| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P T Xu, D Schmechel, T Rothrock-Christian, D S Burkhart, H L Qiu, B Popko, P Sullivan, N Maeda, A M Saunders, A D Roses, J R Gilber. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiology of disease. vol 3. issue 3. 1997-10-23. PMID:8980023. |
apolipoprotein e (apoe) and its three major alleles (apoe2, e3, and e4) have been implicated in alzheimer's disease and other neurological disorders. |
1997-10-23 |
2023-08-12 |
mouse |
| S Helisalmi, A Mannermaa, M Lehtovirta, M Ryynänen, P Riekkinen, H Soinine. No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease. Neuroscience letters. vol 231. issue 1. 1997-10-23. PMID:9280167. |
apolipoprotein e (apoe) has been identified as a major susceptibility marker for alzheimer's disease (ad) and it has been proposed that a common polymorphism in the alpha1-antichymotrypsin (act) gene increases the risk of developing ad, when the combination of act/aa genotype and apoe epsilon4 allele segregate together. |
1997-10-23 |
2023-08-12 |
human |
| A L Svensson, U Warpman, E Hellström-Lindahl, N Bogdanovic, L Lannfelt, A Nordber. Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes. Neuroscience letters. vol 232. issue 1. 1997-10-23. PMID:9292886. |
the number of nicotinic and muscarinic receptors and choline acetyltransferase (chat) activity were investigated in the temporal cortex of patients with alzheimer's disease (ad) with different apolipoprotein e (apoe) genotypes. |
1997-10-23 |
2023-08-12 |
Not clear |
| M Higuchi, H Arai, T Nakagawa, S Higuchi, T Muramatsu, S Matsushita, Y Kosaka, M Itoh, H Sasak. Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and alpha1-antichymotrypsin type A allele in Alzheimer's disease. Neuroreport. vol 8. issue 12. 1997-10-23. PMID:9295092. |
twenty alzheimer's disease (ad) patients with defined apolipoprotein e (apoe), alpha1-antichymotrypsin (act) and presenilin-1 (ps-1) intronic genotypes were examined to quantify the regional cerebral metabolic rate of glucose (rcmrglc) using positron emission tomography (pet) and 18f-2-fluoro-2-deoxy-d-glucose (fdg). |
1997-10-23 |
2023-08-12 |
Not clear |
| T Yoshida, R Fukatsu, K Tsuzuki, Y Aizawa, Y Hayashi, N Sasaki, Y Takamaru, N Fujii, N Takahat. Amyloid precursor protein, A beta and amyloid-associated proteins involved in chloroquine retinopathy in rats--immunopathological studies. Brain research. vol 764. issue 1-2. 1997-10-23. PMID:9295226. |
to understand the retinal changes in alzheimer disease (ad) patients, pathological and immunocytochemical studies were performed on retinal cells in the chloroquine-treated rats at 0, 4, 8, 12, 16, 20, and 24 weeks after the initial injection, using anti-amyloid precursor protein (app), -amyloid beta protein (a beta), -apolipoprotein e (apoe), -ubiquitin, and -cathepsin d antibodies. |
1997-10-23 |
2023-08-12 |
rat |
| I Gozes, M Bachar, A Bardea, A Davidson, S Rubinraut, M Fridkin, E Gilad. Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: implications for early treatment of Alzheimer's disease. Journal of neurobiology. vol 33. issue 3. 1997-10-23. PMID:9298769. |
here, mice deficient in apolipoprotein e (apoe), a molecule associated with the etiology of alzheimer's disease, served as a model to investigate the developmental and protective effects of snv. |
1997-10-23 |
2023-08-12 |
mouse |
| I Gozes, M Bachar, A Bardea, A Davidson, S Rubinraut, M Fridkin, E Gilad. Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: implications for early treatment of Alzheimer's disease. Journal of neurobiology. vol 33. issue 3. 1997-10-23. PMID:9298769. |
as certain genotypes of apoe increase the probability of alzheimer's disease, early counseling and preventive treatments may now offer an important route for therapeutics design. |
1997-10-23 |
2023-08-12 |
mouse |
| X S Wang, E Gruenstei. Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide. Journal of cellular physiology. vol 173. issue 1. 1997-10-23. PMID:9326451. |
apolipoprotein e (apoe) and certain peptides derived from it have been shown to exert neurotoxic effects in vitro, and apoe has been linked to the etiology of alzheimer's disease. |
1997-10-23 |
2023-08-12 |
Not clear |
| P Johannsen, J K Jakobsen, A L Jørgense. [Apolipoprotein E genotypes in patients investigated for dementia]. Ugeskrift for laeger. vol 159. issue 38. 1997-10-21. PMID:9340872. |
certain genotypes of apolipoprotein e (apoe, locus apoe) are associated with an increased risk for development of alzheimer's disease. |
1997-10-21 |
2023-08-12 |
Not clear |
| R Anderson, G A Higgin. Absence of central cholinergic deficits in ApoE knockout mice. Psychopharmacology. vol 132. issue 2. 1997-10-20. PMID:9266610. |
apolipoproteine (apoe) genotype has recently been identified as a major risk factor for alzheimer's disease (ad) but the mechanism(s) by which apoe isoforms influence this disease remain unclear. |
