| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Liu, Xin Li, Fang-Fei Li, Qiao-Hong Ou-Yang, Hong-Xia Zhang, Tao Fen. The predictive value of transcranial sonography in clinically diagnosed patients with early stage Parkinson's disease: comparison with DAT PET scans. Neuroscience letters. vol 582. 2015-05-26. PMID:25218716. |
dopamine transporter (dat) imaging is sensitive to detect presynaptic dopamine neuronal dysfunction, and has been studied as a diagnostic tool for degenerative parkinsonism. |
2015-05-26 |
2023-08-13 |
Not clear |
| M Moccia, S Pappatà, R Erro, M Picillo, C Vitale, M Amboni, K Longo, R Palladino, P Barone, Maria Teresa Pellecchi. Uric acid relates to dopamine transporter availability in Parkinson's disease. Acta neurologica Scandinavica. vol 131. issue 2. 2015-05-18. PMID:25288358. |
among them, both serum uric acid (ua) and dopamine transporter (dat) binding deserve more investigations. |
2015-05-18 |
2023-08-13 |
Not clear |
| P C Hsieh, K C Chen, T L Yeh, I H Lee, P S Chen, W J Yao, N-T Chiu, C-C Chen, M-H Liao, Y K Yan. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24439516. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depressive disorder (mdd) who are in a depressed state in comparison with healthy controls. |
2015-05-15 |
2023-08-12 |
human |
| Marie Bruun, Lena Elisabeth Hjermind, Carsten Thomsen, Else Danielsen, Lise Lykke Thomsen, Lars Hageman Pinborg, Nastaran Khabbazbavani, Joergen Erik Nielse. Familial hemiplegic migraine type 1 associated with parkinsonism: a case report. Case reports in neurology. vol 7. issue 1. 2015-05-13. PMID:25969684. |
dopamine transporter (dat) imaging with single-photon emission computed tomography demonstrated a decreased dat-binding potential in the putamen. |
2015-05-13 |
2023-08-13 |
Not clear |
| Gordana Nedic Erjavec, Korona Nenadic Sviglin, Matea Nikolac Perkovic, Dorotea Muck-Seler, Tanja Jovanovic, Nela Piva. Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes. Progress in neuro-psychopharmacology & biological psychiatry. vol 54. 2015-05-12. PMID:25035107. |
the present study aimed to evaluate the association of alcohol dependence and alcohol dependence-related phenotypes with platelet monoamine oxidase type b (mao-b) activity, val108/158met of catechol-o-methyltransferase (comt), variable number of tandem repeats (vntr) in the third exon of dopamine receptor d4 (drd4) gene, vntr in the 3'-untranslated region of dopamine transporter (dat) gene, -1021c/t of dopamine beta-hydroxylase (dbh) and mao-b intron 13 polymorphisms. |
2015-05-12 |
2023-08-13 |
human |
| Gesine Paul, Olof Zachrisson, Andrea Varrone, Per Almqvist, Markus Jerling, Göran Lind, Stig Rehncrona, Bengt Linderoth, Hjalmar Bjartmarz, Lisa L Shafer, Robert Coffey, Mikael Svensson, Katarina Jansson Mercer, Anton Forsberg, Christer Halldin, Per Svenningsson, Håkan Widner, Jonas Frisén, Sven Pålhagen, Anders Haegerstran. Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients. The Journal of clinical investigation. vol 125. issue 3. 2015-05-12. PMID:25689258. |
recombinant human pdgf-bb (rhpdgf-bb) reduces parkinsonian symptoms and increases dopamine transporter (dat) binding in several animal models of parkinson's disease (pd). |
2015-05-12 |
2023-08-13 |
human |
| S V Faraone, T J Spencer, B K Madras, Y Zhang-James, J Biederma. Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis. Molecular psychiatry. vol 19. issue 8. 2015-05-11. PMID:24061496. |
much psychiatric genetic research has focused on a 40-base pair variable number of tandem repeats (vntr) polymorphism located in the 3'-untranslated region (3'utr) of the dopamine active transporter (dat) gene (slc6a3). |
2015-05-11 |
2023-08-12 |
human |
| Penelope J Hallett, Oliver Cooper, Damaso Sadi, Harold Robertson, Ivar Mendez, Ole Isacso. Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell reports. vol 7. issue 6. 2015-04-16. PMID:24910427. |
