| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
these results, which are the first evidence of apoe mrna localization to microglia in vivo and the control of apoe expression in brain cells by estrogens, are discussed in terms of the possible protective role of e2 in alzheimer's disease and prior findings that emphasize the expression of apoe mrna in astrocytes within the brain. |
1997-04-07 |
2023-08-12 |
rat |
| R A Srivastava, N Bhasin, N Srivastav. Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen. Biochemistry and molecular biology international. vol 38. issue 1. 1997-04-03. PMID:8932523. |
these studies demonstrate that estrogen regulates apoe gene expression in a tissue-specific manner in mice, and increases in apoe mrna in the brain by estrogen may have implications in late-onset of alzheimer's disease. |
1997-04-03 |
2023-08-12 |
mouse |
| T Pirttilä, H Soininen, P D Mehta, O Heinonen, T Lehtimäki, N Bogdanovic, L Paljärvi, K S Kim, O Kosunen, B Winblad, P Riekkinen, H M Wisniewsk. Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains. Neurobiology of aging. vol 18. issue 1. 1997-04-03. PMID:8983040. |
we investigated the effect of apolipoprotein e (apoe) genotype on amyloid load in the frontal and cerebellar cortices of 24 patients with definite alzheimer disease (ad) and 19 controls. |
1997-04-03 |
2023-08-12 |
Not clear |
| D Tsuang, M A Raskind, J Leverenz, E R Peskind, G Schellenberg, T D Bir. The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018389. |
the apolipoprotein e (apoe) epsilon 4 allele is associated with an increased and the epsilon 2 allele a decreased risk for alzheimer's disease (ad). |
1997-04-02 |
2023-08-12 |
Not clear |
| J L Holder, R A Habbak, G D Pearlson, E A Aylward, M Pulsifer, A C Warre. Reduced survival of apolipoprotein E4 homozygotes in Down's syndrome? Neuroreport. vol 7. issue 15-17. 1997-04-01. PMID:8981402. |
an increased frequency of apolipoprotein e (apoe) allele epsilon 4 has been established in alzheimer's disease (ad) subjects. |
1997-04-01 |
2023-08-12 |
human |
| T Saitoh, D Kang, M Mallory, R DeTeresa, E Maslia. Glial cells in Alzheimer's disease: preferential effect of APOE risk on scattered microglia. Gerontology. vol 43. issue 1-2. 1997-04-01. PMID:8996833. |
glial cells in alzheimer's disease: preferential effect of apoe risk on scattered microglia. |
1997-04-01 |
2023-08-12 |
Not clear |
| A Kurz, K Altland, N Lautenschlager, R Zimmer, R Busch, I Gerundt, H Lauter, U Mülle. Apolipoprotein E type 4 allele and Alzheimer's disease: effect on age at onset and relative risk in different age groups. Journal of neurology. vol 243. issue 6. 1997-03-28. PMID:8803817. |
the effect of the apolipoprotein e (apoe) genotype on the age at onset of alzheimer's disease (ad) and the relative risk conferred by the apoe epsilon 4 allele were studied in 91 patients and 69 healthy age-matched controls. |
1997-03-28 |
2023-08-12 |
human |
| J Bronzova, C M van Duijn, L M Havekes, P de Knijff, C Van Broeckhoven, A Hofma. Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. Journal of neurology. vol 243. issue 6. 1997-03-28. PMID:8803820. |
we have studied the relationship between the apolipoprotein e gene (apoe) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset alzheimer's disease (ad). |
1997-03-28 |
2023-08-12 |
Not clear |
| G K Gouras, N R Relkin, D Sweeney, D G Munoz, I R Mackenzie, S Gand. Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. Annals of neurology. vol 41. issue 3. 1997-03-28. PMID:9066363. |
inheritance of the apolipoprotein e (apoe) epsilon 4 allele is a risk factor for alzheimer's disease (ad) and is associated with increased deposition of beta-amyloid (a beta) in ad, down's syndrome, and normal aging. |
1997-03-28 |
2023-08-12 |
Not clear |
| T Pillot, M Goethals, B Vanloo, L Lins, R Brasseur, J Vandekerckhove, M Rossene. Specific modulation of the fusogenic properties of the Alzheimer beta-amyloid peptide by apolipoprotein E isoforms. European journal of biochemistry. vol 243. issue 3. 1997-03-26. PMID:9057828. |
in view of the epidemiologic and biochemical linkages between the pathology of alzheimer's disease and apolipoprotein e (apoe) polymorphism, we examined the potential interaction between the three common apoe isoforms and the c-terminal fragments of the amyloid peptide. |
1997-03-26 |
2023-08-12 |
Not clear |
