| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Egensperger, C Bancher, S Kösel, K Jellinger, P Mehraein, M B Graebe. The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions. Biochemical and biophysical research communications. vol 224. issue 2. 1996-08-30. PMID:8702415. |
we determined apoe allele frequencies in 35 subjects with neuropathologically confirmed lewy body parkinsonism with and without concomitant alzheimer lesions, 27 patients with alzheimer's disease (ad), and 54 controls without neurodegenerative disease. |
1996-08-30 |
2023-08-12 |
human |
| H Blain, A Merched, S Visvikis, M O'Kane, T Pillot, G Siest, C Jeande. [Alzheimer disease: hypotheses implicating apolipoproteins E]. Presse medicale (Paris, France : 1983). vol 25. issue 16. 1996-08-27. PMID:8692753. |
the most promising discovery in the study of alzheimer's disease (ad) markers is undoubtedly the implication of apolipoprotein e (apoe). |
1996-08-27 |
2023-08-12 |
human |
| B T Hyman, T Gomez-Isla, M Briggs, H Chung, S Nichols, F Kohout, R Wallac. Apolipoprotein E and cognitive change in an elderly population. Annals of neurology. vol 40. issue 1. 1996-08-21. PMID:8687193. |
the apolipoprotein e (apoe) epsilon 4 allele is overrepresented, and the apoe epsilon 2 allele underrepresented, in alzheimer's disease. |
1996-08-21 |
2023-08-12 |
Not clear |
| W Chan, J Fornwald, M Brawner, R Wetze. Native complex formation between apolipoprotein E isoforms and the Alzheimer's disease peptide A beta. Biochemistry. vol 35. issue 22. 1996-08-16. PMID:8679539. |
to explore whether the genetic linkage between apolipoprotein e (apoe) alleles and susceptibility to alzheimer's disease might be attributable to a direct molecular interaction between apoe and the amyloid peptide a beta, we have produced apoe variants in escherichia coli and studied their interactions with a beta under native conditions. |
1996-08-16 |
2023-08-12 |
cattle |
| A M Saunders, O Hulette, K A Welsh-Bohmer, D E Schmechel, B Crain, J R Burke, M J Alberts, W J Strittmatter, J C Breitner, C Rosenber. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet (London, England). vol 348. issue 9020. 1996-08-15. PMID:8676723. |
we aimed to determine the specificity, sensitivity, and predictive value of apolipoprotein e (apoe) genotyping in 67 consecutive patients with clinical diagnoses of sporadic alzheimer's disease (ad) who underwent necropsy. |
1996-08-15 |
2023-08-12 |
Not clear |
| J van der Weide, L S Steijns, J L Teepen, W J Noback, G Klaverwijde. [Apolipoprotein E polymorphism and Alzheimer disease]. Tijdschrift voor gerontologie en geriatrie. vol 27. issue 2. 1996-08-08. PMID:8669075. |
the epsilon 4 allele of the apoe gene may be considered as a biological risk factor for the development of alzheimer's disease. |
1996-08-08 |
2023-08-12 |
Not clear |
| M Lehtovirta, H Soininen, M P Laakso, K Partanen, S Helisalmi, A Mannermaa, M Ryynänen, J Kuikka, P Hartikainen, P J Riekkine. SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele. Journal of neurology, neurosurgery, and psychiatry. vol 60. issue 6. 1996-07-19. PMID:8648331. |
the epsilon 4 allele of apolipoprotein e (apoe) is a risk factor for late onset alzheimer's disease. |
1996-07-19 |
2023-08-12 |
Not clear |
| H Payami, S Zareparsi, K R Montee, G J Sexton, J A Kaye, T D Bird, C E Yu, E M Wijsman, L L Heston, M Litt, G D Schellenber. Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. American journal of human genetics. vol 58. issue 4. 1996-07-18. PMID:8644745. |
late-onset alzheimer disease (ad) is associated with the apolipoprotein e (apoe)-epsilon4 allele. |
1996-07-18 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City. American journal of human genetics. vol 58. issue 3. 1996-07-16. PMID:8644717. |
relative risk of alzheimer disease and age-at-onset distributions, based on apoe genotypes among elderly african americans, caucasians, and hispanics in new york city. |
1996-07-16 |
2023-08-12 |
Not clear |
| D Tsuang, W Kukull, L Sheppard, R L Barnhart, E Peskind, S D Edland, G Schellenberg, M Raskind, E B Larso. Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease samples. Journal of the American Geriatrics Society. vol 44. issue 6. 1996-07-12. PMID:8642164. |
impact of sample selection on apoe epsilon 4 allele frequency: a comparison of two alzheimer's disease samples. |
1996-07-12 |