1997-10-20 |
2023-08-12 |
mouse |
| K A Welsh-Bohmer, M Gearing, A M Saunders, A D Roses, S Mirr. Apolipoprotein E genotypes in a neuropathological series from the Consortium to Establish a Registry for Alzheimer's Disease. Annals of neurology. vol 42. issue 3. 1997-10-16. PMID:9307253. |
we evaluated the sensitivity, specificity, and predictive value of the apolipoprotein e (apoe) epsilon4 allele for the neuropathological diagnosis of alzheimer disease (ad) in a clinical series of well-characterized ad patients and controls followed longitudinally in the multicenter study of the consortium to establish a registry for alzheimer's disease (cerad). |
1997-10-16 |
2023-08-12 |
Not clear |
| W K Scott, A M Saunders, P C Gaskell, P A Locke, J H Growdon, L A Farrer, S A Auerbach, A D Roses, J L Haines, M A Pericak-Vanc. Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease. Annals of neurology. vol 42. issue 3. 1997-10-16. PMID:9307262. |
we examined the association of apolipoprotein e (apoe) genotype and the risk of early-onset alzheimer's disease (ad) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. |
1997-10-16 |
2023-08-12 |
Not clear |
| G P Jarvi. Genetic predictors of common disease: apolipoprotein E genotype as a paradigm. Annals of epidemiology. vol 7. issue 5. 1997-10-09. PMID:9250631. |
genetic variation of a common genetic polymorphism at the structural locus for apolipoprotein e (apoe) has been associated with risk of elevated serum lipids, coronary artery disease, and alzheimer disease, all of which are multifactoral disorders and are inherited in a complex fashion. |
1997-10-09 |
2023-08-12 |
Not clear |
| A Császár, J Kálmán, C Szalai, Z Janka, L Romic. Association of the apolipoprotein A-IV codon 360 mutation in patients with Alzheimer's disease. Neuroscience letters. vol 230. issue 3. 1997-09-29. PMID:9272683. |
specific apolipoprotein e (apoe) alleles determines, in large part, the risk and mean age of onset familial and sporadic alzheimer disease. |
1997-09-29 |
2023-08-12 |
Not clear |
| B Nacmias, A Tedde, B M Guarnieri, C Petruzzi, L Ortenzi, A Serio, L Amaducci, S Sorb. Analysis of apolipoprotein E, alpha1-antichymotrypsin and presenilin-1 genes polymorphisms in dementia caused by normal pressure hydrocephalus in man. Neuroscience letters. vol 229. issue 3. 1997-09-24. PMID:9237487. |
apolipoprotein e (apoe) epsilon4 allele has been associated with severity of dementia in alzheimer's disease (ad) and in other forms of dementia. |
1997-09-24 |
2023-08-12 |
Not clear |
| E S O'Meara, W A Kukull, L Sheppard, J D Bowen, W C McCormick, L Teri, M Pfanschmidt, J D Thompson, G D Schellenberg, E B Larso. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype. American journal of epidemiology. vol 146. issue 5. 1997-09-24. PMID:9290497. |
head injury and apolipoprotein e (apoe)-epsilon 4 (e4) genotype have each been associated with increased risk of alzheimer's disease. |
1997-09-24 |
2023-08-12 |
human |
| M Lindh, M Blomberg, M Jensen, H Basun, L Lannfelt, B Engvall, H Scharnagel, W März, L O Wahlund, R F Cowbur. Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein. Neuroscience letters. vol 229. issue 2. 1997-09-16. PMID:9223597. |
cerebrospinal fluid apolipoprotein e (apoe) levels in alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein. |
1997-09-16 |
2023-08-12 |
Not clear |
| M Lindh, M Blomberg, M Jensen, H Basun, L Lannfelt, B Engvall, H Scharnagel, W März, L O Wahlund, R F Cowbur. Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein. Neuroscience letters. vol 229. issue 2. 1997-09-16. PMID:9223597. |
apolipoprotein e (apoe) levels were compared in cerebrospinal fluid (csf) taken on two occasions, with an average 15 months follow up, from groups of patients with alzheimer's disease (ad: n = 18), mild cognitive impairment (mci; n = 9) and other dementia disorders (odd; n = 9). |
1997-09-16 |
2023-08-12 |
Not clear |
| B Urmoneit, I Prikulis, G Wihl, D D'Urso, R Frank, J Heeren, U Beisiegel, R Prio. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy. Laboratory investigation; a journal of technical methods and pathology. vol 77. issue 2. 1997-09-11. PMID:9274858. |
cerebral amyloid angiopathy (caa) is caused by the cerebrovascular deposition of alzheimer amyloid beta protein (abeta) and shows an increased incidence in carriers of the apolipoprotein e (apoe) epsilon4 genotype. |
1997-09-11 |
2023-08-12 |
human |
| M Yamamoto, I Kondo, N Ogawa, M Asanuma, Y Yamashita, Y Mizun. Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism. Brain research. vol 759. issue 1. 1997-09-10. PMID:9219874. |
the apolipoprotein e (apoe*) gene is a major risk factor of developing alzheimer's disease (ad) and the alpha1-antichymotrypsin (act) polymorphism is likely to modify susceptibility of the apoe* gene for ad. |
1997-09-10 |
2023-08-12 |
Not clear |