dat was robustly expressed in transplanted dopamine neuron terminals in the reinnervated host putamen and caudate for at least 14 years after transplantation. |
2015-04-16 |
2023-08-13 |
human |
| Wei Hung Chang, I Hui Lee, Kao Chin Chen, Mei Hung Chi, Nan-Tsing Chiu, Wei Jen Yao, Ru-Band Lu, Yen Kuang Yang, Po See Che. Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits--a SPECT study. Psychoneuroendocrinology. vol 47. 2015-04-16. PMID:25001970. |
considering the dopamine transporter (dat) availability as an endophenotype and the degree of dopamine-mediated neuroticism as a phenotype of the oxtr genotypes, the current molecular imaging study used [(99m)tc]trodat-1 single photon emission computed tomography (spect) to measure the striatal dat availability and the 57-item maudsley personality inventory to measure neuroticism personality traits in healthy individuals to investigate (a) the correlation between the rs53576 (g/a) of oxtr and the striatal dat availability, (b) the correlation between the peripheral oxytocin level and striatal dat availability among different oxtr rs53576 (g/a) genotypes, and (c) whether neuroticism traits could be modified by oxytocin in certain oxtr rs53576 genotypes. |
2015-04-16 |
2023-08-13 |
Not clear |
| Tanya L Daigle, Mark J Ferris, Raul R Gainetdinov, Tatyana D Sotnikova, Nikhil M Urs, Sara R Jones, Marc G Caro. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 10. 2015-04-15. PMID:24776686. |
to elucidate the specific role of grk2 in the brain dopamine (da) system, we used a conditional gene knockout approach to selectively delete grk2 in da d1 receptor (d1r)-, da d2 receptor (d2r)-, adenosine 2a receptor (a2ar)-, or da transporter (dat)-expressing neurons. |
2015-04-15 |
2023-08-13 |
mouse |
| Laura M Vecchio, M Kristel Bermejo, Pieter Beerepoot, Amy J Ramsey, Ali Salahpou. N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24886986. |
the dopamine transporter (dat) is the primary protein responsible for the uptake of dopamine from the extracellular space back into presynaptic neurons. |
2015-04-15 |
2023-08-13 |
mouse |
| Marc A Mergy, Raajaram Gowrishankar, Paul J Gresch, Stephanie C Gantz, John Williams, Gwynne L Davis, C Austin Wheeler, Gregg D Stanwood, Maureen K Hahn, Randy D Blakel. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 44. 2015-04-14. PMID:25331903. |
despite the critical role of the presynaptic dopamine (da) transporter (dat, slc6a3) in da clearance and psychostimulant responses, evidence that dat dysfunction supports risk for mental illness is indirect. |
2015-04-14 |
2023-08-13 |
mouse |
| Sven R Suwijn, Caroline Jm van Boheemen, Rob J de Haan, Gerrit Tissingh, Jan Booij, Rob Ma de Bi. The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson's disease or clinically uncertain parkinsonism: a systematic review. EJNMMI research. vol 5. 2015-04-08. PMID:25853018. |
dopamine transporter single-photon emission computed tomography (dat spect) imaging might have the potential (high diagnostic accuracy and practical to use) to act as reference standard in detecting nigrostriatal cell loss in patients with (early stage) parkinsonism. |
2015-04-08 |
2023-08-13 |
Not clear |
| Yan Sun, Yan-Shu Li, Jun-Wei Yang, Jia Yu, Yan-Ping Wu, Bai-Xiang L. Exposure to atrazine during gestation and lactation periods: toxicity effects on dopaminergic neurons in offspring by downregulation of Nurr1 and VMAT2. International journal of molecular sciences. vol 15. issue 2. 2015-03-30. PMID:24552878. |
dopamine (da) content was examined in striatum samples by hplc-fl; the mrna expressions of tyrosine hydroxylase (th), orphan nuclear hormone (nurr1), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) in the ventral midbrain samples were examined by fluorescence pcr when the offspring reached one year of age. |
2015-03-30 |
2023-08-12 |
rat |
