| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M I Kamboh, D K Sanghera, R E Ferrell, S T DeKosk. APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Nature genetics. vol 10. issue 4. 1995-10-18. PMID:7670501. |
apoe*4-associated alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. |
1995-10-18 |
2023-08-12 |
Not clear |
| M I Kamboh, D K Sanghera, R E Ferrell, S T DeKosk. APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Nature genetics. vol 10. issue 4. 1995-10-18. PMID:7670501. |
genetic studies on alzheimer's disease (ad), a devastating neurodegenerative disorder, have identified the apolipoprotein e (apoe) gene as a strong susceptibility marker for ad. |
1995-10-18 |
2023-08-12 |
Not clear |
| M Tabaton, M Rolleri, P Masturzo, S Cammarata, G Angelini, L A Hansen, T Saitoh, R B Petersen, G Perry, P Riche. Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy. Neurology. vol 45. issue 9. 1995-10-17. PMID:7675243. |
this suggests that in alzheimer's disease the increased frequency of apoe epsilon 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition. |
1995-10-17 |
2023-08-12 |
Not clear |
| C Soto, E M Castaño, F Prelli, R A Kumar, M Bauman. Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, gelsolin and AA amyloids. FEBS letters. vol 371. issue 2. 1995-10-16. PMID:7672107. |
apolipoprotein e (apoe) has been found in association with several different types of systemic and cerebral amyloid deposits and the presence of the epsilon 4 allele constitutes a risk factor for alzheimer's disease. |
1995-10-16 |
2023-08-12 |
human |
| C Soto, E M Castaño, F Prelli, R A Kumar, M Bauman. Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, gelsolin and AA amyloids. FEBS letters. vol 371. issue 2. 1995-10-16. PMID:7672107. |
it has been shown that apoe binds and promotes the fibrillogenesis in vitro of alzheimer's amyloid beta-peptide, suggesting an important role for apoe in the modulation of amyloidogenesis. |
1995-10-16 |
2023-08-12 |
human |
| B O Osuntokun, A Sahota, A O Ogunniyi, O Gureje, O Baiyewu, A Adeyinka, S O Oluwole, O Komolafe, K S Hall, F W Unverzag. Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Annals of neurology. vol 38. issue 3. 1995-10-12. PMID:7668835. |
as part of a community-based study of alzheimer's disease (ad) in a nigerian population aged 65 years and over, we have determined apolipoprotein e (apoe) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with ad). |
1995-10-12 |
2023-08-12 |
human |
| S M Greenberg, G W Rebeck, J P Vonsattel, T Gomez-Isla, B T Hyma. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Annals of neurology. vol 38. issue 2. 1995-09-22. PMID:7654074. |
we tested whether the apolipoprotein e epsilon 4 (apoe epsilon 4) allele was associated with caa and hemorrhage and whether this association was independent of alzheimer's disease. |
1995-09-22 |
2023-08-12 |
Not clear |
| S M Greenberg, G W Rebeck, J P Vonsattel, T Gomez-Isla, B T Hyma. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Annals of neurology. vol 38. issue 2. 1995-09-22. PMID:7654074. |
the increase in caa remained even after controlling for the presence of alzheimer's disease, suggesting that apoe epsilon 4 is a risk factor for caa and caa-related hemorrhage, independent of its association with alzheimer's disease. |
1995-09-22 |
2023-08-12 |
Not clear |
| A R Templeto. A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus. Genetics. vol 140. issue 1. 1995-09-13. PMID:7635303. |
this analysis confirms earlier reports of a strong association of the apoe epsilon 4 allele with alzheimer's disease but indicates that it is premature to consider this association causal, particularly for early onset cases. |
1995-09-13 |
2023-08-12 |
Not clear |
| J C Breitner, K A Welsh, B A Gau, W M McDonald, D C Steffens, A M Saunders, K M Magruder, M J Helms, B L Plassman, M F Folstei. Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance. Archives of neurology. vol 52. issue 8. 1995-09-12. PMID:7639628. |
to detect cases of alzheimer's disease (ad) in a large population of twins living throughout the united states and to examine concordance for ad in twins as a function of age and genotype for apolipoprotein e (apoe). |
1995-09-12 |
2023-08-12 |
Not clear |
