of toxicity in alzheimer's disease brain. |
1999-03-18 |
2023-08-12 |
Not clear |
| R A Lasser, R Dukoff, J Levy, R Levin, T Lehtimäki, P Seubert, T Sunderlan. Apolipoprotein E epsilon 4 allele in association with global cognitive performance and CSF markers in Alzheimer's disease. International journal of geriatric psychiatry. vol 13. issue 11. 1999-03-16. PMID:9850873. |
to better define the influence of apolipoprotein e (apoe) epsilon 4 genotype on the cognitive and biochemical features of alzheimer's disease (ad), cross-sectional analysis of global cognitive measures and cerebrospinal fluid studies gathered on ad subjects at a tertiary care facility between 1986 and 1997 was carried out. |
1999-03-16 |
2023-08-12 |
human |
| G Roks, M Cruts, M J Bullido, H Backhovens, M J Artiga, A Hofman, F Valdivieso, C Van Broeckhoven, C M Van Duij. The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease. Neuroscience letters. vol 258. issue 2. 1999-03-11. PMID:9875528. |
the -491 polymorphism in the promoter region of the apolipoprotein e gene (apoe) has been suggested to be associated with increased risk for alzheimer's disease (ad) independent of apoe status. |
1999-03-11 |
2023-08-12 |
Not clear |
| P Quiroga, C Calvo, C Albala, J Urquidi, J L Santos, H Pérez, G Klaasse. Apolipoprotein E polymorphism in elderly Chilean people with Alzheimer's disease. Neuroepidemiology. vol 18. issue 1. 1999-03-04. PMID:9831815. |
in the present study, apolipoprotein e (apoe) polymorphism genotypes have been compared in 95 patients with alzheimer's disease (ad) (mean age 80.7; 95% ci 79.2-82.2, range 66-97) and 187 healthy people (mean age 78.2; 95% ci 77.2-79.2, range 65-93). |
1999-03-04 |
2023-08-12 |
human |
| P T Xu, J R Gilbert, H L Qiu, J Ervin, T R Rothrock-Christian, C Hulette, D E Schmeche. Specific regional transcription of apolipoprotein E in human brain neurons. The American journal of pathology. vol 154. issue 2. 1999-03-04. PMID:10027417. |
to examine whether apoe might be synthesized by human neurons, we performed in situ hybridization on paraffin-embedded and frozen brain sections from three nondemented controls and five alzheimer's disease (ad) patients using digoxigenin-labeled antisense and sense crna probes to human apoe. |
1999-03-04 |
2023-08-12 |
mouse |
| L Baum, L Chen, H K Ng, Y S Chan, Y T Mak, J Woo, H F Chiu, C P Pan. Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese. Neuroscience letters. vol 247. issue 1. 1999-03-03. PMID:9637403. |
since apolipoprotein e4 (apoe4) is the major genetic risk for late onset alzheimer's disease (ad), proteins that interact with apoe might be involved in ad pathogenesis. |
1999-03-03 |
2023-08-12 |
human |
| K Axelman, H Basun, L Lannfel. Apolipoprotein E and alpha1-antichymotrypsin genotypes and age of onset of familial Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 10. issue 1. 1999-03-03. PMID:9844031. |
apolipoprotein e (apoe) and alpha1-antichymotrypsin (act) genotype and allele frequency distribution were investigated in 113 familial alzheimer's disease (ad) cases. |
1999-03-03 |
2023-08-12 |
Not clear |
| K Ikeda, H Akiyama, T Arai, T Oda, M Kato, E Iseki, K Kosaka, K Wakabayashi, H Takahash. Clinical aspects of 'senile dementia of the tangle type'-- a subset of dementia in the senium separable from late-onset Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 10. issue 1. 1999-03-03. PMID:9844032. |
this patient group was thought to be separable from those with alzheimer's disease based on the results of apoe allele analysis in addition to the substantial absence of amyloid beta deposits and has been designated as senile dementia of the tangle type (sdt). |
1999-03-03 |
2023-08-12 |
Not clear |
| A D Rose. Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg. Annals of the New York Academy of Sciences. vol 855. 1999-02-24. PMID:9929679. |
apolipoprotein e (apoe) is a true susceptibility polymorphism of the common form of alzheimer's disease (ad). |
1999-02-24 |
2023-08-12 |
mouse |
| C Murphy, A W Bacon, M W Bondi, D P Salmo. Apolipoprotein E status is associated with odor identification deficits in nondemented older persons. Annals of the New York Academy of Sciences. vol 855. 1999-02-24. PMID:9929680. |
persons who are either heterozygous or homozygous for the epsilon 4 allele of apolipoprotein e (apoe) have an increased risk of alzheimer's disease, although they show no dementia in the preclinical period. |
1999-02-24 |
2023-08-12 |
human |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
given the association between inheritance of the varepsilon4 allele of the apoe gene (apoe4) and increased susceptibility to alzheimer's disease, we tested the hypothesis that cerebrospinal fluid apolipoproteins may be influenced by apoe genotype and alzheimer's disease. |
1999-02-11 |
2023-08-12 |
human |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
lipoprotein fractions (d < 1.210 g/ml) were isolated from cerebrospinal fluid obtained from individuals with different apoe genotypes and with or without pathologically verified alzheimer's disease. |
1999-02-11 |
2023-08-12 |
human |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
the relative levels of apoe- and apoa-ii-containing apolipoproteins correlated with apoe genotype but were not altered by alzheimer's disease. |
1999-02-11 |
2023-08-12 |
human |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
in contrast to apoe, no apoa-ii immunoreactivity was observed with pathological structures in alzheimer's disease brain. |
1999-02-11 |
2023-08-12 |
human |
| K S Montine, C N Bassett, J J Ou, W R Markesbery, L L Swift, T J Montin. Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins. Journal of lipid research. vol 39. issue 12. 1999-02-11. PMID:9831633. |
these differences in cerebrospinal fluid apolipoproteins may influence lipoprotein trafficking and may be an element in the stratification of risk for alzheimer's disease with apoe genotype. |
1999-02-11 |
2023-08-12 |
human |