| Simon D Brandt, Michael H Baumann, John S Partilla, Pierce V Kavanagh, John D Power, Brian Talbot, Brendan Twamley, Olivia Mahony, John O'Brien, Simon P Elliott, Roland P Archer, Julian Patrick, Kuldip Singh, Nicola M Dempster, Simon H Cosbe. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni'). Drug testing and analysis. vol 6. issue 7-8. 2015-03-30. PMID:24841869. |
(±)-cis-4,4'-dmar was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine and serotonin with ec50 values of 8.6 ± 1.1 nm (dat), 26.9 ± 5.9 nm (net) and 18.5 ± 2.8 nm (sert), respectively. |
2015-03-30 |
2023-08-13 |
rat |
| Tang-Kai Yin, Bi-Fang Lee, Yen Kuang Yang, Nan-Tsing Chi. Differences of various region-of-interest methods for measuring dopamine transporter availability using 99mTc-TRODAT-1 SPECT. TheScientificWorldJournal. vol 2014. 2015-03-30. PMID:25101323. |
this study was to investigate whether various region-of-interest (roi) methods for measuring dopamine transporter (dat) availabilities by single photon emission computed tomography (spect) are statistically different, whether results of medical research are thereby influenced, and causes of these differences. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lieuwe Appel, My Jonasson, Torsten Danfors, Dag Nyholm, Håkan Askmark, Mark Lubberink, Jens Sörense. Use of 11C-PE2I PET in differential diagnosis of parkinsonian disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 2. 2015-03-30. PMID:25593112. |
a dual examination using (123)i-fp-cit ((123)i-n-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane, or (123)i-ioflupane) spect and(18)f-fdg pet provides complementary information on dopamine transporter (dat) availability and overall brain functional activity, respectively. |
2015-03-30 |
2023-08-13 |
Not clear |
| Philippe Huot, Susan H Fox, Jonathan M Brotchi. Monoamine reuptake inhibitors in Parkinson's disease. Parkinson's disease. vol 2015. 2015-03-26. PMID:25810948. |
despite wide discrepancy in the methodology of the studies reviewed, the following conclusions can be drawn: (1) selective serotonin transporter (sert), selective noradrenaline transporter (net), and dual sert/net inhibitors are effective against pd depression; (2) selective dopamine transporter (dat) and dual dat/net inhibitors exert an anti-parkinsonian effect when administered as monotherapy but do not enhance the anti-parkinsonian actions of l-3,4-dihydroxyphenylalanine (l-dopa); (3) dual dat/sert inhibitors might enhance the anti-parkinsonian actions of l-dopa without worsening dyskinesia; (4) triple dat/net/sert inhibitors might exert an anti-parkinsonian action as monotherapy and might enhance the anti-parkinsonian effects of l-dopa, though at the expense of worsening dyskinesia. |
2015-03-26 |
2023-08-13 |
Not clear |
| Grazia Giana, Emilia Romano, Maria Cristina Porfirio, Roberto D'Ambrosio, Silvia Giovinazzo, Miriam Troianiello, Eleonora Barlocci, Domenica Travaglini, Oleg Granstrem, Esterina Pascale, Luigi Tarani, Paolo Curatolo, Giovanni Laviola, Walter Adrian. Detection of auto-antibodies to DAT in the serum: interactions with DAT genotype and psycho-stimulant therapy for ADHD. Journal of neuroimmunology. vol 278. 2015-03-23. PMID:25468771. |
we evaluated the auto-antibodies against dopamine transporter (dat aabs) in 61 children (46 adhd who met dsm-iv-tr criteria, 15 healthy controls). |
2015-03-23 |
2023-08-13 |
Not clear |
| Iroise Dumontheil, Sarah K G Jensen, Nicholas W Wood, Meghan L Meyer, Matthew D Lieberman, Sarah-Jayne Blakemor. Preliminary investigation of the influence of dopamine regulating genes on social working memory. Social neuroscience. vol 9. issue 5. 2015-03-09. PMID:24889756. |
here, we investigated in 131 healthy adults whether dopamine is similarly involved in social wm by testing whether social and nonsocial wm are influenced by genetic variants in three genes coding for molecules regulating the availability of dopamine in the brain: catechol-o-methyltransferase (comt), dopamine active transporter (dat), and monoamine-oxidase a (maoa). |
2015-03-09 |
2023-08-13 |
Not clear |