| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Juottonen, M Lehtovirta, S Helisalmi, P J Riekkinen, H Soinine. Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele. Journal of neurology, neurosurgery, and psychiatry. vol 65. issue 3. 1998-09-15. PMID:9728943. |
recent evidence indicates that the apolipoprotein e (apoe) epsilon4 allele is a risk factor for developing alzheimer's disease. |
1998-09-15 |
2023-08-12 |
Not clear |
| R Egensperger, S Kösel, U von Eitzen, M B Graebe. Microglial activation in Alzheimer disease: Association with APOE genotype. Brain pathology (Zurich, Switzerland). vol 8. issue 3. 1998-09-09. PMID:9669695. |
microglial activation in alzheimer disease: association with apoe genotype. |
1998-09-09 |
2023-08-12 |
Not clear |
| Y Forsell, H Basun, E H Corder, L Lannfelt, B Winbla. Psychotic symptoms and apolipoprotein E genotypes in an elderly population. Biological psychiatry. vol 44. issue 2. 1998-09-08. PMID:9646896. |
genetic variation in the apolipoprotein e (apoe) gene is reported to be associated with variation in the risk of alzheimer's dementia. |
1998-09-08 |
2023-08-12 |
Not clear |
| S D Styren, M I Kamboh, S T DeKosk. Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease. The Journal of comparative neurology. vol 396. issue 4. 1998-09-08. PMID:9651008. |
a variety of factors and processes have been implicated in the development and progression of the pathology of alzheimer's disease (ad), including amyloid fragment deposition, reactive gliosis, alpha-1-antichymotrypsin (act), and apolipoprotein e (apoe). |
1998-09-08 |
2023-08-12 |
human |
| T Pirttilä, K Koivisto, P D Mehta, K Reinikainen, K S Kim, O Kilkku, E Heinonen, H Soininen, P Riekkinen, H M Wisniewsk. Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease. Neuroscience letters. vol 249. issue 1. 1998-09-03. PMID:9672379. |
levels of soluble amyloid beta protein (sabeta), amyloid beta precursor protein (app) and apolipoprotein e (apoe) were examined in cerebrospinal fluid (csf) obtained twice, at baseline and after 3-year follow-up, from 25 patients with probable alzheimer's disease (ad). |
1998-09-03 |
2023-08-12 |
Not clear |
| M R Meyer, J T Tschanz, M C Norton, K A Welsh-Bohmer, D C Steffens, B W Wyse, J C Breitne. APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. Nature genetics. vol 19. issue 4. 1998-09-01. PMID:9697689. |
apoe genotype predicts when--not whether--one is predisposed to develop alzheimer disease. |
1998-09-01 |
2023-08-12 |
Not clear |
| O L Lopez, S Lopez-Pousa, M I Kamboh, R Adroer, R Oliva, M Lozano-Gallego, J T Becker, S T DeKosk. Apolipoprotein E polymorphism in Alzheimer's disease: a comparative study of two research populations from Spain and the United States. European neurology. vol 39. issue 4. 1998-08-27. PMID:9635474. |
we examined the distribution of the apolipoprotein e (apoe) polymorphism in two caucasian populations of alzheimer's disease (ad) patients referred to dementia clinics; one in gerona, spain (66 ad patients, 49 controls), and the other in pittsburgh, pa., usa (209 ad patients, 58 controls). |
1998-08-27 |
2023-08-12 |
Not clear |
| Y Sekijima, S Ikeda, T Tokuda, S Satoh, H Hidaka, E Hidaka, M Ishikawa, N Yanagisaw. Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down's syndrome. European neurology. vol 39. issue 4. 1998-08-27. PMID:9635475. |
we investigated the exact prevalence of dementia of alzheimer type (dat) and apolipoprotein e (apoe) phenotypes in 106 japanese down's syndrome (ds) patients. |
1998-08-27 |
2023-08-12 |
Not clear |
| Y Sekijima, S Ikeda, T Tokuda, S Satoh, H Hidaka, E Hidaka, M Ishikawa, N Yanagisaw. Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down's syndrome. European neurology. vol 39. issue 4. 1998-08-27. PMID:9635475. |
it is very likely that the apoe epsilon4 is a risk factor for dat even in ds patients with a genetic predisposition to alzheimer's disease. |
1998-08-27 |
2023-08-12 |
Not clear |
| N Brindle, Y Song, E Rogaeva, S Premkumar, G Levesque, G Yu, M Ikeda, M Nishimura, A Paterson, S Sorbi, R Duara, L Farrer, P St George-Hyslo. Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease. Human molecular genetics. vol 7. issue 5. 1998-08-26. PMID:9536099. |
the k-variant of butyrylcholinesterase (bche-k) recently has been reported to be associated with alzheimer disease (ad) in carriers of the epsilon4 allele of the apolipoprotein e (apoe) gene. |
1998-08-26 |
2023-08-12 |
Not clear |