2023-08-12 |
Not clear |
| D Tsuang, W Kukull, L Sheppard, R L Barnhart, E Peskind, S D Edland, G Schellenberg, M Raskind, E B Larso. Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease samples. Journal of the American Geriatrics Society. vol 44. issue 6. 1996-07-12. PMID:8642164. |
in a highly selected sample of unrelated alzheimer's disease (ad) patients, we found that the apoe epsilon 4 allele frequency was higher than previously reported. |
1996-07-12 |
2023-08-12 |
Not clear |
| A D Roses, G Einstein, J Gilbert, M Goedert, S H Han, D Huang, C Hulette, E Masliah, M A Pericak-Vance, A M Saunders, D E Schmechel, W J Strittmatter, K H Weisgraber, P T X. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Annals of the New York Academy of Sciences. vol 777. 1996-06-14. PMID:8624078. |
there are two distinct viewpoints on the association of the inheritance of apolipoprotein e (apoe) alleles and the age of onset distribution of alzheimer's disease (ad): genetic and phenotypic expression. |
1996-06-14 |
2023-08-12 |
mouse |
| S Sorbi, B Nacmias, P Forleo, S Piacentini, L Amaducc. Alzheimer's disease and apolipoprotein E in Italy. Annals of the New York Academy of Sciences. vol 777. 1996-06-14. PMID:8624095. |
recent studies have provided evidence of association of apolipoprotein e (apoe) epsilon 4 allele and late onset familial and sporadic alzheimer's disease (ad). |
1996-06-14 |
2023-08-12 |
human |
| R N Kalaria, D L Cohen, D R Premkuma. Apolipoprotein E alleles and brain vascular pathology in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 777. 1996-06-14. PMID:8624096. |
the presence of apolipoprotein e (apoe)-e4 allele has been implicated as a risk factor for alzheimer's disease (ad). |
1996-06-14 |
2023-08-12 |
Not clear |
| R H Myers, E J Schaefer, P W Wilson, R D'Agostino, J M Ordovas, A Espino, R Au, R F White, J E Knoefel, J L Cobb, K A McNulty, A Beiser, P A Wol. Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. Neurology. vol 46. issue 3. 1996-06-13. PMID:8618665. |
apolipoprotein e type 4 allele (apoe epsilon4) is associated with alzheimer's disease (ad) in the late-onset familial form and in sporadic cases, but the age-associated risk in a randomly sampled elderly population is not established. |
1996-06-13 |
2023-08-12 |
Not clear |
| R Blesa, R Adroer, P Santacruz, C Ascaso, E Tolosa, R Oliv. High apolipoprotein E epsilon 4 allele frequency in age-related memory decline. Annals of neurology. vol 39. issue 4. 1996-06-11. PMID:8619535. |
many studies have demonstrated a strong association between the presence of one or two epsilon 4 alleles and alzheimer's disease (ad), although few data are available on the apolipoprotein e (apoe) epsilon 4 frequencies at the preclinical stages of ad. |
1996-06-11 |
2023-08-12 |
Not clear |
| B H Bowman, L Jansen, F Yang, G S Adrian, M Zhao, S S Atherton, J M Buchanan, R Greene, C Walter, D C Herbert, F J Weaker, L K Chiodo, K Kagan-Hallet, J E Hixso. Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 26. 1996-06-07. PMID:8618855. |
the apoe alleles have been implicated in the expression of alzheimer disease, and the human apoe isoforms are reported to interact with different affinities to the brain beta-amyloid and tau protein in vitro. |
1996-06-07 |
2023-08-12 |
mouse |
| B H Bowman, L Jansen, F Yang, G S Adrian, M Zhao, S S Atherton, J M Buchanan, R Greene, C Walter, D C Herbert, F J Weaker, L K Chiodo, K Kagan-Hallet, J E Hixso. Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 26. 1996-06-07. PMID:8618855. |
the model may be used to characterize the interaction of human apoe isoforms with other brain proteins and provide information helpful in designing therapeutic strategies for alzheimer disease. |
1996-06-07 |
2023-08-12 |
mouse |
| V V Shuvaev, G Sies. Interaction between human amphipathic apolipoproteins and amyloid beta-peptide: surface plasmon resonance studies. FEBS letters. vol 383. issue 1-2. 1996-06-06. PMID:8612800. |
several apolipoproteins including apoe and apoa-i are known to be associated with amyloid beta-peptide, a major component of senile plaques in alzheimer's disease. |
1996-06-06 |
2023-08-12 |
human |
| J C Breitne. APOE genotyping and Alzheimer's disease. Lancet (London, England). vol 347. issue 9009. 1996-05-29. PMID:8609780. |
apoe genotyping and alzheimer's disease. |
1996-05-29 |
2023-08-12 |
Not clear |