| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Lucotte, S Visvikis, B Leininger-Müler, F David, S Berriche, S Réveilleau, R Couderc, M C Babron, D Aguillon, G Sies. Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease. American journal of medical genetics. vol 54. issue 3. 1995-02-01. PMID:7810590. |
apolipoprotein e, type epsilon 4 allele (apoe epsilon 4), is associated with late-onset sporadic alzheimer's disease (ad) in french patients. |
1995-02-01 |
2023-08-12 |
Not clear |
| J Nalbantoglu, B M Gilfix, P Bertrand, Y Robitaille, S Gauthier, D S Rosenblatt, J Poirie. Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. Annals of neurology. vol 36. issue 6. 1995-01-19. PMID:7998776. |
apoliprotein e (apoe) is associated with alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. |
1995-01-19 |
2023-08-12 |
human |
| J Nalbantoglu, B M Gilfix, P Bertrand, Y Robitaille, S Gauthier, D S Rosenblatt, J Poirie. Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. Annals of neurology. vol 36. issue 6. 1995-01-19. PMID:7998776. |
recent studies have shown an increased frequency of the epsilon 4 allele of the apoe gene in familial and sporadic cases of alzheimer's disease (ad). |
1995-01-19 |
2023-08-12 |
human |
| T Reed, D Carmelli, G E Swan, J C Breitner, K A Welsh, G P Jarvik, S Deeb, J Auwer. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele. Archives of neurology. vol 51. issue 12. 1995-01-03. PMID:7986172. |
given the strong association of the apolipoprotein e (apoe) allele epsilon 4 with late-onset alzheimer dementia or multi-infarct dementia, we tested whether normal older adult men with at least one epsilon 4 allele demonstrate subclinical changes in cognition and perform more poorly on tests of cognitive function compared with subjects without the epsilon 4 allele. |
1995-01-03 |
2023-08-12 |
human |
| H L West, G W Rebeck, B T Hyma. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7970208. |
recent data have demonstrated genetic disequilibrium between inheritance of the apolipoprotein e (apoe) epsilon 4 allele and increased risk of alzheimer disease. |
1994-12-29 |
2023-08-12 |
Not clear |
| H L West, G W Rebeck, B T Hyma. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7970208. |
we tested the idea that inheritance of other allelic variations of apoe might also increase or decrease the risk of developing alzheimer disease. |
1994-12-29 |
2023-08-12 |
Not clear |
| H L West, G W Rebeck, B T Hyma. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7970208. |
we studied apoe genotypes in a large clinic based population of alzheimer disease patients and age-compatible, tested control individuals. |
1994-12-29 |
2023-08-12 |
Not clear |
| H L West, G W Rebeck, B T Hyma. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7970208. |
we confirm the genetic disequilibrium between apoe epsilon 4 and alzheimer disease and now report that inheritance of apoe epsilon 2, another common variant of the apolipoprotein e gene, is negatively associated with risk of developing alzheimer disease. |
1994-12-29 |
2023-08-12 |
Not clear |
| D St Clair, J Norrman, R Perry, C Yates, G Wilcock, A Brooke. Apolipoprotein E epsilon 4 allele frequency in patients with Lewy body dementia, Alzheimer's disease and age-matched controls. Neuroscience letters. vol 176. issue 1. 1994-12-29. PMID:7970234. |
genotypes of apolipoprotein e (apoe) were determined by polymerase-chain reaction (pcr) amplification and restriction-sizing of brain dna from 39 cases of lewy body dementia (lbd), 68 senile alzheimer's disease (ad) patients and 47 neuropathologically validated non-demented controls. |
1994-12-29 |
2023-08-12 |
Not clear |
| G B Frisoni, L Calabresi, C Geroldi, A Bianchetti, A L D'Acquarica, S Govoni, C R Sirtori, M Trabucchi, G Franceschin. Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia. Dementia (Basel, Switzerland). vol 5. issue 5. 1994-12-13. PMID:7951679. |
the frequency of the epsilon 4 allele of the apolipoprotein e (apoe) is increased in familial and sporadic late-onset alzheimer's disease, but its prevalence in non-alzheimer dementias in caucasian populations is unknown. |
1994-12-13 |
2023-08-12 |
Not clear |