| M Z Kounnas, R D Moir, G W Rebeck, A I Bush, W S Argraves, R E Tanzi, B T Hyman, D K Stricklan. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. vol 82. issue 2. 1995-09-07. PMID:7543026. |
since lrp also binds apolipoprotein e (apoe)-enriched lipoproteins and inheritance of the epsilon 4 allele of the apoe gene is a risk factor for alzheimer's disease (ad), these data link in a single metabolic pathway two molecules strongly implicated in the pathophysiology of ad. |
1995-09-07 |
2023-08-12 |
Not clear |
| J Näslund, J Thyberg, L O Tjernberg, C Wernstedt, A R Karlström, N Bogdanovic, S E Gandy, L Lannfelt, L Terenius, C Nordsted. Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron. vol 15. issue 1. 1995-08-25. PMID:7619525. |
genetic evidence suggests a role for apolipoprotein e (apoe) in alzheimer's disease (ad) amyloidogenesis. |
1995-08-25 |
2023-08-12 |
Not clear |
| E H Corder, A M Saunders, W J Strittmatter, D E Schmechel, P C Gaskell, J B Rimmler, P A Locke, P M Conneally, K E Schmader, R E Tanz. Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. Neurology. vol 45. issue 7. 1995-08-24. PMID:7617191. |
the apolipoprotein e (apoe) epsilon 4 allele carries an increased risk of a patient developing alzheimer's disease (ad) while the epsilon 2 allele carries a decreased risk. |
1995-08-24 |
2023-08-12 |
human |
| E M Castaño, F Prelli, M Pras, B Frangion. Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L. Implications for amyloidogenesis and Alzheimer's disease. The Journal of biological chemistry. vol 270. issue 29. 1995-08-22. PMID:7615568. |
apolipoprotein e (apoe) immunoreactivity is consistently present in the senile plaques and neurofibrillary tangles of alzheimer's disease (ad) brain. |
1995-08-22 |
2023-08-12 |
human |
| S Sorbi, B Nacmias, P Forleo, S Piacentini, S Latorraca, L Amaducc. Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease. Annals of neurology. vol 38. issue 1. 1995-08-16. PMID:7611715. |
we found a new familial alzheimer's disease kindred in which the disease cosegregates with the app717val-->ile mutation and in which all of the three most common apolipoprotein e (apoe) alleles are represented. |
1995-08-16 |
2023-08-12 |
human |
| J A Schneider, M Gearing, R S Robbins, W de l'Aune, S S Mirr. Apolipoprotein E genotype in diverse neurodegenerative disorders. Annals of neurology. vol 38. issue 1. 1995-08-16. PMID:7611717. |
while the apolipoprotein e (apoe) epsilon 4 allele is a recognized risk factor for alzheimer's disease (ad), an association of epsilon 4 with other neurodegenerative diseases (nds) has not been extensively explored. |
1995-08-16 |
2023-08-12 |
Not clear |
| L Buée, B Permanne, J Pérez-Tur, M C Chartier-Harlin, A Delacourt. Alzheimer's disease: A beta or ApoE amyloidosis? Lancet (London, England). vol 346. issue 8966. 1995-08-04. PMID:7603172. |
alzheimer's disease: a beta or apoe amyloidosis? |
1995-08-04 |
2023-08-12 |
Not clear |
| W C Benzing, E J Mufso. Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to Tau and PHF in Alzheimer's disease. Experimental neurology. vol 132. issue 2. 1995-07-26. PMID:7540552. |
the present immunohistochemical study determined the relationship between apoe and the expression of the cytoskeletal protein tau (tau2) and paired helical filaments (phf), within the magnocellular neurons of the nucleus basalis of meynert and layer ii stellate neurons of the entorhinal cortex in alzheimer's disease (ad). |
1995-07-26 |
2023-08-12 |
human |
| G P Jarvik, E M Wijsman, W A Kukull, G D Schellenberg, C Yu, E B Larso. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. vol 45. issue 6. 1995-07-18. PMID:7783869. |
the joint effects of total cholesterol (tc) levels and the apoe genotype in alzheimer's disease (ad) were evaluated because of previous reports that the apoe locus epsilon 4 allele was associated with both late-onset ad and elevated tc. |
1995-07-18 |
2023-08-12 |
Not clear |
| H Soininen, O Kosunen, S Helisalmi, A Mannermaa, L Paljärvi, S Talasniemi, M Ryynänen, P Riekkine. A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele. Neuroscience letters. vol 187. issue 2. 1995-07-14. PMID:7783963. |
we measured the activities of choline acetyltransferase (chat) in the post mortem frontal cortex in 32 alzheimer's disease (ad) patients with different apolipoprotein e (apoe) genotypes. |
1995-07-14 |
2023-08-12 |
Not clear |