| A J Slooter, M X Tang, C M van Duijn, Y Stern, A Ott, K Bell, M M Breteler, C Van Broeckhoven, T K Tatemichi, B Tycko, A Hofman, R Mayeu. Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. JAMA. vol 277. issue 10. 1997-03-19. PMID:9052712. |
to investigate the association between the apolipoprotein e (apoe) genotypes and dementia in patients with stroke, defined as either vascular dementia (vad) or alzheimer disease with cerebrovascular disease (ad with cvd). |
1997-03-19 |
2023-08-12 |
Not clear |
| F Bao, H Arai, S Matsushita, S Higuchi, H Sasak. Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain. Neuroreport. vol 7. issue 11. 1997-02-28. PMID:8905654. |
brains from 21 patients with alzheimer's disease (ad), nine with diffuse lewy body disease (dlbd), six with progressive supranuclear palsy (psp) and five with parkinson's disease (pd) as well as 20 normal subjects were examined to detect apolipoprotein e (apoe) by immunohistochemistry and immunoblotting. |
1997-02-28 |
2023-08-12 |
human |
| T A Treves, N M Bornstein, J Chapman, S Klimovitzki, R Verchovsky, A Asherov, I O Veshchev, A D Korczy. APOE-epsilon 4 in patients with Alzheimer disease and vascular dementia. Alzheimer disease and associated disorders. vol 10. issue 4. 1997-02-25. PMID:8939277. |
the apolipoprotein e (apoe) epsilon 4 allele has been consistently found to be frequent in patients with progressive degenerative dementia of the alzheimer type (dat). |
1997-02-25 |
2023-08-12 |
Not clear |
| M Narita, G Bu, D M Holtzman, A L Schwart. The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development. Journal of neurochemistry. vol 68. issue 2. 1997-02-21. PMID:9003044. |
the epsilon 4 allele of apolipoprotein e (apoe) is an important risk factor for alzheimer's disease. |
1997-02-21 |
2023-08-12 |
mouse |
| D S Yang, J D Smith, Z Zhou, S E Gandy, R N Martin. Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma. Journal of neurochemistry. vol 68. issue 2. 1997-02-21. PMID:9003062. |
the epsilon 4 allele of apolipoprotein e (apoe, protein; apoe, gene) is a major risk factor for alzheimer's disease (ad). |
1997-02-21 |
2023-08-12 |
human |
| P S Puttfarcken, A M Manelli, M T Falduto, G S Getz, M J LaD. Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures. Journal of neurochemistry. vol 68. issue 2. 1997-02-21. PMID:9003067. |
the correlation between the epsilon 4 allele of apolipoprotein e (apoe) and alzheimer's disease is well established. |
1997-02-21 |
2023-08-12 |
human |
| K Morgan, L Morgan, K Carpenter, J Lowe, L Lam, S Cave, J Xuereb, C Wischik, C Harrington, N A Kalsheke. Microsatellite polymorphism of the alpha 1-antichymotrypsin gene locus associated with sporadic Alzheimer's disease. Human genetics. vol 99. issue 1. 1997-02-20. PMID:9003488. |
a variant of the apolipoprotein e gene, apoe*4, is associated with both sporadic alzheimer's disease (ad) and a subset of familial ad and this association is stronger with early as opposed to late onset ad. |
1997-02-20 |
2023-08-12 |
Not clear |
| G Weng, D Feinstein, D Reis, C Wahlested. Neuropeptide Y receptor gene regulation in mouse adrenocortical Y-1 cells. Regulatory peptides. vol 63. issue 1. 1997-02-13. PMID:8795089. |
the role of apoe in such regulation is of particular interest in view of evidence that the isoform of the molecule is highly correlated to the age of onset of alzheimer's disease. |
1997-02-13 |
2023-08-12 |
mouse |
| G Weng, D Feinstein, D Reis, C Wahlested. Neuropeptide Y receptor gene regulation in mouse adrenocortical Y-1 cells. Regulatory peptides. vol 63. issue 1. 1997-02-13. PMID:8795089. |
the effect observed in the y-1 cell line which expresses apoe may implicate a possible role of this protein in the process of neuronal death that occurred in the alzheimer's disease. |
1997-02-13 |
2023-08-12 |
mouse |
| H Bickeböller, D Campion, A Brice, P Amouyel, D Hannequin, O Didierjean, C Penet, C Martin, J Pérez-Tur, A Michon, B Dubois, F Ledoze, C Thomas-Anterion, F Pasquier, M Puel, J F Demonet, O Moreaud, M C Babron, D Meulien, D Guez, M C Chartier-Harlin, T Frebourg, Y Agid, M Martinez, F Clerget-Darpou. Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. American journal of human genetics. vol 60. issue 2. 1997-02-13. PMID:9012418. |
the distribution of apolipoprotein e (apoe) genotypes as a function of age and sex has been examined in a french population of 417 alzheimer disease (ad) patients and 1,030 control subjects. |
1997-02-13 |
2023-08-12 |
human |