| G B Frisoni, L Calabresi, C Geroldi, A Bianchetti, A L D'Acquarica, S Govoni, C R Sirtori, M Trabucchi, G Franceschin. Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia. Dementia (Basel, Switzerland). vol 5. issue 5. 1994-12-13. PMID:7951679. |
we found that the frequency of the apoe epsilon 4 allele was 0.45 in 93 alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the frontal type patients, and 0.18 in 51 elderly controls. |
1994-12-13 |
2023-08-12 |
Not clear |
| G B Frisoni, L Calabresi, C Geroldi, A Bianchetti, A L D'Acquarica, S Govoni, C R Sirtori, M Trabucchi, G Franceschin. Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia. Dementia (Basel, Switzerland). vol 5. issue 5. 1994-12-13. PMID:7951679. |
the association of apoe epsilon 4 allele is not unique to alzheimer's disease, and its importance as a risk factor for the disease should be reconsidered. |
1994-12-13 |
2023-08-12 |
Not clear |
| W J Strittmatter, A M Saunders, M Goedert, K H Weisgraber, L M Dong, R Jakes, D Y Huang, M Pericak-Vance, D Schmechel, A D Rose. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 23. 1994-12-12. PMID:7972031. |
the apolipoprotein e (apoe) type 4 allele (apoe4) is a susceptibility gene for late-onset familial and sporadic alzheimer disease. |
1994-12-12 |
2023-08-12 |
Not clear |
| W J Strittmatter, A M Saunders, M Goedert, K H Weisgraber, L M Dong, R Jakes, D Y Huang, M Pericak-Vance, D Schmechel, A D Rose. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 23. 1994-12-12. PMID:7972031. |
isoform-specific interactions of apoe with tau may regulate intraneuronal tau metabolism in alzheimer disease and alter the rate of formation of paired helical filaments and neurofibrillary tangles. |
1994-12-12 |
2023-08-12 |
Not clear |
| J Kawamata, S Tanaka, S Shimohama, K Ueda, J Kimur. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. Journal of neurology, neurosurgery, and psychiatry. vol 57. issue 11. 1994-12-08. PMID:7964823. |
to clarify the association of apoe polymorphism with alzheimer's disease and vascular dementia in japan, 13 patients with early onset (age > or = 65) sporadic alzheimer's disease, 40 patients with late onset (age < or = 65) sporadic alzheimer's disease, 19 patients with vascular dementia, and 49 non-demented control subjects were analysed. |
1994-12-08 |
2023-08-12 |
human |
| J Ma, A Yee, H B Brewer, S Das, H Potte. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. vol 372. issue 6501. 1994-11-29. PMID:7969426. |
the protease inhibitor alpha 1-antichymotrypsin and the lipid transport protein apolipoprotein e (apoe) are intimately associated with the 42-amino-acid beta-peptide (a beta) in the filamentous amyloid deposits of alzheimer's disease. |
1994-11-29 |
2023-08-12 |
Not clear |
| J Ma, A Yee, H B Brewer, S Das, H Potte. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. vol 372. issue 6501. 1994-11-29. PMID:7969426. |
addition of either alpha 1-anti-chymotrypsin or apoe to the a beta peptide promoted a 10- to 20-fold increase in filament formation, with apoe-4, the isoform recently linked to the development of late-onset alzheimer's disease, showing the highest catalytic activity. |
1994-11-29 |
2023-08-12 |
Not clear |
| D Galasko, T Saitoh, Y Xia, L J Thal, R Katzman, L R Hill, L Hanse. The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. Neurology. vol 44. issue 10. 1994-11-16. PMID:7936253. |
the frequency of the apoe epsilon 4 allele was 39.6% in alzheimer's disease (ad), 29.0% in the lewy body variant of ad (lbv), and 6.25% in diffuse lewy body disease. |
1994-11-16 |
2023-08-12 |
Not clear |
| E H Corder, A M Saunders, N J Risch, W J Strittmatter, D E Schmechel, P C Gaskell, J B Rimmler, P A Locke, P M Conneally, K E Schmade. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nature genetics. vol 7. issue 2. 1994-11-09. PMID:7920638. |
gene dosage of the apolipoprotein e (apoe) epsilon 4 allele is a major risk factor for familial alzheimer disease (ad) of late onset (after age 60). |
1994-11-09 |
2023-08-12 |
human |
| M Gearing, G W Rebeck, B T Hyman, J Tigges, S S Mirr. Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 20. 1994-10-27. PMID:7937774. |
senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein e (apoe) in the nonhuman primates, recapitulating findings in human aging and alzheimer disease. |
1994-10-27 |
2023-08-12 |
human |