| T J van der Cammen, C J Verschoor, C P van Loon, F van Harskamp, I de Koning, W J Schudel, A J Slooter, C Van Broeckhoven, C M van Duij. Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele. Journal of the American Geriatrics Society. vol 46. issue 8. 1998-08-26. PMID:9706883. |
risk of left ventricular dysfunction in patients with probable alzheimer's disease with apoe*4 allele. |
1998-08-26 |
2023-08-12 |
Not clear |
| T J van der Cammen, C J Verschoor, C P van Loon, F van Harskamp, I de Koning, W J Schudel, A J Slooter, C Van Broeckhoven, C M van Duij. Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele. Journal of the American Geriatrics Society. vol 46. issue 8. 1998-08-26. PMID:9706883. |
to examine the association between the apoe genotype and cardiovascular disease in alzheimer's disease (ad) patients. |
1998-08-26 |
2023-08-12 |
Not clear |
| W S Wu, P Holmans, F Wavrant-DeVrièze, S Shears, P Kehoe, R Crook, J Booth, N Williams, J Pérez-Tur, K Roehl, I Fenton, M C Chartier-Harlin, S Lovestone, J Williams, M Hutton, J Hardy, M J Owen, A Goat. Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA. vol 280. issue 7. 1998-08-26. PMID:9718053. |
the only genetic locus universally accepted to be important as a risk factor for late-onset alzheimer disease (ad) is the apolipoprotein e (apoe) locus on chromosome 19. |
1998-08-26 |
2023-08-12 |
Not clear |
| F Licastro, M Mallory, L A Hansen, E Maslia. Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype. Journal of neuroimmunology. vol 88. issue 1-2. 1998-08-24. PMID:9688331. |
increased levels of alpha-1-antichymotrypsin in brains of patients with alzheimer's disease correlate with activated astrocytes and are affected by apoe 4 genotype. |
1998-08-24 |
2023-08-12 |
Not clear |
| P De Sarno, R S Jop. Phosphoinositide hydrolysis activated by muscarinic or glutamatergic, but not adrenergic, receptors is impaired in ApoE-deficient mice and by hydrogen peroxide and peroxynitrite. Experimental neurology. vol 152. issue 1. 1998-08-17. PMID:9682019. |
these differential sensitivities to apoe and to oxidative stress may contribute to selective impairments in signaling activity in neurodegenerative conditions associated with apoe isoform-sensitivity or oxidative stress, such as alzheimer's disease. |
1998-08-17 |
2023-08-12 |
mouse |
| J Bratosiewicz-Zapart, I Kłoszewska, T Sobów, P P Libersk. Distribution of apolipoprotein E4 isoform in Alzheimer's disease in Poland. Archivum immunologiae et therapiae experimentalis. vol 45. issue 2-3. 1998-08-12. PMID:9597090. |
alzheimer's disease (ad) is the most common human progressive dementia linked, in its sporadic form, to a common polymorphism within a gene for apolipoprotein e (apoe) mapped to chromosome 19. |
1998-08-12 |
2023-08-12 |
human |
| A J Slooter, M Cruts, S Kalmijn, A Hofman, M M Breteler, C Van Broeckhoven, C M van Duij. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Archives of neurology. vol 55. issue 7. 1998-08-06. PMID:9678314. |
to provide risk estimates of dementia and alzheimer disease as a function of the apolipoprotein e (apoe) genotypes and to assess the proportion of dementia that is attributable to the apoe genotypes. |
1998-08-06 |
2023-08-12 |
Not clear |
| M J McNamara, T Gomez-Isla, B T Hyma. Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease. Archives of neurology. vol 55. issue 7. 1998-08-06. PMID:9678319. |
to examine the differential deposition of amyloid beta (abeta) peptide isoforms abeta40 and abeta42 in the alzheimer disease (ad) brain in relation to the apolipoprotein e (apoe) genotype. |
1998-08-06 |
2023-08-12 |
Not clear |
| K Czyzewski, A Pfeffer, M Barcikowsk. [Apolipoprotein E function in the nervous system]. Neurologia i neurochirurgia polska. vol 32. issue 1. 1998-08-04. PMID:9631384. |
in the nervous system apoe may also be involved in processes unrelated to lipid transport, the processes that were completely unsuspected until very recently and have led to the link between apoe and the neurodegenerative disorder--alzheimer's disease. |
1998-08-04 |
2023-08-12 |
human |
| C Masullo, A Daniele, D Seripa, V Filippini, C Gravina, G Carbone, G Gainotti, V M Fazi. Apolipoprotein E genotype in sporadic early- and late-onset Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 9. issue 3. 1998-07-31. PMID:9621997. |
the 84 isoform of apolipoprotein e (apoe) has been proposed as a risk factor for alzheimer's disease (ad), while the possible role of the epsilon2 allele in ad is controversial. |
1998-07-31 |
2023-08-12 |
Not clear |